{"id":11190,"date":"2025-10-02T14:50:09","date_gmt":"2025-10-02T14:50:09","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/oncologic-hyperthermia-phase-3-trials\/"},"modified":"2025-10-03T09:35:55","modified_gmt":"2025-10-03T09:35:55","slug":"%ce%bc%ce%b5%ce%bb%ce%ad%cf%84%ce%b5%cf%82-%cf%86%ce%ac%cf%83%ce%b7%cf%82-iii-%ce%b3%ce%b9%ce%b1-%cf%85%cf%80%ce%b5%cf%81%ce%b8%ce%b5%cf%81%ce%bc%ce%af%ce%b1","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/el\/%ce%bc%ce%b5%ce%bb%ce%ad%cf%84%ce%b5%cf%82-%cf%86%ce%ac%cf%83%ce%b7%cf%82-iii-%ce%b3%ce%b9%ce%b1-%cf%85%cf%80%ce%b5%cf%81%ce%b8%ce%b5%cf%81%ce%bc%ce%af%ce%b1\/","title":{"rendered":"\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u0395\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03a3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u039a\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u0394\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ba\u03b1\u03b9 \u039c\u03b5\u03c4\u03b1-\u0391\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03c9\u03bd (\u03a4\u03b5\u03bb\u03b9\u03ba\u03ac \u03a3\u03b7\u03bc\u03b5\u03af\u03b1 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0391\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 (OS), \u0395\u03c0\u03b9\u03b2\u03bb\u03b1\u03b2\u03bf\u03cd\u03c2 \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 (DFS), \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03a0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 (CR))"},"content":{"rendered":"<p><script type=\"application\/ld+json\">\n    {\n      \"@context\": \"https:\/\/schema.org\",\n      \"@type\": \"MedicalScholarlyArticle\",\n      \"headline\": \"\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u0395\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03a3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u039a\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u0394\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ba\u03b1\u03b9 \u039c\u03b5\u03c4\u03b1-\u0391\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03c9\u03bd (\u03a4\u03b5\u03bb\u03b9\u03ba\u03ac \u03a3\u03b7\u03bc\u03b5\u03af\u03b1 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0391\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 (OS), \u0395\u03c0\u03b9\u03b2\u03bb\u03b1\u03b2\u03bf\u03cd\u03c2 \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 (DFS), \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03a0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 (CR))\",\n      \"author\": {\n        \"@type\": \"Person\",\n        \"name\": \"Gologan Cristian, M.Sc.\",\n        \"jobTitle\": \"CEO\",\n        \"affiliation\": {\n          \"@type\": \"MedicalOrganization\",\n          \"name\": \"Andromedichyperthermia Center\"\n        }\n      },\n      \"keywords\": \"\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1, \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u0394\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III, \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7, \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS), \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7, \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7, \u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (CR), \u03a3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1, \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2, E-E-A-T\"\n      \/* ... Schema FAQPage would be added separately for the FAQ section *\/\n    }\n<\/script><\/p>\n<div class=\"author-info\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03be\u03bf\u03c5\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 (EEAT): <\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c0\u03cc <\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/el\/doctor-veronica-iatan\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c4\u03b7\u03bd \u0394\u03c1. Veronica Iatan, MD<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , \u03ba\u03b1\u03b9 <\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/el\/cristian-gologan\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c4\u03bf\u03bd Cristian Gologan M.Sc.<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , \u0391\u03bd\u03b4\u03c1\u03bf\u03bc\u03b5\u03c4\u03b9\u03ba\u03ae \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1<\/span><\/span><\/strong><\/div>\n<h1><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u0395\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03a3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u039a\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u0394\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ba\u03b1\u03b9 \u039c\u03b5\u03c4\u03b1-\u0391\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03c9\u03bd (\u03a4\u03b5\u03bb\u03b9\u03ba\u03ac \u03a3\u03b7\u03bc\u03b5\u03af\u03b1 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0391\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 (OS), \u0395\u03c0\u03b9\u03b2\u03bb\u03b1\u03b2\u03bf\u03cd\u03c2 \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 (DFS), \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03a0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 (CR))<\/span><\/span><\/h1>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u0395\u03ba\u03c4\u03b5\u03bb\u03b5\u03c3\u03c4\u03b9\u03ba\u03ae \u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03b9 \u0392\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u0391\u03c1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (\u03a5\u03a0)<\/span><\/span><\/h2>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (\u039f\u03a5)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , \u03c0\u03bf\u03c5 \u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b7 \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b8\u03b5\u03c1\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">39\u00b0C \u03ad\u03c9\u03c2 45\u00b0C<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2, \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ( <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ), \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03b1\u03b6\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03ce\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd.<\/span><\/span><\/p>\n<div class=\"key-points\">\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b1\u03c3\u03b9\u03ba\u03ac \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 &#8211; \u0391\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391:<\/span><\/span><\/h3>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a1\u03cc\u03bb\u03bf\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03c5\u03b4\u03c1\u03bf\u03c7\u03bb\u03c9\u03c1\u03b9\u03ba\u03ae \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7 (HT) \u03b4\u03b5\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf\u00b7 \u03b4\u03c1\u03b1 \u03c9\u03c2 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c2 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> .<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03ba\u03b1\u03b9 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c3\u03c4\u03bf \u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (CR)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> .<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03cd\u03c1\u03b9\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03a3\u03b1\u03c1\u03ba\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2, \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03ba\u03b1\u03ba\u03cc\u03b7\u03b8\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd \u03ba\u03b1\u03b9 \u03cc\u03b3\u03ba\u03bf\u03b9 \u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 (HNC).<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ae \u03c3\u03bf\u03b2\u03b1\u03c1\u03ce\u03bd \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (\u0392\u03b1\u03b8\u03bc\u03bf\u03cd 3 \u03ae 4).<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03bf\u03c1\u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03b5\u03bd\u03b9\u03c3\u03c7\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03b5 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ac \u03c0\u03bf\u03bb\u03c5\u03c4\u03c1\u03bf\u03c0\u03b9\u03ba\u03ac \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2.<\/span><\/span><\/li>\n<\/ul>\n<\/div>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1. \u03a4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.1. \u03a4\u03bf\u03c0\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (LR HT)<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03cc \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b2\u03b1\u03b8\u03b9\u03ac \u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c0\u03c5\u03b5\u03bb\u03b9\u03ba\u03ce\u03bd, \u03b8\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd. \u039f\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c7\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c1\u03b1\u03b4\u03b9\u03bf\u03c3\u03c5\u03c7\u03bd\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd (RF) \u03ba\u03b1\u03b9 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03af\u03c7\u03b9\u03c3\u03b7 \u03ba\u03b5\u03c1\u03b1\u03af\u03b1\u03c2-\u03c3\u03c5\u03c3\u03c4\u03bf\u03b9\u03c7\u03af\u03b1\u03c2. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03c3\u03b5 \u03b2\u03ac\u03b8\u03bf\u03c2, \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b5\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5, \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03bf\u03c1\u03af\u03c9\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2. \u039f \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03bf \u03bf\u03bc\u03bf\u03b9\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 (\u03b9\u03c3\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae) \u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03ac\u03b6\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.2. \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 RF (mHT)<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 RF (mHT) \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ae \u03bc\u03b7 \u03b5\u03c0\u03b5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7. \u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ae \u03b9\u03c3\u03cc\u03b8\u03b5\u03c1\u03bc\u03b7 \u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7, \u03b7 mHT \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c7\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03c3\u03cd\u03b6\u03b5\u03c5\u03be\u03b7 \u03c3\u03b5 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c6\u03bf\u03c1\u03ad\u03b1 13,56 MHz, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c6\u03c1\u03b1\u03ba\u03c4\u03b1\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c5\u03bc\u03ac\u03bd\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5. \u0397 \u03b1\u03c1\u03c7\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c3\u03c4\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2. \u03a5\u03c8\u03b7\u03bb\u03ae \u03b4\u03b9\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c0\u03c1\u03bf\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b5\u03c2 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03bb\u03cc\u03b3\u03c9 \u03c4\u03c9\u03bd \u03b1\u03bb\u03bb\u03bf\u03b9\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03b9\u03ba\u03ce\u03bd \u03b9\u03b4\u03b9\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2), \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03b9\u03b1\u03ba\u03ae \u03ba\u03bb\u03af\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b4\u03bf\u03cd\u03c2. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u00ab\u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03bc\u03ad\u03c3\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03ad\u03be\u03c9\u00bb \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03bd\u03b4\u03bf\u03bf\u03b3\u03ba\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b9\u03c3\u03c4\u03cc, \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03ae \u03c7\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.3. \u0394\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b8\u03b5\u03c1\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03ad\u03c3\u03c9 \u03ba\u03b5\u03c1\u03b1\u03b9\u03ce\u03bd, \u03c1\u03ac\u03b2\u03b4\u03c9\u03bd \u03ae \u03c3\u03c0\u03cc\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03b9\u03c3\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03cc\u03b3\u03ba\u03c9\u03bd \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5 (\u03b3\u03bb\u03bf\u03b9\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd) \u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1\u03c2 \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.2. \u0393\u03b9\u03b1\u03c4\u03af \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c4\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b8\u03c5\u03c1\u03bf \u03c4\u03c9\u03bd 39-45\u00b0C; (\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a5\u03a4 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b5\u03af\u03bd\u03b1\u03b9 \u03ac\u03c1\u03c1\u03b7\u03ba\u03c4\u03b1 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b4\u03b5\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03c9\u03bd \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c4\u03b7\u03c2. \u0391\u03c5\u03c4\u03bf\u03af \u03bf\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c5\u03c0\u03b5\u03c1\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03c0\u03bb\u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae, \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03a5\u03a4 \u03c9\u03c2 \u03ad\u03bd\u03b1\u03bd <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c0\u03bf\u03bb\u03c5\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03c4\u03c9\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd *39-45\u00b0C* \u03b5\u03c0\u03b9\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bc\u03b5\u03b3\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf. \u0397 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf, \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (RT) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (CHT) \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc.<\/span><\/span><\/p>\n<hr \/>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2: \u03a0\u03ce\u03c2 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2;<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1\u03c2, \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.1. \u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7: \u03a5\u03c0\u03b5\u03c1\u03bd\u03af\u03ba\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 DNA<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03ad\u03bd\u03b1\u03c2 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2, \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b4\u03cd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b7\u03b3\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2:<\/span><\/span><\/p>\n<ol>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03c5\u03b4\u03c1\u03bf\u03c7\u03bb\u03c9\u03c1\u03b9\u03ba\u03ae \u03bf\u03c1\u03bc\u03cc\u03bd\u03b7 (HT) \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03c3\u03c4\u03b5\u03af \u03b2\u03bb\u03ac\u03b2\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1, \u03b5\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03bc\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f\u03be\u03c5\u03b3\u03cc\u03bd\u03c9\u03c3\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c1\u03bf\u03ae \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bf\u03be\u03c5\u03b3\u03cc\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5, \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03c5\u03c0\u03bf\u03be\u03b9\u03ba\u03cc (\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1) \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1.