{"id":11299,"date":"2025-10-03T11:36:08","date_gmt":"2025-10-03T11:36:08","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/hyperthermia-survival-cancer-patients\/"},"modified":"2025-10-03T16:53:52","modified_gmt":"2025-10-03T16:53:52","slug":"%cf%85%cf%80%ce%b5%cf%81%ce%b8%ce%b5%cf%81%ce%bc%ce%af%ce%b1-%ce%b5%cf%80%ce%b9%ce%b2%ce%af%cf%89%cf%83%ce%b7-%ce%b1%cf%83%ce%b8%ce%b5%ce%bd%ce%b5%ce%af%cf%82","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/el\/%cf%85%cf%80%ce%b5%cf%81%ce%b8%ce%b5%cf%81%ce%bc%ce%af%ce%b1-%ce%b5%cf%80%ce%b9%ce%b2%ce%af%cf%89%cf%83%ce%b7-%ce%b1%cf%83%ce%b8%ce%b5%ce%bd%ce%b5%ce%af%cf%82\/","title":{"rendered":"\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2: \u03a4\u03b1 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) \u03ba\u03b1\u03c4\u03ac \u03a0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 50%"},"content":{"rendered":"<p><script type=\"application\/ld+json\">\n    {\n      \"@context\": \"https:\/\/schema.org\",\n      \"@type\": \"MedicalScholarlyArticle\",\n      \"headline\": \"\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2: \u03a4\u03b1 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) \u03ba\u03b1\u03c4\u03ac \u03a0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 50%\",\n      \"author\": {\n        \"@type\": \"Person\",\n        \"name\": \"Gologan Cristian, M.Sc.\",\n        \"jobTitle\": \"CEO\",\n        \"affiliation\": {\n          \"@type\": \"MedicalOrganization\",\n          \"name\": \"Centrum Andromedichyperthermia\"\n        }\n      },\n      \"keywords\": \"\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1, \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u0394\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III, \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7, OS, \u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7, \u03a0\u0391, \u0393\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2, \u03a3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, E-E-A-T\"\n      \/* ... \u03a4\u03bf Schema FAQPage \u03b8\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b5\u03b8\u03b5\u03af \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03a3\u03c5\u03c7\u03bd\u03ce\u03bd \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03c9\u03bd *\/\n    }\n<\/script><\/p>\n<div class=\"author-info\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03b8\u03b5\u03bd\u03c4\u03af\u03b1 \u03ba\u03b1\u03b9 \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 (E-E-A-T): <\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/el\/doctor-veronica-iatan\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Dr. Veronica Iatan<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">, MD, \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd <\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/el\/cristian-gologan\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Cristian Gologan M.Sc<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">, Andromedichyperthermia<\/span><\/span><\/strong><\/div>\n<article>\n<header>\n<h1><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2: \u03a4\u03b1 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) \u03ba\u03b1\u03c4\u03ac \u03a0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 50 % \u03c3\u03b5 \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03a0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/span><\/h1>\n<\/header>\n<section><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c4\u03bf\u03bd \u03b1\u03b3\u03ce\u03bd\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03bf \u03b1\u03c0\u03ce\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (Overall Survival, OS) <\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03bc\u03b5 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b7 \u03ae \u03ba\u03b1\u03b8\u03cc\u03bb\u03bf\u03c5 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u039b\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bd\u03b1 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b7 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (HT)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03ad\u03c7\u03b5\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b2\u03b5\u03af \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c3\u03c4\u03cc\u03c7\u03bf. \u03a4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc <\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/el\/%ce%bc%ce%b5%ce%bb%ce%ad%cf%84%ce%b5%cf%82-%cf%86%ce%ac%cf%83%ce%b7%cf%82-iii-%ce%b3%ce%b9%ce%b1-%cf%85%cf%80%ce%b5%cf%81%ce%b8%ce%b5%cf%81%ce%bc%ce%af%ce%b1\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">* <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III (\u03a4\u039a\u0394) \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2<\/span><\/span><\/strong> <span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b1 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ac \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">*\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac 20%, 50% \u03ba\u03b1\u03b9 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 100% **<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03c3\u03b5 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1. \u03a0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c0\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03bc\u03b5 \u03ac\u03bc\u03b5\u03c3\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b5\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2:<\/span><\/span><\/a><\/section>\n<hr \/>\n<section>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u0394\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03bf\u03cd 2\u03b5\u03c4\u03bf\u03cd\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2: \u03a0\u03bf\u03bb\u03cd\u03bc\u03bf\u03c1\u03c6\u03bf \u0393\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u03a0\u03bf\u03bb\u03cd\u03bc\u03bf\u03c1\u03c6\u03bf \u0393\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1 (GBM) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5 <\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9457811\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">. \u039c\u03b9\u03b1 \u03c4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 \u0399\/\u0399\u0399<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> [1] \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03b2\u03c1\u03b1\u03c7\u03c5\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b5\u03af\u03c7\u03b5 \u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd, \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1, <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03af\u03b1\u03c3\u03b5 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 2\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> :<\/span><\/span><\/p>\n<table style=\"width: 100%; border-collapse: collapse;\" border=\"1\">\n<thead>\n<tr style=\"background-color: #f2f2f2;\">\n<th><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u0394\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/span><\/span><\/th>\n<th><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u03a7\u03c9\u03c1\u03af\u03c2 HT)<\/span><\/span><\/th>\n<th><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 + \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (HT)<\/span><\/span><\/th>\n<th><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 (%)<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 &#8211; 2 \u0388\u03c4\u03b7<\/span><\/span><\/strong><\/td>\n<td><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">%15<\/span><\/span><\/td>\n<td><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">%31<\/span><\/span><\/td>\n<td><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 OS \u03ba\u03b1\u03c4\u03ac +107%<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 100% \u03c3\u03c4\u03b1 2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c0\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03b4\u03b5\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c9\u03c2 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> .<\/span><\/span><\/p>\n<p><a href=\"https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b9\u03bf \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 [2]<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u0394\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 RF \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (mHT) \u03c3\u03b5 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03b8\u03ad\u03bd\u03c4\u03b1 \u03bd\u03cc\u03c3\u03bf, \u03bc\u03b5 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 1 \u03ad\u03c4\u03bf\u03c5\u03c2 73% \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 37% \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (\u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c2) (p = 0.0021).<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03c4\u03c9\u03bd \u03b3\u03bb\u03bf\u03b9\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03c4\u03b1\u03be\u03b7 \u03c4\u03b7\u03c2 HT \u03c9\u03c2 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2.<\/span><\/span><\/strong><\/p>\n<\/section>\n<hr \/>\n<section>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u03a0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7: \u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 OS \u03ba\u03b1\u03c4\u03ac \u03a0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 50 % \u03c3\u03c4\u03bf\u03bd \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03a0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03a0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 (PC) \u03ad\u03c7\u03b5\u03b9 \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c7\u03b5\u03b9\u03c1\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03c1\u03bf\u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2. \u03a4\u03b1 \u03b5\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1, \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 OS \u03c3\u03b5 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 50%:<\/span><\/span><\/p>\n<ol>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">* <\/span><\/span><a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2023.41.16_suppl.e16316\" target=\"_blank\" rel=\"noopener\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HEAT \u0395\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03a4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u0394\u03bf\u03ba\u03b9\u03bc\u03ae (2022)<\/span><\/span><\/strong><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> [3]:* \u03a3\u03c4\u03bf \u03b5\u03be\u03b1\u03b9\u03c1\u03ad\u03c3\u03b9\u03bc\u03bf \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c1\u03bf\u03b3\u03b5\u03bd\u03ad\u03c2 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1, \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (RHT) \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03b5 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac 5\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 28.4% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 18.7%\\* ( <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 *52%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> ).<\/span><\/span><\/strong><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">* <\/span><\/span><strong><a href=\"https:\/\/doi.org\/10.1038\/s41598-024-51693-5\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u039f\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 (2023)<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> [4]:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u200b\u200b* \u03a3\u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2, \u03b7 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u0394\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 RF \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2, mHT) \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/span><\/span>\n<p><figure id=\"attachment_11256\" aria-describedby=\"caption-attachment-11256\" style=\"width: 1010px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-11256 size-full\" src=\"https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/pancreatic-cancer-OS-comparison-IMT-vs-CT-vs-mHT-CT.jpg\" alt=\"\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 - \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 OS - \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd (\u0399\u039c\u03a4) VS \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (\u03a7\u0398) VS \u0394\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 RF \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (mHT) + \u03a7\u0398\" width=\"1010\" height=\"850\" title=\"\" srcset=\"https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/pancreatic-cancer-OS-comparison-IMT-vs-CT-vs-mHT-CT.jpg 1010w, https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/pancreatic-cancer-OS-comparison-IMT-vs-CT-vs-mHT-CT-300x252.jpg 300w, https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/pancreatic-cancer-OS-comparison-IMT-vs-CT-vs-mHT-CT-768x646.jpg 768w\" sizes=\"auto, (max-width: 1010px) 100vw, 1010px\" \/><figcaption id=\"caption-attachment-11256\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 &#8211; \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 OS &#8211; \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd (\u0399\u039c\u03a4) VS \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (\u03a7\u0398) VS \u0394\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 RF \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (mHT) + \u03a7\u0398<\/span><\/span><\/figcaption><\/figure><\/li>\n<li>\u00a0<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b5\u03b3\u03ac\u03bb\u03b7 \u03a0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03bd\u03b1\u03b4\u03c1\u03bf\u03bc\u03b9\u03ba\u03ae \u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u039c\u03b5\u03bb\u03ad\u03c4\u03b7<\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37398545\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> [5]<\/span><\/span><\/a><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (N=217 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 PC \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 III-IV) \u03c3\u03c5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b5 \u03c4\u03b7 \u0394\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7 RF \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (mHT) + \u03a7\u0398 (\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7 \u03b3\u03b5\u03bc\u03c3\u03b9\u03c4\u03b1\u03b2\u03af\u03bd\u03b7) \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03bc\u03cc\u03bd\u03bf \u03a7\u0398. <\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS): \u0397 OS \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac (\u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u0394\u0399\u03a0\u039b\u0391\u03a3\u0399\u0391\u03a3\u039c\u039f\u03a3) \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03b7\u03c2 \u0394\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 RF \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (mHT) (20 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 9 \u03bc\u03b7\u03bd\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03a7\u0398, P &lt; 0.001). <\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03a7\u03c9\u03c1\u03af\u03c2 \u0395\u03be\u03ad\u03bb\u03b9\u03be\u03b7 (PFS): \u0397 PFS \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac (7 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 5 \u03bc\u03b7\u03bd\u03ce\u03bd, P &lt; 0.05). <\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u038c\u03b3\u03ba\u03bf\u03c5: \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae RF \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 (mHT) \u03b5\u03af\u03c7\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u039c\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (PR) (45% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 24%, P = 0.0018) \u03ba\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u0395\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 (PD) (4% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 31%, P &lt; 0.01).<\/span><\/span><\/strong><\/li>\n<\/ol>\n<\/section>\n<hr \/>\n<section>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u039c\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03a4\u03b5\u03ba\u03bc\u03b7\u03c1\u03af\u03c9\u03c3\u03b7 \u03a6\u03ac\u03c3\u03b7\u03c2 III: \u03a3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u039c\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u039c\u03bf\u03c1\u03af\u03c9\u03bd (EORTC 62961)<\/span><\/span><\/h2>\n<p><strong><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b5 \u03bc\u03b9\u03b1 \u03c4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7, \u03c0\u03bf\u03bb\u03c5\u03b5\u03b8\u03bd\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 III (\u03a4\u039a\u0394), \u03c4\u03bf \u03c7\u03c1\u03c5\u03c3\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf,<\/span><\/span><\/span><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> * <\/span><\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2672386\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">EORTC 62961\/ESHO 95<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> * [5] , <\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u039d\u0391\u03a7\u0398 (\u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1) \u03b3\u03b9\u03b1 \u03a3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u039c\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u039c\u03bf\u03c1\u03af\u03c9\u03bd (STS), <\/span><\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS) \u03c5\u03c0\u03b5\u03c1\u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">, \u03bc\u03b5 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 <\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03c4\u03b7\u03bd \u03ad\u03bd\u03c4\u03b1\u03be\u03b7 \u03c4\u03b7\u03c2 HT \u03c3\u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03c9\u03bd NCCN \u03ba\u03b1\u03b9 ESMO.<\/span><\/span><\/span><\/strong><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03be\u03b5\u03ba\u03af\u03bd\u03b7\u03c3\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <\/span><\/span><a href=\"http:\/\/esho.info\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 (ESHO)<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03c4\u03bf\u03bd\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf Klinikum der Universit\u00e4t M\u00fcnchen, \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1, \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u039f\u03bc\u03ac\u03b4\u03b1 \u03a3\u03b1\u03c1\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u039c\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u039c\u03bf\u03c1\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u039f\u03c3\u03c4\u03ce\u03bd (STBSG) \u03c4\u03bf\u03c5 \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03bf\u03cd \u039f\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u0388\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03ba\u03b1\u03b9 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 (EORTC). \u03a4\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1 \u03b1\u03ba\u03b1\u03b4\u03b7\u03bc\u03b1\u03ca\u03ba\u03ac \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1 (6), \u03c4\u03b7 \u039d\u03bf\u03c1\u03b2\u03b7\u03b3\u03af\u03b1 (1), \u03c4\u03b7\u03bd \u0391\u03c5\u03c3\u03c4\u03c1\u03af\u03b1 (1) \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u0397\u03a0\u0391 (1).