{"id":2768,"date":"2017-08-12T11:12:57","date_gmt":"2017-08-12T11:12:57","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/2017\/08\/12\/kvazi-studie-proveditelnosti-kontrola-pripadu-spojujici-lecbu-hlubokou-lokalni-hypertermii-se-standardni-lecbou-rakoviny-a-popisujici-vzorce-odpovedi-esho\/"},"modified":"2025-09-01T16:51:24","modified_gmt":"2025-09-01T16:51:24","slug":"klinicka-studie-hypertermie-2","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/cs\/klinicka-studie-hypertermie-2\/","title":{"rendered":"Kvazi-provediteln\u00e1 klinick\u00e1 studie spojuj\u00edc\u00ed l\u00e9\u010dbu hlubokou lok\u00e1ln\u00ed hypertermi\u00ed se standardn\u00ed l\u00e9\u010dbou rakoviny a popisuj\u00edc\u00ed vzorce reakce"},"content":{"rendered":"

Kvazi-provediteln\u00e1 klinick\u00e1 studie spojuj\u00edc\u00ed l\u00e9\u010dbu hlubokou lok\u00e1ln\u00ed hypertermi\u00ed se standardn\u00ed l\u00e9\u010dbou rakoviny a popisuj\u00edc\u00ed vzorce reakce<\/span><\/span><\/a><\/h1>\n

Klinick\u00e1 studie andromedick\u00e9 hypertermie – kongres Evropsk\u00e9 spole\u010dnosti pro hypertermickou onkologii 2014\u00a0<\/span><\/span><\/a><\/h2>\n
\"Klinick\u00e1
Kvazi studie proveditelnosti (p\u0159\u00edpadov\u00e1 kontrola) spojuj\u00edc\u00ed l\u00e9\u010dbu hlubokou lok\u00e1ln\u00ed hypertermi\u00ed HyDeep 600WM se standardn\u00ed l\u00e9\u010dbou rakoviny a popisuj\u00edc\u00ed vzorce odezvy<\/span><\/span><\/figcaption><\/figure>\n

Zaveden\u00ed:<\/span><\/span><\/strong><\/p>\n

Toto je prvn\u00ed klinick\u00e1 studie kombinuj\u00edc\u00ed hlubokou lok\u00e1ln\u00ed hypertermii se standardn\u00ed l\u00e9\u010dbou rakoviny ve \u0160pan\u011blsku a Andalusii.<\/span><\/span><\/p>\n

Materi\u00e1ly a metody:<\/span><\/span><\/strong><\/p>\n

C\u00edle:<\/span><\/span><\/strong><\/p>\n

Zaprv\u00e9:<\/span><\/span><\/strong> Analyzovat klinick\u00e9 p\u0159\u00ednosy, odpov\u011b\u010f na l\u00e9\u010dbu, proveditelnost l\u00e9\u010dby a pohodl\u00ed hypertermie v kombinaci se standardn\u00ed l\u00e9\u010dbou rakoviny v r\u00e1mci syst\u00e9mu ve\u0159ejn\u00e9ho zdravotnictv\u00ed. <\/span><\/span>
\nSekund\u00e1rn\u00ed:<\/span><\/span><\/strong> Analyzovat p\u0159e\u017eit\u00ed, kvalitu \u017eivota a toxicitu (obecn\u00e1 a specifick\u00e1 hypertermie u rakoviny).<\/span><\/span><\/p>\n

Design:<\/span><\/span><\/strong> Prospektivn\u00ed, kvaziexperiment\u00e1ln\u00ed studie p\u0159\u00edpad\u016f a kontrol, ve kter\u00e9 byla hypertermie (6\u201310 sezen\u00ed s frekvenc\u00ed 2\u20133 t\u00fddn\u011b) pod\u00e1v\u00e1na v kombinaci se standardn\u00ed radioterapi\u00ed (RT), chemoterapi\u00ed (CT) nebo kombinac\u00ed obou. Pacienti s prim\u00e1rn\u00edmi n\u00e1dory v 9 lokalizac\u00edch nebo metastatick\u00fdmi n\u00e1dory, l\u00e9\u010den\u00ed radik\u00e1ln\u00ed nebo kombinovanou l\u00e9\u010dbou, byli retrospektivn\u011b porovn\u00e1ni se dv\u011bma kontroln\u00edmi p\u0159\u00edpady l\u00e9\u010den\u00fdmi v p\u0159edchoz\u00edm roce.<\/span><\/span><\/p>\n

