{"id":11192,"date":"2025-10-02T14:50:09","date_gmt":"2025-10-02T14:50:09","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/oncologic-hyperthermia-phase-3-trials\/"},"modified":"2025-10-03T09:26:39","modified_gmt":"2025-10-03T09:26:39","slug":"%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95-%e7%ac%aciii%e7%9b%b8%e8%a9%a6%e9%a8%93","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/ja\/%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95-%e7%ac%aciii%e7%9b%b8%e8%a9%a6%e9%a8%93\/","title":{"rendered":"\u73fe\u4ee3\u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u306e\u6cbb\u7642\u7d71\u5408\uff1a\u7b2cIII\u76f8\u8a66\u9a13\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u6279\u5224\u7684\u5206\u6790\uff08OS\u3001DFS\u3001CR\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff09"},"content":{"rendered":"<p><script type=\"application\/ld+json\">\n    {\n      \"@context\": \"https:\/\/schema.org\",\n      \"@type\": \"MedicalScholarlyArticle\",\n      \"headline\": \"\u73fe\u4ee3\u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u306e\u6cbb\u7642\u7d71\u5408\uff1a\u7b2cIII\u76f8\u8a66\u9a13\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u6279\u5224\u7684\u5206\u6790\uff08OS\u3001DFS\u3001CR\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff09\",\n      \"author\": {\n        \"@type\": \"Person\",\n        \"name\": \"Gologan Cristian, M.Sc.\",\n        \"jobTitle\": \"CEO\",\n        \"affiliation\": {\n          \"@type\": \"MedicalOrganization\",\n          \"name\": \"Andromedichyperthermia Center\"\n        }\n      },\n      \"keywords\": \"\u6e29\u71b1\u7642\u6cd5\u3001\u816b\u760d\u5b66\u3001\u7b2cIII\u76f8\u8a66\u9a13\u3001\u751f\u5b58\u7387\u3001\u5168\u751f\u5b58\u671f\u9593\u3001\u5b8c\u5168\u594f\u52b9\u3001CR\u3001\u8089\u816b\u3001\u5b50\u5bae\u9838\u304c\u3093\u3001E-E-A-T\"\n      \/* ... Schema FAQPage would be added separately for the FAQ section *\/\n    }\n<\/script><\/p>\n<div class=\"author-info\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6a29\u5a01\u3068\u5c02\u9580\u77e5\u8b58\uff08EEAT\uff09\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><strong><a href=\"https:\/\/andromedichyperthermia.com\/ja\/doctor-veronica-iatan\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Veronica Iatan\u533b\u5e2b\uff08\u533b\u5b66\u535a\u58eb\uff09<\/span><\/a><\/strong><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3068<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">Cristian <\/span><a href=\"https:\/\/andromedichyperthermia.com\/ja\/cristian-gologan\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Gologan\u7406\u5b66\u4fee\u58eb<\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08\u30a2\u30f3\u30c9\u30ed\u30e1\u30c7\u30a3\u30ab\u30eb\u30d2\u30da\u30eb\u30b5\u30fc\u30df\u30a2\uff09<\/span><\/span><\/strong><\/div>\n<h1><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u73fe\u4ee3\u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u306e\u6cbb\u7642\u7d71\u5408\uff1a\u7b2cIII\u76f8\u8a66\u9a13\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u6279\u5224\u7684\u5206\u6790\uff08OS\u3001DFS\u3001CR\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff09<\/span><\/span><\/h1>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\uff08HT\uff09\u306e\u6982\u8981\u3068\u57fa\u672c\u539f\u5247<\/span><\/span><\/h2>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u816b\u760d\u5b66\u7684\u6e29\u71b1\u7642\u6cd5\uff08HT\uff09\u306f\u3001 <\/span><\/span><\/strong><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">39\u00b0C<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u304b\u308945\u00b0C\u306e\u6e29\u5ea6\u3067\u5236\u5fa1\u3055\u308c\u305f\u71b1\u306e\u9069\u7528\u3068\u5b9a\u7fa9\u3055\u308c\u3001\u3055\u307e\u3056\u307e\u306a\u9032\u884c\u6027\u304a\u3088\u3073\u518d\u767a\u6027\u56fa\u5f62\u816b\u760d\u306b\u5bfe\u3057\u3066<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3001\u30ec\u30d9\u30eb1A\u306e\u8a3c\u62e0<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30d5\u30a7\u30fc\u30baIII\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u304a\u3088\u3073\u30e1\u30bf\u5206\u6790<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3055\u308c\u305f\u3001\u5927\u304d\u306a\u81e8\u5e8a\u7684\u5229\u70b9\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u308b\u88dc\u52a9\u6cbb\u7642<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cd5\u3067\u3059\u3002<\/span><\/span><\/p>\n<div class=\"key-points\">\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u91cd\u8981\u306a\u30dd\u30a4\u30f3\u30c8 &#8211; \u30ec\u30d9\u30eb 1A \u306e\u8a3c\u62e0:<\/span><\/span><\/h3>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f79\u5272:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u306f\u816b\u760d\u3092\u76f4\u63a5\u7834\u58ca\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u5f37\u529b\u306a<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u7269\u5b66\u7684\u611f\u4f5c\u5264<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u78ba\u8a8d\u3055\u308c\u305f\u5229\u70b9:\u30ec\u30d9\u30eb 1A \u30c7\u30fc\u30bf\u306e\u7d71\u5408\u306b\u3088\u308a<\/span><\/span><\/strong><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3001\u5168\u751f\u5b58\u7387 (OS)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3068<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u594f\u52b9\u7387 (CR)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u306e\u4e00\u8cab\u3057\u305f\u6539\u5584\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u306a\u9069\u5fdc\u75c7:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8edf\u90e8\u8089\u816b\u3001\u5b50\u5bae\u9838\u304c\u3093\u3001\u518d\u767a\u4e73\u304c\u3093\u3001\u60aa\u6027\u9ed2\u8272\u816b\u3001\u8180\u80f1\u304c\u3093\u3001\u76f4\u8178\u304c\u3093\u3001\u982d\u9838\u90e8 (HNC) \u816b\u760d\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b89\u5168\u6027:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u5f37\u529b\u306a\u6cbb\u7642\u52b9\u679c\u306f\u3001\u5168\u8eab\u6bd2\u6027\u3084\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">(\u30b0\u30ec\u30fc\u30c9 3 \u307e\u305f\u306f 4)<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u306e\u5927\u5e45\u306a\u5897\u52a0\u306a\u3057\u306b\u3001\u4e00\u8cab\u3057\u3066\u9054\u6210\u3055\u308c\u307e\u3059\u3002<\/span><\/span><\/strong><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d50\u8ad6:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u306f\u3001\u7279\u5b9a\u306e\u816b\u760d\u306b\u5bfe\u3059\u308b\u6a19\u6e96\u7684\u306a\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30eb\u30ec\u30b8\u30e1\u30f3\u306b\u304a\u3044\u3066\u4e0d\u53ef\u6b20\u306a\u88dc\u52a9\u7642\u6cd5\u3067\u3042\u308b\u3002<\/span><\/span><\/li>\n<\/ul>\n<\/div>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1. \u816b\u760d\u6027\u6e29\u71b1\u7642\u6cd5\u306e\u5206\u985e\u3068\u6cbb\u7642\u6cd5<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.1. \u5c40\u6240\u5c40\u6240\u6e29\u71b1\u7642\u6cd5\uff08LR HT\uff09<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u308c\u306f\u3001\u9aa8\u76e4\u3001\u80f8\u90e8\u3001\u8179\u90e8\u306e\u816b\u760d\u306e\u6df1\u90e8\u52a0\u71b1\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u6280\u8853\u3068\u3057\u3066\u306f\u3001\u5bb9\u91cf\u6027\u9ad8\u5468\u6ce2\uff08RF\uff09\u30b7\u30b9\u30c6\u30e0\u3068\u3001\u30a2\u30f3\u30c6\u30ca\u30a2\u30ec\u30a4\u30de\u30c3\u30c1\u30f3\u30b0\u3092\u7528\u3044\u305f\u653e\u5c04\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u65b9\u6cd5\u306f\u3001\u816b\u760d\u4f53\u7a4d\u5185\u306e\u6cbb\u7642\u6e29\u5ea6\u3092\u6a19\u7684\u3068\u3057\u3001\u5065\u5e38\u7d44\u7e54\u3092\u8a31\u5bb9\u7bc4\u56f2\u5185\u306b\u7dad\u6301\u3057\u306a\u304c\u3089\u6df1\u90e8\u306b\u71b1\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u9001\u9054\u3059\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u76ee\u7684\u306f\u3001\u816b\u760d\u584a\u5168\u4f53\u3092\u6700\u3082\u5747\u4e00\uff08\u7b49\u6e29\uff09\u306b\u52a0\u71b1\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.2. RF\u5909\u8abf\u6e29\u71b1\u7642\u6cd5\uff08mHT\uff09<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5909\u8abf\u9ad8\u5468\u6ce2\u6e29\u71b1\u7642\u6cd5\uff08mHT\uff09\u306f\u3001\u4ed6\u306b\u985e\u3092\u898b\u306a\u3044\u975e\u4fb5\u8972\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002\u5f93\u6765\u306e\u7b49\u6e29\u52a0\u71b1\u3068\u306f\u7570\u306a\u308a\u3001mHT\u306f13.56MHz\u306e\u642c\u9001\u5468\u6ce2\u6570\u3067\u5bb9\u91cf\u7d50\u5408\u3057\u3001\u6642\u9593\u7d4c\u904e\u306b\u4f34\u3046\u30d5\u30e9\u30af\u30bf\u30eb\u5909\u52d5\u306b\u3088\u3063\u3066\u5909\u8abf\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u52d5\u4f5c\u539f\u7406\u306f\u3001\u7d30\u80de\u819c\u30ec\u30d9\u30eb\u306b\u96c6\u4e2d\u3057\u305f\u30a8\u30cd\u30eb\u30ae\u30fc\u4f1d\u9054\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002\u304c\u3093\u7d30\u80de\u819c\u3067\u306f\u3001\u305d\u306e\u96fb\u6c17\u7279\u6027\u306e\u5909\u5316\u306b\u3088\u308a\u9ad8\u3044\u8a98\u96fb\u640d\u5931\u304c\u512a\u5148\u7684\u306b\u767a\u751f\u3057\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3092\u523a\u6fc0\u3059\u308b\u7279\u5b9a\u306e\u6e29\u5ea6\u52fe\u914d\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u3053\u306e\u300c\u5185\u5074\u304b\u3089\u5916\u5074\u3078\u52a0\u71b1\u3059\u308b\u300d\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u3001\u816b\u760d\u5185\u306e\u6e29\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u6b63\u5e38\u7d44\u7e54\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u304c\u8efd\u6e1b\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u70b9\u304c\u3001mHT\u3092\u6a19\u6e96\u7684\u306a\u653e\u5c04\u7dda\u7642\u6cd5\u3084\u5bb9\u91cf\u7642\u6cd5\u3068\u6839\u672c\u7684\u306b\u5dee\u5225\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.3. \u7d44\u7e54\u5185\u9ad8\u4f53\u6e29<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u816b\u760d\u306b\u76f4\u63a5\u633f\u5165\u3055\u308c\u305f\u30a2\u30f3\u30c6\u30ca\u3001\u30ed\u30c3\u30c9\u3001\u307e\u305f\u306f\u30b7\u30fc\u30c9\u3092\u4ecb\u3057\u3066\u3001\u4fb5\u8972\u7684\u306b\u71b1\u3092\u7167\u5c04\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u4e3b\u306b\u8133\u816b\u760d\uff08\u795e\u7d4c\u81a0\u816b\uff09\u3084\u518d\u767a\u6027\u8868\u5728\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.2. 39\uff5e45\u2103\u306e\u6cbb\u7642\u57df\u304c\u306a\u305c\u6709\u52b9\u306a\u306e\u304b\uff1f\uff08\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u304c\u7b2cIII\u76f8\u8a66\u9a13\u3067\u5b9f\u8a3c\u3057\u305f\u81e8\u5e8a\u52b9\u679c\u306f\u3001\u305d\u306e\u8907\u96d1\u306a\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u89e3\u3068\u5207\u308a\u96e2\u305b\u306a\u3044\u3082\u306e\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5358\u7d14\u306a\u7d30\u80de\u7834\u58ca\u3092\u8d85\u8d8a\u3057\u3066\u304a\u308a\u3001HT\u306f\u6a19\u6e96\u6cbb\u7642\u306b\u5bfe\u3059\u308b<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u6a5f\u80fd\u306a\u611f\u4f5c\u5264<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3068\u3057\u3066\u4f4d\u7f6e\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u816b\u760d\u7279\u7570\u7684\u306a\u7d30\u80de\u30a2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u6700\u5927\u5316\u3059\u308b\u305f\u3081\u3001*39\uff5e45\u2103*\u3068\u3044\u3046\u6700\u9069\u6e29\u5ea6\u304c\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u5168\u4f53\u7684\u306a\u6210\u529f\u306f\u3001\u3053\u306e\u611f\u4f5c\u4f5c\u7528\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u304a\u3088\u3073\u7d30\u80de\u6a5f\u69cb\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u901a\u3058\u3066\u653e\u5c04\u7dda\u7642\u6cd5\uff08RT\uff09\u304a\u3088\u3073\u5316\u5b66\u7642\u6cd5\uff08CHT\uff09\u306e\u6709\u52b9\u6027\u3092\u9ad8\u3081\u307e\u3059\u3002<\/span><\/span><\/p>\n<hr \/>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u4f5c\u7528\u6a5f\u5e8f\uff1a\u6e29\u71b1\u7642\u6cd5\u306f\u816b\u760d\u6cbb\u7642\u306e\u52b9\u679c\u3092\u3069\u306e\u3088\u3046\u306b\u9ad8\u3081\u308b\u306e\u304b\uff1f<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f75\u7528\u7642\u6cd5\u306e\u512a\u308c\u305f\u81e8\u5e8a\u52b9\u679c\u306f\u3001\u8907\u6570\u306e\u30ec\u30d9\u30eb\u3067\u816b\u760d\u8010\u6027\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u5f37\u529b\u306a\u751f\u7269\u5b66\u7684\u76f8\u4e57\u52b9\u679c\u306e\u7d50\u679c\u3067\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.1. \u653e\u5c04\u7dda\u5897\u611f\uff1a\u816b\u760d\u8010\u6027\u3068DNA\u4fee\u5fa9\u306e\u514b\u670d<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u71b1\u7642\u6cd5\u306f\u5f37\u529b\u306a\u653e\u5c04\u7dda\u5897\u611f\u5264\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u304a\u308a\u3001\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u5931\u6557\u306e\u6700\u3082\u91cd\u5927\u306a\u539f\u56e0\u306e\u3046\u3061 2 \u3064\u306b\u5bfe\u51e6\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<ol>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">DNA \u4fee\u5fa9\u306e\u963b\u5bb3:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u306f\u653e\u5c04\u7dda\u306b\u3088\u3063\u3066\u640d\u50b7\u3057\u305f DNA \u4fee\u5fa9\u6a5f\u69cb\u3092\u963b\u5bb3\u3057\u3001\u3088\u308a\u52b9\u7387\u7684\u3067\u4e0d\u53ef\u9006\u7684\u306a\u7d30\u80de\u6b7b\u3092\u78ba\u5b9f\u306b\u3057\u307e\u3059\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5fae\u5c0f\u74b0\u5883\u306e\u9178\u7d20\u5316\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u306f\u8840\u6d41\u3092\u5897\u52a0\u3055\u305b\u3001\u816b\u760d\u306e\u9178\u7d20\u5316\u3092\u6539\u5584\u3057\u3001\u4f4e\u9178\u7d20\uff08\u653e\u5c04\u7dda\u62b5\u6297\u6027\uff09\u90e8\u5206\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002<\/span><\/span><\/li>\n<\/ol>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306e\u3053\u3046\u3057\u305f\u6a5f\u80fd\u7684\u5909\u5316\u306b\u3088\u308a\u3001\u4ee5\u524d\u306f\u62b5\u6297\u6027\u3067\u3042\u3063\u305f\u764c\u7d30\u80de\u306f\u3001\u5f93\u6765\u306e\u653e\u5c04\u7dda\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u5927\u5e45\u306b\u9ad8\u307e\u308a\u307e\u3059\u3002\u3053\u306e\u5fae\u5c0f\u5faa\u74b0\u306e\u5909\u5316\u306f\u3001\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u764c\uff08LACC\uff09\u3084\u982d\u9838\u90e8\u764c\uff08HNC\uff09\u306a\u3069\u306e\u816b\u760d\u306b\u5bfe\u3059\u308b\u6e29\u71b1\u7642\u6cd5\u4f75\u7528\u5316\u5b66\u653e\u5c04\u7dda\u7642\u6cd5\uff08CCRT+HT\uff09\u306b\u304a\u3044\u3066\u3001*\u9ad8\u3044\u5c40\u6240\u5236\u5fa1\u7387\u3068CR*\u3092\u88cf\u4ed8\u3051\u308b\u6c7a\u5b9a\u7684\u306a\u8981\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2. \u5316\u5b66\u611f\u53d7\u6027\uff1a\u85ac\u7269\u8f38\u9001\u3068\u7d30\u80de\u5185\u53d6\u308a\u8fbc\u307f\u306e\u6539\u5584<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2.1. \u4e3b\u8981\u85ac\u5264\u3068\u306e\u76f8\u4e57\u52b9\u679c\u3068\u76f8\u52a0\u52b9\u679c<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u306f\u3001\u7279\u5b9a\u306e\u5fc5\u9808\u816b\u760d\u5316\u5b66\u7642\u6cd5\u85ac\u3068\u5f37\u529b\u306a\u76f8\u4e57\u52b9\u679c\u3092\u793a\u3057\u307e\u3059\u3002\u7279\u306b\u3001HT\u306f\u30d7\u30e9\u30c1\u30ca\u88fd\u5264\uff08\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3001\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\uff09\u304a\u3088\u3073\u30de\u30a4\u30c8\u30de\u30a4\u30b7\u30f3C\u3068\u76f8\u4e57\u7684\u306b\u4f5c\u7528\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u85ac\u5264\u306f\u3001\u5b50\u5bae\u9838\u304c\u3093\u3084\u982d\u9838\u90e8\u60aa\u6027\u816b\u760d\u306a\u3069\u306e\u4e3b\u8981\u306a\u7b2cIII\u76f8\u81e8\u5e8a\u8a66\u9a13\u3067\u983b\u7e41\u306b\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u52b9\u679c\u306f\u3001\u71b1\u3060\u3051\u3067\u306a\u304f\u3001\u76f8\u88dc\u7684\u306a\u751f\u7269\u5b66\u7684\u95a2\u9023\u6027\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002HT\u306f\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3001\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\u3001\u30b2\u30e0\u30b7\u30bf\u30d3\u30f3\u306a\u3069\u306e\u85ac\u5264\u3068\u3082\u76f8\u52a0\u52b9\u679c\u3092\u793a\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2.2. \u85ac\u7269\u52d5\u614b\u5b66\u7684\u5897\u5e45<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u306f\u3001\u816b\u760d\u304a\u3088\u3073\u30ea\u30f3\u30d1\u7bc0\uff08LN\uff09\u3078\u306e\u85ac\u7269\u8f38\u9001\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u816b\u760d\u30ec\u30d9\u30eb\u3078\u306e\u85ac\u7269\u9001\u9054\u3092\u6700\u9069\u5316\u3057\u307e\u3059\u3002\u3053\u306e\u52b9\u679c\u306f\u3001HT\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u704c\u6d41\uff08\u8840\u6d41\uff09\u306e\u5897\u52a0\u3068\u7d30\u80de\u819c\u900f\u904e\u6027\u306e\u5909\u5316\u306b\u8d77\u56e0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002mHT\u306e\u5834\u5408\u3001\u9ad8\u3044\u8a98\u96fb\u640d\u5931\u306b\u3088\u3063\u3066\u4fc3\u9032\u3055\u308c\u308b\u7d30\u80de\u819c\u30ec\u30d9\u30eb\u3067\u306e\u5c40\u6240\u52a0\u71b1\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u3001\u5316\u5b66\u7642\u6cd5\u5264\u306e\u7d30\u80de\u5185\u53d6\u308a\u8fbc\u307f\u304c\u5897\u5e45\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.3. \u514d\u75ab\u8abf\u7bc0\uff1a\u300c\u51b7\u305f\u3044\u300d\u816b\u760d\u3092\u300c\u71b1\u3044\u300d\uff08\u514d\u75ab\u539f\u6027\uff09\u816b\u760d\u306b\u5909\u63db\u3059\u308b<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u307e\u3059\u307e\u3059\u8a8d\u8b58\u3055\u308c\u3064\u3064\u3042\u308b\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001HT \u304c\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u7bc0\u3057\u3001\u514d\u75ab\u5b66\u7684\u306b\u300c\u51b7\u305f\u3044\u300d\u816b\u760d\u3092\u300c\u71b1\u3044\u300d\uff08\u708e\u75c7\u3092\u8d77\u3053\u3057\u305f\uff09\u816b\u760d\u306b\u52b9\u679c\u7684\u306b\u5909\u63db\u3059\u308b\u80fd\u529b\u3067\u3059\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u306f\u3001\u71b1\u30b7\u30e7\u30c3\u30af\u30bf\u30f3\u30d1\u30af\u8cea\uff08HSP\uff09\u3068\u816b\u760d\u6297\u539f\u306e\u653e\u51fa\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u3001\u300cin situ\u816b\u760d\u30ef\u30af\u30c1\u30f3\u300d\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002HSP70\u306a\u3069\u306eHSP\u306f\u5371\u967a\u4fe1\u53f7\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u6a39\u72b6\u7d30\u80de\uff08DC\uff09\u306b\u3088\u308b\u6297\u539f\u53d6\u308a\u8fbc\u307f\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002DC\u306f\u4e00\u65e6\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3068\u3001\u30ea\u30f3\u30d1\u7bc0\uff08LN\uff09\u3078\u904a\u8d70\u3057\u3001\u305d\u3053\u3067\u7d30\u80de\u50b7\u5bb3\u6027CD8+ T\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3001\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u3057\u307e\u3059\u3002\u3053\u306e\u514d\u75ab\u8abf\u7bc0\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u30ca\u30c1\u30e5\u30e9\u30eb\u30ad\u30e9\u30fc\uff08NK\uff09\u7d30\u80de\u3068CD8+ T\u7d30\u80de\u306b\u3088\u308b\u764c\u7d30\u80de\u6eb6\u89e3\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001HT\u306f\u7d30\u80de\u63a5\u7740\u5206\u5b50\uff08CAM\uff09\u306e\u767a\u73fe\u3092\u6539\u5584\u3057\u3001\u816b\u760d\u90e8\u4f4d\u3078\u306e\u30ea\u30f3\u30d1\u7403\u306e\u79fb\u52d5\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 1 \u306f\u3001\u6e29\u71b1\u7642\u6cd5\u3068\u6a19\u6e96\u7684\u306a\u816b\u760d\u6cbb\u7642\u3068\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3059\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u88681\uff1a\u6e29\u71b1\u7642\u6cd5\u3068\u6a19\u6e96\u7684\u306a\u816b\u760d\u6cbb\u7642\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/span><\/span><\/strong><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30bf\u30fc\u30b2\u30c3\u30c8\u30e1\u30ab\u30cb\u30ba\u30e0<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u7269\u5b66\u7684\u52b9\u679c\uff0839\u2103\uff5e45\u2103\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cbb\u7642\u306e\u76f8\u4e57\u52b9\u679c<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f8\u4e57\u52b9\u679c\u306e\u3042\u308b\u85ac\u5264<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">DNA\u4fee\u5fa9\u306e\u963b\u5bb3<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">DNA\u4fee\u5fa9\u6a5f\u69cb\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">S\u671f\u306e\u7d30\u80de\u3092\u611f\u4f5c\u3059\u308b<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f37\u529b\u306a\u653e\u5c04\u7dda\u5897\u611f\u5264\uff08RT\u3092\u88dc\u5b8c\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u7dda\u7642\u6cd5\uff08RT\uff09<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u816b\u760d\u5fae\u5c0f\u74b0\u5883<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8840\u6d41\u3092\u5897\u52a0\u3055\u305b\u3001\u816b\u760d\u306e\u9178\u7d20\u5316\u3092\u6539\u5584\u3057\u3001\u8840\u7ba1\u65b0\u751f\u3092\u5897\u52a0\u3055\u305b\u308b<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RT\u52b9\u679c\u3092\u5897\u5f37\u3057\u3001\u85ac\u7269\u8f38\u9001\u3092\u6539\u5584\u3059\u308b\uff08\u5316\u5b66\u611f\u53d7\u6027\u5264\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RT\u3001\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3001\u30de\u30a4\u30c8\u30de\u30a4\u30b7\u30f3C<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d30\u80de\u819c\/\u69cb\u9020<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8a98\u96fb\u640d\u5931\u306e\u5897\u52a0;<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u63a5\u7684\u306a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u85ac\u7269\u5438\u53ce\u306e\u6539\u5584;<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3001\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3001\u30d6\u30ec\u30aa\u30de\u30a4\u30b7\u30f3<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u7cfb<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HSP\u653e\u51fa\u3001\u6a39\u72b6\u7d30\u80de\uff08DC\uff09\u6d3b\u6027\u5316\u3001T\u7d30\u80de\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u3001NK\/CD8+ T\u7d30\u80de\u306b\u3088\u308b\u6eb6\u89e3\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u816b\u760d\u514d\u75ab\u8abf\u7bc0\u5264\uff1b\u6297\u816b\u760d\u514d\u75ab\u306e\u5897\u5f37<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u7642\u6cd5\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u3001\u71b1\u4e2d\u75c7\u6cbb\u7642<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_11120\" aria-describedby=\"caption-attachment-11120\" style=\"width: 747px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11120\" src=\"https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie.jpg\" alt=\"\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u9ad8\u4f53\u6e29 - \u6e29\u71b1\u7642\u6cd5\" width=\"747\" height=\"412\" title=\"\" srcset=\"https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie.jpg 747w, https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie-300x165.jpg 300w\" sizes=\"auto, (max-width: 747px) 100vw, 747px\" \/><figcaption id=\"caption-attachment-11120\" class=\"wp-caption-text\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u9ad8\u4f53\u6e29<\/span><\/span><\/figcaption><\/figure>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u30ec\u30d9\u30eb1A\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u7d71\u5408\uff1a\u30e1\u30bf\u5206\u6790\u3068\u96c6\u8a08\u30c7\u30fc\u30bf\u306e\u7d50\u679c<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u306e\u5805\u7262\u306a\u8a55\u4fa1\u306f\u3001\u7b2cIII\u76f8\u8a66\u9a13\u306e\u7dcf\u5408\u7684\u306a\u89e3\u6790\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30ec\u30d9\u30eb1A\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u7d71\u5408\u3057\u305f\u7d50\u679c\u3001\u8907\u6570\u306e\u816b\u760d\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u304a\u3044\u3066\u3001\u6a19\u6e96\u6cbb\u7642\u306bHT\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067\u3001\u4e00\u822c\u7684\u306a\u81e8\u5e8a\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3.1. \u30e1\u30bf\u5206\u6790\u306e\u7d50\u8ad6\u306e\u6982\u8981<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12\u4ef6\u306e\u7b2cIII\u76f8\u8a66\u9a13\u3092\u542b\u3080\u6700\u8fd1\u306eHT\u306e\u6709\u52b9\u6027\u89e3\u6790\u3067\u306f\u3001\u5c40\u6240\u9818\u57dfHT\u306b\u95a2\u3059\u308b6\u4ef6\u306e\u8a66\u9a13\u3068\u3001\u8179\u8154\u5185\u6e29\u71b1\u5316\u5b66\u7642\u6cd5\uff08HIPEC\uff09\u3092\u542b\u30806\u4ef6\u306e\u8a66\u9a13\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f[2]\u3002\u3053\u308c\u3089\u306e6\u4ef6\u306e\u5c40\u6240\u9818\u57dfHT\u8a66\u9a13\u306e\u3046\u30615\u4ef6\u3067\u306f\u3001\u6a19\u6e96\u7684\u306a\u5316\u5b66\u7642\u6cd5\u304a\u3088\u3073\uff0f\u307e\u305f\u306f\u653e\u5c04\u7dda\u7642\u6cd5\u306bHT\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067\u3001\u5168\u751f\u5b58\u7387\uff08OS\uff09\u306e\u5ef6\u9577\u304a\u3088\u3073\uff0f\u307e\u305f\u306f\u5b8c\u5168\u594f\u52b9\u7387\uff08CR\uff09\u306e\u6539\u5584\u304c\u793a\u3055\u308c\u307e\u3057\u305f[2]\u3002\u3053\u308c\u306f\u3001\u5e45\u5e83\u3044\u5c40\u6240\u9818\u57df\u816b\u760d\u90e8\u4f4d\u306b\u5bfe\u3059\u308b\u30ec\u30d9\u30eb1A\u306e\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066HT\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u78ba\u56fa\u305f\u308b\u79d1\u5b66\u7684\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u3092\u78ba\u7acb\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3.2. \u5b9a\u91cf\u5316\u53ef\u80fd\u306a\u5229\u76ca\uff1a\u5168\u751f\u5b58\u7387\uff08OS\uff09\u3001\u5b8c\u5168\u594f\u52b9\uff08CR\uff09\u3001\u5c40\u6240\u5236\u5fa1<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u306e\u81e8\u5e8a\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u3001\u91cd\u8981\u306a\u816b\u760d\u5b66\u7684\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u304a\u3044\u3066\u5b9a\u91cf\u5316\u53ef\u80fd\u3067\u3059\u3002*\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u304c\u3093\uff08LACC\uff09*\u306b\u95a2\u3059\u308b\u96c6\u8a08\u30c7\u30fc\u30bf\u306f\u3001\u4ee5\u4e0b\u306e\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u594f\u52b9\uff08CR\uff09\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067 CR \u7387\u304c\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3059\uff08\u76f8\u5bfe\u30ea\u30b9\u30af &#8211; *RR 0.56\u300195% CI 0.39 \uff5e 0.79\u3001**p &lt; 0.001*\uff09\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u518d\u767a\u306e\u5236\u5fa1\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u306f\u5c40\u6240\u518d\u767a\u7387\u3092\u5927\u5e45\u306b\u4f4e\u4e0b\u3055\u305b\u307e\u3059 (\u30cf\u30b6\u30fc\u30c9\u6bd4 &#8211; *HR 0.48\u300195% CI 0.37 \uff5e 0.63\u3001**p &lt; 0.001*)\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5168\u751f\u5b58\u7387\uff08OS\uff09\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u306b\u3088\u308b\u591a\u89d2\u7684\u6cbb\u7642\u306b\u3088\u308a\u3001OS \u304c\u6539\u5584\u3057\u307e\u3057\u305f\uff08HR *0.67\u300195% CI 0.45\uff5e0.99\u3001**p = 0.05*\uff09\u3002<\/span><\/span><\/li>\n<\/ul>\n<h2><\/h2>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u304c\u3093\u7a2e\u5225\u306e\u7b2cIII\u76f8\u8a66\u9a13\u306e\u5206\u6790<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u8a73\u7d30\u306a\u5206\u6790\u3067\u306f\u3001\u4e3b\u8981\u306a\u751f\u5b58\u7387\u3068\u53cd\u5fdc\u7d50\u679c\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3001*HT \u304c\u6700\u9ad8\u30ec\u30d9\u30eb\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u81e8\u5e8a\u8a66\u9a13\u306b\u3088\u3063\u3066\u30b5\u30dd\u30fc\u30c8\u3055\u308c\u3066\u3044\u308b\u816b\u760d\u90e8\u4f4d*\u3092\u8abf\u67fb\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><\/h3>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.1. \u8edf\u90e8\u8089\u816b\uff08STS\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8edf\u90e8\u8089\u816b\u306f\u3001HT\u7d71\u5408\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30af\u9069\u5fdc\u75c7\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u7b2cIII\u76f8\u8a66\u9a13\u306b\u3088\u3063\u3066\u88cf\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6a19\u6e96\u7684\u306a\u8853\u524d\u5316\u5b66\u7642\u6cd5\u3068\u3001\u8853\u524d\u5316\u5b66\u7642\u6cd5\u3068\u5c40\u6240\u6e29\u71b1\u7642\u6cd5\uff08RHT\uff09\u306e\u4f75\u7528\u3092\u6bd4\u8f03\u3057\u305f\u8a66\u9a13\u3067\u306f\u3001*HT\u306e\u8ffd\u52a0\u306b\u3088\u308a\u751f\u5b58\u7387\u306e\u4e0a\u6607\u3068\u5c40\u6240\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\uff08LPFS\uff09\u306e\u6539\u5584*\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u6027\u9ad8\u30ea\u30b9\u30af\u8089\u816b\u306e\u5834\u5408\u3001\u8853\u524d\u6cbb\u7642\u306e\u5bfe\u8c61\u3068\u306a\u308b\u60a3\u8005\u306b\u5bfe\u3057\u3066RHT\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u306f\u3001\u751f\u5b58\u8ee2\u5e30\u306e\u6539\u5584\u306b\u57fa\u3065\u3044\u3066\u6b63\u5f53\u5316\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u306e\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u89e3\u6790\u306b\u3088\u308a\u3001\u91cd\u8981\u306a\u514d\u75ab\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002RHT\u3092\u4f75\u7528\u3057\u305f\u8853\u524d\u7642\u6cd5\u306f\u3001\u3082\u3068\u3082\u3068\u975e\u708e\u75c7\u6027\u3067\u3042\u3063\u305f\u816b\u760d\u3092\u708e\u75c7\u6027\u816b\u760d\u3078\u3068\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306e\u3053\u306e\u518d\u30d7\u30ed\u30b0\u30e9\u30e0\u5316\u306b\u3088\u308a\u3001\u6297\u816b\u760d\u514d\u75ab\u6d3b\u6027\u306e\u5897\u5f37\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u52b9\u679c\u306f\u3001\u9577\u671f\u751f\u5b58\u306e\u5229\u70b9\u304c\u76f4\u63a5\u7684\u306a\u5316\u5b66\u7642\u6cd5\u611f\u53d7\u6027\u5316\u3060\u3051\u3067\u306a\u304f\u5f37\u529b\u306a\u514d\u75ab\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001HT \u306f\u8cb4\u91cd\u306a\u5fae\u5c0f\u74b0\u5883\u8abf\u7bc0\u30c4\u30fc\u30eb\u3068\u3057\u3066\u4f4d\u7f6e\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2. \u5a66\u4eba\u79d1\u304c\u3093\uff1a\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u304c\u3093\uff08LACC\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u540c\u6642\u5316\u5b66\u653e\u5c04\u7dda\u7642\u6cd5 (CCRT) \u306b\u8ffd\u52a0\u3055\u308c\u305f LACC \u306b\u304a\u3051\u308b HT \u306e\u8a3c\u62e0\u306f\u3001\u816b\u760d\u5b66\u306b\u304a\u3044\u3066\u6700\u3082\u8aac\u5f97\u529b\u306e\u3042\u308b\u3082\u306e\u306e 1 \u3064\u3067\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.1. \u8a66\u9a13\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\uff08CR\u304a\u3088\u3073\u5c40\u6240\u518d\u767a\uff09<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3068\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u306e\u96c6\u8a08\u30c7\u30fc\u30bf\u306f\u3001\u4f53\u7cfb\u7684\u306b\u3001\u4e09\u69d8\u5f0f\u7642\u6cd5\uff08CCRT + HT\uff09\u306e\u5229\u70b9\u3092\u88cf\u4ed8\u3051\u3066\u3044\u307e\u3059\u3002<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u96c6\u8a08\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u3067\u306f\u3001\u4f75\u7528\u7642\u6cd5\u306b\u304a\u3044\u3066\u3001\u5b8c\u5168\u594f\u52b9\u7387\uff08CR\uff09\u304c\u6709\u610f\u306b\u9ad8\u304f\uff08RR 0.56; p &lt; 0.001\uff09\u3001\u5c40\u6240\u518d\u767a\u7387\u3082\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08HR 0.48; p &lt; 0.001\uff09\u3002\u3053\u306e\u512a\u308c\u305f\u5c40\u6240\u5236\u5fa1\u306b\u3088\u308a\u3001\u4e09\u69d8\u5f0f\u7642\u6cd5\u306f\u5b9f\u73fe\u53ef\u80fd\u304b\u3064\u52b9\u679c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/strong><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.2. \u5168\u751f\u5b58\u671f\u9593\uff08OS\uff09\u306e\u5b9a\u91cf\u5316<\/span><\/span><\/h4>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5168\u751f\u5b58\u7387\uff08OS\uff09\u306f\u3001CCRT\u3068HT\u306e\u4f75\u7528\u306b\u3088\u308a\u6709\u610f\u306b\u6539\u5584\u3057\u3001HR\u306f0.67\uff0895%\u4fe1\u983c\u533a\u95930.45\uff5e0.99\u3001p = 0.05\uff09\u3067\u3057\u305f\u3002<\/span><\/span><\/strong><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u904e\u53bb\u306e\u30c7\u30fc\u30bf\u306f\u73fe\u5728\u306e\u6cbb\u7642\u57fa\u6e96\u306b\u7167\u3089\u3057\u3066\u89e3\u91c8\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5f53\u6642\u306eN3\u6241\u5e73\u4e0a\u76ae\u9838\u90e8\u30ea\u30f3\u30d1\u7bc0\u306b\u5bfe\u3059\u308bRT +- HT\u3092\u8a55\u4fa1\u3057\u305f\u30a4\u30bf\u30ea\u30a2\u306e\u7b2cIII\u76f8\u8a66\u9a13\u3067\u306f\u3001\u9855\u8457\u306a\u5dee\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002*\u4f75\u7528\u6cbb\u7642\u7fa4\u306eCR\u7387\u306f82.3%\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u307f\u3092\u53d7\u3051\u305f\u816b\u760d\u60a3\u8005\u3067\u306f36.8%\u3067\u3057\u305f* [3,4]\u3002\u540c\u8a66\u9a13\u306e\u9577\u671f\u89e3\u6790\u3067\u306f\u3001*5\u5e74\u5168\u751f\u5b58\u7387\u306f\u6e29\u71b1\u7642\u6cd5\u7fa4\u306755%\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u5358\u72ec\u7fa4\u30670%\u3067\u3042\u3063\u305f* [3,4]\u3002\u5236\u5fa1\u30ec\u30b8\u30e1\u30f3\uff08RT\u5358\u72ec\u7642\u6cd5\uff09\u306f\u73fe\u4ee3\u306e\u57fa\u6e96\uff08CCRT\u3092\u4f7f\u7528\uff09\u3067\u306f\u52a3\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u6b74\u53f2\u7684\u7d50\u679c\u306f\u4f9d\u7136\u3068\u3057\u3066\u975e\u5e38\u306b\u8cb4\u91cd\u3067\u3042\u308a\u3001\u7279\u306b\u901a\u5e38\u306f\u9ad8\u5ea6\u306b\u4f4e\u9178\u7d20\u3067\u6cbb\u7642\u62b5\u6297\u6027\u3067\u3042\u308b\u9ad8\u4f53\u7a4d\u30ea\u30f3\u30d1\u7bc0\u75be\u60a3\u306b\u304a\u3044\u3066\u3001HT\u306e\u4e26\u5916\u308c\u305f\u653e\u5c04\u7dda\u5897\u611f\u80fd\u529b\u3092\u5b9f\u8a3c\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3. \u8ffd\u52a0\u8a3c\u62e0\uff08OS\uff09<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u3082\u5f37\u529b\u306a\u30ec\u30d9\u30eb\u306e\u8ffd\u52a0\u8a3c\u62e0\u306f\u5b50\u5bae\u9838\u304c\u3093\u306b\u3088\u3063\u3066\u63d0\u4f9b\u3055\u308c\u3066\u304a\u308a\u3001\u5c40\u6240\u9818\u57df\u6e29\u71b1\u7642\u6cd5\u3068\u653e\u5c04\u7dda\u7642\u6cd5 (RT) \u307e\u305f\u306f\u5316\u5b66\u653e\u5c04\u7dda\u7642\u6cd5 (CTRT) \u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6cbb\u7642\u304c\u591a\u6570\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u3067\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u308c\u3089\u306e\u7d50\u679c\uff08\u5b50\u5bae\u9838\u304c\u3093\u306b\u95a2\u3059\u308b\u9ad8\u30ec\u30d9\u30eb\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\uff09\u306f\u3001\u6a19\u6e96\u6cbb\u7642\uff08RT \u307e\u305f\u306f CTRT\uff09\u3068\u4f75\u7528\u6cbb\u7642\uff08RT\/CTRT + \u6e29\u71b1\u7642\u6cd5\uff09\u3092\u6bd4\u8f03\u3057\u305f\u30e1\u30bf\u5206\u6790\u304b\u3089\u62bd\u51fa\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81e8\u5e8a\u6307\u6a19<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RT + \u6e29\u71b1\u7642\u6cd5\u3067\u9054\u6210\u3055\u308c\u305f\u7d50\u679c<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003\u6587\u732e\uff08\u67fb\u8aad\u6e08\u307f\u5f15\u7528\u6587\u732e\uff09<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u594f\u52b9\uff08CR\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR \u7387\u304c\u4e00\u8cab\u3057\u3066\u5411\u4e0a:<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5358\u7d14\u306a RT \u3068\u6bd4\u8f03\u3057\u3066<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">+22.1% \u3002<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30e1\u30bf\u5206\u6790<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9818\u57df\u5236\u5fa1\uff08LRC\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5927\u5e45\u306a\u6539\u5584:<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5358\u7d14\u306a RT \u3068\u6bd4\u8f03\u3057\u3066<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">+23.1% \u3002<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30e1\u30bf\u5206\u6790<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5168\u751f\u5b58\u7387\uff08OS\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u71b1\u7642\u6cd5\u306e\u8ffd\u52a0\u306b\u3088\u308a\u3001\u9577\u671f OS \u306e\u6539\u5584\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f (HR 0.67\u3001p = 0.03)\u3002<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30e1\u30bf\u5206\u6790\u306e\u66f4\u65b0<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7121\u75c5\u751f\u5b58\u7387\uff08DFS\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CTRT \u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u30012 \u5e74\u304a\u3088\u3073 3 \u5e74\u306e DFS \u304c\u5927\u5e45\u306b\u6539\u5584\u3055\u308c\u307e\u3059\u3002<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ee5\u4e0b\u306b\u3001\u8a00\u53ca\u3055\u308c\u3066\u3044\u308b 3 \u3064\u306e\u30e1\u30bf\u5206\u6790\u3068\u30d5\u30a7\u30fc\u30ba III \u8a66\u9a13\u3001\u304a\u3088\u3073\u5bfe\u5fdc\u3059\u308b\u30ea\u30f3\u30af\u3092\u793a\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.1. \u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff1aCR\u3001\u5c40\u6240\u9818\u57df\u5236\u5fa1\uff08LRC\uff09\u3001\u5168\u751f\u5b58\u7387\uff08OS\uff09\uff08Lutgens et al.\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u308c\u306f\u3001\u8907\u6570\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u306e\u7d50\u679c\u3092\u7d71\u5408\u3057\u3001\u6e29\u71b1\u7642\u6cd5\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u5927\u304d\u306a\u5229\u70b9\u3092\u78ba\u8a8d\u3057\u305f\u57fa\u790e\u7814\u7a76 (\u30b3\u30af\u30e9\u30f3\u30ec\u30d3\u30e5\u30fc) \u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u78ba\u8a8d\u3055\u308c\u305f\u6307\u6a19<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u306a\u6210\u679c<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u594f\u52b9\uff08CR\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6709\u610f\u306a\u6539\u5584\uff08RR 0.56; p &lt; 0.001\uff09<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9818\u57df\u5236\u5fa1\uff08LRC\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6709\u610f\u306a\u6539\u5584\uff08HR 0.48; p &lt; 0.001\uff09<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5168\u751f\u5b58\u7387\uff08OS\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3\u5e74\u5f8c\u306b\u6709\u610f\u306a\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\uff08HR 0.67; p = 0.05\uff09<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30bf\u30a4\u30c8\u30eb:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u764c\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u3068\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u4f75\u7528<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8457\u8005:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Lutgens L\u3001van der Zee J\u3001Pijls-Johannesma M\u3001\u4ed6\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">PubMed\u30ea\u30f3\u30af\uff082010\u5e74\u66f4\u65b0\uff09: <\/span><\/span><\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20091593\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/20091593\/<\/span><\/span><\/a><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.2. \u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u5206\u6790\uff08NMA\uff09\uff1a\u6700\u5584\u306e\u6226\u7565\uff08Datta et al. 2019\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u9ad8\u5ea6\u306a\u65b9\u6cd5 (\u30cd\u30c3\u30c8\u30ef\u30fc\u30af \u30e1\u30bf\u5206\u6790) \u3092\u4f7f\u7528\u3057\u3066\u3001\u6e29\u71b1\u7642\u6cd5\u3092\u4ed6\u306e 13 \u7a2e\u985e\u306e\u6cbb\u7642\u4ecb\u5165\u3068\u6bd4\u8f03\u3057\u3001\u6e29\u71b1\u7642\u6cd5\u3092\u6700\u4e0a\u4f4d\u306e\u9078\u629e\u80a2\u306e 1 \u3064\u3068\u3057\u3066\u30e9\u30f3\u30af\u4ed8\u3051\u3057\u307e\u3057\u305f\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u78ba\u8a8d\u3055\u308c\u305f\u6307\u6a19<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u306a\u6210\u679c<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cbb\u7642\u30e9\u30f3\u30ad\u30f3\u30b0<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RT+HT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3068<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CTRT+HT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u306f\u3001LRC\u3001OS\u3001\u6bd2\u6027\u306b\u5bfe\u3059\u308b\u7dcf\u5408\u7684\u306a\u5f71\u97ff\u304c\u6700\u3082\u512a\u308c\u305f\u4ecb\u5165\u6cd5\u3068\u3057\u3066\u4e0a\u4f4d 3 \u3064\u306b\u30e9\u30f3\u30af\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30bf\u30a4\u30c8\u30eb\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u304c\u3093\u306b\u304a\u3051\u308b\u69d8\u3005\u306a\u6cbb\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u306e\u8a55\u4fa1\uff1a\u30e9\u30f3\u30c0\u30e0\u5316\u81e8\u5e8a\u8a66\u9a13\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8457\u8005:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Datta NR\u3001Stutz E\u3001Gomez S\u3001Bodis S.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">PubMed\u30ea\u30f3\u30af: <\/span><\/span><\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30391522\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30391522\/<\/span><\/span><\/a><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.3. \u7b2cIII\u76f8\u8a66\u9a13\uff1amEHT\u306b\u3088\u308b\u7121\u75c5\u751f\u5b58\u671f\u9593\uff08DFS\uff09\u3068QOL<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u308c\u306f\u3001\u5316\u5b66\u653e\u5c04\u7dda\u7642\u6cd5 (CTRT) \u306b\u6700\u65b0\u306e\u6e29\u71b1\u7642\u6cd5 (mEHT) \u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067\u5f97\u3089\u308c\u308b DFS \u3084\u751f\u6d3b\u306e\u8cea (QoL) \u306e\u5411\u4e0a\u306a\u3069\u306e\u5229\u70b9\u3092\u78ba\u8a8d\u3057\u305f\u6700\u8fd1\u306e\u7b2c III \u76f8\u8a66\u9a13\u306e 1 \u3064\u3067\u3059\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u78ba\u8a8d\u3055\u308c\u305f\u6307\u6a19<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u306a\u6210\u679c<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7121\u75c5\u751f\u5b58\u7387\uff08DFS\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CTRT \u306b mEHT \u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067\u30012 \u5e74\u304a\u3088\u3073 3 \u5e74\u306e DFS \u304c\u5927\u5e45\u306b\u6539\u5584\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u6d3b\u306e\u8cea\uff08QoL\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6bd2\u6027\u306e\u5897\u52a0\u306a\u3057\u306b\u3001QOL\u304c\u5927\u5e45\u306b\u5411\u4e0a\u3057\u307e\u3059\u3002<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30bf\u30a4\u30c8\u30eb:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u304c\u3093\u60a3\u8005\u306e2\u5e74\u751f\u5b58\u7387\u304a\u3088\u30733\u5e74\u751f\u5b58\u7387\u306b\u5bfe\u3059\u308b\u5909\u8abf\u96fb\u6c17\u6e29\u71b1\u7642\u6cd5\uff08mEHT\uff09\u306e\u52b9\u679c<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8457\u8005:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Minnaar CA\u3001Maposa I\u3001Kotzen JA\u3001\u4ed6\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MDPI\u30ea\u30f3\u30af\uff08\u5168\u6587\u95b2\u89a7\u53ef\u80fd\uff09: <\/span><\/span><\/strong> <a href=\"https:\/\/www.mdpi.com\/2072-6694\/14\/3\/656\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.mdpi.com\/2072-6694\/14\/3\/656<\/span><\/span><\/a><\/li>\n<\/ul>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u304c\u3093\u306e\u5834\u5408\u3001\u5c40\u6240\u9818\u57df\u6e29\u71b1\u7642\u6cd5\u3092\u8ffd\u52a0\u3059\u308b\u3068\u3001\u5c40\u6240\u816b\u760d\u6839\u7d76\uff08CR\uff09\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u9577\u671f\u751f\u5b58\uff08OS\u304a\u3088\u3073DFS\uff09\u306b\u3082\u5927\u304d\u306a\u30d7\u30e9\u30b9\u306e\u5f71\u97ff\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.3. \u982d\u9838\u90e8\u304c\u3093\uff08HNC\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9818\u57df\u6e29\u71b1\u7642\u6cd5\u306f\u3001\u518d\u767a\u3084\u9032\u884c\u764c\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u982d\u9838\u90e8\u816b\u760d\u306b\u5bfe\u3059\u308b\u30ec\u30d9\u30eb 1A \u306e\u6cbb\u7642\u6cd5\u3067\u3042\u308a\u3001\u5c40\u6240\u5236\u5fa1\u304c\u751f\u6d3b\u306e\u8cea\u3068\u751f\u5b58\u306b\u76f4\u63a5\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.3.1. \u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u30c7\u30fc\u30bf<\/span><\/span><\/h4>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u524d\u5411\u304d\u30e9\u30f3\u30c0\u30e0\u5316\u7b2cIII\u76f8\u8a66\u9a13\u3067\u306f\u3001\u9f3b\u54bd\u982d\u304c\u3093\uff08NPC\uff09\u306b\u304a\u3044\u3066\u3001\u5316\u5b66\u653e\u5c04\u7dda\u7642\u6cd5\uff08CRT\uff09\u3068HT\u306e\u4f75\u7528\u306f\u3001CRT\u5358\u72ec\u3068\u6bd4\u8f03\u3057\u3066\u660e\u3089\u304b\u306a\u5229\u70b9\u304c\u3042\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/strong><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u25cf <\/span><\/span><strong><a href=\"https:\/\/doi.org\/10.7314\/apjcp.2013.14.12.7395\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Kang 2013<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08NPC\uff09\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u7b2cIII\u76f8\u8a66\u9a13\u3067\u306f\u3001\u6709\u610f\u306a\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u7121\u75c5\u751f\u5b58\u7387\uff08DFS\uff09\u306f25.5%\u304b\u308951.3%\uff08p &lt; 0.005\uff09\u306b\u5897\u52a0\u3057\u30015\u5e74\u5168\u751f\u5b58\u7387\uff08OS\uff09\u306f50%\u304b\u308968.4%\uff08p &lt; 0.005\uff09\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002CR\u7387\u308262.8%\u304b\u308981.6%\u306b\u5897\u52a0\u3057\u307e\u3057\u305f<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf <\/span><\/span><strong><a href=\"https:\/\/journals.lww.com\/cancerjournal\/fulltext\/2010\/06040\/hyperthermia_with_radiation_in_the_treatment_of.16.aspx\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Huilgol 2010<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08\u53e3\u8154\uff0f\u4e2d\u54bd\u982d\uff0f\u4e0b\u54bd\u982d\uff09\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u594f\u52b9\u306f\u3001<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u7dda\u7642\u6cd5\u5358\u72ec\u7fa4\u306e42.4%\u3067\u89b3\u5bdf\u3055\u308c\u305f\u306e\u306b\u5bfe\u3057\u3001HT\u4f75\u7528\u7fa4\u3067\u306f78.6%\u3067\u3057\u305f<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u3053\u306e\u5dee\u306f\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u3057\u305f\uff08&lt; 0.05\uff09\u3002\u30ab\u30d7\u30e9\u30f3\u30fb\u30de\u30a4\u30e4\u30fc\u751f\u5b58\u7387\u89e3\u6790\u3067\u3082\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u4f75\u7528HT\u304c\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u7dda\u91cf\u5236\u9650\u71b1\u50b7\u3084\u904e\u5ea6\u306e\u7c98\u819c\u6bd2\u6027\u3001\u71b1\u6bd2\u6027\u306f\u8a18\u9332\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u518d\u767a\u7387\u304c\u9ad8\u3044\u3053\u3068\u304c\u591a\u3044\u982d\u9838\u90e8\u764c\uff08HNC\uff09\u306b\u304a\u3051\u308bDFS\u3068OS\u306e\u5927\u5e45\u304b\u3064\u4e00\u8cab\u3057\u305f\u6539\u5584\u306f\u3001HT\u304c\u5c40\u6240\u653e\u5c04\u7dda\u62b5\u6297\u6027\u306e\u514b\u670d\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u304a\u308a\u3001\u6cbb\u7652\u76ee\u7684\u306e\u6cbb\u7642\u306b\u4e0d\u53ef\u6b20\u306a\u8981\u7d20\u3068\u306a\u3063\u3066\u3044\u308b[5]\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4. \u6d88\u5316\u5668\u304c\u3093\uff1a\u76f4\u8178\u304c\u3093\u3068\u809b\u9580\u304c\u3093<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9032\u884c\u76f4\u8178\u304c\u3093\u306b\u304a\u3051\u308b HT \u3068\u8853\u524d\u5316\u5b66\u653e\u5c04\u7dda\u7642\u6cd5 (CRT) \u306e\u7d71\u5408\u306f\u3001\u5c40\u6240\u9818\u57df\u306e\u5236\u5fa1\u3068\u751f\u5b58\u306b\u91cd\u8981\u306a\u5229\u70b9\u304c\u3042\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4.1. \u76f4\u8178\u304c\u3093\u306b\u304a\u3051\u308b\u7b2cIII\u76f8\u8a66\u9a13\u306e\u7d50\u679c<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u524d\u5411\u304d\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13* <\/span><\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Ott 2019<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> *\u3067\u306f\u3001CRT\u3068CRT + HT\u3092\u6bd4\u8f03\u3057\u3001HT\u7fa4\u30675\u5e74\u9593\u306e\u6709\u610f\u306a\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf\u5168\u751f\u5b58\u7387\uff08OS\uff09\uff1a95.8% vs. 74.5%\uff08P = 0.045\uff09\u3002<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf\u7121\u75c5\u751f\u5b58\u7387\uff08DFS\uff09\uff1a89.1% vs. 70.4%\uff08P = 0.027\uff09\u3002<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf\u5c40\u6240\u518d\u767a\u306a\u3057\u751f\u5b58\u7387\uff08LRFS\uff09\uff1a97.7% vs. 78.7%\uff08P = 0.006\uff09<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4.2. \u75c5\u7406\u5b66\u7684\u53cd\u5fdc\u3068\u81e8\u5e8a\u7684\u610f\u7fa9<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u75c5\u7406\u5b66\u7684\u5b8c\u5168\u594f\u52b9\uff08pCR\uff09\u7387\u3082\u3001HT \u306e\u8ffd\u52a0\u306b\u3088\u3063\u3066\u6539\u5584\u3055\u308c\u307e\u3057\u305f\u3002*\u30e1\u30bf\u5206\u6790\u3067\u306f\u300116%\uff08CRT\uff09\u304b\u3089 22.5%\uff08CRT+HT\u3001p = 0.043\uff09\u3078\u306e\u5897\u52a0\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002*<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u3082\u91cd\u8981\u306a\u306e\u306f\u3001\u512a\u308c\u305f LRFS \u7387\uff0897.7%\uff09\u3068\u4eba\u5de5\u809b\u9580\u306a\u3057\u306e\u751f\u5b58\u7387\u306e\u6539\u5584\uff0887.7% vs. 69.0%\u3001P = 0.016\uff09\u306b\u3088\u308a\u3001HT \u304c\u5c40\u6240\u816b\u760d\u306e\u6bba\u83cc\u3060\u3051\u3067\u306a\u304f\u62ec\u7d04\u7b4b\u6e29\u5b58\u6226\u7565\u306b\u304a\u3044\u3066\u3082\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u3002<\/span><\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.5. \u60aa\u6027\u9ed2\u8272\u816b\uff08\u5c40\u6240\u9818\u57df\u6027\u75be\u60a3\uff09<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u57fa\u790e\u7684\u306a\u7b2c III \u76f8\u7814\u7a76 ( <\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Overgaard \u3089\u30011995 \u5e74<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">) \u3067\u306f\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u3068 HT \u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u9032\u884c\u6027\u9ed2\u8272\u816b\u306e\u5b8c\u5168\u594f\u52b9\u7387\u3068 OS \u304c\u6539\u5584\u3055\u308c\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/strong><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u306a\u7d50\u679c: RT + \u6e29\u71b1\u7642\u6cd5 vs. \u653e\u5c04\u7dda\u7642\u6cd5<\/span><\/span><\/strong><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6b27\u5dde\u306e\u591a\u65bd\u8a2d\u5171\u540c\u7814\u7a76\u3067\u306f\u300170\u4eba\u306e\u60a3\u8005\u306e\u8ee2\u79fb\u6027\u307e\u305f\u306f\u518d\u767a\u6027\u9ed2\u8272\u816b\u75c5\u5909134\u500b\u3092\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u307f\u3092\u53d7\u3051\u308b\u7fa4\u3001\u307e\u305f\u306f\u653e\u5c04\u7dda\u7642\u6cd5\u5f8c\u306b\u6e29\u71b1\u7642\u6cd5\uff0843\u2103\u306760\u5206\uff09\u3092\u53d7\u3051\u308b\u7fa4\u306b\u5206\u3051\u307e\u3057\u305f\u3002<\/span><\/span><\/p>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u5c40\u6240\u816b\u760d\u5236\u5fa1\uff08\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u3082\u91cd\u8981\u306a\u7d50\u679c\u306f\u3001\u9577\u671f\u7684\u306a\u5c40\u6240\u816b\u760d\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u5927\u5e45\u306b\u6539\u5584\u3055\u308c\u305f\u3053\u3068\u3067\u3059\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d42\u70b9<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u7dda\u7642\u6cd5\u5358\u72ec\uff08RT\uff09<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u7dda\u7642\u6cd5 + \u6e29\u71b1\u7642\u6cd5\uff08RT + HT\uff09<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u306a\u9055\u3044<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\u5e74\u76ee\u306e\u4fdd\u967a\u6570\u7406\u7684\u30ed\u30fc\u30ab\u30eb\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28%<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46%<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6709\u610f\u306a\u6539\u5584\uff08p = 0.008\uff09<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d50\u8ad6:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u306e\u8ffd\u52a0\u306b\u3088\u308a\u30012 \u5e74\u6642\u70b9\u3067\u5c40\u6240\u816b\u760d\u306e\u5236\u5fa1\u304c *18 \u30d1\u30fc\u30bb\u30f3\u30c8\u30dd\u30a4\u30f3\u30c8* \u6539\u5584\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u591a\u5909\u91cf\u89e3\u6790\uff08\u4e88\u5f8c\u56e0\u5b50\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u5909\u91cf Cox \u56de\u5e30\u5206\u6790\u306b\u3088\u308a\u3001*\u9ad8\u4f53\u6e29*\u304c 2 \u5e74\u6642\u70b9\u3067\u306e\u5c40\u6240\u5236\u5fa1\u306e\u6700\u3082\u91cd\u8981\u306a\u4e88\u5f8c\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e88\u5f8c\u5909\u6570<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30ea\u30b9\u30af\uff08\u30aa\u30c3\u30ba\u6bd4\uff09<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P\u5024<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ad8\u4f53\u6e29<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.73<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08\u30ed\u30fc\u30ab\u30eb\u5236\u5fa1\u7528\uff09<\/span><\/span><\/td>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0.023<\/span><\/span><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u7dda\u91cf<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.17<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0.05<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u816b\u760d\u306e\u5927\u304d\u3055<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.91<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0.05<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d50\u8ad6:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u308c\u306f\u3001HT \u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u308b\u5229\u70b9\u304c\u3001\u4f7f\u7528\u3055\u308c\u308b\u653e\u5c04\u7dda\u91cf\u3084\u816b\u760d\u306e\u30b5\u30a4\u30ba\u3068\u306f\u72ec\u7acb\u3057\u3066\u304a\u308a\u3001\u5c11\u306a\u304f\u3068\u3082\u305d\u308c\u3089\u3068\u540c\u7a0b\u5ea6\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u751f\u5b58\uff08\u5c40\u6240\u5236\u5fa1\u304c\u6cbb\u7652\u306b\u3064\u306a\u304c\u308b\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u5c40\u6240\u5236\u5fa1\u306e\u6210\u529f\u3068\u9577\u671f\u751f\u5b58\u306e\u9593\u306b\u5f37\u3044\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u5168\u751f\u5b58\u7387\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5168\u4f53\u7684\u5272\u5408\u306f19%\u3067\u3057\u305f\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u75c5\u6c17\u304c\u5b8c\u5168\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u305f\u60a3\u8005\u306e 5 \u5e74\u751f\u5b58\u7387:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> *38%* \u306b\u5897\u52a0\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d50\u8ad6:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5358\u4e00\u307e\u305f\u306f\u5c11\u6570\u306e\u8ee2\u79fb\u75c5\u5909\u306e\u5c40\u6240\u5236\u5fa1\u306e\u6210\u529f\u306b\u306f*\u9855\u8457\u306a\u6cbb\u7652\u306e\u53ef\u80fd\u6027*\u304c\u3042\u308a\u3001HT \u306b\u3088\u308b\u5c40\u6240\u52b9\u679c\u306e\u5411\u4e0a\u306e\u91cd\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u6bd2\u6027\u3068\u5b89\u5168\u6027<\/span><\/span><\/h5>\n<ul>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u71b1\u3092\u52a0\u3048\u308b\u3053\u3068\u3067\u3001*\u6025\u6027\u307e\u305f\u306f\u9045\u767a\u6027\u306e\u653e\u5c04\u7dda\u53cd\u5fdc\u304c\u5927\u5e45\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093*\u3002<\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u52a0\u71b1\u51e6\u7406\u306f\u4e00\u822c\u7684\u306b*\u8010\u5bb9\u6027\u826f\u597d*\u3067\u3057\u305f\u3002<\/span><\/span><\/li>\n<\/ul>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6ce8:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u3067\u306f\u3001\u6e29\u71b1\u30d7\u30ed\u30c8\u30b3\u30eb\u306e\u76ee\u6a19 (43\u00b0C) \u3092\u9054\u6210\u3059\u308b\u306e\u304c\u56f0\u96e3\u3067\u3042\u308a\u3001\u6cbb\u7642\u306e\u308f\u305a\u304b 14% \u3057\u304b\u9054\u6210\u3067\u304d\u306a\u304b\u3063\u305f\u3068\u8ff0\u3079\u3089\u308c\u3066\u304a\u308a\u3001\u6700\u9069\u5316\u3055\u308c\u305f\u52a0\u71b1\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u4f7f\u7528\u3059\u308c\u3070\u5b9f\u969b\u306e\u5229\u70b9\u304c\u3055\u3089\u306b\u5927\u304d\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ed2\u8272\u816b\u306f\u514d\u75ab\u539f\u6027\u304c\u975e\u5e38\u306b\u9ad8\u3044\u75be\u60a3\u3067\u3042\u308a\u3001\u514d\u75ab\u7642\u6cd5\u306e\u6700\u521d\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306e1\u3064\u3067\u3042\u3063\u305f\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001HT\u304c\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3057\u3001\u5c40\u6240\u5236\u5fa1\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u304a\u308a\u3001\u65b0\u3057\u3044\u514d\u75ab\u816b\u760d\u85ac\u3068\u306e\u7d71\u5408\u306e\u91cd\u8981\u306a\u81e8\u5e8a\u6a5f\u4f1a\u304c\u958b\u304b\u308c\u3001\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u6709\u52b9\u6027\u304c\u5897\u5e45\u3055\u308c\u307e\u3059[4]\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6 \u518d\u767a\u4e73\u304c\u3093<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.1. \u518d\u767a\u4e73\u304c\u3093\u306b\u304a\u3051\u308b\u6e29\u71b1\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3092\u78ba\u8a8d\u3059\u308b\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30e1\u30bf\u5206\u6790\u3067\u306f\u3001\u30d5\u30a7\u30fc\u30ba III \u81e8\u5e8a\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001*\u5c40\u6240\u9818\u57df\u518d\u767a\u4e73\u304c\u3093 (LRBC)* \u306e\u5834\u5408\u306e\u4f75\u7528\u7642\u6cd5 (\u653e\u5c04\u7dda\u7642\u6cd5 + \u6e29\u71b1\u7642\u6cd5) \u306e\u5b8c\u5168\u594f\u52b9\u7387 (CR) \u3092\u5b9f\u8a3c\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u308c\u306f\u3001\u4f75\u7528\u6cbb\u7642\u306e*60\uff5e66% CR*\u7387\u3092\u542b\u3080\u30ec\u30d9\u30eb 1A \u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u7d50\u8ad6\u3092\u88cf\u4ed8\u3051\u308b\u7814\u7a76\u3067\u3059\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\uff1a<\/span><\/span><\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u518d\u767a\u6027\u4e73\u304c\u3093\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u3068\u653e\u5c04\u7dda\u7642\u6cd5\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u5206\u6790\u3002<\/span><\/span><\/strong><\/a><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8457\u8005:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Datta NR\u3001Puric E\u3001Klingbiel D\u3001Gomez S\u3001Bodis S.