<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03bd\u03b7\u03bb\u03b9\u03ba\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 (\u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u226518 \u03b5\u03c4\u03ce\u03bd) \u03bc\u03b5 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd (\u03cc\u03b3\u03ba\u03bf\u03c2 \u22655 cm, \u03b2\u03b1\u03b8\u03bc\u03cc\u03c2 2 \u03ae 3, \u03b2\u03b1\u03b8\u03cd\u03c2, \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0393\u03b1\u03bb\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03b8\u03bd\u03b9\u03ba\u03ae\u03c2 \u039f\u03bc\u03bf\u03c3\u03c0\u03bf\u03bd\u03b4\u03af\u03b1\u03c2 \u039a\u03ad\u03bd\u03c4\u03c1\u03c9\u03bd \u039a\u03b1\u03c4\u03b1\u03c0\u03bf\u03bb\u03ad\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 [FNCLCC]) \u03b5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 9 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u0399\u03bf\u03cd\u03bb\u03b9\u03bf \u03c4\u03bf\u03c5 1997 \u03ad\u03c9\u03c2 \u03c4\u03bf\u03bd \u039d\u03bf\u03ad\u03bc\u03b2\u03c1\u03b9\u03bf \u03c4\u03bf\u03c5 2006. \u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ad\u03ba\u03bb\u03b5\u03b9\u03c3\u03b5 \u03c4\u03bf\u03bd \u0394\u03b5\u03ba\u03ad\u03bc\u03b2\u03c1\u03b9\u03bf \u03c4\u03bf\u03c5 2014. <\/span><\/span><\/p>\n<p><span dir=\"auto\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (RHT) \u03c0\u03b1\u03c1\u03ac\u03c4\u03b5\u03b9\u03bd\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03cc\u03c3\u03bf \u03b1\u03c0\u03cc 17.4 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03c3\u03b5 33.3 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (HR \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ae \u03ae \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03c5\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1 \u03ae \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf, 0.71, 95% CI, 0.55\u20130.93; <\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0\u2009= 0.01;\u00a0 <\/span><\/span><\/span><a class=\"figure-link section-jump-link\" href=\"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2672386#coi170090f2\" data-tab-toggle=\".tab-nav-figure-table\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2\u0392<\/span><\/span><\/span><\/a><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0).<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><strong>\u0397 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03bf\u03bc\u03ac\u03b4\u03c9\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u039d\u0391\u03a7\u0398 \u03c3\u03c5\u03bd RHT, \u03bc\u03b5 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 15.4 \u03ad\u03c4\u03b7 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 6.2 \u03ad\u03c4\u03b7 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03cc\u03bd\u03bf \u039d\u0391\u03a7\u0398<\/strong> (HR 0.73; 95% CI, 0.54-0.98;\u00a0<i>P<\/i>\u2009=\u20090.04;\u00a0<a class=\"figure-link section-jump-link\" href=\"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2672386#coi170090f2\" data-tab-toggle=\".tab-nav-figure-table\" target=\"_blank\" rel=\"noopener\">\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2<\/a>C). <\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><strong>\u03a4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac 5\u03b5\u03c4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 10\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03ae\u03c4\u03b1\u03bd 62.7% (95% CI, 55.2%-70.1%) \u03ba\u03b1\u03b9 52.6% (95% CI, 44.7%-60.6%) \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u039d\u0391\u03a7\u0398 \u03c3\u03c5\u03bd RHT<\/strong>, \u03ba\u03b1\u03b9 51.3% (95% CI, 43.7%-59.0%) \u03ba\u03b1\u03b9 42.7% (95% CI, 35.0%-50.4%) \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03cc\u03bd\u03bf \u039d\u0391\u03a7\u0398, \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1. \u039f \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 5 \u03ba\u03b1\u03b9 10 \u03ad\u03c4\u03b7 \u03ae\u03c4\u03b1\u03bd 8.8 \u03ba\u03b1\u03b9 10.1, \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1. \u039f\u03b9 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b5\u03b9\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03c4\u03c9\u03bd \u03ac\u03ba\u03c1\u03c9\u03bd, \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac 5\u03b5\u03c4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 10\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03b7\u03c2 RHT \u03ae\u03c4\u03b1\u03bd 75.2% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 60.8% (\u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac, 14.4%, 95% CI, 0.0%-29.5%) \u03ba\u03b1\u03b9 68.3% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 59.2% (\u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac, 9.1%, 95% CI, 0%-24.7%). \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03ac\u03ba\u03c1\u03c9\u03bd, \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac 5\u03b5\u03c4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 10\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c5\u03c0\u03ad\u03c1 \u03c4\u03b7\u03c2 RHT \u03ae\u03c4\u03b1\u03bd 53.5% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 44% (\u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac, 9.5%, 95% CI, 0%-23.8%) \u03ba\u03b1\u03b9 41.3% \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 29.9% (\u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac, 11.4%, 95% CI 0%-25.1%) (<a class=\"figure-link section-jump-link\" href=\"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2672386#coi170090f2\" data-tab-toggle=\".tab-nav-figure-table\" target=\"_blank\" rel=\"noopener\">\u0395\u03b9\u03ba\u03cc\u03bd\u03b1 2<\/a>D). \u039c\u03b9\u03b1 \u03c3\u03cd\u03bd\u03bf\u03c8\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03a0\u03af\u03bd\u03b1\u03ba\u03b1 e1 \u03c3\u03c4\u03bf\u00a0<a class=\"supplement-link section-jump-link\" href=\"https:\/\/jamanetwork.com\/journals\/jamaoncology\/fullarticle\/2672386#note-COI170090-1\" data-tab-toggle=\".tab-nav-supplemental\" target=\"_blank\" rel=\"noopener\">\u03a0\u03b1\u03c1\u03ac\u03c1\u03c4\u03b7\u03bc\u03b1 2<\/a>.