{"id":4271,"date":"2017-08-12T11:12:57","date_gmt":"2017-08-12T11:12:57","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/2017\/08\/12\/quasi-feasibility-studycase-control-associating-deep-local-hyperthermia-treatment-with-standard-cancer-treatments-and-describing-patterns-of-response-esho-poster\/"},"modified":"2025-09-04T16:17:53","modified_gmt":"2025-09-04T16:17:53","slug":"kliniskais-petijums-par-hipertermija","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/lv\/kliniskais-petijums-par-hipertermija\/","title":{"rendered":"Kvazi-iesp\u0113jam\u012bbas kl\u012bniskais p\u0113t\u012bjums, kas saista dzi\u013cas lok\u0101las hipertermijas \u0101rst\u0113\u0161anu ar standarta v\u0113\u017ea \u0101rst\u0113\u0161anas metod\u0113m un apraksta atbildes reakcijas mode\u013cus"},"content":{"rendered":"

Kvazi-iesp\u0113jam\u012bbas kl\u012bniskais p\u0113t\u012bjums, kas saista dzi\u013cas lok\u0101las hipertermijas \u0101rst\u0113\u0161anu ar standarta v\u0113\u017ea \u0101rst\u0113\u0161anas metod\u0113m un apraksta atbildes reakcijas mode\u013cus<\/span><\/span><\/a><\/h1>\n

Andromedic hipertermijas kl\u012bniskais p\u0113t\u012bjums – Eiropas Hipertermisk\u0101s onkolo\u0123ijas biedr\u012bbas kongress 2014. gad\u0101\u00a0<\/span><\/span><\/a><\/h2>\n
\"Kl\u012bniskais
Kvazi-iesp\u0113jam\u012bbas p\u0113t\u012bjums (kontroles gad\u012bjums), kas saista dzi\u013cas lok\u0101las hipertermijas HyDeep 600WM \u0101rst\u0113\u0161anu ar standarta v\u0113\u017ea \u0101rst\u0113\u0161anas metod\u0113m un apraksta atbildes reakcijas mode\u013cus.<\/span><\/span><\/figcaption><\/figure>\n

Ievads:<\/span><\/span><\/strong><\/p>\n

\u0160is ir pirmais kl\u012bniskais p\u0113t\u012bjums Sp\u0101nij\u0101 un Andal\u016bzij\u0101, kur\u0101 dzi\u013ca lok\u0101la hipertermija tiek apvienota ar standarta v\u0113\u017ea \u0101rst\u0113\u0161anas metod\u0113m.<\/span><\/span><\/p>\n

Materi\u0101li un metodes:<\/span><\/span><\/strong><\/p>\n

M\u0113r\u0137i:<\/span><\/span><\/strong><\/p>\n

Pirmk\u0101rt:<\/span><\/span><\/strong> analiz\u0113t kl\u012bniskos ieguvumus, \u0101rst\u0113\u0161anas reakciju, \u0101rst\u0113\u0161anas iesp\u0113jam\u012bbu un komfortu, lietojot hipertermiju kombin\u0101cij\u0101 ar standarta v\u0113\u017ea \u0101rst\u0113\u0161anas metod\u0113m sabiedr\u012bbas vesel\u012bbas sist\u0113m\u0101. <\/span><\/span>
\nOtrk\u0101rt:<\/span><\/span><\/strong> analiz\u0113t izdz\u012bvo\u0161anu, dz\u012bves kvalit\u0101ti un toksicit\u0101ti (visp\u0101r\u0113jo un specifisko v\u0113\u017ea hipertermiju).<\/span><\/span><\/p>\n

Dizains:<\/span><\/span><\/strong> Prospekt\u012bvs, kvazieksperiment\u0101ls, gad\u012bjumu kontroles p\u0113t\u012bjums, kur\u0101 hipertermijas terapija (6\u201310 sesijas ar bie\u017eumu 2\u20133 reizes ned\u0113\u013c\u0101) tika veikta kop\u0101 ar standarta staru terapiju (RT), \u0137\u012bmijterapiju (DT) vai abu kombin\u0101ciju. Pacienti ar prim\u0101riem audz\u0113jiem 9 lokaliz\u0101cij\u0101s vai metast\u0101tiskiem audz\u0113jiem, kuri tika \u0101rst\u0113ti ar radik\u0101lu vai kombin\u0113tu \u0101rst\u0113\u0161anu, tika retrospekt\u012bvi sal\u012bdzin\u0101ti ar diviem kontroles pacientiem, kuri tika \u0101rst\u0113ti iepriek\u0161\u0113j\u0101 gada laik\u0101.<\/span><\/span><\/p>\n

