{"id":2759,"date":"2017-08-12T11:10:18","date_gmt":"2017-08-12T11:10:18","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/2017\/08\/12\/klinicka-a-translacni-onkologie-proveditelnost-programu-hluboke-hypertermie-a-radioterapie-pokrocilych-nadoru-prvni-zkusenost-se-spanelstinou\/"},"modified":"2025-09-01T16:50:20","modified_gmt":"2025-09-01T16:50:20","slug":"klinicka-studie-hypertermie","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/cs\/klinicka-studie-hypertermie\/","title":{"rendered":"Klinick\u00e1 studie: P\u0159edb\u011b\u017en\u00e9 v\u00fdsledky chemoradiace s hypertermi\u00ed a brachyterapie s vysokou d\u00e1vkou u lok\u00e1ln\u011b pokro\u010dil\u00e9ho karcinomu d\u011blo\u017en\u00edho hrdla"},"content":{"rendered":"
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Klinick\u00e1 studie: P\u0159edb\u011b\u017en\u00e9 v\u00fdsledky chemoradiace s hypertermi\u00ed a brachyterapie s vysokou d\u00e1vkou u lok\u00e1ln\u011b pokro\u010dil\u00e9ho karcinomu d\u011blo\u017en\u00edho hrdla<\/span><\/span><\/a><\/h1>\n

Klinick\u00e1 studie Andromedic hypertermie – kongres Evropsk\u00e9 spole\u010dnosti pro hypertermickou onkologii 2014\u00a0<\/span><\/span><\/a><\/h2>\n

<\/h2>\n
\"Klinick\u00e1
P\u0159edb\u011b\u017en\u00e9 v\u00fdsledky chemoradiace s andromedicn\u00ed hypertermi\u00ed a brachyterapie s vysokou d\u00e1vkou u lok\u00e1ln\u011b pokro\u010dil\u00e9ho karcinomu d\u011blo\u017en\u00edho hrdla<\/span><\/span><\/figcaption><\/figure>\n

E. Clarke, V. De Sanctis, C. Scaringi, M. Valeriani, MF Osti, R. Maurizi Enrici Nemocnice Sant’Andrea, odd\u011blen\u00ed radioterapie, University of Rome ‚Sapienza‘, \u0158\u00edm. It\u00e1lie<\/span><\/span><\/p>\n

C\u00edle<\/span><\/span><\/strong> Zkoumat v\u00fdsledky chemoradioterapie s hypertermi\u00ed (HT) a brachyterapie s vysokou d\u00e1vkou (BRT) u lok\u00e1ln\u011b pokro\u010dil\u00e9ho karcinomu d\u011blo\u017en\u00edho hrdla (LACC). Zda je chemoradioterapie pova\u017eov\u00e1na za standardn\u00ed l\u00e9\u010dbu u LACC? P\u0159id\u00e1n\u00ed HT k radioterapii (RT) samotn\u00e9 prok\u00e1zalo zlep\u0161en\u00ed lok\u00e1ln\u00ed kontroly n\u00e1doru a celkov\u00e9ho p\u0159e\u017eit\u00ed bez ovlivn\u011bn\u00ed akutn\u00ed nebo pozdn\u00ed toxicity 3. a\u017e 4. stupn\u011b souvisej\u00edc\u00ed s l\u00e9\u010dbou u t\u00e9to skupiny pacientek.<\/span><\/span><\/p>\n

MATERI\u00c1LY A METODY<\/span><\/span><\/strong> Od ledna 2013 do prosince 2013 bylo do pilotn\u00ed studie kombinuj\u00edc\u00ed t\u00fddenn\u00ed cisplatinu a hormon\u00e1ln\u00ed terapii (HT) s radioterapi\u00ed s modulovanou intenzitou (IMRT) a n\u00e1slednou BRT (Business Retirement – biomedic\u00ednsk\u00e1 radioterapie). B\u011bhem 5,5 t\u00fddn\u016f byla pod\u00e1na d\u00e1vka 50,4 Gy do p\u00e1nevn\u00edch lymfatick\u00fdch uzlin se sou\u010dasn\u00fdm integrovan\u00fdm boostem (SIB) na hrub\u00fd objem n\u00e1doru (GTV) v celkov\u00e9 d\u00e1vce 61,8 Gy ve 28 frakc\u00edch. D\u00e1vka BRT \u010dinila 21 Gy ve 3 frakc\u00edch. Sou\u010dasn\u00fd chemoterapeutick\u00fd re\u017eim sest\u00e1val z t\u00fddenn\u00ed cisplatiny 4 mg\/mg\/m2 a HT byla pod\u00e1v\u00e1na jednou t\u00fddn\u011b.<\/span><\/span><\/p>\n