Dv\u011b f\u00e1ze:<\/span><\/span><\/strong> prvn\u00ed f\u00e1ze u\u010den\u00ed (20 pacient\u016f). Druh\u00e1 f\u00e1ze aktivn\u00ed l\u00e9\u010dby s 97 za\u0159azen\u00fdmi pacienty ve srovn\u00e1n\u00ed se 196 kontroln\u00edmi pacienty l\u00e9\u010den\u00fdmi radioterapi\u00ed nebo terapi\u00ed QT intervalu bez hypertermie v roce 2012 v obou nemocnic\u00edch (celkem 293 pacient\u016f).<\/span><\/span><\/p>\n

Dev\u011bt n\u00e1dorov\u00fdch lokalit:<\/span><\/span><\/strong><\/p>\n

\n
    \n
  • D\u011blo\u017en\u00ed \u010d\u00edpek, prostata, mo\u010dov\u00fd m\u011bch\u00fd\u0159<\/span><\/span><\/li>\n
  • Slinivka b\u0159i\u0161n\u00ed, neoperovateln\u00e1 hlava a krk<\/span><\/span><\/li>\n
  • Mozkov\u00e9 n\u00e1dory, p\u0159edopera\u010dn\u00ed rektum<\/span><\/span><\/li>\n
  • Neoperovateln\u00e1 neoadjuvantn\u00ed l\u00e9\u010dba pokro\u010dil\u00e9ho karcinomu prsu<\/span><\/span><\/li>\n
  • Nemalobun\u011b\u010dn\u00fd karcinom plic (NSCLC)<\/span><\/span><\/li>\n
  • Paliativn\u00ed l\u00e9\u010dba na r\u016fzn\u00fdch m\u00edstech<\/span><\/span><\/li>\n<\/ul>\n<\/blockquote>\n

    V\u00fdsledky:<\/span><\/span><\/strong><\/p>\n

    P\u0159edb\u011b\u017en\u00e9 \u00fadaje ze seznamu:<\/span><\/span><\/strong> 22 pacient\u016f (9 v nemocnici Juan Roman Jimenez a 13 v nemocnici Carlos Haya).<\/span><\/span><\/p>\n

    Pohlav\u00ed: 13 mu\u017e\u016f a 9 \u017een.<\/span><\/span><\/p>\n

    Pr\u016fm\u011brn\u00fd v\u011bk: 55 let (34\u201376 let).<\/span><\/span><\/p>\n

    Lokalizace n\u00e1doru: Glioblastom (2c), hlava a krk (7c), p\u0159edopera\u010dn\u00ed rektum (3c), prsa (3c1), pl\u00edce (11c), prostata (4c), d\u011blo\u017en\u00ed \u010d\u00edpek (lc), metast\u00e1zy do sakroiliak\u00e1ln\u00ed kosti.<\/span><\/span><\/p>\n

    L\u00e9\u010dba:<\/span><\/span><\/strong> Hypertermick\u00fd p\u0159\u00edstroj HyDeep 600WM (Andromedic) s 10 sezen\u00edmi, 2\u20133kr\u00e1t t\u00fddn\u011b, v d\u00e9lce 1 hodiny, s v\u00fdkonem 150 W a\u017e 400 W v z\u00e1vislosti na m\u00edst\u011b pou\u017eit\u00ed, standardn\u00ed onkologick\u00e1 l\u00e9\u010dba.<\/span><\/span><\/p>\n

    D\u016fvody pro ukon\u010den\u00ed l\u00e9\u010dby:<\/span><\/span><\/strong><\/p>\n

    Nemocnice Juana R. Jim\u00e9neze v Huelv\u011b: 3 p\u0159\u00edpady, infekce m\u00edsto l\u00e9\u010dby (celulitida u rakoviny kone\u010dn\u00edku), d\u011blo\u017en\u00ed krv\u00e1cen\u00ed (rakovina d\u011blo\u017en\u00edho \u010d\u00edpku) a dobrovoln\u00e9 ukon\u010den\u00ed l\u00e9\u010dby.<\/span><\/span><\/p>\n

    Nemocnice C Haya de Melaga: 2 pacienti, 1 v 6. sezen\u00ed, kter\u00fd o\u0161et\u0159en\u00ed dob\u0159e sn\u00e1\u0161el, a dal\u0161\u00ed v 6. sezen\u00ed, proto\u017ee do\u0161lo k dobr\u00e9mu pokroku.<\/span><\/span><\/p>\n