<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u63b2\u8f09\u8a8c\uff1a<\/span><\/span><\/strong> <em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">International Journal of Radiation Oncology Biology Physics<\/span><\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30012016\u5e74\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d50\u8ad6:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u71b1\u653e\u5c04\u7dda\u7642\u6cd5 (RT + \u6e29\u71b1\u7642\u6cd5) \u3067\u306f\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u5358\u72ec\u3068\u6bd4\u8f03\u3057\u3066\u5b8c\u5168\u594f\u52b9\u7387 (CR) \u304c\u7d04 *22%* \u5897\u52a0\u3057\u307e\u3059\u30022 \u3064\u306e\u6cbb\u7642\u7fa4\u3092\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u3067\u306f\u3001RT + \u6e29\u71b1\u7642\u6cd5 (HT) \u3067\u306f *60.2%* \u306e\u5b8c\u5168\u594f\u52b9\u7387\u304c\u9054\u6210\u3055\u308c\u305f\u306e\u306b\u5bfe\u3057\u3001RT (\u653e\u5c04\u7dda\u7642\u6cd5) \u5358\u72ec\u3067\u306f 38.1% \u3067\u3042\u308a\u3001\u6e29\u71b1\u7642\u6cd5\u306b\u3088\u308b\u518d\u7167\u5c04\u306e\u5834\u5408\u306f CR \u7387\u304c *66.6%* \u306b\u9054\u3057\u307e\u3057\u305f\u3002<\/span><\/span><\/li>\n<\/ul>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.2 \u4e73\u304c\u3093\u306e\u80f8\u90e8\u518d\u767a<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u71b1\u7642\u6cd5\u306f\u3001\u901a\u5e38\u653e\u5c04\u7dda\u7642\u6cd5\u3068\u4f75\u7528\u3055\u308c\u3001\u4e73\u304c\u3093\u306e\u80f8\u90e8\u518d\u767a\u6cbb\u7642\u306b\u304a\u3044\u3066\u30ec\u30d9\u30eb1A\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u4f75\u7528\u7642\u6cd5\u306f\u3001\u6cbb\u7642\u9078\u629e\u80a2\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u3044\u80f8\u58c1\u518d\u767a\u306b\u304a\u3044\u200b\u200b\u3066\u7279\u306b\u6709\u52b9\u3067\u3059\u3002\u7814\u7a76\u3067\u306f\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u3068\u6e29\u71b1\u7642\u6cd5\u3092\u4f75\u7528\u3057\u305f\u5834\u5408\u300140%\u304b\u308986%\u306e\u9ad8\u3044\u5b8c\u5168\u594f\u52b9\u7387\uff08CR\uff09\u300170%\u304b\u308976%\u306e\u5c40\u6240\u5236\u5fa1\u7387\uff08LC\uff09\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u518d\u767a\u6027\u75be\u60a3\u306e5\u5e74\u5168\u751f\u5b58\u7387\u306f\u6700\u592750%\u306b\u9054\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u7dda\u7642\u6cd5\u3068\u6e29\u71b1\u7642\u6cd5\u306e\u4f75\u7528\u306f\u3001\u7de9\u548c\u7642\u6cd5\u3068\u9577\u671f\u5236\u5fa1\u306e\u305f\u3081\u306e\u52b9\u679c\u7684\u306a\u5c40\u6240\u7642\u6cd5\u3067\u3042\u308a\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u9ad8\u7dda\u91cf\u30b5\u30eb\u30d9\u30fc\u30b8\u7642\u6cd5\u3084\u6839\u6cbb\u624b\u8853\u306e\u5fc5\u8981\u6027\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.3. \u5c40\u6240\u9818\u57df\u7642\u6cd5\u306e\u4e00\u822c\u7684\u50be\u5411 &#8211; \u30ec\u30d9\u30eb1\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u6709\u3059\u308b\u305d\u306e\u4ed6\u306e\u816b\u760d\u5b66\u7684\u9069\u5fdc\u75c7<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d50\u8ad6\u306e\u5c40\u6240\u9818\u57df\u7642\u6cd5\u3078\u306e\u62e1\u5f35\uff1a<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8a3c\u62e0\u306e\u7d71\u5408: <\/span><\/span><\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2 \u56de\u76ee\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">( <\/span><\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1 \u56de\u76ee\u306f Hildenbrandt \u3089\u306b\u3088\u308b\u30ec\u30d3\u30e5\u30fc<\/span><\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">) \u3067\u306f\u3001*6 \u3064\u306e\u30d5\u30a7\u30fc\u30ba III \u8a66\u9a13\u306e\u3046\u3061 5 \u3064* (\u4e73\u304c\u3093\u3001\u982d\u9838\u90e8\u304c\u3093\u3001\u9ed2\u8272\u816b\u306a\u3069\u306e\u8868\u5728\u6027\u304a\u3088\u3073\u5c40\u6240\u9818\u57df\u6027\u816b\u760d\u3092\u5bfe\u8c61) \u3067\u3001\u6a19\u6e96\u6cbb\u7642\u306b\u6e29\u71b1\u7642\u6cd5\u3092\u8ffd\u52a0\u3057\u305f\u5834\u5408\u3001*\u5168\u751f\u5b58\u7387 (OS)* \u304a\u3088\u3073\/\u307e\u305f\u306f *\u5b8c\u5168\u594f\u52b9 (CR)* \u306e\u5897\u52a0\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7de9\u548c\u7684\u5fdc\u7528:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u6e29\u71b1\u7642\u6cd5\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001\u75db\u307f\u3092\u4f34\u3046\u9aa8\u8ee2\u79fb\u306e\u5834\u5408\u306b\u300c\u75db\u307f\u306b\u5bfe\u3059\u308b\u5b8c\u5168\u306a\u53cd\u5fdc\u300d\u304c\u5927\u5e45\u306b\u5897\u52a0\u3057\u3001\u60a3\u8005\u306e\u751f\u6d3b\u306e\u8cea (QoL) \u304c\u5927\u5e45\u306b\u6539\u5584\u3055\u308c\u307e\u3059\u3002<\/span><\/span><\/li>\n<\/ul>\n<h3><\/h3>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7. \u8180\u80f1\u304c\u3093\uff1a\u6e29\u71b1\u8180\u80f1\u5185\u5316\u5b66\u7642\u6cd5\uff08HIVEC\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u71b1\u8180\u80f1\u5185\u5316\u5b66\u7642\u6cd5\uff08HIVEC\uff09\u3067\u306f\u3001\u975e\u7b4b\u5c64\u6d78\u6f64\u6027\u8180\u80f1\u764c\uff08NMIBC\uff09\u306b\u5bfe\u3059\u308b\u8180\u80f1\u6ce8\u5165\u6642\u306b\u30de\u30a4\u30c8\u30de\u30a4\u30b7\u30f3C\uff08MMC\uff09\u3092\uff08\u901a\u5e3843\u2103\u307e\u3067\uff09\u52a0\u71b1\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3042\u308b[6]\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7.1. HIVEC-1\u7b2cIII\u76f8\u8a66\u9a13\u306e\u7d50\u679c<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HIVEC-1\u8a66\u9a13\u306f\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u7b2c3\u76f8\u8a66\u9a13\u3067\u3042\u308a\u3001\u4e2d\u7b49\u5ea6\u30ea\u30b9\u30afNMIBC\uff08IR-NMIBC\uff09\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u5e38\u6e29MMC\u3068\u6e29\u71b1MMC\uff0843\u2103\u300130\u5206\u307e\u305f\u306f60\u5206\uff09\u306e\u7121\u518d\u767a\u751f\u5b58\u7387\uff08RFS\uff09\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f[6]\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff08RFS\uff09\uff1a\u6cbb\u7642\u610f\u56f3\uff08ITT\uff09\u96c6\u56e3\u306b\u304a\u3051\u308b24\u30f6\u6708\u6642\u70b9\u306eRFS\u306f\u3001\u5bfe\u7167\u7fa4\uff08\u5e38\u6e29\uff09\u306777%\u3001\u6e29\u71b130\u5206\u306782%\u3001\u6e29\u71b160\u5206\u306780%\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u8a66\u9a13\u3067\u306f\u300124\u30f6\u6708\u6642\u70b9\u306eRFS\u306b\u304a\u3044\u3066\u6e29\u71b1\u7642\u6cd5\u306f\u5e38\u6e29MMC\u3088\u308a\u3082\u7d71\u8a08\u7684\u306b\u512a\u308c\u3066\u3044\u308b\u3068\u306f\u7d50\u8ad6\u4ed8\u3051\u3089\u308c\u305a\u3001p\u5024\u306f0.6\u3067\u3042\u3063\u305f[6]\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81e8\u5e8a\u7684\u610f\u7fa9: IR-NMIBC \u306e\u512a\u4f4d\u6027\u306e\u6b20\u5982\u306f\u3001\u4e2d\u7b49\u5ea6\u30ea\u30b9\u30af\u306e\u60a3\u8005\u96c6\u56e3\u304c\u6e29\u71b1\u7642\u6cd5\u3068\u5316\u5b66\u7642\u6cd5\u306e\u76f8\u4e57\u52b9\u679c\u304b\u3089\u5341\u5206\u306a\u6069\u6075\u3092\u53d7\u3051\u3089\u308c\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3001\u307e\u305f\u306f\u8a66\u9a13\u3067\u4f7f\u7528\u3055\u308c\u305f\u7279\u5b9a\u306e\u6e29\u71b1\u30d7\u30ed\u30c8\u30b3\u30eb (\u4f8b: \u56fa\u5b9a\u6301\u7d9a\u6642\u9593) \u304c\u6700\u9069\u3067\u306f\u306a\u304b\u3063\u305f\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7.2. \u30cb\u30e5\u30a2\u30f3\u30b9\u3068\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">IR-NMIBC\u306eRFS\u7d50\u679c\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u4ed6\u306e\u7814\u7a76\u30c7\u30fc\u30bf\u306f\u3001\u7279\u306bBCG\u7642\u6cd5\u304c\u594f\u52b9\u3057\u306a\u304b\u3063\u305f\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6709\u76ca\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002\u3042\u308b\u89e3\u6790\u3067\u306f\u3001ITT\u89e3\u6790\u306b\u304a\u3044\u3066\u3001HIVEC\u306fBCG\u3068\u6bd4\u8f03\u3057\u3066\u7121\u5897\u60aa\u751f\u5b58\u7387\uff08PFS\uff09\u304c\u6709\u610f\u306b\u512a\u308c\u3066\u3044\u305f\uff0895.7% vs. 71.8%\u3001p = 0.043\uff09\u3053\u3068\u304c\u793a\u3055\u308c\u305f[7]*\u3002\u5225\u306e\u7814\u7a76\u3067\u306f\u3001HIVEC\u3092\u7528\u3044\u305f\u5316\u5b66\u7642\u6cd5\u306b\u3088\u308a1\u5e74RFS\u7387\u304c60%\u3001\u8180\u80f1\u6e29\u5b58\u7387\u304c92.4%\u306b\u9054\u3057\u305f\u3082\u306e\u306e\u3001BCG\u7642\u6cd5\u304c\u594f\u52b9\u3057\u306a\u304b\u3063\u305f\u8d85\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e\u5834\u5408\u3001\u8180\u80f1\u6458\u51fa\u8853\u304c\u4f9d\u7136\u3068\u3057\u3066\u6a19\u6e96\u6cbb\u7642\u3067\u3042\u308a\u3001\u624b\u8853\u304c\u4e0d\u53ef\u80fd\u306a\u60a3\u8005\u306b\u306fHIVEC\u304c\u4ee3\u66ff\u7642\u6cd5\u3068\u306a\u308a\u5f97\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f[8]\u3002\u3053\u308c\u306f\u3001\u8180\u80f1\u764c\u306b\u304a\u3051\u308bHT\u306e\u6709\u52b9\u6027\u304c\u60a3\u8005\u306e\u5c64\u5225\u5316\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3059\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u3066\u3044\u308b\u3002<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 2 \u306f\u3001\u6e29\u71b1\u7642\u6cd5\u7d71\u5408\u306b\u95a2\u3059\u308b\u4e3b\u8981\u306a\u7b2c III \u76f8\u81e8\u5e8a\u7d50\u679c\u3092\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3059\u3002<\/span><\/span><\/strong><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u88682\uff1a\u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u306e\u4e3b\u8981\u306a\u7b2cIII\u76f8\u81e8\u5e8a\u7d50\u679c\uff08\u6e29\u71b1\u7642\u6cd5\uff0b\u6a19\u6e96\u6cbb\u7642 vs. \u6a19\u6e96\u6cbb\u7642\u5358\u72ec\uff09<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u304c\u3093\u306e\u7a2e\u985e\uff08HT\u30e2\u30c0\u30ea\u30c6\u30a3\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u306e\u7a2e\u985e\/\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT + \u6a19\u6e96\u30b1\u30a2<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6a19\u6e96\u6cbb\u7642\u5358\u5264\u7642\u6cd5<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7d71\u8a08\u7684\u6709\u610f\u6027\/\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u7d50\u679c<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u7167<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8edf\u90e8\u8089\u816b\uff08LR HT + CT\uff0911.3\u5e74<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\uff08<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74OS<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">10\u5e74OS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">62.7%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">52.6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">51.3%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">42.7%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8853\u524d\u5316\u5b66\u7642\u6cd5\u5358\u72ec\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5c40\u6240\u6e29\u71b1\u7642\u6cd5\u306e\u8ffd\u52a0\u306b\u3088\u308a\u3001\u5c40\u6240\u7684\u306b\u7121\u75c5\u751f\u5b58\u7387\uff08DFS\uff09\u304c\u6539\u5584\u3057\u307e\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff090.65\u300195% CI 0.49-0.86\u3001P = 0.002\uff09\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5316\u5b66\u7642\u6cd5\u3068\u6e29\u71b1\u7642\u6cd5\u306e\u4f75\u7528\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u60a3\u8005\u306f\u3001\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u307f\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001*\u5168\u751f\u5b58\u7387*\u304c\u5ef6\u9577\u3057\u3066\u304a\u308a\uff08HR\u30010.73\u300195% CI\u30010.54-0.98\u3001P = 0.04\uff09\u30015\u5e74\u751f\u5b58\u7387\u306f\u305d\u308c\u305e\u308c62.7%\uff0895% CI\u300155.2%-70.1%\uff09\u306851.3%\uff0895% CI\u300143.7%-59.0%\uff09\u300110\u5e74\u751f\u5b58\u7387\u306f\u305d\u308c\u305e\u308c52.6%\uff0895% CI\u300144.7%-60.6%\uff09\u306842.7%\uff0895% CI\u300135.0%-50.4%\uff09\u3067\u3042\u3063\u305f\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b50\u5bae\u9838\u304c\u3093\uff08LACC\uff09\uff08LR HT + RT\uff0912\u5e74<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\uff08<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12\u5e74OS<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">20%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6709\u610f\u306b\u826f\u597d\u306aOS\uff08P &lt; 0.05\uff09<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17881144\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17881144\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u8178\u304c\u3093\uff08CRT + HT\uff095\u5e74<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74OS<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3001<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u9593\u306eDFS<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u9593\u5c40\u6240\u518d\u767a\u306e\u306a\u3044LRF<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u9593\u306e\u4eba\u5de5\u809b\u9580\u624b\u8853\u306a\u3057\u306e\u751f\u5b58\u7387 CFSR<\/span><\/span><\/p>\n<p>&nbsp;<\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">95.8%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">89.1<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">97.7<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">87.7<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">74.5%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">70.4%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">78.7%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69.0%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">OS\u306e\u6539\u5584\uff08P = 0.045\uff09<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">DFS\u306e\u6539\u5584\uff08<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.027\uff09\u3001<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584\u3055\u308c\u305fLRF\uff08<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.006\uff09<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CFSR\u306e\u6539\u5584\uff08<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.016\uff09<\/span><\/span><\/p>\n<p>&nbsp;<\/td>\n<td width=\"104\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u982d\u9838\u90e8\u764cNPC\uff08CRT + HT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\uff085\u5e74DFS<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u305d\u3057\u3066<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74OS<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u305d\u3057\u3066<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR )<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">51.3%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">68.4%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">81.6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">25.5%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">50%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">62.8%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u7b2c3\u76f8\u8a66\u9a13\u3067\u306f\u3001\u9855\u8457\u306a\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/td>\n<td width=\"104\"><strong><a href=\"https:\/\/doi.org\/10.7314\/apjcp.2013.14.12.7395\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30ab\u30f3 2013<\/span><\/span><\/a><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u982d\u9838\u90e8\u764c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53e3\u8154\/\u4e2d\u54bd\u982d\/\u4e0b\u54bd\u982d<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08RT + HT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\uff08CR\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">78.6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">42.4%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u5dee\u306f\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u3057\u305f\uff08&lt; 