<\/span><\/span><\/li>\n<\/ol>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03c5\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03c4\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 *\u03c5\u03c8\u03b7\u03bb\u03ac \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (CR) \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03b8\u03b5\u03af \u03c3\u03b5 \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (CCRT+HT) \u03b3\u03b9\u03b1 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03bf \u03a4\u03bf\u03c0\u03b9\u03ba\u03ac \u03a0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2 (LACC) \u03ba\u03b1\u03b9 \u03bf\u03b9 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03b9 \u039a\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 (HNC)*.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2. \u03a7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7: \u0392\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03ba\u03af\u03bd\u03b7\u03c3\u03b7\u03c2 \u03bd\u03b1\u03c1\u03ba\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2.1. \u03a3\u03c5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03a0\u03c1\u03bf\u03c3\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5 \u0392\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 HT \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd. \u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1, \u03b7 HT \u03b4\u03c1\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b1 (\u03c3\u03b9\u03c3\u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b7, \u03ba\u03b1\u03c1\u03b2\u03bf\u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b7) \u03ba\u03b1\u03b9 \u03bc\u03b9\u03c4\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7 C. \u0391\u03c5\u03c4\u03bf\u03af \u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03b5 \u03ba\u03cd\u03c1\u03b9\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III, \u03cc\u03c0\u03c9\u03c2 \u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03cc\u03b3\u03ba\u03bf\u03b9 HNC, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7, \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1. \u0397 HT \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b4\u03bf\u03be\u03bf\u03c1\u03bf\u03c5\u03b2\u03b9\u03ba\u03af\u03bd\u03b7, \u03b7 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03c9\u03c3\u03c6\u03b1\u03bc\u03af\u03b4\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b3\u03b5\u03bc\u03c3\u03b9\u03c4\u03b1\u03b2\u03af\u03bd\u03b7.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2.2. \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u0395\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 HT \u03b2\u03b5\u03bb\u03c4\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c7\u03ae \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03af\u03bd\u03b7\u03c3\u03b7 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c3\u03b5 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03bc\u03c6\u03b1\u03b4\u03ad\u03bd\u03b5\u03c2 (LN). \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7\u03c2 (\u03c1\u03bf\u03ae\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2) \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd HT \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c0\u03b5\u03c1\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2. \u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 mHT, \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2, \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03c5\u03ba\u03bf\u03bb\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c8\u03b7\u03bb\u03ae \u03b4\u03b9\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.3. \u0391\u03bd\u03bf\u03c3\u03bf\u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7: \u039c\u03b5\u03c4\u03b1\u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03bd\u03cc\u03c2 \u00ab\u03a8\u03c5\u03c7\u03c1\u03bf\u03cd\u00bb \u038c\u03b3\u03ba\u03bf\u03c5 \u03c3\u03b5 \u00ab\u0398\u03b5\u03c1\u03bc\u03cc\u00bb (\u0391\u03bd\u03bf\u03c3\u03bf\u03b3\u03cc\u03bd\u03bf) \u038c\u03b3\u03ba\u03bf<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0388\u03bd\u03b1\u03c2 \u03bf\u03bb\u03bf\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 HT \u03bd\u03b1 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7, \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u00ab\u03c8\u03c5\u03c7\u03c1\u03bf\u03cd\u03c2\u00bb \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03c3\u03b5 \u00ab\u03b8\u03b5\u03c1\u03bc\u03bf\u03cd\u03c2\u00bb (\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2) \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 HT \u03b4\u03c1\u03b1 \u03c9\u03c2 \u00ab\u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03bf \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 in situ\u00bb \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03a0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u0398\u03b5\u03c1\u03bc\u03b9\u03ba\u03bf\u03cd \u03a3\u03bf\u03ba (HSPs) \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03cc\u03b3\u03ba\u03bf\u03c5. \u039f\u03b9 HSPs, \u03cc\u03c0\u03c9\u03c2 \u03b7 HSP70, \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c9\u03c2 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b5\u03c5\u03ba\u03bf\u03bb\u03cd\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (DCs). \u039c\u03cc\u03bb\u03b9\u03c2 \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03b5\u03c5\u03b8\u03bf\u03cd\u03bd, \u03c4\u03b1 DCs \u03bc\u03b5\u03c4\u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bb\u03b5\u03bc\u03c6\u03b1\u03b4\u03ad\u03bd\u03b5\u03c2 (LNs), \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ac CD8+ \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03cd\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c6\u03bf\u03bd\u03b5\u03af\u03c2 (NK) \u03ba\u03b1\u03b9 \u03c4\u03b1 CD8+ \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 HT \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03c3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03b7\u03c2 (CAMs), \u03b4\u03b9\u03b5\u03c5\u03ba\u03bf\u03bb\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1 \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2.<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1: \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/span><\/span><\/strong><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03a3\u03c4\u03cc\u03c7\u03bf\u03c5<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 (39\u00b0C &#8211; 45\u00b0C)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03a3\u03c5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03af \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA.<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 S <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0399\u03c3\u03c7\u03c5\u03c1\u03cc\u03c2 \u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2 (\u03a3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1 RT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (RT)<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf\u03c5<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c1\u03bf\u03ae \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bf\u03be\u03c5\u03b3\u03cc\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5, \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03c3\u03b7<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. \u0392\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03ba\u03af\u03bd\u03b7\u03c3\u03b7 \u03bd\u03b1\u03c1\u03ba\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd (\u03a7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2).<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RT, \u03a3\u03b9\u03c3\u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b7, \u039c\u03b9\u03c4\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7 C<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\/\u03b4\u03bf\u03bc\u03ae<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0386\u03bc\u03b5\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7.<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd;<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b9\u03c3\u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b7, \u039a\u03b1\u03c1\u03b2\u03bf\u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b7, \u0392\u03bb\u03b5\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03a3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 HSP, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 DC, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03a4 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b1\u03bd\u03bf\u03b4\u03b9\u03ba\u03ae \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03cd\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc NK\/CD8+ \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03bf\u03c3\u03bf\u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd\u00b7 \u0395\u03bd\u03b9\u03c3\u03c7\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c5\u03c0\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_11120\" aria-describedby=\"caption-attachment-11120\" style=\"width: 747px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11120\" src=\"https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie.jpg\" alt=\"\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2\" width=\"747\" height=\"412\" title=\"\" srcset=\"https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie.jpg 747w, https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie-300x165.jpg 300w\" sizes=\"auto, (max-width: 747px) 100vw, 747px\" \/><figcaption id=\"caption-attachment-11120\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2<\/span><\/span><\/figcaption><\/figure>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u03a3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u0391\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391: \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u039c\u03b5\u03c4\u03b1-\u0391\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03a3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1\u03c2 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III. <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b9\u03b1 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b3\u03b5\u03bd\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd.<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3.1. \u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b5\u03c1\u03b9\u03b5\u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b5 12 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III, \u03b5\u03bd\u03c4\u03cc\u03c0\u03b9\u03c3\u03b5 \u03ad\u03be\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03ad\u03be\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 \u0395\u03bd\u03b4\u03bf\u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03ae\u03c2 \u03a7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (HIPEC)[2]. \u0391\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2, \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03ad\u03be\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) \u03ae\/\u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (CR) \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ae\/\u03ba\u03b1\u03b9 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1[2]. \u0391\u03c5\u03c4\u03cc \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03ce\u03bd\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03bd\u03b1\u03af\u03bd\u03b5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c9\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b5\u03bd\u03b9\u03c3\u03c7\u03c5\u03c4\u03b9\u03ba\u03cc \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03bf\u03c0\u03bf-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ce\u03bd \u03b8\u03ad\u03c3\u03b5\u03c9\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd.<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3.2. \u03a0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b9\u03bc\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7: \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS), \u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (CR) \u03ba\u03b1\u03b9 \u03a4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03bf\u03c6\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 (HT) \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b9\u03bc\u03b1 \u03c3\u03b5 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b1 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1. \u03a4\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd *\u03a4\u03bf\u03c0\u03b9\u03ba\u03ac \u03a0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2 (LACC)* \u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd:<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (CR):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc CR \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 HT (\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 &#8211; *RR 0,56, 95% CI 0,39 \u03ad\u03c9\u03c2 0,79; **p &lt; 0,001*).<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03a4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 HT \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 (\u039b\u03cc\u03b3\u03bf\u03c2 \u039a\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 &#8211; *HR 0,48, 95% CI 0,37 \u03ad\u03c9\u03c2 0,63; **p &lt; 0,001*).<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03c0\u03bf\u03bb\u03c5\u03c4\u03c1\u03bf\u03c0\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 HT \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (HR *0,67, 95% CI 0,45 \u03ad\u03c9\u03c2 0,99; **p = 0,05*).<\/span><\/span><\/li>\n<\/ul>\n<h2><\/h2>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03c6\u03ac\u03c3\u03b7\u03c2 III \u03b1\u03bd\u03ac \u03c4\u03cd\u03c0\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03b9 \u03b5\u03ba\u03b5\u03af\u03bd\u03b5\u03c2 \u03c4\u03b9\u03c2 *\u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 (HT) \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5, \u03b5\u03c3\u03c4\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2*.<\/span><\/span><\/p>\n<h3><\/h3>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.1. \u03a3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd (STS)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (HT), \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III. \u039f\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (RHT) \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 *\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 HT \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (LPFS).* <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03bf\u03c5 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c3\u03b1\u03c1\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b9\u03bc\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b7 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 RHT \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03b1\u03c0\u03bf\u03ba\u03ac\u03bb\u03c5\u03c8\u03b5 \u03ad\u03bd\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc. \u0397 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03b5\u03b3\u03c7\u03b5\u03b9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 RHT \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03cc\u03c4\u03b9 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf, \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03ae\u03c4\u03b1\u03bd \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7\u03c2, \u03c3\u03b5 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03cc\u03b3\u03ba\u03bf. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1. \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03b4\u03b5\u03bd \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b7\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1, \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd HT \u03c9\u03c2 \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd\u03c4\u03b9\u03bc\u03bf \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03b4\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2.