<\/span><\/span><\/span><\/p>\n<p><span dir=\"auto\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0397 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03bc\u03b5 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac 11.4% \u03c3\u03c4\u03b1 5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03b9 9.9% \u03c3\u03c4\u03b1 10 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1,<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03b5\u03bf\u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf.<\/span><\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<\/section>\n<hr \/>\n<section>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03b1\u03c0\u03cc \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u0394\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III: \u0392\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (RC) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS)<\/span><\/span><\/h2>\n<ul>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">* <\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17881144\/\" target=\"_blank\" rel=\"noopener\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u039c\u03ae\u03c4\u03c1\u03b1\u03c2 (12\u03b5\u03c4\u03ae\u03c2 \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7)<\/span><\/span><\/strong><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> [7]:* \u0397 \u039f\u03bb\u03bb\u03b1\u03bd\u03b4\u03b9\u03ba\u03ae \u0394\u03bf\u03ba\u03b9\u03bc\u03ae \u0392\u03b1\u03b8\u03b9\u03ac\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 (\u03a6\u03ac\u03c3\u03b7 III), \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 12 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2, \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 (OS): <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37% \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 RT+HT \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 20% \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03cc\u03bd\u03bf RT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> .<\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">* <\/span><\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03c9\u03bd \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u039c\u03b1\u03c3\u03c4\u03bf\u03cd (\u0398\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03cc \u03a4\u03bf\u03af\u03c7\u03c9\u03bc\u03b1)<\/span><\/span><\/strong><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> :* \u039c\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\">[8]<\/a> \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03a0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 (RC) \u03ba\u03b1\u03c4\u03ac +58% \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 HT \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd-\u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03cc\u03bb\u03b7\u03c3\u03b7. <\/span><\/span><\/strong>\u00a0<span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03cd\u03bf \u03b2\u03c1\u03b1\u03c7\u03b9\u03cc\u03bd\u03c9\u03bd, <strong>\u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (RC) \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf 60.2%<\/strong> <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03bc\u03b5 RT + HT \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 38.1% \u03bc\u03b5 \u03bc\u03cc\u03bd\u03bf RT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0(\u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd 2.64, 95% \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b5\u03bc\u03c0\u03b9\u03c3\u03c4\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 [CI] 1.66\u20134.18, <\/span><\/span><\/span><em><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/span><\/em><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0&lt;0.0001). \u039f \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ae\u03c4\u03b1\u03bd 1.57 (95% CI 1.25\u20131.96,\u00a0 <\/span><\/span><\/span><em><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/span><\/em><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0&lt;0.0001) \u03ba\u03b1\u03b9 0.22 (95% CI 0.11\u20130.33,\u00a0 <\/span><\/span><\/span><em><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P\u00a0<\/span><\/span><\/span><\/em><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> &lt;0.0001), \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1.<\/span><\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">* <\/span><\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u039f\u03c1\u03b8\u03bf\u03cd (\u03a0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2\/\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03c9\u03bd)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[9]<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">:<\/span><\/span><\/strong><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> * <\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2, \u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">(95.8 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 74.5%, <\/span><\/span><\/strong><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.045), \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03a7\u03c9\u03c1\u03af\u03c2 \u039d\u03cc\u03c3\u03bf (DFS) ( <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">89.1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 70.4%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">, <\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.027), \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03a7\u03c9\u03c1\u03af\u03c2 \u03a4\u03bf\u03c0\u03b9\u03ba\u03ae \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae ( <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">97.7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 78.7%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">, <\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.006) \u03ba\u03b1\u03b9 