Divas f\u0101zes:<\/span><\/span><\/strong> pirm\u0101 m\u0101c\u012bbu f\u0101ze (20 pacienti). Otr\u0101 akt\u012bv\u0101s \u0101rst\u0113\u0161anas f\u0101ze, kur\u0101 piedal\u012bj\u0101s 97 pacienti, sal\u012bdzinot ar 196 kontroles grupu, kas 2012. gad\u0101 ab\u0101s slimn\u012bc\u0101s tika \u0101rst\u0113ti ar staru terapiju vai QT interv\u0101la terapiju bez hipertermijas (kop\u0101 293 pacienti).<\/span><\/span><\/p>\n

Devi\u0146as audz\u0113ja vietas:<\/span><\/span><\/strong><\/p>\n

\n
    \n
  • Dzemdes kakls, prostata, ur\u012bnp\u016bslis<\/span><\/span><\/li>\n
  • Aizku\u0146\u0123a dziedzeris, neoper\u0113jama galva un kakls<\/span><\/span><\/li>\n
  • Smadze\u0146u audz\u0113ji, pirmsoper\u0101cijas taisn\u0101s zarnas<\/span><\/span><\/li>\n
  • Neoper\u0113jama neoadjuvanta terapija progres\u0113jo\u0161a kr\u016bts v\u0113\u017ea \u0101rst\u0113\u0161anai<\/span><\/span><\/li>\n
  • Nes\u012bk\u0161\u016bnu plau\u0161u v\u0113zis (NSCLC)<\/span><\/span><\/li>\n
  • Paliat\u012bv\u0101 \u0101rst\u0113\u0161ana da\u017e\u0101d\u0101s viet\u0101s<\/span><\/span><\/li>\n<\/ul>\n<\/blockquote>\n

    Rezult\u0101ti:<\/span><\/span><\/strong><\/p>\n

    Provizoriskie dati no saraksta:<\/span><\/span><\/strong> 22 pacienti (9 Huana Romana Himeness slimn\u012bc\u0101 un 13 Karlosa Hajas slimn\u012bc\u0101).<\/span><\/span><\/p>\n

    Dzimums: 13 v\u012brie\u0161i un 9 sievietes.<\/span><\/span><\/p>\n

    Vid\u0113jais vecums: 55 gadi (34\u201376 gadi).<\/span><\/span><\/p>\n

    Audz\u0113ja atra\u0161an\u0101s vieta: glioblastoma (2c), galva un kakls (7c), pirms oper\u0101cijas taisn\u0101 zarna (3c), kr\u016bts (3c1), plau\u0161as (11c), prostata (4c), dzemdes kakls (lc), sakroiliak\u0101l\u0101 kaula metast\u0101zes.<\/span><\/span><\/p>\n

    \u0100rst\u0113\u0161ana:<\/span><\/span><\/strong> HyDeep 600WM hipertermijas ier\u012bce (Andromedic), kas veic 10 seansus 2\u20133 reizes ned\u0113\u013c\u0101, katra 1 stundas garum\u0101, izmantojot jaudu no 150 W l\u012bdz 400 W atkar\u012bb\u0101 no atra\u0161an\u0101s vietas, kas saist\u012bta ar standarta onkolo\u0123ijas \u0101rst\u0113\u0161anu.<\/span><\/span><\/p>\n

    \u0100rst\u0113\u0161anas p\u0101rtrauk\u0161anas iemesli:<\/span><\/span><\/strong><\/p>\n