0.05\uff09\u3002\u30ab\u30d7\u30e9\u30f3\u30fb\u30de\u30a4\u30e4\u30fc\u751f\u5b58\u7387\u89e3\u6790\u3067\u3082\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u4f75\u7528HT\u304c\u6709\u610f\u306b\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u7dda\u91cf\u5236\u9650\u71b1\u50b7\u3084\u904e\u5ea6\u306e\u7c98\u819c\u6bd2\u6027\u307e\u305f\u306f\u71b1\u6bd2\u6027\u306f\u8a18\u9332\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/span><\/td>\n<td width=\"104\"><strong><a href=\"https:\/\/journals.lww.com\/cancerjournal\/fulltext\/2010\/06040\/hyperthermia_with_radiation_in_the_treatment_of.16.aspx\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30d2\u30e5\u30a4\u30eb\u30b4\u30eb 2010<\/span><\/span><\/a><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u60aa\u6027\u9ed2\u8272\u816b\uff08RT + HT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\uff08CR\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2\u5e74\u9593\u306e\u4fdd\u967a\u6570\u7406\u7684\u30ed\u30fc\u30ab\u30eb\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u6709\u610f\u306a\u6539\u5584\uff08p = 0.008\uff09<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u518d\u767a\u4e73\u304c\u3093\uff08RT + HT\uff09 &#8211; NCCN\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306bHT\u304c\u542b\u307e\u308c\u308b<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\uff08CR\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">60.2%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">38.1%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR\u7387\u306f57%\u5897\u52a0\u3057\u305f\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8180\u80f1\u764c IR NMI (HIVEC-1)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\uff0824\u30f6\u6708RFS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">80%\uff5e82%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">77%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6709\u610f\u5dee\u306a\u3057\uff08p = 0.6\uff09<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9aa8\u8ee2\u79fb\uff08WBH + RT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\uff08\u75bc\u75db\u306b\u5bfe\u3059\u308bCR\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">47.4%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.3%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR\u306e\u6539\u5584\uff08P &lt; 0.05\uff09; \u53cd\u5fdc\u307e\u3067\u306e\u6642\u9593\u304c10\u65e5\u306b\u77ed\u7e2e<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38460451\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38460451\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9aa8\u8ee2\u79fb\uff08RF HT + RT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\uff08\u75bc\u75db\u306b\u5bfe\u3059\u308bCR\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37.9%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">58.6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.1%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">32.1%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3\u30f5\u6708\u6642\u70b9\u3067CR\u304c\u6539\u5584\uff08P = 0.006\uff09<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cbb\u7642\u5f8c3\u30f6\u6708\u4ee5\u5185\u306e\u7d2f\u7a4dCR P=0.045);<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29066122\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nihs.gov\/29066122\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div id=\"IDtable-wrap-foot\" class=\"NLM_table-wrap-foot\">\n<div id=\"TF4\">\n<p class=\"first last\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">mEHT: \u5909\u8abf\u96fb\u6c17\u6e29\u71b1\u7642\u6cd5\u3001CT: \u5316\u5b66\u7642\u6cd5\u3001RT: \u653e\u5c04\u7dda\u7642\u6cd5\u3001HT: \u6e29\u71b1\u7642\u6cd5\u3001RITE: \u9ad8\u5468\u6ce2\u8a98\u5c0e\u6e29\u71b1\u5316\u5b66\u7642\u6cd5\u3001HIPEC: \u8179\u8154\u5185\u6e29\u71b1\u5316\u5b66\u7642\u6cd5\u3001OS: \u5168\u751f\u5b58\u671f\u9593\u3001DFS: \u7121\u75c5\u751f\u5b58\u671f\u9593\u3001CR: \u5b8c\u5168\u594f\u52b9\u3001LC: \u5c40\u6240\u5236\u5fa1\u3001PFS: \u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u3001ST: \u751f\u5b58\u671f\u9593<\/span><\/span><\/span><\/p>\n<\/div>\n<\/div>\n<h2><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5. \u4fb5\u8972\u6027\u304a\u3088\u3073\u518d\u767a\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\uff08\u65b0\u305f\u306a\u9069\u5fdc\u75c7\uff09<\/span><\/span><\/strong><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u3067\u306f\u3001\u30ec\u30d9\u30eb 1A \u306e\u8a3c\u62e0\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u304b\u958b\u767a\u4e2d\u3067\u3042\u308b\u304c\u3001\u9ad8\u54c1\u8cea\u306e\u6bd4\u8f03\u7814\u7a76\u306b\u3088\u308a\u3001\u7279\u306b mHT \u3092\u4ecb\u3057\u305f HT \u306e\u91cd\u8981\u306a\u5f79\u5272\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u56f0\u96e3\u306a\u816b\u760d\u90e8\u4f4d\u3092\u5206\u6790\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.1. \u795e\u7d4c\u81a0\u816b\uff08\u591a\u5f62\u6027\u795e\u7d4c\u81a0\u82bd\u816b\uff08GBM\uff09\u304a\u3088\u3073\u661f\u7d30\u80de\u816b\uff08AST\uff09\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u795e\u7d4c\u81a0\u816b\u3001\u7279\u306b\u591a\u5f62\u6027\u795e\u7d4c\u81a0\u82bd\u816b\uff08GBM\uff09\u306f\u3001\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u6975\u3081\u3066\u9ad8\u3044\u62b5\u6297\u6027\u3092\u793a\u3059\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u30021998\u5e74\u306b\u5b9f\u65bd\u3055\u308c\u305fGBM\u306b\u5bfe\u3059\u308b\u5bc6\u5c01\u5c0f\u7dda\u6e90\u6cbb\u7642\u3068\u30d6\u30fc\u30b9\u30c8\u7642\u6cd5\u304a\u3088\u3073\u6e29\u71b1\u7642\u6cd5\u3092\u6bd4\u8f03\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u306f\u3001\u4f75\u7528\u7642\u6cd5\u7fa4\u3067\u751f\u5b58\u7387\u306e\u6709\u610f\u306a\u5411\u4e0a\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f[9]\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.1.1. RF\u5909\u8abf\u6e29\u71b1\u7642\u6cd5\uff08mHT\uff09\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf<\/span><\/span><\/h4>\n<p><a href=\"https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u8fd1\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> mEHT\u3068\u816b\u760d\u6cbb\u7642\u96fb\u5834\uff08TTF\uff09\u306e\u4e21\u65b9\u304c\u795e\u7d4c\u81a0\u82bd\u816b\u306e\u751f\u5b58\u7387\u3092\u6539\u5584\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b[10]\u3002\u305d\u306e\u5229\u70b9\u306f\u65b0\u898f\u8a3a\u65ad\u60a3\u8005\u3067\u6700\u3082\u5927\u304d\u3044\u3088\u3046\u3067\u3042\u308b\u3002\u4f8b\u3048\u3070\u3001*mHT\u7814\u7a76\u306b\u304a\u3051\u308b\u65b0\u898f\u8a3a\u65ad\u60a3\u8005\u306e1\u5e74\u751f\u5b58\u7387\u306f73%\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u5bfe\u7167\u7fa4\u3067\u306f37%\u3067\u3042\u3063\u305f*\uff08p = 0.0021\uff09[10]\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u518d\u767a\u6027\u75be\u60a3\u306b\u3064\u3044\u3066\u306f\u3001*\u89b3\u5bdf\u6bd4\u8f03\u89e3\u6790\u306b\u3088\u308a\u3001mHT\u306e\u65b9\u304cOS\u304c\u9577\u304b\u3063\u305f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff08GBM\u4e2d\u592e\u502414\u304b\u6708\u5bfe12\u304b\u6708\u3001p = 0.026\uff09\u3002\u661f\u7d30\u80de\u816b\uff08AST\uff09\u306e\u5834\u5408\u3001mHT\u306f\u6709\u610f\u306a\u5229\u70b9\u3092\u793a\u3057\u3001OS\u306e\u5e73\u5747\/\u4e2d\u592e\u5024\u306f72\/91.6\u304b\u6708\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u6700\u5584\u306e\u7de9\u548c\u30b5\u30dd\u30fc\u30c8\u7fa4\u3067\u306f17\/34\u304b\u6708\u3067\u3042\u3063\u305f\uff08p = 0.0006\uff09\u3002\u518d\u767a\u6027GBM\u306e\u5834\u5408\u3067\u3082\u3001mHT\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e5\u5e74OS\u306f3.5\uff05\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u6700\u5584\u306e\u30b5\u30dd\u30fc\u30c8\u7fa4\u3067\u306f1.2\uff05\u3067\u3042\u3063\u305f[*11]\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u795e\u7d4c\u81a0\u816b\u306e\u56f0\u96e3\u306a\u81e8\u5e8a\u72b6\u6cc1\u4e0b\u3067\u3082\u3001\u6bd4\u8f03\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u305f\u5f37\u529b\u306a\u751f\u5b58\u5146\u5019\u306b\u3088\u308a\u3001HT \u3092\u81e8\u5e8a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u30ec\u30d9\u30eb 1A \u306e\u9069\u5fdc\u75c7\u306b\u542b\u3081\u308b\u3053\u3068\u304c\u6b63\u5f53\u5316\u3055\u308c\u307e\u3059\u3002<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2. \u81b5\u81d3\u304c\u3093\uff08PC\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81b5\u81d3\u304c\u3093\u306f\u6975\u3081\u3066\u81f4\u6b7b\u6027\u306e\u9ad8\u3044\u5168\u8eab\u6027\u75be\u60a3\u3067\u3042\u308a\u3001HT\u306f\u73fe\u5728\u300c\u4e00\u822c\u7684\u306a\u7de9\u548c\u7684\u81e8\u5e8a\u30a8\u30d3\u30c7\u30f3\u30b9\uff08\u7b2cII\u76f8\u8a66\u9a13\u306b\u57fa\u3065\u304f\uff09\u300d\u306b\u5206\u985e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8fd1\u5e74\u306e\u5927\u898f\u6a21\u306a\u6bd4\u8f03\u7814\u7a76\u306b\u3088\u308a\u3001\u5f37\u3044\u81e8\u5e8a\u7684\u30b7\u30b0\u30ca\u30eb\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2.1. \u8ee2\u79fb\u6027\u524d\u7acb\u817a\u764c\u306b\u304a\u3051\u308bmEHT\u306e\u6bd4\u8f03\u89e3\u6790<\/span><\/span><\/h4>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37398545\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5927\u898f\u6a21\u306a\u5f8c\u308d\u5411\u304d\u89b3\u5bdf\u591a\u65bd\u8a2d\u7814\u7a76<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30b9\u30c6\u30fc\u30b8III-IV\u306ePC\u60a3\u8005217\u540d\uff09\u3067\u306f\u3001mEHT + CHT\uff08\u4e3b\u306b\u30b2\u30e0\u30b7\u30bf\u30d3\u30f3\u30d9\u30fc\u30b9\uff09\u3068CHT\u5358\u72ec\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf\u5168\u751f\u5b58\u671f\u9593\uff08OS\uff09\uff1amEHT\u7fa4\u3067\u306fOS\u304c\u6709\u610f\u306b\u6539\u5584\u3057\u307e\u3057\u305f\uff0820\u304b\u6708\u3001CHT\u7fa49\u304b\u6708\u3001P &lt; 0.001\uff09\u3002<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\uff08PFS\uff09\uff1aPFS\u3082\u6709\u610f\u306b\u6539\u5584\u3057\u307e\u3057\u305f\uff087\u304b\u6708\u3001CHT\u7fa45\u304b\u6708\u3001P &lt; 0.05\uff09\u3002<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf\u816b\u760d\u53cd\u5fdc\uff1amEHT\u3067\u6cbb\u7642\u3057\u305f\u60a3\u8005\u3067\u306f\u3001\u90e8\u5206\u594f\u52b9\u7387\uff08PR\uff09\u304c\u5927\u5e45\u306b\u9ad8\u304f\uff0845% vs. 24%\u3001P = 0.0018\uff09\u3001\u9032\u884c\u75be\u60a3\uff08PD\uff09\u7387\u304c\u5927\u5e45\u306b\u4f4e\u304f\u306a\u308a\u307e\u3057\u305f\uff084% vs. 31%\u3001P &lt; 0.01\uff09\u3002<\/span><\/span><\/strong><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2.2. \u5e74\u9f62\u306b\u3088\u308bHT\u306e\u5f71\u97ff<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e74\u9f62\u5225\u306e\u751f\u5b58\u89e3\u6790\u306b\u3088\u308a\u3001\u72ec\u7279\u306a\u81e8\u5e8a\u7684\u5074\u9762\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001\u5909\u8abf\u9ad8\u5468\u6ce2\u6e29\u71b1\u7642\u6cd5\uff08mHT\uff09\u306b\u3088\u308b OS \u306e\u30e1\u30ea\u30c3\u30c8\u306f\u3001\u60a3\u8005\u306e\u5e74\u9f62\u304c 70 \u6b73\u4ee5\u4e0b\u304b 70 \u6b73\u8d85\u304b\u306b\u95a2\u4fc2\u306a\u304f\u7dad\u6301\u3055\u308c\u307e\u3057\u305f\uff08\u4e21\u30b0\u30eb\u30fc\u30d7\u3068\u3082 OS \u306e\u4e2d\u592e\u5024\u306f 20 \u304b\u6708\uff09\u3002\u5bfe\u7167\u7684\u306b\u3001CHT \u306e\u307f\u3092\u53d7\u3051\u305f\u9ad8\u9f62\u60a3\u8005\u306e OS \u306f 8 \u304b\u6708\u3067\u3001\u82e5\u5e74\u60a3\u8005\uff0812 \u304b\u6708\uff09\u3088\u308a\u3082\u6709\u610f\u306b\u4f4e\u304f\u3001\u5e74\u9f62\u3068\u3068\u3082\u306b CHT \u306e\u6709\u52b9\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002*\u3053\u308c\u306f\u3001mHT \u304c\u6a19\u6e96\u7684\u306a CHT \u3067\u89b3\u5bdf\u3055\u308c\u308b\u52a0\u9f62\u306b\u4f34\u3046\u4f4e\u4e0b\u306a\u3057\u306b\u3001\u5805\u7262\u306a\u6709\u52b9\u6027\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u304a\u305d\u3089\u304f\u305d\u306e\u597d\u307e\u3057\u3044\u6bd2\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u3002*<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u5927\u304d\u306a\u81e8\u5e8a\u7684\u6539\u5584\uff08OS \u306e\u4e2d\u592e\u5024\u304c 9 \u304b\u6708\u304b\u3089 20 \u304b\u6708\u306b\u500d\u5897\uff09\u306b\u3088\u308a\u3001\u56fd\u969b\u7684\u306a\u30e9\u30f3\u30c0\u30e0\u5316\u7b2c III \u76f8\u8a66\u9a13\u306e\u7dca\u6025\u306e\u7d44\u7e54\u5316\u306b\u5bfe\u3059\u308b\u5f37\u3044\u8981\u671b\u304c\u751f\u3058\u3066\u304a\u308a\u3001\u305d\u306e\u3044\u304f\u3064\u304b\u306f\u3059\u3067\u306b\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u4f8b: NCT02862015\u3001\u8ee2\u79fb\u6027\u81b5\u81d3\u304c\u3093\u306b\u304a\u3051\u308b\u30aa\u30f3\u30b3\u30b5\u30fc\u30df\u30a2\u306e\u591a\u65bd\u8a2d RCT\uff09\u3002<\/span><\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6. \u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u751f\u6d3b\u306e\u8cea\uff08QALY\uff09\uff1aHT\u306e\u9ad8\u3044\u6cbb\u7642\u6307\u6570<\/span><\/span><\/h2>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u306e\u9ad8\u3044\u6cbb\u7642\u6307\u6570<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e83\u7bc4\u306a\u81e8\u5e8a\u5c0e\u5165\u306f\u3001\u826f\u597d\u306a\u6cbb\u7642\u6307\u6570\u306e\u7dad\u6301\u306b\u304b\u304b\u3063\u3066\u3044\u307e\u3059\u3002*\u7b2cIII\u76f8\u8a66\u9a13\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001HT\u304c\u91cd\u7be4\u306a\u6bd2\u6027\u3092\u8457\u3057\u304f\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u3001\u3053\u306e\u8981\u4ef6\u3092\u6e80\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5727\u5012\u7684\u306b\u88cf\u4ed8\u3051\u3066\u3044\u307e\u3059\u3002*<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.1. \u5168\u8eab\u6bd2\u6027\u306e\u5206\u6790\uff08\u30b0\u30ec\u30fc\u30c93\uff5e4\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u306e\u4f53\u7cfb\u7684\u306a\u5206\u6790\u306b\u3088\u308a\u3001HT \u306f RT \u307e\u305f\u306f CHT \u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5168\u8eab\u6bd2\u6027\u3092\u60aa\u5316\u3055\u305b\u306a\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b50\u5bae\u9838\u304c\u3093\uff08LACC\uff09\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6025\u6027\u307e\u305f\u306f\u5f8c\u671f\u30b0\u30ec\u30fc\u30c93\uff5e4\u306e\u6bd2\u6027\u306b\u306f\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08RR \u2248 1.0\uff09\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u8178\u304c\u3093\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6bd2\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u540c\u7b49\u3067\u3057\u305f\u3002\u30b0\u30ec\u30fc\u30c93\uff5e4\u306e\u91cd\u7be4\u306a\u76ae\u819a\u53cd\u5fdc\u307e\u305f\u306f\u6d88\u5316\u7ba1\u53cd\u5fdc\u306e\u5897\u52a0\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81b5\u81d3\u304c\u3093 (mHT):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5316\u5b66\u7642\u6cd5\u306b\u8d77\u56e0\u3059\u308b\u8840\u6db2\u6bd2\u6027\u3001\u809d\u81d3\u6bd2\u6027\u3001\u80ba\u6bd2\u6027\u3001\u307e\u305f\u306f\u4ee3\u8b1d\u6bd2\u6027\u306f\u5897\u52a0\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/span><\/li>\n<\/ul>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.2. \u6e29\u71b1\u7642\u6cd5\u306b\u7279\u6709\u306e\u6709\u5bb3\u4e8b\u8c61<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u71b1\u7642\u6cd5\u306b\u76f4\u63a5\u95a2\u9023\u3059\u308b\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u4e3b\u306b\u5c40\u6240\u7684\u3067\u3042\u308a\u3001\u901a\u5e38\u306f\u7ba1\u7406\u53ef\u80fd\u3067\u3059\u3002<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u5c40\u6240\u9818\u57df\u6e29\u71b1\u7642\u6cd5\uff08LR HT\uff09\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u518d\u767a\u4e73\u304c\u3093\u75c7\u4f8b\u306e10\uff5e32%\u3067\u30b0\u30ec\u30fc\u30c93\uff5e4\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u4e3b\u306b\u5c40\u6240\u7684\u306a\u76ae\u819a\u53cd\u5fdc\uff08\u8efd\u5ea6\u306e\u71b1\u50b7\u307e\u305f\u306f\u4e0d\u5feb\u611f\uff09\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RF\u5909\u8abf\u6e29\u71b1\u7642\u6cd5\uff08mHT\uff09<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1amHT\u306f\u7279\u306b\u826f\u597d\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u81b5\u81d3\u304c\u3093\u306e\u7814\u7a76\u3067\u306f\u3001mHT\u30bb\u30c3\u30b7\u30e7\u30f3\u306e\u308f\u305a\u304b2.6%\u3067\u6709\u5bb3\u4e8b\u8c61\u304c\u5831\u544a\u3055\u308c\u3001\u305d\u306e\u4e2d\u306b\u306f\u30b0\u30ec\u30fc\u30c91\u306e\u76ae\u819a\u75db\u307e\u305f\u306f\u30b0\u30ec\u30fc\u30c91\uff5e2\u306e\u71b1\u50b7\uff08\u75c7\u4f8b\u306e1.1%\uff09\u304c\u542b\u307e\u308c\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306f\u3059\u3050\u306b\u89e3\u6d88\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HIVEC-1 \u8a66\u9a13 (\u8180\u80f1\u304c\u3093):<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u4e21\u7fa4\u9593\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f (p = 0.5) \u3082\u306e\u306e\u3001\u6709\u5bb3\u4e8b\u8c61\u5168\u4f53 (\u4e3b\u306b\u5c40\u6240\u7684\u306a\u4e0d\u5feb\u611f\u3068\u75d9\u6523) \u306f HT \u7fa4\u3067\u308f\u305a\u304b\u306b\u9ad8\u304f (35%\uff5e48% \u5bfe 33% \u5bfe\u7167\u7fa4\u3001p = 0.05)\u3001\u91cd\u7be4\u306a\u7f79\u60a3\u7387\u306b\u95a2\u3057\u3066\u306f\u5c40\u6240\u7684\u3067\u306f\u3042\u308b\u304c\u91cd\u8981\u3067\u306a\u3044\u5f71\u97ff\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.3. \u8cea\u8abf\u6574\u751f\u5b58\u5e74\u6570\uff08QALY\uff09\u3078\u306e\u5f71\u97ff<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">QALY\uff08\u8cea\u8abf\u6574\u751f\u5b58\u5e74\uff09\u6982\u5ff5\u306f\u3001\u5bff\u547d\u306e\u5ef6\u9577\u3068\u751f\u6d3b\u306e\u8cea\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u52b9\u679c\u306b\u5bfe\u3059\u308b\u7d4c\u6e08\u7684\u304a\u3088\u3073\u4eba\u7684\u8996\u70b9\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002HT\u306e\u81e8\u5e8a\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\uff08\u751f\u5b58\u7387\u306e\u6539\u5584\u3001CR\u7387\u306e\u5411\u4e0a\u3001\u5c40\u6240\u5236\u5fa1\u306e\u512a\u4f4d\u6027\uff09\u306f\u3001\u9577\u671f\u7684\u306a\u30b3\u30b9\u30c8\u524a\u6e1b\u3068\u60a3\u8005\u306eQALY\u5411\u4e0a\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u81e8\u5e8a\u5c0e\u5165\u306e\u6839\u62e0\u3092\u5f37\u56fa\u306a\u3082\u306e\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u88683\u306f\u3001HT\u7d71\u5408\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6a19\u6e96\u6cbb\u7642\u3068\u6bd4\u8f03\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u88683\uff1a\u5b89\u5168\u6027\u3068\u6bd2\u6027\u306e\u6bd4\u8f03\uff08HT\u7d71\u5408\u3068\u6a19\u6e96\u6cbb\u7642\uff09<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u304c\u3093\u306e\u7a2e\u985e<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6a19\u6e96\u6cbb\u7642\uff08\u5bfe\u7167\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ecb\u5165\uff08HT + \u6a19\u6e96\u6cbb\u7642\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30b0\u30ec\u30fc\u30c93\uff5e4\u306e\u6bd2\u6027\u6240\u898b<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81e8\u5e8a\u7684\u7d50\u8ad6<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u7167<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u304c\u3093<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CCRT\u306e\u307f<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CCRT + LR HT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6025\u6027\u6bd2\u6027\u307e\u305f\u306f\u6669\u671f\u6bd2\u6027\u306b\u6709\u610f\u5dee\u306a\u3057\uff08RR \\sim 1.0\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u826f\u597d\u306a\u6cbb\u7642\u6307\u6570; \u5168\u8eab\u7684\u526f\u4f5c\u7528\u306f\u60aa\u5316\u3057\u307e\u305b\u3093\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u8178\u30fb\u809b\u9580\u304c\u3093<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30d6\u30e9\u30a6\u30f3\u7ba1<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CRT + LR HT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u540c\u7b49\u306e\u6bd2\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb; \u91cd\u7be4\u306a\u6d88\u5316\u7ba1\u53cd\u5fdc\u307e\u305f\u306f\u76ae\u819a\u53cd\u5fdc\u306e\u5897\u52a0\u306a\u3057<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT \u306f\u9aa8\u76e4 CRT \u30d7\u30ed\u30c8\u30b3\u30eb\u3068\u7d44\u307f\u5408\u308f\u305b\u3066\u3082\u5b89\u5168\u3067\u3059\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8089\u816b\uff08EORTC\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CHT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RHT + CHT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u91cd\u7be4\u306a\u6bd2\u6027\u7387\u306f\u7814\u7a76\u306e\u5b8c\u4e86\u3092\u59a8\u3052\u306a\u304b\u3063\u305f<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5fcd\u5bb9\u6027\u304c\u9ad8\u304f\u3001\u9577\u671f\u306e\u5b89\u5168\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8180\u80f1\u764c IR NMI (HIVEC-1)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e38\u6e29MMC<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u71b1MMC<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306b\u306f\u5dee\u306f\u306a\u304b\u3063\u305f\uff08p = 0.5\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u91cd\u7be4\u306a\u7f79\u60a3\u7387\u306f\u5909\u5316\u3057\u306a\u304b\u3063\u305f\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7. \u7d50\u8ad6\u3001\u81e8\u5e8a\u7d71\u5408\u3001\u305d\u3057\u3066\u4eca\u5f8c\u306e\u65b9\u5411\u6027<\/span><\/span><\/h2>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.1. \u30ec\u30d9\u30eb1A\u306e\u9069\u5fdc\u75c7\u306e\u8981\u7d04<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u304a\u3088\u3073\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u57fa\u3065\u304f\u6587\u732e\u306e\u53b3\u5bc6\u306a\u5206\u6790\u306b\u3088\u308a\u3001\u6e29\u71b1\u7642\u6cd5\u306f\u5b9f\u9a13\u7684\u306a\u6cbb\u7642\u6cd5\u3067\u306f\u306a\u304f\u3001\u7279\u5b9a\u306e\u816b\u760d\u90e8\u4f4d\u306b\u5bfe\u3059\u308b\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30eb\u30aa\u30f3\u30b3\u30ed\u30b8\u30fc\u306e\u91cd\u8981\u306a\u8981\u7d20\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u305f\u3002\u6e29\u71b1\u7642\u6cd5\u306f\u3001\u8edf\u90e8\u8089\u816b\u3001\u5c40\u6240\u9032\u884c\u5b50\u5bae\u9838\u304c\u3093\u3001\u982d\u9838\u90e8\u304c\u3093\u3001\u76f4\u8178\u30fb\u809b\u9580\u304c\u3093\u3001\u60aa\u6027\u9ed2\u8272\u816b\uff08\u5c40\u6240\u9818\u57df\u75c5\u5909\uff09\u3001\u304a\u3088\u3073\u4e73\u304c\u3093\u306e\u80f8\u90e8\u518d\u767a\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u6839\u6cbb\u7684\u751f\u5b58\u7387\u3001\u7121\u75c5\u751f\u5b58\u7387\u3001\u304a\u3088\u3073\u5b8c\u5168\u594f\u52b9\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306b\u95a2\u3059\u308b\u30ec\u30d9\u30eb1A\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u6709\u3057\u3066\u3044\u307e\u3059[2]\u3002<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u308c\u3089\u306e\u9069\u5fdc\u75c7\u306b\u304a\u3044\u3066\u3001\u6e29\u71b1\u7642\u6cd5\u306f\u6a19\u6e96\u7684\u306a\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30eb\u30aa\u30f3\u30b3\u30ed\u30b8\u30fc\u306e\u4e0d\u53ef\u6b20\u306a\u8981\u7d20\u3068\u307f\u306a\u3055\u308c\u308b\u3079\u304d\u3067\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.2. \u6709\u52b9\u6027\u3068\u6280\u8853\u7684\u91cd\u8981\u6027\u306e\u30cb\u30e5\u30a2\u30f3\u30b9<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u6cbb\u7642\u306e\u6709\u52b9\u6027\u306f\u3001\u6280\u8853\u7684\u306a\u7cbe\u5ea6\u3068\u52a0\u71b1\u65b9\u6cd5\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3057\u307e\u3059\u3002\u6df1\u90e8\u56fa\u5f62\u816b\u760d\uff08LACC\u3001HNC\u306a\u3069\uff09\u306b\u304a\u3051\u308b\u5c40\u6240\u9818\u57dfHT\u306e\u9855\u8457\u304b\u3064\u4e00\u8cab\u3057\u305f\u6210\u529f\u306f\u3001\u4e2d\u7b49\u5ea6\u30ea\u30b9\u30af\u306eNMIBC\u306b\u304a\u3051\u308bHIVEC\u306e\u7d50\u679c\u304c\u307e\u3061\u307e\u3061\u3067\u3042\u308b\u3053\u3068\u3068\u306f\u5bfe\u7167\u7684\u3067\u3059\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3053\u306e\u5bfe\u7167\u306f\u3001\u6700\u9069\u306a\u81e8\u5e8a\u7684\u52b9\u679c\u306f\u5358\u306b\u52a0\u71b1\u3059\u308b\u3060\u3051\u3067\u306f\u5f97\u3089\u308c\u305a\u3001\u816b\u760d\u5168\u4f53\u306b\u308f\u305f\u3063\u3066\u5747\u4e00\u304b\u3064\u751f\u7269\u5b66\u7684\u306b\u6709\u52b9\u306a\u71b1\u91cf\u3092\u78ba\u4fdd\u3059\u308b\u305f\u3081\u306b\u3001\u53b3\u683c\u306a\u54c1\u8cea\u4fdd\u8a3c\uff08QA\uff09\u3068\u6280\u8853\u7684\u306a\u6700\u9069\u5316\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30c7\u30fc\u30bf\u306fHT\u306e\u6709\u52b9\u6027\u304c\u30ea\u30b9\u30af\u306b\u3088\u3063\u3066\u5c64\u5225\u5316\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u518d\u767a\u6027\u75be\u60a3\u3001\u9ad8\u30ea\u30b9\u30af\u8089\u816b\u3001BCG\u62b5\u6297\u6027\u306eNMIBC\u306a\u3069\u3001\u6cbb\u7642\u62b5\u6297\u6027\u306e\u9ad8\u3044\u74b0\u5883\u3067\u6700\u3082\u9855\u8457\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3. \u6709\u671b\u306a\u9069\u5fdc\u75c7\u3068\u5c06\u6765\u306e\u81e8\u5e8a\u8a66\u9a13<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3.1. \u81b5\u81d3\u304c\u3093<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8ee2\u79fb\u6027\u81b5\u81d3\u304c\u3093\u306b\u304a\u3051\u308b\u5909\u8abf\u9ad8\u5468\u6ce2\u6e29\u71b1\u7642\u6cd5\uff08mHT\uff09+ CHT \u306b\u3088\u308a OS \u4e2d\u592e\u5024\u304c 2 \u500d\uff089 \u304b\u6708\u304b\u3089 20 \u304b\u6708\uff09\u306b\u306a\u308b\u3053\u3068\u3092\u793a\u3059\u6bd4\u8f03\u89b3\u5bdf\u30c7\u30fc\u30bf\u306f\u3001\u6975\u3081\u3066\u5f37\u3044\u81e8\u5e8a\u7684\u30b7\u30b0\u30ca\u30eb\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002* \u3053\u308c\u3089\u306e\u7d50\u679c\u306b\u3088\u308a\u3001\u6700\u9ad8\u30ec\u30d9\u30eb\u306e\u8a3c\u62e0\u3067\u3053\u308c\u3089\u306e\u5168\u751f\u5b58\u671f\u9593\u306e\u30e1\u30ea\u30c3\u30c8\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u56fd\u969b\u7684\u306a\u30e9\u30f3\u30c0\u30e0\u5316\u7b2c III \u76f8\u8a66\u9a13\uff08NCT02862015 \u306a\u3069\uff09\u3092\u7dca\u6025\u306b\u958b\u59cb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3.2. \u514d\u75ab\u816b\u760d\u5b66\u3068\u306e\u7d71\u5408<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u306fHSP\u3092\u653e\u51fa\u3057T\u7d30\u80de\u3092\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u5b66\u7684\u306b\u300c\u30b3\u30fc\u30eb\u30c9\u300d\u306a\u816b\u760d\u3092\u300c\u30db\u30c3\u30c8\u300d\uff08\u708e\u75c7\u3092\u8d77\u3053\u3057\u305f\uff09\u816b\u760d\u3078\u3068\u5909\u5316\u3055\u305b\u308b\u305f\u3081\u3001\u4eca\u5f8c\u306e\u7b2cIII\u76f8\u8a66\u9a13\u3067\u306f\u3001HT\u3068\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306a\u3069\u306e\u6700\u65b0\u306e\u514d\u75ab\u7642\u6cd5\u85ac\u3068\u306e\u76f8\u4e57\u52b9\u679c\u3092\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u4f75\u7528\u306f\u3001\u7279\u306b\u4ee5\u524d\u306f\u96e3\u6cbb\u6027\u3067\u3042\u3063\u305f\u816b\u760d\u306b\u304a\u3044\u3066\u3001\u514d\u75ab\u7642\u6cd5\u3078\u306e\u53cd\u5fdc\u3092\u5897\u5f37\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81e8\u5e8a\u7d4c\u9a13\uff08EEAT\uff09\uff1a<\/span><\/span><\/strong><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30a2\u30f3\u30c9\u30ed\u30e1\u30c7\u30a3\u30ad\u30da\u30eb\u30b5\u30fc\u30df\u30a2\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u30ec\u30d9\u30eb 1A \u30d7\u30ed\u30c8\u30b3\u30eb ( <\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/ja\/%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a8%93-%e6%b8%a9%e7%86%b1%e7%99%82%e6%b3%95-%e3%82%a2%e3%83%b3%e3%83%89%e3%83%ad%e3%83%a1%e3%83%87%e3%82%a3%e3%83%83%e3%82%af-%e5%ad%90%e5%ae%ae%e9%a0%b8%e3%81%8c\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">LACC \u306b\u5bfe\u3059\u308b\u6e29\u71b1\u7642\u6cd5 + CCRT + BRT \u306e\u7d44\u307f\u5408\u308f\u305b\u306a\u3069<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">) \u3092\u6a19\u6e96\u6cbb\u7642\u3068\u3057\u3066\u7814\u7a76\u3057\u3001\u81e8\u5e8a\u8a66\u9a13\u3067\u5b9f\u8a3c\u3055\u308c\u305f\u5229\u70b9\u3092\u60a3\u8005\u306e\u500b\u5225\u6cbb\u7642\u8a08\u753b\u306b\u76f4\u63a5\u53cd\u6620\u3055\u305b\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.4. \u81e8\u5e8a\u63a1\u7528\u306e\u57fa\u6e96<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u3092\u65bd\u8a2d\u3067\u6210\u529f\u88cf\u306b\u5b9f\u65bd\u3059\u308b\u306b\u306f\u3001\u591a\u5206\u91ce\u306e\u5c02\u9580\u77e5\u8b58\uff08\u533b\u7642\u7269\u7406\u5b66\u8005\u3001\u653e\u5c04\u7dda\u816b\u760d\u533b\u3001\u5316\u5b66\u7642\u6cd5\u58eb\uff09\u3068\u3001\u71b1\u7dda\u91cf\u6e2c\u5b9a\u30d7\u30ed\u30c8\u30b3\u30eb\u306e\u53b3\u683c\u306a\u9075\u5b88\u304c\u5fc5\u8981\u3067\u3059\u3002\u30ec\u30d9\u30eb1A\u306e\u7d50\u679c\u3092\u518d\u73fe\u3059\u308b\u306b\u306f\u3001\u6cbb\u7642\u65bd\u8a2d\u306f\u5c02\u9580\u6a5f\u95a2\u304c\u7b56\u5b9a\u3057\u305f\u56fd\u969b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3068\u57fa\u6e96\u3092\u9075\u5b88\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u88684\uff1a\u65b0\u305f\u306a\u9069\u5fdc\u75c7\u3068\u7b2c2\u76f8\/\u89b3\u5bdf\u30c7\u30fc\u30bf\uff08\u751f\u5b58\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff09<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u304c\u3093\u306e\u7a2e\u985e\uff08HT\u30e2\u30c0\u30ea\u30c6\u30a3\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u306e\u7a2e\u985e\/\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT + \u6a19\u6e96\u6cbb\u7642 (OS\/PFS\/QoL)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6a19\u6e96\u6cbb\u7642\u306e\u307f\uff08OS\/PFS\/QoL\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u306a\u767a\u898b\/P\u5024<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u7167<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u81b5\u81d3\u304c\u3093\uff08mEHT + CHT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f8c\u65b9\u8996\u7684\u6bd4\u8f03\uff08OS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e73\u5747\u751f\u5b58\u671f\u9593\uff1a20\u304b\u6708<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e73\u5747\u751f\u5b58\u671f\u9593\uff1a9\u304b\u6708<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">OS\u304c\u5927\u5e45\u306b\u6539\u5584\u3057\u307e\u3057\u305f\uff08\u76f8\u5bfe\u5897\u52a0\u738777%\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[\u30d5\u30a3\u30aa\u30ec\u30f3\u30c6\u30a3\u30fc\u30cb\u4ed6\u30012021]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65b0\u898f\u8a3a\u65ad\u306e\u795e\u7d4c\u81a0\u82bd\u816b\uff08mEHT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff081\u5e74OS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">73%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6709\u610f\u306aOS\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\uff08p=0.0021\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08<\/span><\/span><a href=\"https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u661f\u7d30\u80de\u816b\uff08mEHT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f8c\u65b9\u8996\u7684\u6bd4\u8f03\uff08OS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e73\u5747OS\u671f\u9593\uff1a72\u304b\u6708<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e73\u5747\u751f\u5b58\u671f\u9593\uff1a17\u304b\u6708<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">OS\u306f\u6709\u610f\u306b\u6539\u5584\u3057\u305f\uff08p=0.0006\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[\u30d5\u30a3\u30aa\u30ec\u30f3\u30c6\u30a3\u30fc\u30cb\u4ed6\u30012019]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u8178\u304c\u3093\uff08pCR\u3001\u6a5f\u80fd\u6027\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30d5\u30a7\u30fc\u30baIII\uff08\u4eba\u5de5\u809b\u9580\u306e\u306a\u3044\u751f\u5b58\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">87.7%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69.0%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">QOL\/\u6a5f\u80fd\u306e\u6539\u5584\uff08P=0.016\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[\u30d5\u30a7\u30fc\u30baIII\u30012019\u5e7410\u6708]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b50\u5bae\u9838\u304c\u3093\uff08LACC\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RCT\uff08DFS\/QoL\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u611f\u60c5\u7684\/\u8eab\u4f53\u7684QOL\u306e\u5411\u4e0a<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">QOL\u306e\u5b89\u5b9a\/\u4f4e\u4e0b<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6bd2\u6027\u306e\u5897\u52a0\u306a\u304fQOL\u304c\u5927\u5e45\u306b\u6539\u5584<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8833695\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8833695\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8179\u819c\u8ee2\u79fb\uff08HIPEC\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u89b3\u5bdf\u30ec\u30d3\u30e5\u30fc\uff08\u611f\u60c5\u7684QOL\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6025\u901f\u306a\u56de\u5fa9\uff08\u8853\u5f8c3\u304b\u6708\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56de\u5fa9\u306f\u9045\u3044<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6025\u901f\u306a\u5fc3\u7406\u7684\u5229\u76ca<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/dmr.amegroups.org\/article\/view\/6846\/html\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/dmr.amegroups.org\/article\/view\/6846\/html<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">8. \u816b\u760d\u6027\u6e29\u71b1\u7642\u6cd5\u306b\u95a2\u3059\u308b\u3088\u304f\u3042\u308b\u8cea\u554f\uff08FAQ\uff09<\/span><\/span><\/h2>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Q: \u6e29\u71b1\u7642\u6cd5\u306f\u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u5b9f\u9a13\u7684\u306a\u6cbb\u7642\u6cd5\u3067\u3059\u304b?<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">A:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3044\u3044\u3048\u3002\u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2 (HT) \u306f\u3001\u8edf\u90e8\u8089\u816b\u3001\u5b50\u5bae\u9838\u304c\u3093\u3001\u518d\u767a\u6027\u4e73\u304c\u3093\u3001\u60aa\u6027\u9ed2\u8272\u816b\u3001\u76f4\u8178\u304c\u3093\u3001\u8180\u80f1\u304c\u3093\u3001\u982d\u9838\u90e8 (HNC) \u816b\u760d\u306a\u3069\u306e\u4e3b\u8981\u306a\u816b\u760d\u9069\u5fdc\u75c7\u306b\u5bfe\u3057\u3066\u3001*\u30ec\u30d9\u30eb 1A \u306e\u8a3c\u62e0* (\u30d5\u30a7\u30fc\u30ba III \u306e\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u3068\u30e1\u30bf\u5206\u6790\u306b\u57fa\u3065\u304f) \u3092\u6709\u3059\u308b\u5b9f\u8a3c\u6e08\u307f\u306e\u6cbb\u7642\u6cd5\u3067\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Q: \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306e\u6700\u9069\u306a\u52d5\u4f5c\u6e29\u5ea6\u306f\u3069\u308c\u304f\u3089\u3044\u3067\u3059\u304b?<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">A:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u9069\u306a\u52d5\u4f5c\u6e29\u5ea6\u306f*39\u2103\uff5e45\u2103*\u3067\u3059\u3002\u3053\u306e\u300c\u6cbb\u7642\u57df\u300d\u306f\u3001\u304c\u3093\u7d30\u80de\u3092\u76f4\u63a5\u7834\u58ca\uff08\u30a2\u30d6\u30ec\u30fc\u30b7\u30e7\u30f3\uff09\u3059\u308b\u3053\u3068\u3067\u306f\u306a\u304f\u3001\u5316\u5b66\u7642\u6cd5\u3084\u653e\u5c04\u7dda\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u304c\u3093\u7d30\u80de\u306e\u751f\u7269\u5b66\u7684\u611f\u53d7\u6027\u3092\u6700\u5927\u9650\u306b\u9ad8\u3081\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u8a2d\u8a08\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Q: \u6e29\u71b1\u7642\u6cd5\u306f\u5316\u5b66\u7642\u6cd5\u3084\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u6bd2\u6027\u3092\u9ad8\u3081\u307e\u3059\u304b?<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">A:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2cIII\u76f8\u8a66\u9a13\u306e\u89e3\u6790\u306b\u3088\u308a\u3001\u6e29\u71b1\u7642\u6cd5\u306e\u8ffd\u52a0\u306f*\u91cd\u7be4\u306a\u5168\u8eab\u6bd2\u6027\uff08\u30b0\u30ec\u30fc\u30c93\uff5e4\uff09\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u306a\u3044\u3053\u3068*\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6e29\u71b1\u7642\u6cd5\u306b\u4f34\u3046\u6709\u5bb3\u4e8b\u8c61\u306f\u4e3b\u306b\u5c40\u6240\u6027\u3067\u3042\u308a\u3001\u5bb9\u6613\u306b\u7ba1\u7406\u53ef\u80fd\u3067\u3059\uff08\u4f8b\uff1a\u8efd\u5ea6\u306e\u76ae\u819a\u53cd\u5fdc\uff09\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Q: \u30cf\u30a4\u30d1\u30fc\u30b5\u30fc\u30df\u30a2\u306f\u653e\u5c04\u7dda\u7642\u6cd5\u3092\u3069\u306e\u3088\u3046\u306b\u6539\u5584\u3057\u307e\u3059\u304b?<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">A:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u71b1\u7642\u6cd5\u306f\u30012 \u3064\u306e\u4e3b\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u901a\u3058\u3066\u5f37\u529b\u306a\u653e\u5c04\u7dda\u5897\u611f\u5264\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002*1) \u653e\u5c04\u7dda\u306b\u3088\u3063\u3066\u640d\u50b7\u3057\u305f DNA \u4fee\u5fa9\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002*2) \u8840\u6d41\u3068\u816b\u760d\u306e\u9178\u7d20\u5316\u3092\u6539\u5584\u3057\u3001\u4ee5\u524d\u306f\u62b5\u6297\u6027\u3067\u3042\u3063\u305f\u7d30\u80de\u306e\u653e\u5c04\u7dda\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u5927\u5e45\u306b\u9ad8\u3081\u307e\u3059\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Q: \u6e29\u71b1\u7642\u6cd5\u304c\u6700\u3082\u6709\u52b9\u306a\u304c\u3093\u7a2e\u306f\u4f55\u3067\u3059\u304b?<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">A:<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30ec\u30d9\u30eb 1A \u306e\u8a3c\u62e0\u306b\u3088\u308b\u3068\u3001\u4ee5\u4e0b\u306e\u304c\u3093\u306b\u5bfe\u3057\u3066\u751f\u5b58\u5229\u76ca\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059: *\u8edf\u90e8\u8089\u816b\u3001\u5b50\u5bae\u9838\u304c\u3093\u3001\u518d\u767a\u6027\u4e73\u304c\u3093\u3001\u60aa\u6027\u9ed2\u8272\u816b\u3001\u76f4\u8178\u304c\u3093\u3001\u8180\u80f1\u304c\u3093\u3001\u304a\u3088\u3073 HNC\u3002*<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f15\u7528\u6587\u732e\uff08\u5f15\u7528\u6587\u306f\u63d0\u4f9b\u3055\u308c\u305f\u307e\u307e\u3067\u3059\uff09<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u304c\u3093\u306e\u88dc\u52a9\u7684\u6cbb\u7642\u306b\u304a\u3051\u308b\u5c40\u6240\u9818\u57df\u4e2d\u7b49\u5ea6\u9ad8\u4f53\u6e29\u7642\u6cd5\u306b\u95a2\u3059\u308b\u6700\u65b0\u306e\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u30ec\u30d3\u30e5\u30fc\u3001https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u8ad6\u6587\u5168\u6587\uff1a\u816b\u760d\u6027\u6e29\u71b1\u7642\u6cd5\u306b\u95a2\u3059\u308b\u767b\u9332\u81e8\u5e8a\u8a66\u9a13\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc &#8211; Taylor &amp; Francis Online\u3001https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2022.2076292<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u6e29\u71b1\u7642\u6cd5\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u3001\u5316\u5b66\u7642\u6cd5\uff1a\u591a\u79d1\u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u306e\u5f79\u5272 &#8211; Jefferson Digital Commons\u3001https:\/\/jdc.jefferson.edu\/cgi\/viewcontent.cgi?article=1070&amp;context=radoncfp<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u8a18\u4e8b\u5168\u6587\uff1a\u6e29\u71b1\u7642\u6cd5\u3068\u514d\u75ab\u7642\u6cd5\uff1a\u81e8\u5e8a\u7684\u53ef\u80fd\u6027 &#8211; Taylor &amp; Francis Online\u3001https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2019.1653499<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5. \u6e29\u71b1\u7642\u6cd5\u306f\u30d2\u30c8\u8180\u80f1\u304c\u3093\u306b\u304a\u3051\u308b\u304c\u3093\u7d30\u80de\u306e\u6d78\u6f64\u3092\u6291\u5236\u3057\u3001\u5316\u5b66\u7642\u6cd5\u62b5\u6297\u6027\u3068\u514d\u75ab\u56de\u907f\u3092\u6291\u5236\u3059\u308b &#8211; PMC\u3001https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11575926\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6. \u4e2d\u7b49\u5ea6\u30ea\u30b9\u30af\u306e\u975e\u7b4b\u5c64\u6d78\u6f64\u6027\u8840\u7ba1\u5185\u6cbb\u7642\u306b\u304a\u3051\u308b\u30de\u30a4\u30c8\u30de\u30a4\u30b7\u30f3C\u306e\u6e29\u71b1\u7642\u6cd5\u3001https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7. \u9ad8\u30ea\u30b9\u30af\u975e\u7b4b\u5c64\u6d78\u6f64\u6027\u8180\u80f1\u764c\u306b\u304a\u3051\u308b\u30de\u30a4\u30c8\u30de\u30a4\u30b7\u30f3C\uff08HIVEC\uff09\u3092\u7528\u3044\u305f\u518d\u5faa\u74b0\u6e29\u71b1\u8180\u80f1\u5185\u5316\u5b66\u7642\u6cd5\u3068BCG\u306e\u6bd4\u8f03\u3001https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8994727\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">8. \u8ad6\u6587\u5168\u6587\uff1aBCG\u7981\u5fcc\u306e\u9ad8\u30ea\u30b9\u30af\u975e\u7b4b\u5c64\u6d78\u6f64\u6027\u8180\u80f1\u304c\u3093\u60a3\u8005\u304a\u3088\u3073BCG\u7642\u6cd5\u304c\u594f\u52b9\u3057\u306a\u3044\u60a3\u8005\u306b\u304a\u3051\u308bHIVEC\u306e\u6709\u52b9\u6027 &#8211; Taylor &amp; Francis Online\u3001https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2021.2002435<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">9. \u816b\u760d\u6cbb\u7642\u7528\u306e\u96fb\u5834\u3068\u6e29\u71b1\u7642\u6cd5\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001STAT3\u306e\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u3063\u3066\u795e\u7d4c\u81a0\u82bd\u816b\u7d30\u80de\u306b\u76f8\u4e57\u7684\u306a\u6cbb\u7642\u52b9\u679c\u3092\u3082\u305f\u3089\u3059 &#8211; PubMed Central\u3001https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8984886\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">10. \u81a0\u82bd\u816b\u6cbb\u7642\u306b\u304a\u3051\u308b\u5909\u8abf\u96fb\u6c17\u6e29\u71b1\u7642\u6cd5\u3068\u816b\u760d\u6cbb\u7642\u96fb\u5834\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9 &#8211; MDPI\u3001https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">11.\u518d\u767a\u6027\u60aa\u6027\u795e\u7d4c\u81a0\u82bd\u816b\u304a\u3088\u3073\u661f\u7d30\u80de\u816b\u306b\u5bfe\u3059\u308b\u7d71\u5408\u764c\u6cbb\u7642\u306b\u304a\u3051\u308b\u5909\u8abf\u96fb\u6c17\u6e29\u71b1\u7642\u6cd5\uff1a\u5f8c\u308d\u5411\u304d\u591a\u65bd\u8a2d\u5bfe\u7167\u8a66\u9a13\u3001\u5f8c\u308d\u5411\u304d\u7814\u7a76\u3001\u8457\u8005\uff1a<\/span><\/span><\/p>\n<div class=\"entry-content\">\n<div class=\"container\">\n<div class=\"acf-fields \">\n<div class=\"publ-acf acf-row acf-flex\">\n<div class=\"szerzok\"><span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30d5\u30a3\u30aa\u30ec\u30f3\u30c6\u30a3\u30fc\u30cb G<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30b5\u30eb\u30c6\u30a3 D<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30df\u30e9\u30f3\u30c9\u30ea C<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30c7\u30f3\u30c6\u30a3\u30b3 P<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30de\u30f3\u30d6\u30ea\u30fc\u30cb A<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30d5\u30a3\u30aa\u30ec\u30f3\u30c6\u30a3\u30fc\u30cb C<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30de\u30c3\u30c6\u30a3\u30aa\u30fc\u30ea G<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30ab\u30b5\u30c7\u30a4<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u30b0\u30a2\u30c0\u30fc\u30cb S<\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12. \u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u5909\u8abf\u96fb\u6c17\u6e29\u71b1\u7642\u6cd5\u306e\u73fe\u72b6 &#8211; Kosin Medical Journal, https:\/\/www.kosinmedj.org\/journal\/view.php?number=1294<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6a29\u5a01\u3068\u5c02\u9580\u77e5\u8b58\uff08EEAT\uff09\uff1aVeronica Iatan\u533b\u5e2b\uff08\u533b\u5b66\u535a\u58eb\uff09 \u3068Cristian Gologan\u7406\u5b66\u4fee\u58eb\uff08\u30a2\u30f3\u30c9\u30ed\u30e1\u30c7\u30a3\u30ab\u30eb\u30d2\u30da\u30eb\u30b5\u30fc\u30df\u30a2\uff09 \u73fe\u4ee3\u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u6e29\u71b1\u7642\u6cd5\u306e\u6cbb\u7642\u7d71\u5408\uff1a\u7b2cIII\u76f8\u8a66\u9a13\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[943,107,22],"tags":[385,127],"class_list":["post-11192","post","type-post","status-publish","format-standard","hentry","category-studii-clinice-ja","category-107","category-22","tag-iii","tag-127"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/posts\/11192","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/comments?post=11192"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/posts\/11192\/revisions"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/media?parent=11192"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/categories?post=11192"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/ja\/wp-json\/wp\/v2\/tags?post=11192"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}