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03a7\u03c9\u03c1\u03af\u03c2 \u039a\u03bf\u03bb\u03bf\u03c3\u03c4\u03bf\u03bc\u03af\u03b1 ( <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">87.7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 69.0%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">, <\/span><\/span><\/span><i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/span><\/i><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.016) \u03ae\u03c4\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/span><\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">* <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u039a\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03a4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 (HNC)<\/span><\/span><\/strong><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">: <\/span><\/span><\/strong><a href=\"https:\/\/doi.org\/10.7314\/apjcp.2013.14.12.7395\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c3\u03c5\u03bd\u03b5\u03c7\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 5\u03b5\u03c4\u03bf\u03cd\u03c2 OS \u03b1\u03c0\u03cc 50% \u03c3\u03b5 68.4% (p &lt; 0.005). \u0397 5\u03b5\u03c4\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03a7\u03c9\u03c1\u03af\u03c2 \u039d\u03cc\u03c3\u03bf (DFS) \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc 25.5% \u03c3\u03b5 51.3% (p &lt; 0.005). \u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc RC \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc 62.8% \u03c3\u03b5 81.6%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> . \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03ac\u03bb\u03bb\u03b7 <\/span><\/span><a href=\"https:\/\/journals.lww.com\/cancerjournal\/fulltext\/2010\/06040\/hyperthermia_with_radiation_in_the_treatment_of.16.aspx\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03a6\u03ac\u03c3\u03b7\u03c2 III[10] <\/span><\/span><\/a><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u0391\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 (RC) \u03c3\u03c4\u03bf 42.4 % \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 78.6 % \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5 HT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> . \u0397 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03ae\u03c4\u03b1\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae (&lt; 0.05).<\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">* <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03ba\u03cc\u03b7\u03b8\u03b5\u03c2 \u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 \u03a5\u03c8\u03b7\u03bb\u03bf\u03cd \u039a\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (EORTC 18951\/ESHO 1.96)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> :* \u039c\u03b9\u03b1 <\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03a6\u03ac\u03c3\u03b7\u03c2 \u0399\u0399\/\u0399\u0399\u0399[11]<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03ae \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7, \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1:<\/span><\/span>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u03b5\u03c4\u03ae\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03a4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03ae\u03c4\u03b1\u03bd 19%.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u03b5\u03c4\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">38%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> .<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\u03b5\u03c4\u03ae\u03c2 \u039a\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03a4\u03bf\u03c0\u03b9\u03ba\u03ae \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 <\/span><\/span><\/strong><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28% \u0395\u039d\u0391\u039d\u03a4\u0399 <\/span><\/span><\/strong><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46% \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5 HT <\/span><\/span><\/strong><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u0392\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 (p = 0.008)<\/span><\/span><\/strong><\/li>\n<\/ul>\n<\/li>\n<li>\n<section><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u039f\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u039a\u03cd\u03c3\u03c4\u03b7\u03c2 (\u039c\u03b7 \u0394\u03b9\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c4\u03bf\u03c5 \u039c\u03c5\u03cc\u03c2)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u039f \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u0395\u03c0\u03b9\u03c0\u03ad\u03b4\u03bf\u03c5 1\u0391 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.[12] \u0397 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u0395\u03bd\u03b4\u03bf\u03ba\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03a7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (HIVEC) \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u039c\u03b9\u03c4\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7 C \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2:<\/span><\/span><\/p>\n<ul>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2: \u03a3\u03c4\u03bf\u03bd \u03bc\u03b7 \u03b4\u03b9\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03bc\u03c5\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2 \u03bc\u03b5 \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf, \u03c4\u03bf HIVEC \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b5\u03b3\u03c7\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5.<\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1: \u039c\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 (\u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd) \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b1\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 30 % \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 [12]<\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03a0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u0391\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1\u03c2 BCG: \u03a4\u03bf HIVEC \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bb\u03cd\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03b7 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 BCG (Bacillus Calmette-Gu\u00e9rin) \u03b1\u03c0\u03ad\u03c4\u03c5\u03c7\u03b5 \u03ae \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9, \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03a7\u03c9\u03c1\u03af\u03c2 \u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae (RFS).