V\u00ddSLEDKY V\u0161ichni pacienti dos\u00e1hli lok\u00e1ln\u00ed kontroly. U jednoho pacienta do\u0161lo k recidiv\u011b mimo p\u00e1nev s posti\u017een\u00edm mnoha kost\u00ed a paraaort\u00e1ln\u00edch uzlin. Nebyla pozorov\u00e1na \u017e\u00e1dn\u00e1 akutn\u00ed ani pozdn\u00ed toxicita 3. a\u017e 4. stupn\u011b souvisej\u00edc\u00ed s l\u00e9\u010dbou.<\/span><\/span><\/strong><\/p>\n

Z\u00c1V\u011aRY Tento re\u017eim byl dob\u0159e sn\u00e1\u0161en s dobrou klinickou odpov\u011bd\u00ed. P\u0159id\u00e1n\u00ed HT k chemoradioterapii p\u0159edstavuje slibnou novou strategii.<\/span><\/span><\/strong> Pro potvrzen\u00ed jej\u00ed \u00fa\u010dinnosti je zapot\u0159eb\u00ed spolupr\u00e1ce v\u00edce instituc\u00ed a del\u0161\u00ed sledov\u00e1n\u00ed.<\/span><\/span><\/p>\n

BIBLIOGRAFIE<\/span><\/span><\/p>\n

1. Lutgens L. van der Zee J. Pijls-Johannesma M, De Haas-Kock DF, Buijsen J. Mastrigt GA. Lammering G. De Ruysscher DK. Lambin R Kombinovan\u00e9 pou\u017eit\u00ed hypertermie a radioterapie k l\u00e9\u010db\u011b lok\u00e1ln\u011b pokro\u010dil\u00e9ho karcinomu d\u011blo\u017en\u00edho hrdla. Cochrane Database Syst Rev. 2010 17. b\u0159ezna:(3):CD008377. doi:10.1002\/14851858.CD006377.pub3.<\/span><\/span><\/p>\n

2. van der Zee J. Gonzalez Gonzalez D. van Rhoon GC, van Dijk JD. van Pullen WL, Hart AA. Srovn\u00e1n\u00ed samotn\u00e9 radioterapie s radioterapi\u00ed a hypertermi\u00ed u lok\u00e1ln\u011b pokro\u010dil\u00fdch p\u00e1nevn\u00edch n\u00e1dor\u016f: prospektivn\u00ed, randomizovan\u00e1, multicentrick\u00e1 studie. Dutch Deep Hyperthemba Group. Lancet. 2000 Apr 1:355(9210):1119-25.<\/span><\/span><\/p>\n

3. Green J, Kirwan .1, Tremey J. Vale C. Symonds R Fresco L. Williams C. Collingwood M. Sou\u010dasn\u00e1 chemoterapie a radioterapie u rakoviny d\u011blo\u017en\u00edho \u010d\u00edpku. Cochrane Database Syst Rev. 20. \u010dervence 2005;(3):C0002225.<\/span><\/span><\/p>\n

 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Klinick\u00e1 studie: P\u0159edb\u011b\u017en\u00e9 v\u00fdsledky chemoradiace s hypertermi\u00ed a brachyterapie s vysokou d\u00e1vkou u lok\u00e1ln\u011b pokro\u010dil\u00e9ho karcinomu d\u011blo\u017en\u00edho hrdla Klinick\u00e1 studie Andromedic hypertermie – kongres Evropsk\u00e9 spole\u010dnosti pro hypertermickou onkologii 2014\u00a0 E. Clarke, V. De Sanctis, C. Scaringi, M. Valeriani, MF Osti, R. Maurizi Enrici Nemocnice Sant’Andrea, odd\u011blen\u00ed radioterapie, University of Rome ‚Sapienza‘, \u0158\u00edm. It\u00e1lie C\u00edle…<\/p>\n","protected":false},"author":1,"featured_media":7012,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[111],"tags":[152,154,153,151,150],"class_list":["post-2759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zpravy","tag-hypertermie","tag-lokalni-hypertermie","tag-meht-cs","tag-pokrocile-nadory","tag-radioterapie"],"gutentor_comment":74,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/posts\/2759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/comments?post=2759"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/posts\/2759\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/media\/7012"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/media?parent=2759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/categories?post=2759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/tags?post=2759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}