<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2. \u0393\u03c5\u03bd\u03b1\u03b9\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2: \u03a4\u03bf\u03c0\u03b9\u03ba\u03ac \u03a0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2 (LACC)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 (HT) \u03c3\u03c4\u03bf LACC, \u03c0\u03c1\u03bf\u03c3\u03c4\u03b9\u03b8\u03ad\u03bc\u03b5\u03bd\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (CCRT), \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c0\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.1. \u039f\u03bc\u03cc\u03c6\u03c9\u03bd\u03b7 \u03b3\u03bd\u03ce\u03bc\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae (CR \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae)<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac, \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c1\u03b9\u03c4\u03c1\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (CCRT + HT). <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b9\u03b1 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (CR) (RR 0,56; p &lt; 0,001) \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 (HR 0,48; p &lt; 0,001) \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c4\u03c1\u03b9\u03c4\u03c1\u03bf\u03c0\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b9\u03b1 \u03b5\u03c6\u03b9\u03ba\u03c4\u03ae \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7.<\/span><\/span><\/strong><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.2. \u03a0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS)<\/span><\/span><\/h4>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc CCRT \u03bc\u03b5 HT, \u03bc\u03b5 HR 0,67 (95% CI 0,45 \u03ad\u03c9\u03c2 0,99, p = 0,05).<\/span><\/span><\/strong><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03c9\u03bd \u03c4\u03c1\u03b5\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd, \u03bc\u03b9\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u0399\u03c4\u03b1\u03bb\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd RT +- HT \u03b3\u03b9\u03b1 \u03c0\u03bb\u03b1\u03ba\u03ce\u03b4\u03b5\u03b9\u03c2 \u03c4\u03c1\u03b1\u03c7\u03b7\u03bb\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bb\u03b5\u03bc\u03c6\u03b1\u03b4\u03ad\u03bd\u03b5\u03c2 N3 \u03b1\u03c0\u03cc \u03b5\u03ba\u03b5\u03af\u03bd\u03b7 \u03c4\u03b7\u03bd \u03b5\u03c0\u03bf\u03c7\u03ae \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03bc\u03b9\u03b1 \u03b5\u03bd\u03c4\u03c5\u03c0\u03c9\u03c3\u03b9\u03b1\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac: *\u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc CR \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ae\u03c4\u03b1\u03bd 82,3% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 36,8% \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03bc\u03cc\u03bd\u03bf \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1* [3,4]. \u039c\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b5 *5\u03b5\u03c4\u03ae \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 55% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 0% \u03c3\u03c4\u03bf \u03c3\u03ba\u03ad\u03bb\u03bf\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c3\u03ba\u03ad\u03bb\u03bf\u03c5\u03c2 \u03bc\u03cc\u03bd\u03bf \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1\u03c2* [3,4]. \u0391\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (\u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 RT) \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b1 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b1 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 (\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd CCRT), \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03bb\u03cd\u03c4\u03b9\u03bc\u03b1, \u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 HT, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03bb\u03b5\u03bc\u03c6\u03b1\u03b4\u03b5\u03bd\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03cc\u03b3\u03ba\u03bf\u03c5, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c5\u03c0\u03bf\u03be\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3. \u03a0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1 \u0391\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 (OS)<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03c9\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd *\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2*, \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (RT) \u03ae \u03a7\u03b7\u03bc\u03b5\u03b9\u03bf-\u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (CTRT) \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03bf\u03bb\u03c5\u03ac\u03c1\u03b9\u03b8\u03bc\u03b5\u03c2 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 (\u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2) \u03b5\u03be\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (RT \u03ae CTRT) \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (RT\/CTRT + \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1):<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u0394\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 + \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac (\u0391\u03bd\u03b1\u03b8\u03b5\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2)<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u0391\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 (CR)<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03b5\u03c0\u03ae\u03c2 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc CR: <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">+22,1%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bb\u03ae RT.<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2-\u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 (LRC)<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7: <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">+23,1%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bb\u03ae RT.<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS)<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) (HR 0,67; p = 0,03) \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2.<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7\u03c2 \u039d\u03cc\u03c3\u03bf\u03c5 (DFS)<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd DFS \u03c3\u03c4\u03b1 2 \u03ba\u03b1\u03b9 3 \u03ad\u03c4\u03b7 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 CTRT.<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 III<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bf\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9, \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5\u03c2:<\/span><\/span><\/p>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.1. \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7: CR, \u03a4\u03bf\u03c0\u03bf-\u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 (LRC) \u03ba\u03b1\u03b9 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) (Lutgens et al.)<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b8\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 (Cochrane Review) \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03ad\u03b8\u03b5\u03c3\u03b5 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd, \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2.<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u0394\u03b5\u03af\u03ba\u03c4\u03b5\u03c2<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b1\u03c3\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u0391\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 (CR)<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 (RR 0,56; p &lt; 0,001)<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2-\u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 (LRC)<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 (HR 0,48; p &lt; 0,001)<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS)<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 3 \u03ad\u03c4\u03b7 (HR 0,67; p = 0,05)<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03af\u03c4\u03bb\u03bf\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Lutgens L, van der Zee J, Pijls-Johannesma M, et al.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03bc\u03bf\u03c2 PubMed (\u0395\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 2010): <\/span><\/span><\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20091593\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/20091593\/<\/span><\/span><\/a><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.2. \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u0394\u03b9\u03ba\u03c4\u03cd\u03bf\u03c5 (NMA): \u0392\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b5\u03c2 \u03a3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 (Datta et al. 2019)<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf (Network Meta-Analysis) \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03bc\u03b5 13 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2, \u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03ac\u03c2 \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03ba\u03bf\u03c1\u03c5\u03c6\u03b1\u03af\u03c9\u03bd \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ce\u03bd.<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u0394\u03b5\u03af\u03ba\u03c4\u03b5\u03c2<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b1\u03c3\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c4\u03ac\u03c4\u03b1\u03be\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f\u03b9 RT+HT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03ba\u03b1\u03b9 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CTRT+HT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c4\u03c1\u03b9\u03ce\u03bd \u03ba\u03bf\u03c1\u03c5\u03c6\u03b1\u03af\u03c9\u03bd \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf LRC, \u03c4\u03b7\u03bd OS \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03af\u03c4\u03bb\u03bf\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd \u0394\u03b9\u03ac\u03c6\u03bf\u03c1\u03c9\u03bd \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u0395\u03c0\u03b9\u03bb\u03bf\u03b3\u03ce\u03bd \u03c3\u03c4\u03bf\u03bd \u03a4\u03bf\u03c0\u03b9\u03ba\u03ac \u03a0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2: \u039c\u03b9\u03b1 \u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u0391\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u039c\u03b5\u03c4\u03b1-\u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u0394\u03b9\u03ba\u03c4\u03cd\u03bf\u03c5 \u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u0394\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Datta NR, Stutz E, Gomez S, Bodis S.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03bc\u03bf\u03c2 PubMed: <\/span><\/span><\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30391522\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30391522\/<\/span><\/span><\/a><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.3. \u0394\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 III: \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7\u03c2 \u039d\u03cc\u03c3\u03bf\u03c5 (DFS) \u03ba\u03b1\u03b9 \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2 \u03bc\u03b5 mEHT<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03bf\u03c6\u03ad\u03bb\u03b7 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (DFS) \u03ba\u03b1\u03b9 \u03b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2 (QoL) \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (mEHT) \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ad\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7 \u03a7\u03b7\u03bc\u03b5\u03b9\u03bf-\u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (CTRT).<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u0394\u03b5\u03af\u03ba\u03c4\u03b5\u03c2<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b1\u03c3\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7\u03c2 \u039d\u03cc\u03c3\u03bf\u03c5 (DFS)<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (DFS) \u03c3\u03c4\u03b1 2 \u03ba\u03b1\u03b9 3 \u03ad\u03c4\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 mEHT \u03c3\u03c4\u03b7\u03bd CTRT.<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2 (\u03a0\u0396)<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03af\u03c4\u03bb\u03bf\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0395\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 \u0394\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf-\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (mEHT) \u03c3\u03c4\u03b7\u03bd \u0394\u03b9\u03b5\u03c4\u03ae \u03ba\u03b1\u03b9 \u03a4\u03c1\u03b9\u03b5\u03c4\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u0391\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a4\u03bf\u03c0\u03b9\u03ba\u03ac \u03a0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Minnaar CA, Maposa I, Kotzen JA, et al.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03bc\u03bf\u03c2 MDPI (\u0394\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf \u03c0\u03bb\u03ae\u03c1\u03b5\u03c2 \u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf): <\/span><\/span><\/strong> <a href=\"https:\/\/www.mdpi.com\/2072-6694\/14\/3\/656\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.mdpi.com\/2072-6694\/14\/3\/656<\/span><\/span><\/a><\/li>\n<\/ul>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2, \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03b5\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 (CR) \u03b1\u03bb\u03bb\u03ac \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03ba\u03c4\u03c5\u03c0\u03bf \u03c3\u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS \u03ba\u03b1\u03b9 DFS).<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.3. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03b9 \u039a\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 (\u039a\u039a\u03a4)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03cc\u03c0\u03bf\u03c5 \u03bf \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03bf \u03b1\u03bd\u03c4\u03af\u03ba\u03c4\u03c5\u03c0\u03bf \u03c3\u03c4\u03b7\u03bd \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b6\u03c9\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.3.1. \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 III<\/span><\/span><\/h4>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2, \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae \u03bf\u03c6\u03ad\u03bb\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (CRT) \u03bc\u03b5 HT \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03bc\u03cc\u03bd\u03bf CRT \u03c3\u03c4\u03bf \u03c1\u03b9\u03bd\u03bf\u03c6\u03b1\u03c1\u03c5\u03b3\u03b3\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 (NPC).