<\/span><\/span><\/li>\n<\/ul>\n<\/section>\n<section>\n<h2><\/h2>\n<\/section>\n<\/li>\n<\/ul>\n<\/section>\n<hr \/>\n<section>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5. \u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u0395\u03c5\u03bd\u03bf\u03ca\u03ba\u03cc\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u0394\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 (\u03a4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1)<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u039c\u03b9\u03b1 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03c0\u03c4\u03c5\u03c7\u03ae \u03c4\u03b7\u03c2 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03af\u03c9\u03c3\u03b7\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c4\u03b5\u03c1\u03ac\u03c3\u03c4\u03b9\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u0392\u03b1\u03b8\u03bc\u03bf\u03cd 3 \u03ae 4. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1-\u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03ad\u03c6\u03b5\u03c1\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b1 \u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 (RR 0.99 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b1 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, RR 1.01 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1).<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2, \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03b5\u03c0\u03b9\u03c7\u03b5\u03af\u03c1\u03b7\u03bc\u03b1 \u03cc\u03c4\u03b9 \u03b7 HT \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03ad\u03bd\u03b1\u03bd \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b1 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03a0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u0396\u03c9\u03ae\u03c2 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1.<\/span><\/span><\/p>\n<\/section>\n<hr \/>\n<section>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1: \u039c\u03b9\u03b1 \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03af\u03c4\u03b5 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 OS \u03ba\u03b1\u03c4\u03ac 52% (\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2), \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac +17 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b5\u03c2 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b1 12 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 (\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2) \u03ae \u0394\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (\u0393\u03bb\u03bf\u03b9\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03a3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u039c\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u039c\u03bf\u03c1\u03af\u03c9\u03bd),<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03b7 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03af\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03ad\u03bd\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03ac\u03bd \u03bf \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c3\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03b3\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2, \u03b7 \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf \u03c4\u03c5\u03c0\u03b9\u03ba\u03cc \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ac \u03b5\u03c0\u03b9\u03ba\u03c5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 50% \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2.<\/span><\/span><\/strong><\/p>\n<\/section>\n<footer>\n<hr \/>\n<p><small><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7 E-E-A-T:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 III \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03c5\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2, \u03c0\u03bf\u03c5 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c4\u03b1 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac. \u039f\u03b9 \u03c0\u03bb\u03ae\u03c1\u03b5\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b5\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2.<\/span><\/span><\/small><\/p>\n<\/footer>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u03a0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ad\u03c2:<\/span><\/span><\/p>\n<ol>\n<li>Sneed PK, Stauffer PR, McDermott MW, Diederich CJ, Lamborn KR, Prados MD, Chang S, Weaver KA, Spry L, Malec MK, Lamb SA, Voss B, Davis RL, Wara WM, Larson DA, Phillips TL, Gutin PH. Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +\/- hyperthermia for glioblastoma multiforme. Int J Radiat Oncol Phys. 1998 Jan 15;40(2):287-95. doi: 10.1016\/s0360-3016(97)00731-1. PMID: 9457811.<\/li>\n<li>Szasz, A.M.; Arrojo Alvarez, E.E.; Fiorentini, G.; Herold, M.; Herold, Z.; Sarti, D.; Dank, M. Meta-Analysis of Modulated Electro-Hyperthermia and Tumor Treating Fields in the Treatment of Glioblastomas.\u00a0<em>Cancers<\/em>\u00a0<b>2023<\/b>,\u00a0<em>15<\/em>, 880. https:\/\/doi.org\/10.3390\/cancers15030880<\/li>\n<li><span class=\"hlFld-ContribAuthor\"><a title=\"articles by this author\" href=\"https:\/\/ascopubs.org\/action\/doSearch?ContribAuthorRaw=Issels%2C+Rolf+D\" target=\"_blank\" rel=\"noopener\">Rolf D. Issels et al.<\/a><\/span>Regional hyperthermia with cisplatin added to gemcitabine versus gemcitabine in patients with resected pancreatic ductal adenocarcinoma: The HEAT randomized clinical trial.. <i>J Clin Oncol<\/i>\u00a0<b>41<\/b>, e16316-e16316(2023).DOI:<a title=\"Link to DOI\" href=\"https:\/\/doi.org\/10.1200\/JCO.2023.41.16_suppl.e16316\" target=\"_blank\" rel=\"noopener\">10.1200\/JCO.2023.41.16_suppl.e16316\u00a0<\/a><\/li>\n<li><span style=\"font-size: 16px;\">Kleef, R., Dank, M., Herold, M. <i>et al.<\/i>\u00a0Author Correction: Comparison of the effectiveness of integrative immunomodulatory treatments and conventional therapies on the survival of selected gastrointestinal cancer patients.\u00a0<i>Sci Rep<\/i>\u00a0<b>14<\/b>, 1129 (2024).