    V\u00fdsledek l\u00e9\u010dby pacient\u016f:<\/span><\/span><\/strong> 19 pacient\u016f \u017eije a \u010dek\u00e1 na vyhodnocen\u00ed odpov\u011bdi na l\u00e9\u010dbu. 3 pacienti zem\u0159eli v d\u016fsledku progrese onemocn\u011bn\u00ed (2 dost\u00e1vali v\u00fdhradn\u011b chemoterapii a hematopoezii (HT) v d\u016fsledku relapsu n\u00e1doru v d\u0159\u00edve oz\u00e1\u0159en\u00e9 oblasti hlavy a krku a dal\u0161\u00ed pacient s relapsem n\u00e1doru hltanu dost\u00e1val paliativn\u00ed radioterapii a hematopoezii).<\/span><\/span><\/p>\n

    Tolerance: 81,2 % pacient\u016f (18 b.) uvedlo, \u017ee jsou spokojeni nebo velmi spokojeni, a 18,8 % (4 b.) uvedlo, \u017ee jsou p\u0159ijateln\u00ed.<\/span><\/span><\/strong><\/p>\n

    Toxicita: P\u00e1l\u00edc\u00ed \u200b\u200btoxicita 1. stupn\u011b se vyskytla u 8 z 22 pacientek (36,3 %). U 66,6 % se nevyskytla \u017e\u00e1dn\u00e1 toxicita. Bolest\/pocit premixu v o\u0161et\u0159ovan\u00e9 oblasti, 1. stupn\u011b (v ulcerovan\u00e9m prsu), u jedn\u00e9 pacientky.<\/span><\/span><\/strong><\/p>\n

    Na\u0161e p\u0159edb\u011b\u017en\u00e9 zku\u0161enosti nazna\u010duj\u00ed proveditelnost l\u00e9\u010dby ve ve\u0159ejn\u00e9m nemocni\u010dn\u00edm prost\u0159ed\u00ed, v r\u00e1mci b\u011b\u017en\u00e9 rutinn\u00ed p\u00e9\u010de bez nutnosti mimo\u0159\u00e1dn\u00fdch zdroj\u016f a s vysokou toleranc\u00ed.<\/span><\/span><\/strong><\/p>\n

    Z\u00c1V\u011aRY: L\u00e9\u010dba je provediteln\u00e1 a pohodln\u00e1 pro 81,2 % na\u0161ich pacient\u016f v syst\u00e9mu ve\u0159ejn\u00e9ho zdravotnictv\u00ed, p\u0159i\u010dem\u017e m\u00edrn\u00e1 toxicita je u 33 % p\u0159ipisov\u00e1na l\u00e9\u010db\u011b hypertermi\u00ed. Vhodn\u00fd v\u00fdb\u011br pacient\u016f je kl\u00ed\u010dov\u00fd.<\/span><\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

    Kvazi-provediteln\u00e1 klinick\u00e1 studie spojuj\u00edc\u00ed l\u00e9\u010dbu hlubokou lok\u00e1ln\u00ed hypertermi\u00ed se standardn\u00ed l\u00e9\u010dbou rakoviny a popisuj\u00edc\u00ed vzorce reakce Klinick\u00e1 studie andromedick\u00e9 hypertermie – kongres Evropsk\u00e9 spole\u010dnosti pro hypertermickou onkologii 2014\u00a0 Zaveden\u00ed: Toto je prvn\u00ed klinick\u00e1 studie kombinuj\u00edc\u00ed hlubokou lok\u00e1ln\u00ed hypertermii se standardn\u00ed l\u00e9\u010dbou rakoviny ve \u0160pan\u011blsku a Andalusii. Materi\u00e1ly a metody: C\u00edle: Zaprv\u00e9: Analyzovat klinick\u00e9 p\u0159\u00ednosy, odpov\u011b\u010f…<\/p>\n","protected":false},"author":1,"featured_media":1935,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[879,111],"tags":[],"class_list":["post-2768","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-studii-clinice-cs","category-zpravy"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/posts\/2768","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/comments?post=2768"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/posts\/2768\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/media\/1935"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/media?parent=2768"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/categories?post=2768"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/cs\/wp-json\/wp\/v2\/tags?post=2768"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}