<\/span><\/span><\/strong><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u25cf <\/span><\/span><strong><a href=\"https:\/\/doi.org\/10.7314\/apjcp.2013.14.12.7395\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Kang 2013<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (NPC):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03c5\u03c4\u03ae \u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7. <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 5\u03b5\u03c4\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03cc\u03c3\u03bf (DFS) \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc 25,5% \u03c3\u03b5 51,3% (p &lt; 0,005) \u03ba\u03b1\u03b9 \u03b7 5\u03b5\u03c4\u03ae\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc 50% \u03c3\u03b5 68,4% (p &lt; 0,005). \u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc 62,8% \u03c3\u03b5 81,6%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> . <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf <\/span><\/span><strong><a href=\"https:\/\/journals.lww.com\/cancerjournal\/fulltext\/2010\/06040\/hyperthermia_with_radiation_in_the_treatment_of.16.aspx\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Huilgol 2010<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (\u03a3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03bf\u03b9\u03bb\u03cc\u03c4\u03b7\u03c4\u03b1\/\u03a3\u03c4\u03bf\u03bc\u03b1\u03c4\u03bf\u03c6\u03ac\u03c1\u03c5\u03b3\u03b3\u03b1\u03c2\/\u03a5\u03c0\u03bf\u03c6\u03ac\u03c1\u03c5\u03b3\u03b3\u03b1\u03c2):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">42,4% \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u03bc\u03cc\u03bd\u03bf \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 78,6% \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b5 HT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> . \u0397 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03ae\u03c4\u03b1\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae (&lt; 0,05). \u0397 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 Kaplan-Meir \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2-HT. \u0394\u03b5\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b1\u03bd \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03b5\u03b3\u03ba\u03b1\u03cd\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03ae \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03ae \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03bf\u03c6\u03ad\u03bb\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (DFS) \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 (HNC), \u03cc\u03c0\u03bf\u03c5 \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c5\u03c8\u03b7\u03bb\u03ac, \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c5\u03c0\u03b5\u03c1\u03ae\u03c7\u03bf\u03c5\u03c2 (HT) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03bd\u03af\u03ba\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03ba\u03bf\u03c0\u03cc [5].<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03b9 \u03c4\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2: \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03c9\u03ba\u03c4\u03bf\u03cd<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (HT) \u03bc\u03b5 \u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (CRT) \u03c3\u03b5 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4.1. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae * <\/span><\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Ott 2019<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> * \u03c3\u03c5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b5 \u03c4\u03b7\u03bd CRT \u03bc\u03b5 \u03c4\u03b7\u03bd CRT + HT \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 5\u03b5\u03c4\u03b5\u03af\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03ba\u03ad\u03bb\u03bf\u03c2 HT: <\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS): 95,8% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 74,5% (P = 0,045). <\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7 \u039d\u03cc\u03c3\u03bf\u03c5 (DFS): 89,1% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 70,4% (P = 0,027). <\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7 \u03a4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 (LRFS): 97,7% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 78,7% (P = 0,006)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> .<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4.2. \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u0395\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (pCR) \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 HT, *\u03bc\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc 16% (CRT) \u03c3\u03b5 22,5% (CRT+HT, p = 0,043).* <\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc LRFS (97,7%) \u03ba\u03b1\u03b9 \u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03bf\u03bb\u03bf\u03c3\u03c4\u03bf\u03bc\u03af\u03b1 (87,7% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 69,0%, P = 0,016) \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c1\u03cc\u03bb\u03bf \u03c4\u03b7\u03c2 HT \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c3\u03c4\u03b5\u03af\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c6\u03b9\u03b3\u03ba\u03c4\u03ae\u03c1\u03b1.<\/span><\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.5. \u039a\u03b1\u03ba\u03cc\u03b7\u03b8\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 (\u03c4\u03bf\u03c0\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2)<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03a6\u03ac\u03c3\u03b7\u03c2 III ( <\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Overgaard et al., 1995<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ) \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) \u03c3\u03c4\u03bf \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1.<\/span><\/span><\/strong><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b1\u03c3\u03b9\u03ba\u03ac \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1: \u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 + \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/span><\/span><\/strong><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b5\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae \u03c0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b5 134 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b5\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03bc\u03b5\u03bb\u03b1\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03b5 70 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b5\u03af\u03c4\u03b5 \u03bc\u03cc\u03bd\u03bf \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03af\u03c4\u03b5 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (43\u00b0C \u03b3\u03b9\u03b1 60 \u03bb\u03b5\u03c0\u03c4\u03ac).<\/span><\/span><\/p>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u03a4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5 (\u03c0\u03c1\u03c9\u03c4\u03b5\u03cd\u03bf\u03bd \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf)<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03bf \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5.<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b5\u03bb\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03cc\u03bd\u03bf \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (RT)<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 + \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (RT + HT)<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03a4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03c4\u03b1 2 \u0388\u03c4\u03b7<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28%<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46%<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 (p = 0,008)<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 HT \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b5 \u03c4\u03bf\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac *18 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b5\u03c2 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2* \u03c3\u03c4\u03b1 2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1.<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u03a0\u03bf\u03bb\u03c5\u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 (\u03a0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03af \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2)<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c0\u03bf\u03bb\u03c5\u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c0\u03b1\u03bb\u03b9\u03bd\u03b4\u03c1\u03cc\u03bc\u03b7\u03c3\u03b7\u03c2 Cox \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b5 \u03cc\u03c4\u03b9 \u03b7 *\u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1* \u03ae\u03c4\u03b1\u03bd \u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c3\u03c4\u03b1 2 \u03ad\u03c4\u03b7.<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u039c\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03ae<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 (\u0394\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03a0\u03b9\u03b8\u03b1\u03bd\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd)<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b9\u03bc\u03ae P<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1,73<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (\u03b3\u03b9\u03b1 \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf)<\/span><\/span><\/td>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0,023<\/span><\/span><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03cc\u03c3\u03b7 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1\u03c2<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.17<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0,05<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0,91<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0,05<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03c5\u03c4\u03cc \u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03b5\u03be\u03af\u03c3\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5.<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (\u039f \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2)<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2:<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 5 \u03b5\u03c4\u03ce\u03bd:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03a4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03ae\u03c4\u03b1\u03bd 19%.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u03b5\u03c4\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 *38%*.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u039f \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ae\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bc\u03af\u03b1\u03c2 \u03ae \u03bb\u03af\u03b3\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03b5\u03af\u03c7\u03b5 *\u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03cc*, \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1.<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u03a4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1<\/span><\/span><\/h5>\n<ul>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03b8\u03b5\u03c1\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 *\u03b4\u03b5\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b9\u03c2 \u03bf\u03be\u03b5\u03af\u03b5\u03c2 \u03ae \u03cc\u03c8\u03b9\u03bc\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1\u03c2*.<\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac *\u03ba\u03b1\u03bb\u03ac \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae*.<\/span><\/span><\/li>\n<\/ul>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b7:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b5 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03bf\u03cd \u03c0\u03c1\u03c9\u03c4\u03bf\u03ba\u03cc\u03bb\u03bb\u03bf\u03c5 (43\u00b0C), \u03bc\u03b5 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf 14% \u03c4\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03bc\u03b5 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03bf\u03c3\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03ae\u03c4\u03b1\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03c0\u03c1\u03ce\u03c4\u03c9\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b7 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b4\u03b5\u03b9\u03b3\u03bc\u03ad\u03bd\u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b1\u03bd\u03bf\u03af\u03b3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c5\u03ba\u03b1\u03b9\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03bd\u03ad\u03bf\u03c5\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf-\u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2, \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 [4].<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6 \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.1. \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b5\u03bd\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III, \u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (CR) \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 + \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1) \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 *\u03c4\u03bf\u03c0\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03bf\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd (LRBC)*.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ce\u03bd *60-66% CR* \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1:<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b5\u03bb\u03ad\u03c4\u03b7: <\/span><\/span><\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03b5 \u03a4\u03bf\u03c0\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03bf\u03cd\u03c2 \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b5\u03c2 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u039c\u03b1\u03c3\u03c4\u03bf\u03cd: \u039c\u03b9\u03b1 \u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u0391\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7.<\/span><\/span><\/strong><\/a><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03b5\u03af\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Datta NR, Puric E, Klingbiel D, Gomez S, Bodis S.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c4\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf: <\/span><\/span><\/strong> <em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b9\u03b5\u03b8\u03bd\u03ad\u03c2 \u03a0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03cc \u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u03a6\u03c5\u03c3\u03b9\u03ba\u03ae\u03c2<\/span><\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> , 2016.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03b8\u03b5\u03c1\u03bc\u03bf\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (RT + \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1) \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (CR) \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 *22%* \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf. \u200b\u200b\u03a3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b1\u03bd \u03c4\u03b1 \u03b4\u03cd\u03bf \u03c3\u03ba\u03ad\u03bb\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (CR) *60,2%* \u03bc\u03b5 RT + \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (HT), \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 38,1% \u03bc\u03b5 RT (\u0391\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1) \u03bc\u03cc\u03bd\u03bf, \u03c6\u03c4\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc CR *66,6%* \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b5\u03c0\u03b1\u03bd\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1.<\/span><\/span><\/li>\n<\/ul>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.2 \u0398\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03ad\u03c7\u03b5\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c0\u03bf\u03bb\u03cd\u03c4\u03b9\u03bc\u03bf\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b8\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03bf\u03cd \u03c4\u03bf\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03cc\u03c0\u03bf\u03c5 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c5\u03c8\u03b7\u03bb\u03ac \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (CR), \u03c0\u03bf\u03c5 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 40% \u03ad\u03c9\u03c2 86%, \u03ba\u03b1\u03b9 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (LC) \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 70% \u03ba\u03b1\u03b9 76% \u03cc\u03c4\u03b1\u03bd \u03b7 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) \u03c3\u03b5 5 \u03ad\u03c4\u03b7 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c6\u03c4\u03ac\u03c3\u03bf\u03c5\u03bd \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 50% \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1 \u03bd\u03cc\u03c3\u03bf. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2+\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1\u03c2 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b7\u03b3\u03bf\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03b1\u03b9 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf, \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b9\u03ac\u03c3\u03c9\u03c3\u03b7\u03c2 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03ae \u03c1\u03b9\u03b6\u03b9\u03ba\u03ae \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.3. \u0393\u03b5\u03bd\u03b9\u03ba\u03ae \u03c4\u03ac\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 &#8211; \u0386\u03bb\u03bb\u03b5\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2:<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03bd\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0391\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd: <\/span><\/span><\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b9\u03b1 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ( <\/span><\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Hildenbrandt et al<\/span><\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ) \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 *5 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 6 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III* (\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u2013 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c4\u03b7\u03c2 \u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5, \u03c4\u03bf\u03c5 \u03bc\u03b5\u03bb\u03b1\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2) \u03ba\u03b1\u03c4\u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7 *\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS)* \u03ae\/\u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd *\u03a0\u03bb\u03ae\u03c1\u03b7 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (CR)* \u03cc\u03c4\u03b1\u03bd \u03b7 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ad\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b1\u03c1\u03b7\u03b3\u03bf\u03c1\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c2:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1, \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 *\u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03a0\u03cc\u03bd\u03bf* \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b5\u03c0\u03ce\u03b4\u03c5\u03bd\u03c9\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd, \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2 (\u03a0\u0396) \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<\/span><\/span><\/li>\n<\/ul>\n<h3><\/h3>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2: \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (HIVEC)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u0395\u03bd\u03b4\u03bf\u03ba\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03a7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (HIVEC) \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 43\u00b0C) \u03bc\u03b9\u03c4\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7\u03c2 C (MMC) \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03bd\u03c3\u03c4\u03ac\u03bb\u03b1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b7 \u03bc\u03c5\u03bf\u03b4\u03b9\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 (NMIBC) [6].<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7.1. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 III \u03c4\u03bf\u03c5 HIVEC-1<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 HIVEC-1, \u03bc\u03b9\u03b1 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 3, \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf \u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae (RFS) \u03bc\u03b5 \u03bd\u03bf\u03c1\u03bc\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae MMC \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 MMC (43\u00b0C \u03b3\u03b9\u03b1 30 \u03ae 60 \u03bb\u03b5\u03c0\u03c4\u03ac) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 NMIBC \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (IR-NMIBC) [6]. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03c1\u03c9\u03c4\u03b5\u03cd\u03bf\u03bd \u039a\u03b1\u03c4\u03b1\u03bb\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03a3\u03b7\u03bc\u03b5\u03af\u03bf (RFS): \u0397 RFS \u03c3\u03c4\u03bf\u03c5\u03c2 24 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03bc\u03b5 \u03a0\u03c1\u03cc\u03b8\u03b5\u03c3\u03b7 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (ITT) \u03ae\u03c4\u03b1\u03bd 77% \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (\u03bd\u03bf\u03c1\u03bc\u03bf\u03b8\u03b5\u03c1\u03bc\u03af\u03b1) \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 82% (HT 30 \u03bb\u03b5\u03c0\u03c4\u03ac) \u03ba\u03b1\u03b9 80% (HT 60 \u03bb\u03b5\u03c0\u03c4\u03ac). \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ba\u03b1\u03c4\u03ad\u03bb\u03b7\u03be\u03b5 \u03c3\u03c4\u03bf \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03cc\u03c4\u03b9 \u03b7 HT \u03b4\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03bd\u03bf\u03c1\u03bc\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae MMC \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd RFS \u03c3\u03c4\u03bf\u03c5\u03c2 24 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03bc\u03b5 \u03c4\u03b9\u03bc\u03ae p 0,6 [6]. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u0395\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7: \u0397 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03b1\u03bd\u03c9\u03c4\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd IR-NMIBC \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b5\u03c0\u03c9\u03c6\u03b5\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\/\u03c7\u03b7\u03bc\u03b9\u03ba\u03ae \u03c3\u03c5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03ae \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae (\u03c0.\u03c7., \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1) \u03ae\u03c4\u03b1\u03bd \u03bc\u03b7 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b1.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7.2. \u03a7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c7\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 RFS \u03b3\u03b9\u03b1 \u03c4\u03bf IR-NMIBC, \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1 \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03b5\u03ba\u03b5\u03af\u03bd\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03ad\u03c4\u03c5\u03c7\u03b1\u03bd \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 BCG. \u039c\u03b9\u03b1 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 *\u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03a7\u03c9\u03c1\u03af\u03c2 \u0395\u03be\u03ad\u03bb\u03b9\u03be\u03b7 (PFS) \u03b3\u03b9\u03b1 HIVEC \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 BCG (95,7% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 71,8%, p = 0,043) \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 ITT [7]*. \u039c\u03b9\u03b1 \u03ac\u03bb\u03bb\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b5\u03bd\u03ce \u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03bc\u03b5 HIVEC \u03c0\u03ad\u03c4\u03c5\u03c7\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc RFS 60% \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 1 \u03ad\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 92,4%, \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf BCG, \u03b7 \u03ba\u03c5\u03c3\u03c4\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf HIVEC \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bb\u03cd\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03cc\u03c3\u03bf\u03c5\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b9\u03bc\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 [8]. \u0391\u03c5\u03c4\u03cc \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 HT \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c3\u03c4\u03c1\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2 \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1.<\/span><\/span><\/strong><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2: \u0392\u03b1\u03c3\u03b9\u03ba\u03ac \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 (\u03a5\u03a0 + \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03a6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u039c\u03cc\u03bd\u03bf \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae\u03c2 \u03a6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1\u03c2)<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03cd\u03c0\u03bf\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 (\u03c4\u03c1\u03bf\u03c0\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 HT)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03cd\u03c0\u03bf\u03c2\/\u039a\u03b1\u03c4\u03b1\u03bb\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT + \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03a6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae\u03c2 \u03a6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1\u03c2<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03a3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\/\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03a4\u03b5\u03bb\u03b9\u03ba\u03bf\u03cd \u03a3\u03b7\u03bc\u03b5\u03af\u03bf\u03c5<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd (LR HT + CT) 11,3 \u03ad\u03c4\u03b7<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03a6\u03ac\u03c3\u03b7\u03c2 III (<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u03b5\u03c4\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">10\u03b5\u03c4\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">62,7%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">52,6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">51,3%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">42,7%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf, \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b5 \u03c4\u03b7\u03bd *\u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7 \u03bd\u03cc\u03c3\u03bf \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5* \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac (\u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 [HR], 0,65; 95% CI, 0,49-0,86; P = 0,002).<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c5\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b5\u03af\u03c7\u03b1\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac *\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 OS* \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03b5\u03ba\u03b5\u03af\u03bd\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf (HR, 0,73; 95% CI, 0,54-0,98; P = 0,04), \u03bc\u03b5 5\u03b5\u03c4\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 62,7% (95% CI, 55,2%-70,1%) \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 51,3% (95% CI, 43,7%-59,0%) \u03ba\u03b1\u03b9 10\u03b5\u03c4\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 52,6% (95% CI, 44,7%-60,6%) \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 42,7% (95% CI, 35,0%-50,4%) \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1.<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2 (LACC) (LR HT + RT) 12 \u03b5\u03c4\u03ce\u03bd<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a6\u03ac\u03c3\u03b7 III ( <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12\u03b5\u03c4\u03ae\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> )<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">20%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) (P &lt; 0,05)<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17881144\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17881144\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bf\u03c1\u03b8\u03bf\u03cd (CRT + HT) 5 \u03ad\u03c4\u03b7<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a6\u03ac\u03c3\u03b7 III \u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">( <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u03b5\u03c4\u03ae\u03c2 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b6\u03c9\u03ae\u03c2<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ,<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u03b5\u03c4\u03ae\u03c2 DFS<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u03b5\u03c4\u03ae\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae LRF<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03bf\u03bb\u03bf\u03c3\u03c4\u03bf\u03bc\u03af\u03b1 5 \u03b5\u03c4\u03ce\u03bd (CFSR)<\/span><\/span><\/p>\n<p>&nbsp;<\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">95,8%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">89,1<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">97,7<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">87,7<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">74,5%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">70,4%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">78,7%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69,0%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (P = 0,045)<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 DFS ( <\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0,027),<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf LRF ( <\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0,006),<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 CFSR ( <\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0,016))<\/span><\/span><\/p>\n<p>&nbsp;<\/td>\n<td width=\"104\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u039a\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 NPC (CRT + HT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a6\u03ac\u03c3\u03b7 III \u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 (5\u03b5\u03c4\u03ae\u03c2 DFS)<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03ba\u03b1\u03b9<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u03b5\u03c4\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03ba\u03b1\u03b9<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">51,3%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">68,4%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">81,6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">25,5%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">50%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">62,8%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7.