\u00a0<\/span><\/li>\n<li>Fiorentini G, Sarti D, Mambrini A, Hammarberg Ferri I, Bonucci M, Sciacca PG, Ballerini M, Bonanno S, Milandri C, Nani R, Guadagni S, Dentico P, Fiorentini C. Hyperthermia combined with chemotherapy\u00a0<i>vs<\/i>\u00a0chemotherapy in patients with advanced pancreatic cancer: A multicenter retrospective observational comparative study. World J Clin Oncol. 2023 Jun 24;14(6):215-226. doi: 10.5306\/wjco.v14.i6.215. PMID: 37398545; PMCID: PMC10311475.<\/li>\n<li><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Issels RD <\/span><\/span><\/span><span class=\"al-author-delim\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">,<\/span><\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0Lindner LH\u00a0 <\/span><\/span><\/span><span class=\"al-author-delim\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">,<\/span><\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0Verweij J et al. Effect of neoadjuvant chemotherapy plus regional hyperthermia on long-term outcomes in patients with high-risk localized soft tissue sarcoma\u00a0 <\/span><\/span><\/span><span class=\"subtitle\"><span class=\"colon-for-citation-subtitle\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">:<\/span><\/span><\/span><\/span><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u00a0the EORTC 62961-ESHO 95 randomized clinical trial.\u00a0 <\/span><\/span><\/span><\/span><em><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">JAMA Oncol.<\/span><\/span><\/span><\/em><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> 2018 ;4(4):483\u2013492. doi:10.1001\/jamaoncol.2017.4996\u00a0<\/span><\/span><\/span><\/li>\n<li>Franckena M, Stalpers LJ, Koper PC, Wiggenraad RG, Hoogenraad WJ, van Dijk JD, W\u00e1rl\u00e1m-Rodenhuis CC, Jobsen JJ, van Rhoon GC, van der Zee J. Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial. Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):1176-82. doi: 10.1016\/j.ijrobp.2007.07.2348. Epub 2007 Sep 19. PMID: 17881144.<\/li>\n<li><span class=\"title-text\"><span class=\"anchor-text-container\"><span class=\"anchor-text\"><span class=\"react-xocs-alternative-link\"><span class=\"given-name\">Niloy R.<\/span>\u00a0<span class=\"text surname\">Datta<\/span> MD, Emsad Puric MD,<\/span><\/span><\/span>\u00a0<span class=\"anchor-text-container\"><span class=\"anchor-text\"><span class=\"react-xocs-alternative-link\"><span class=\"given-name\">Dirk<\/span>\u00a0<span class=\"text surname\">Klingbiel<\/span> PhD\u00a0<\/span><\/span><\/span>, Silvia Gomez MD,\u00a0<span class=\"anchor-text-container\"><span class=\"anchor-text\"><span class=\"react-xocs-alternative-link\"><span class=\"given-name\">Stephan<\/span>\u00a0<span class=\"text surname\">Bodis<\/span> MD ,<\/span><\/span><\/span>Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis<\/span>\n<div id=\"banner\" class=\"Banner\"><\/div>\n<\/li>\n<li>Ott, O.J., Schmidt, M., Semrau, S.\u00a0<i>et al.<\/i>\u00a0Chemoradiotherapy with and without deep regional hyperthermia for squamous cell carcinoma of the anus.\u00a0<i>Strahlenther Onkol<\/i>\u00a0<b>195<\/b>, 607\u2013614 (2019). https:\/\/doi.org\/10.1007\/s00066-018-1396-x<\/li>\n<li>Huilgol, Nagraj G.; Gupta, Sapna; C. R., Sridhar. Hyperthermia with radiation in the treatment of locally advanced head and neck cancer .A report of randomized trial. <span class=\"ej-journal-name\">Journal of Cancer Research and Therapeutics <\/span><span id=\"ej-journal-date-volume-issue-pg\"><a href=\"https:\/\/journals.lww.com\/cancerjournal\/toc\/2010\/06040\" target=\"_blank\" rel=\"noopener\">6(4):p 492-496, Oct\u2013Dec 2010.<\/a><\/span><span class=\"ej-journal-doi\">DOI:\u00a0<\/span>10.4103\/0973-1482.77101<\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[ Abstract ] Overgaard J, Gonzalez Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Mella O, Bentzen SM. Randomized trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. European Society for Hyperthermic Oncology. The Lancet. 1995 Mar 4;345(8949):540-3. doi: 10.1016\/s0140-6736(95)90463-8. PMID: 7776772.<\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Angulo JC, Alvarez-Ossorio JL, Dominguez-Escrig JL, Moyano JL, Sousa A, Fernandez JM, Gomez-Veiga F, Unda M, Carballido J, Carrero V, Fernandez-Aparicio T, Garcia de Jalon AA, Solsona E, Inman B, Palou JC. Non-muscle-invasive Bladder Cancer: Results of the HIVEC-1 Trial. Eur Urol Oncol. 2023 Feb;6(1):58-66. doi: 10.1016\/j.euo.2022.10.008. Epub 2022 Nov 23. PMID:36435738.<\/span><\/span><\/span><\/span><\/li>\n<\/ol>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\u0391\u03c5\u03b8\u03b5\u03bd\u03c4\u03af\u03b1 \u03ba\u03b1\u03b9 \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 (E-E-A-T): \u0391\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Dr. Veronica Iatan, MD, \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd Cristian Gologan M.Sc, Andromedichyperthermia \u03a5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2: \u03a4\u03b1 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (OS) \u03ba\u03b1\u03c4\u03ac \u03a0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 50 % \u03c3\u03b5 \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03a0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03a3\u03c4\u03bf\u03bd \u03b1\u03b3\u03ce\u03bd\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03bf \u03b1\u03c0\u03ce\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 (Overall&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[927,112,27],"tags":[526,529,934,806,397,398,808,807,403,396,805,804,402,147],"class_list":["post-11299","post","type-post","status-publish","format-standard","hentry","category-studii-clinice-el","category-112","category-27","tag-cr-el","tag-os-el","tag-studii-faza-iii-el","tag-806","tag---iii","tag-398","tag-808","tag-807","tag-403","tag-396","tag-805","tag-804","tag-402","tag-147"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/posts\/11299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/comments?post=11299"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/posts\/11299\/revisions"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/media?parent=11299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/categories?post=11299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/el\/wp-json\/wp\/v2\/tags?post=11299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}