<\/span><\/span><\/td>\n<td width=\"104\"><strong><a href=\"https:\/\/doi.org\/10.7314\/apjcp.2013.14.12.7395\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03bd\u03b3\u03ba 2013<\/span><\/span><\/a><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u039a\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u039a\u03bf\u03b9\u03bb\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2\/\u03a3\u03c4\u03bf\u03bc\u03b1\u03c4\u03bf\u03c6\u03ac\u03c1\u03c5\u03b3\u03b3\u03b1\/\u03a5\u03c0\u03bf\u03c6\u03ac\u03c1\u03c5\u03b3\u03b3\u03b1<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (RT + HT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a6\u03ac\u03c3\u03b7 III (CR)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">78,6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">42,4%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03ae\u03c4\u03b1\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae (&lt; 0,05). \u0397 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 Kaplan-Meir \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2-HT. \u0394\u03b5\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b1\u03bd \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03b5\u03b3\u03ba\u03b1\u03cd\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03ae \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03ae \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/span><\/span><\/td>\n<td width=\"104\"><strong><a href=\"https:\/\/journals.lww.com\/cancerjournal\/fulltext\/2010\/06040\/hyperthermia_with_radiation_in_the_treatment_of.16.aspx\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a7\u03bf\u03c5\u03b9\u03bb\u03b3\u03ba\u03cc\u03bb 2010<\/span><\/span><\/a><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03ba\u03cc\u03b7\u03b8\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 (RT + HT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a6\u03ac\u03c3\u03b7 III (CR)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd 2\u03b5\u03c4\u03ae \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf (p = 0,008)<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd (RT + HT) &#8211; \u0397 HT \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 NCCN<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a6\u03ac\u03c3\u03b7 III (CR)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">60,2%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">38,1%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc CR \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03c4\u03ac 57% \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NMI IR \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 (HIVEC-1)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a6\u03ac\u03c3\u03b7 III \u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 (RFS 24 \u03bc\u03b7\u03bd\u03ce\u03bd)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">80%-82%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">77%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03bc\u03af\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac (p = 0,6)<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 (WBH + RT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a6\u03ac\u03c3\u03b7 III (CR \u03b3\u03b9\u03b1 \u03a0\u03cc\u03bd\u03bf)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">47,4%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5,3%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 CR (P &lt; 0,05). \u039f \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03ad\u03c9\u03c2 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 10 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2.<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38460451\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38460451\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u039c\u03b5\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 (RF HT + RT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a6\u03ac\u03c3\u03b7 III (CR \u03b3\u03b9\u03b1 \u03a0\u03cc\u03bd\u03bf)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37,9%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">58,6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7,1%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">32,1%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (CR) \u03c3\u03c4\u03bf\u03c5\u03c2 3 \u03bc\u03ae\u03bd\u03b5\u03c2 (P = 0,006).<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 CR \u03b5\u03bd\u03c4\u03cc\u03c2 3 \u03bc\u03b7\u03bd\u03ce\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (P=0,045).<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29066122\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nihs.gov\/29066122\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div id=\"IDtable-wrap-foot\" class=\"NLM_table-wrap-foot\">\n<div id=\"TF4\">\n<p class=\"first last\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">mEHT: \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf-\u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u00b7 CT: \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u00b7 RT: \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u00b7 HT: \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u00b7 RITE: \u03b8\u03b5\u03c1\u03bc\u03bf\u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03c0\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c1\u03b1\u03b4\u03b9\u03bf\u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2\u00b7 HIPEC: \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03b5\u03bd\u03b4\u03bf\u03c0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u00b7 OS: \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u00b7 DFS: \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03cc\u03c3\u03bf\u00b7 CR: \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u00b7 LC: \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2\u00b7 PFS: \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5\u00b7 ST: \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2<\/span><\/span><\/span><\/p>\n<\/div>\n<\/div>\n<h2><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5. \u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03c3\u03b5 \u0395\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b5\u03c2 \u0391\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 (\u0391\u03bd\u03b1\u03b4\u03c5\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2)<\/span><\/span><\/strong><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03b5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03b1\u03bb\u03cd\u03b5\u03b9 \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b5\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd \u03cc\u03c0\u03bf\u03c5 \u03c4\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ae \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c0\u03bf\u03c5 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1\u03bd \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 (HT), \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 mHT.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.1. \u0393\u03bb\u03bf\u03b9\u03ce\u03bc\u03b1\u03c4\u03b1 (\u03a0\u03bf\u03bb\u03cd\u03bc\u03bf\u03c1\u03c6\u03bf \u0393\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1 &#8211; GBM \u03ba\u03b1\u03b9 \u0391\u03c3\u03c4\u03c1\u03bf\u03ba\u03cd\u03c4\u03c9\u03bc\u03b1 &#8211; AST)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b1 \u03b3\u03bb\u03bf\u03b9\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c4\u03bf \u03a0\u03bf\u03bb\u03cd\u03bc\u03bf\u03c1\u03c6\u03bf \u0393\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1 (GBM), \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u039c\u03b9\u03b1 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03ae \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b1\u03c0\u03cc \u03c4\u03bf 1998, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03b2\u03c1\u03b1\u03c7\u03c5\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b5\u03bd\u03b9\u03c3\u03c7\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 +- \u03b3\u03b9\u03b1 \u03c4\u03bf GBM, \u03ba\u03b1\u03c4\u03ad\u03b3\u03c1\u03b1\u03c8\u03b5 \u03ad\u03bd\u03b1 \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c3\u03ba\u03ad\u03bb\u03bf\u03c5\u03c2 [9].<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.1.1. \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc RF (mHT)<\/span><\/span><\/h4>\n<p><a href=\"https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b9\u03bf \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c4\u03cc\u03c3\u03bf \u03b7 mEHT \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03a0\u03b5\u03b4\u03af\u03b1 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u038c\u03b3\u03ba\u03c9\u03bd (TTF) \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b3\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1 [10]. \u03a4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c3\u03b5 \u03bd\u03b5\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, *\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 1 \u03ad\u03c4\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 mHT \u03b3\u03b9\u03b1 \u03bd\u03b5\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ae\u03c4\u03b1\u03bd 73% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 37% \u03c3\u03c4\u03bf \u03c3\u03ba\u03ad\u03bb\u03bf\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5* (p = 0,0021) [10]. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1 \u03bd\u03cc\u03c3\u03bf, *\u03bc\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b5 \u03cc\u03c4\u03b9 \u03b7 mHT \u03c0\u03c1\u03bf\u03c3\u03ad\u03c6\u03b5\u03c1\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 GBM 14 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 12 \u03bc\u03b7\u03bd\u03ce\u03bd, p=0,026). \u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c3\u03c4\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (AST), \u03b7 mHT \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2, \u03bc\u03b5 \u03bc\u03ad\u03c3\u03b7\/\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 OS 72\/91,6 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 17\/34 \u03bc\u03b7\u03bd\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c0\u03b1\u03c1\u03b7\u03b3\u03bf\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7\u03c2 (p=0,0006). \u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1 GBM, \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd mHT \u03b5\u03af\u03c7\u03b1\u03bd 5\u03b5\u03c4\u03ae \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 3,5% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 1,2% \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7\u03c2 [*11].<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03c3\u03b7\u03bc\u03ac\u03b4\u03b9\u03b1 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03c9\u03bd \u03b3\u03bb\u03bf\u03b9\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03c4\u03b1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 (HT) \u03c9\u03c2 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03c2.<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 (PC)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b8\u03b1\u03bd\u03b1\u03c4\u03b7\u03c6\u03cc\u03c1\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2, \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 (HT) \u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03c9\u03c2 \u00ab\u039a\u03bf\u03b9\u03bd\u03ae \u03a0\u03b1\u03c1\u03b7\u03b3\u03bf\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b7 (\u03b1\u03c0\u03cc \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 II)\u00bb. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2.1. \u03a3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 mEHT \u03c3\u03b5 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b9\u03b1 <\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37398545\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b1\u03bd\u03b1\u03b4\u03c1\u03bf\u03bc\u03b9\u03ba\u03ae, \u03c0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (N=217 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 III-IV) \u03c3\u03c5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b5 \u03c4\u03b7\u03bd mEHT + CHT (\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7 \u03b3\u03b5\u03bc\u03c3\u03b9\u03c4\u03b1\u03b2\u03af\u03bd\u03b7) \u03bc\u03b5 \u03bc\u03cc\u03bd\u03bf CHT. <\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS): \u0397 OS \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 mEHT (20 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 9 \u03bc\u03b7\u03bd\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 CHT, P &lt; 0,001). <\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03a7\u03c9\u03c1\u03af\u03c2 \u0395\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u039d\u03cc\u03c3\u03bf\u03c5 (PFS): \u0397 PFS \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac (7 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 5 \u03bc\u03b7\u03bd\u03ce\u03bd, P &lt; 0,05). <\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u038c\u03b3\u03ba\u03bf: \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 mEHT \u03ba\u03b1\u03c4\u03ad\u03b3\u03c1\u03b1\u03c8\u03b1\u03bd \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u039c\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (PR) (45% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 24%, P = 0,0018) \u03ba\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u0395\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u039d\u03cc\u03c3\u03bf\u03c5 (PD) (4% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 31%, P &lt; 0,01).<\/span><\/span><\/strong><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2.2. \u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03b1\u03bd\u03ac \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03b1\u03c0\u03bf\u03ba\u03ac\u03bb\u03c5\u03c8\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c4\u03c5\u03c7\u03ae: \u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03ad\u03c6\u03b5\u03c1\u03b5 \u03b7 \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 RF (mHT) \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ae\u03c4\u03b1\u03bd &lt;= 70 \u03b5\u03c4\u03ce\u03bd \u03ae &gt; 70 \u03b5\u03c4\u03ce\u03bd (\u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b5\u03af\u03c7\u03b1\u03bd \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) 20 \u03bc\u03b7\u03bd\u03ce\u03bd). \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03bf\u03b9 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03bc\u03cc\u03bd\u03bf CHT \u03b5\u03af\u03c7\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (8 \u03bc\u03ae\u03bd\u03b5\u03c2) \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 (12 \u03bc\u03ae\u03bd\u03b5\u03c2), \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 CHT \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1. *\u0391\u03c5\u03c4\u03cc \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 mHT \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae CHT, \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03bf\u03cd \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac\u03c2 \u03c4\u03b7\u03c2.* <\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 (\u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) \u03b1\u03c0\u03cc 9 \u03c3\u03b5 20 \u03bc\u03ae\u03bd\u03b5\u03c2) \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03b4\u03b9\u03b5\u03b8\u03bd\u03ce\u03bd \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III, \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 (\u03c0.\u03c7., NCT02862015, \u03a0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03bf\u03b3\u03ba\u03bf\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2).<\/span><\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6. \u03a0\u03c1\u03bf\u03c6\u03af\u03bb \u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2 (QALY): \u039f \u03a5\u03c8\u03b7\u03bb\u03cc\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u0394\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1\u03c2<\/span><\/span><\/h2>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f \u03a5\u03c8\u03b7\u03bb\u03cc\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u0394\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1\u03c2<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03b9\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03bf\u03cd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b4\u03b5\u03af\u03ba\u03c4\u03b7. *\u03a4\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03c4\u03c1\u03b9\u03c0\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03bf\u03c1\u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bb\u03b7\u03c1\u03bf\u03af \u03b1\u03c5\u03c4\u03ae\u03bd \u03c4\u03b7\u03bd \u03b1\u03c0\u03b1\u03af\u03c4\u03b7\u03c3\u03b7, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.*<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.1. \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b9\u03ba\u03ae\u03c2 \u03a4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (\u0392\u03b1\u03b8\u03bc\u03cc\u03c2 3\u20134)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 *\u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1* \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ae \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1:<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2 (LACC):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0394\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b1 \u03ae \u03cc\u03c8\u03b9\u03bc\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u0392\u03b1\u03b8\u03bc\u03bf\u03cd 3-4 (RR \u2248 1,0).<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03a4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ae\u03c4\u03b1\u03bd \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf. \u0394\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ae \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd 3-4.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 (mHT):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0394\u03b5\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae, \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/span><\/span><\/li>\n<\/ul>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.2. \u0391\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f\u03b9 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03b9\u03b1\u03c7\u03b5\u03b9\u03c1\u03af\u03c3\u03b9\u03bc\u03b5\u03c2: <\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u03a4\u03bf\u03c0\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (LR HT):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd 3-4 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 10% \u03ad\u03c9\u03c2 32% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03bf\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 (\u03ae\u03c0\u03b9\u03b1 \u03b5\u03b3\u03ba\u03b1\u03cd\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b4\u03c5\u03c3\u03c6\u03bf\u03c1\u03af\u03b1). <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 RF (mHT)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> : \u0397 mHT \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2. \u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2, \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 2,6% \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03b5\u03b4\u03c1\u03b9\u03ce\u03bd mHT, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd 1 \u03ae \u03b5\u03b3\u03ba\u03b1\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd 1-2 (1,1% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd) \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c7\u03ce\u03c1\u03b7\u03c3\u03b1\u03bd \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03bf\u03ba\u03b9\u03bc\u03ae HIVEC-1 (\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03ae\u03c4\u03b1\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03bf\u03bc\u03ac\u03b4\u03c9\u03bd (p = 0,5), \u03bf\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 (\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03c6\u03bf\u03c1\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c0\u03b1\u03c3\u03bc\u03bf\u03af) \u03ae\u03c4\u03b1\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c3\u03c4\u03bf \u03c3\u03ba\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (35%-48% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 33% \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5, p = 0,05), \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b1\u03c3\u03ae\u03bc\u03b1\u03bd\u03c4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.3. \u0395\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b1 \u0388\u03c4\u03b7 \u0396\u03c9\u03ae\u03c2 \u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03b7\u03bd \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 (QALY)<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03b4\u03cc\u03ba\u03b9\u03bc\u03bf\u03c5 \u03b6\u03c9\u03ae\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b6\u03c9\u03ae\u03c2, \u03b7 \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1 QALY (Quality-Adjusted Life Years &#8211; \u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03b7\u03bd \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0388\u03c4\u03b7 \u0396\u03c9\u03ae\u03c2) \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2. \u03a4\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03bf\u03c6\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (HT) &#8211; \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7, \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (CR) \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 &#8211; \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03c5\u03c8\u03b7\u03bb\u03ae \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7\u03c2 \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7\u03c2 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 QALY \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03b5\u03c0\u03b9\u03c7\u03b5\u03af\u03c1\u03b7\u03bc\u03b1 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03b9\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7\u03c2. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f \u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 3 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 3: \u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (\u0395\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 HT \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae\u03c2 \u03a6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1\u03c2)<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03cd\u03c0\u03bf\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 (HT + \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd 3-4<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf\u03c0\u03b9\u03ba\u03ac \u03a0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03cc\u03bd\u03bf CCRT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CCRT + LR HT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b1 \u03ae \u03cc\u03c8\u03b9\u03bc\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 (RR \\sim 1.0)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c5\u03bd\u03bf\u03ca\u03ba\u03cc\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2. \u039f\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9.<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bf\u03c1\u03b8\u03bf\u03cd\/\u03c0\u03c1\u03c9\u03ba\u03c4\u03bf\u03cd<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CRT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CRT + LR HT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u039a\u03b1\u03bc\u03af\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03ae \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2.<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (HT) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03c0\u03c5\u03b5\u03bb\u03b9\u03ba\u03ae\u03c2 CRT.<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 (EORTC)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CHT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b5\u03be\u03b9\u03ac + \u03a7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b4\u03b5\u03bd \u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c8\u03b7\u03bb\u03ae \u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u0397 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1.<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">NMI IR \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 (HIVEC-1)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039d\u03bf\u03c1\u03bc\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae MMC<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae MMC<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b5\u03bd \u03c5\u03c0\u03ae\u03c1\u03be\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b9\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 (p = 0,5)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b5\u03b9\u03bd\u03b5 \u03b1\u03bc\u03b5\u03c4\u03ac\u03b2\u03bb\u03b7\u03c4\u03b7.<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7. \u03a3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1, \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u0395\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u039c\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03c3\u03b5\u03b9\u03c2<\/span><\/span><\/h2>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.1. \u03a3\u03cd\u03bd\u03bf\u03c8\u03b7 \u039f\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03c9\u03bd \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b1\u03c5\u03c3\u03c4\u03b7\u03c1\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03ad\u03bd\u03b1 \u03b6\u03c9\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 \u03c0\u03bf\u03bb\u03c5\u03c4\u03c1\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd. <\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03ba\u03b1\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03b3\u03b9\u03b1 \u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7, \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03b1\u03c1\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd, \u03c4\u03bf\u03c5 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2, \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd \u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5, \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd\/\u03c0\u03c1\u03c9\u03ba\u03c4\u03bf\u03cd, \u03c4\u03bf\u03c5 \u03bc\u03b5\u03bb\u03b1\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 (\u03c4\u03bf\u03c0\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd [2].<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2, \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bf\u03bb\u03c5\u03c4\u03c1\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.2. \u03a7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc (HT) \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b8\u03ad\u03c1\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2. \u0397 \u03b1\u03be\u03b9\u03bf\u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ae\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03bf-\u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 HT \u03c3\u03b5 \u03b2\u03b1\u03b8\u03b9\u03bf\u03cd\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03b5\u03af\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 (\u03c0.\u03c7., LACC, HNC) \u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03bd\u03ac\u03bc\u03b5\u03b9\u03ba\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd HIVEC \u03c3\u03b5 NMIBC \u03bc\u03b5\u03c3\u03b1\u03af\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5. <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b8\u03b5\u03c1\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b1\u03c5\u03c3\u03c4\u03b7\u03c1\u03ae \u0394\u03b9\u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (QA) \u03ba\u03b1\u03b9 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b9\u03b1 \u03bf\u03bc\u03bf\u03b9\u03cc\u03bc\u03bf\u03c1\u03c6\u03b7 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7 \u03c3\u03b5 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03bf \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5. \u03a4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 HT \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b1\u03bd\u03ac \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf, \u03bc\u03b5 \u03c0\u03b9\u03bf \u03ad\u03bd\u03c4\u03bf\u03bd\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c2, \u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ae NMIBC \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf BCG.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3. \u03a5\u03c0\u03bf\u03c3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3.1. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd *\u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) (\u03b1\u03c0\u03cc 9 \u03c3\u03b5 20 \u03bc\u03ae\u03bd\u03b5\u03c2) \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 RF (mHT) + CHT \u03c3\u03b5 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03ad\u03bd\u03b1 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1.* \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b4\u03b9\u03b5\u03b8\u03bd\u03ce\u03bd \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III (\u03cc\u03c0\u03c9\u03c2 \u03b7 NCT02862015), \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03b8\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd.<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3.2. \u0395\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u0391\u03bd\u03bf\u03c3\u03bf-\u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2 (HT) \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u00ab\u03c8\u03c5\u03c7\u03c1\u03bf\u03cd\u03c2\u00bb \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03c3\u03b5 \u00ab\u03b8\u03b5\u03c1\u03bc\u03bf\u03cd\u03c2\u00bb (\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2) \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 HSP \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bf\u03b9 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 HT \u03bc\u03b5 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03bf\u03c5\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03c5\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2.<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 (EEAT):<\/span><\/span><\/strong><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c4\u03b7\u03bd Andromedichyperthermia, \u03bc\u03b5\u03bb\u03b5\u03c4\u03ac\u03bc\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 ( <\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/el\/%ce%ba%ce%bb%ce%b9%ce%bd%ce%b9%ce%ba%ce%ae-%ce%b4%ce%bf%ce%ba%ce%b9%ce%bc%ce%ae-%cf%85%cf%80%ce%b5%cf%81%ce%b8%ce%b5%cf%81%ce%bc%ce%af%ce%b1%cf%82\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03cc\u03c0\u03c9\u03c2 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 + CCRT + BRT \u03b3\u03b9\u03b1 LACC<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ) \u03c9\u03c2 \u03c4\u03bf \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1\u03c2, \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b4\u03b5\u03b9\u03b3\u03bc\u03ad\u03bd\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7 \u03c4\u03c9\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03c3\u03c4\u03b1 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c7\u03ad\u03b4\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b1\u03c2.<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.4. \u03a0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03a5\u03b9\u03bf\u03b8\u03ad\u03c4\u03b7\u03c3\u03b7<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ae\u03c2 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03c3\u03b5 \u03b9\u03b4\u03c1\u03cd\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b4\u03b9\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 (\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03ba\u03bf\u03af, \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03cc\u03b3\u03bf\u03b9, \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03ad\u03c2) \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c3\u03c4\u03b7\u03c1\u03ae \u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03ba\u03cc\u03bb\u03bb\u03c9\u03bd \u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b4\u03bf\u03c3\u03b9\u03bc\u03b5\u03c4\u03c1\u03af\u03b1\u03c2. \u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391, \u03c4\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03bf\u03c1\u03c6\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2.<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 4: \u0391\u03bd\u03b1\u03b4\u03c5\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03a6\u03ac\u03c3\u03b7\u03c2 II\/\u03a0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 (\u03a4\u03b5\u03bb\u03b9\u03ba\u03ac \u03a3\u03b7\u03bc\u03b5\u03af\u03b1 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2)<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03cd\u03c0\u03bf\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 (\u03c4\u03c1\u03bf\u03c0\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 HT)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03cd\u03c0\u03bf\u03c2\/\u039a\u03b1\u03c4\u03b1\u03bb\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT + \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03a6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 (OS\/PFS\/QoL)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03a6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u039c\u03cc\u03bd\u03bf (OS\/PFS\/QoL)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b1\u03c3\u03b9\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1\/\u03a4\u03b9\u03bc\u03ae P<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 (mEHT + CHT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03b4\u03c1\u03bf\u03bc\u03b9\u03ba\u03ae \u03a3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae (OS)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u0396\u03c9\u03ae\u03c2: 20 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u0396\u03c9\u03ae\u03c2: 9 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 (\u03a3\u039f) (\u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 77%)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[\u03a6\u03b9\u03bf\u03c1\u03b5\u03bd\u03c4\u03af\u03bd\u03b9 \u03ba.\u03ac., 2021]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039d\u03b5\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b3\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1 (mEHT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 (1 \u03ad\u03c4\u03bf\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">73%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (p=0,0021)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">( <\/span><\/span><a href=\"https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> )<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c3\u03c4\u03c1\u03bf\u03ba\u03cd\u03c4\u03c9\u03bc\u03b1 (mEHT)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03b4\u03c1\u03bf\u03bc\u03b9\u03ba\u03ae \u03a3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae (OS)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u0396\u03c9\u03ae\u03c2: 72 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0394\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u0396\u03c9\u03ae\u03c2: 17 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac (p=0,0006)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[\u03a6\u03b9\u03bf\u03c1\u03b5\u03bd\u03c4\u03af\u03bd\u03b9 \u03ba.\u03ac., 2019]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bf\u03c1\u03b8\u03bf\u03cd (pCR, \u039b\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c2)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a6\u03ac\u03c3\u03b7 III (\u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u039a\u03bf\u03bb\u03bf\u03c3\u03c4\u03bf\u03bc\u03af\u03b1)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">87,7%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69,0%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2\/\u039b\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 (P=0,016)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[\u03a6\u03ac\u03c3\u03b7 III, \u039f\u03ba\u03c4\u03ce\u03b2\u03c1\u03b9\u03bf\u03c2 2019]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2 (LACC)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 (DFS\/QoL)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03a3\u03c5\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\/\u03a3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae\/\u039c\u03b5\u03b9\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b6\u03c9\u03ae\u03c2 (QoL) \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8833695\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8833695\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b5\u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03ca\u03ba\u03ad\u03c2 \u039c\u03b5\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 (HIPEC)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u0391\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 (\u03a3\u03c5\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b1\u03bd\u03ac\u03c1\u03c1\u03c9\u03c3\u03b7 (3 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c1\u03b3\u03ae \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03bf \u03c8\u03c5\u03c7\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/dmr.amegroups.org\/article\/view\/6846\/html\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/dmr.amegroups.org\/article\/view\/6846\/html<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">8. \u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ) \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1<\/span><\/span><\/h2>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395: \u0395\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03bc\u03b9\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1;<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u038c\u03c7\u03b9. \u0397 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (\u03a5\u03a0) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b4\u03b5\u03b9\u03b3\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 *\u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391* (\u03b2\u03ac\u03c3\u03b5\u03b9 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03c9\u03bd) \u03b3\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2, \u03cc\u03c0\u03c9\u03c2: \u03a3\u03b1\u03c1\u03ba\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2, \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03ba\u03b1\u03ba\u03cc\u03b7\u03b8\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03b3\u03ba\u03bf\u03b9 \u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 (\u039a\u039a\u03a4).<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395: \u03a0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1;<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc *39\u00b0C \u03ad\u03c9\u03c2 45\u00b0C*. \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u00ab\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b8\u03c5\u03c1\u03bf\u00bb \u03b4\u03b5\u03bd \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae (\u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7), \u03b1\u03bb\u03bb\u03ac \u03bc\u03b5\u03b3\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395: \u0391\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c4\u03b7\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ae \u03c4\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2;<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 *\u03b4\u03b5\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 (\u0392\u03b1\u03b8\u03bc\u03cc\u03c2 3-4)*. \u039f\u03b9 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03c3\u03b9\u03bc\u03b5\u03c2 (\u03c0.\u03c7. \u03ae\u03c0\u03b9\u03b5\u03c2 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2).<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395: \u03a0\u03ce\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1;<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0397 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b4\u03c1\u03b1 \u03c9\u03c2 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03b4\u03cd\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd: *1)* \u0391\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03c3\u03c4\u03b5\u03af \u03b2\u03bb\u03ac\u03b2\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 *2)* \u0392\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c1\u03bf\u03ae \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03be\u03c5\u03b3\u03cc\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03c5\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1.<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395: \u03a0\u03bf\u03b9\u03bf\u03b9 \u03c4\u03cd\u03c0\u03bf\u03b9 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c9\u03c6\u03b5\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1;<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391, \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03bf\u03c6\u03ad\u03bb\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1: *\u03a3\u03b1\u03c1\u03ba\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2, \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03ba\u03b1\u03ba\u03cc\u03b7\u03b8\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03ba\u03b1\u03b9 HNC.*<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ad\u03c2 (\u03a4\u03bf \u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u03c0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9) <\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u0391\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4\u03c1\u03b5\u03c7\u03bf\u03c5\u03c3\u03ce\u03bd \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03a4\u03bf\u03c0\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03b9\u03ba\u03ae \u039c\u03ad\u03c4\u03c1\u03b9\u03b1 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03a3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u0394\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd, https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u03a0\u03bb\u03ae\u03c1\u03b5\u03c2 \u03ac\u03c1\u03b8\u03c1\u03bf: \u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c4\u03b1\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 &#8211; Taylor &amp; Francis Online, https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2022.2076292<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1, \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1: \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5. &#8211; Jefferson Digital Commons, https:\/\/jdc.jefferson.edu\/cgi\/viewcontent.cgi?article=1070&amp;context=radoncfp<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u03a0\u03bb\u03ae\u03c1\u03b5\u03c2 \u03ac\u03c1\u03b8\u03c1\u03bf: \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1: \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c5\u03ba\u03b1\u03b9\u03c1\u03af\u03b5\u03c2 &#8211; Taylor &amp; Francis Online, https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2019.1653499<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5. \u0397 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03b9\u03c3\u03b2\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c0\u03bf\u03bb\u03b5\u03bc\u03ac \u03c4\u03b7\u03bd \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf &#8211; PMC, https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11575926\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6. \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u039c\u03b9\u03c4\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7 C \u03c3\u03b5 \u03bc\u03b7 \u03bc\u03c5\u03bf\u03b5\u03c0\u03b5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5\u03c3\u03b1\u03af\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 &#8230;, https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7. \u0391\u03bd\u03b1\u03ba\u03c5\u03ba\u03bb\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03bc\u03b9\u03c4\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7 C (HIVEC) \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 BCG \u03c3\u03b5 \u03bc\u03b7 \u03bc\u03c5\u03bf\u03b4\u03b9\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8994727\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">8. \u03a0\u03bb\u03ae\u03c1\u03b5\u03c2 \u03ac\u03c1\u03b8\u03c1\u03bf: \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 HIVEC \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03b7 \u03bc\u03c5\u03bf\u03b4\u03b9\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 BCG \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 BCG &#8211; Taylor &amp; Francis Online, https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2021.2002435<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">9. \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c0\u03b5\u03b4\u03af\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd STAT3 &#8211; PubMed Central, https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8984886\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">10. \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf-\u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c0\u03b5\u03b4\u03af\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd &#8211; MDPI, https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">11. \u0394\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03cb\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u039f\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd \u039a\u03b1\u03ba\u03bf\u03ae\u03b8\u03b7 \u0393\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 \u0391\u03c3\u03c4\u03c1\u03bf\u03ba\u03cd\u03c4\u03c9\u03bc\u03b1: \u0391\u03bd\u03b1\u03b4\u03c1\u03bf\u03bc\u03b9\u03ba\u03ae \u03a0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u0395\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u039c\u03b5\u03bb\u03ad\u03c4\u03b7, \u0391\u03bd\u03b1\u03b4\u03c1\u03bf\u03bc\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03a3\u03c5\u03b3\u03b3\u03c1\u03b1\u03c6\u03ad\u03b1\u03c2:<\/span><\/span><\/p>\n<div class=\"entry-content\">\n<div class=\"container\">\n<div class=\"acf-fields \">\n<div class=\"publ-acf acf-row acf-flex\">\n<div class=\"szerzok\"><span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Fiorentini G <\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Sarti D <\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Milandri C <\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Dentico P <\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Mambrini A <\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Fiorentini C <\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Mattioli G <\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Casadei <\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Guadagni S<\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12. \u03a3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf-\u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 -; Kosin Medical Journal, https:\/\/www.kosinmedj.org\/journal\/view.php?number=1294<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u0395\u03be\u03bf\u03c5\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 (EEAT): \u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u0394\u03c1. Veronica Iatan, MD , \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd Cristian Gologan M.Sc. , \u0391\u03bd\u03b4\u03c1\u03bf\u03bc\u03b5\u03c4\u03b9\u03ba\u03ae \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u0395\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03a3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u039a\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u0394\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ba\u03b1\u03b9 \u039c\u03b5\u03c4\u03b1-\u0391\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03c9\u03bd (\u03a4\u03b5\u03bb\u03b9\u03ba\u03ac \u03a3\u03b7\u03bc\u03b5\u03af\u03b1 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0391\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 (OS), \u0395\u03c0\u03b9\u03b2\u03bb\u03b1\u03b2\u03bf\u03cd\u03c2 \u0394\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 (DFS), \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03a0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 (CR)) 1. \u0395\u03ba\u03c4\u03b5\u03bb\u03b5\u03c3\u03c4\u03b9\u03ba\u03ae \u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03b9 \u0392\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u0391\u03c1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (\u03a5\u03a0) \u0397 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[927,112,27],"tags":[397,398,403,396,401,400,402,399,147],"class_list":["post-11190","post","type-post","status-publish","format-standard","hentry","category-studii-clinice-el","category-112","category-27","tag---iii","tag-398","tag-403","tag-396","tag---cr","tag-400","tag-402","tag---os","tag-147"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/posts\/11190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/comments?post=11190"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/posts\/11190\/revisions"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/media?parent=11190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/categories?post=11190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/tags?post=11190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}