    Huana R. Himeness slimn\u012bca Velv\u0101: 3 gad\u012bjumi, infekcija \u0101rst\u0113\u0161anas viet\u0101 (celul\u012bts taisn\u0101s zarnas v\u0113\u017ea gad\u012bjum\u0101), dzemdes asi\u0146o\u0161ana (dzemdes kakla v\u0113zis) un br\u012bvpr\u0101t\u012bga \u0101rst\u0113\u0161anas p\u0101rtrauk\u0161ana.<\/span><\/span><\/p>\n

    C slimn\u012bca Haya de Melaga: 2 pacienti, viens sestaj\u0101 seans\u0101, labi panesot proced\u016bru, un v\u0113l viens sestaj\u0101 seans\u0101, pateicoties labi panesam\u012bbai.<\/span><\/span><\/p>\n

    Pacienta izn\u0101kums:<\/span><\/span><\/strong> 19 pacienti ir dz\u012bvi, gaida atbildes reakcijas nov\u0113rt\u0113jumu, un 3 pacienti ir miru\u0161i slim\u012bbas progres\u0113\u0161anas d\u0113\u013c (2 sa\u0146\u0113ma tikai \u0137\u012bmijterapiju un HT audz\u0113ja recid\u012bva d\u0113\u013c iepriek\u0161 apstarotaj\u0101 galvas un kakla rajon\u0101, un v\u0113l viens pacients ar r\u012bkles audz\u0113ja recid\u012bvu sa\u0146\u0113ma paliat\u012bvu staru terapiju un HT).<\/span><\/span><\/p>\n

    Tolerance: 81,2\u00a0% pacientu (18\u00a0p.) nor\u0101d\u012bja, ka ir apmierin\u0101ti vai \u013coti apmierin\u0101ti, un 18,8\u00a0% (4\u00a0p.) nor\u0101d\u012bja, ka tie ir pie\u0146emami.<\/span><\/span><\/strong><\/p>\n

    Toksicit\u0101te: 1. pak\u0101pes dedzin\u0101\u0161anas saj\u016btai l\u012bdz\u012bga toksicit\u0101te rad\u0101s 8 no 22 pacientiem (36,3%). 66,6% pacientu toksicit\u0101te netika nov\u0113rota. Vienam pacientam bija 1. pak\u0101pes s\u0101pes\/premikss \u0101rst\u0113\u0161anas zon\u0101 (\u010d\u016blainas kr\u016bts gad\u012bjum\u0101).<\/span><\/span><\/strong><\/p>\n

    M\u016bsu s\u0101kotn\u0113j\u0101 pieredze liecina par \u0101rst\u0113\u0161anas iesp\u0113jam\u012bbu valsts slimn\u012bc\u0101, ikdienas apr\u016bp\u0113 bez nepiecie\u0161am\u012bbas p\u0113c \u0101rk\u0101rt\u0113jiem resursiem un ar augstu toleranci.<\/span><\/span><\/strong><\/p>\n

    SECIN\u0100JUMI: \u0100rst\u0113\u0161ana ir iesp\u0113jama un \u0113rta 81,2\u00a0% m\u016bsu pacientu valsts vesel\u012bbas apr\u016bpes sist\u0113m\u0101, un 33\u00a0% gad\u012bjumu viegla toksicit\u0101te ir saist\u012bta ar hipertermijas \u0101rst\u0113\u0161anu. Atbilsto\u0161a pacientu atlase ir \u013coti svar\u012bga.<\/span><\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

    Kvazi-iesp\u0113jam\u012bbas kl\u012bniskais p\u0113t\u012bjums, kas saista dzi\u013cas lok\u0101las hipertermijas \u0101rst\u0113\u0161anu ar standarta v\u0113\u017ea \u0101rst\u0113\u0161anas metod\u0113m un apraksta atbildes reakcijas mode\u013cus Andromedic hipertermijas kl\u012bniskais p\u0113t\u012bjums – Eiropas Hipertermisk\u0101s onkolo\u0123ijas biedr\u012bbas kongress 2014. gad\u0101\u00a0 Ievads: \u0160is ir pirmais kl\u012bniskais p\u0113t\u012bjums Sp\u0101nij\u0101 un Andal\u016bzij\u0101, kur\u0101 dzi\u013ca lok\u0101la hipertermija tiek apvienota ar standarta v\u0113\u017ea \u0101rst\u0113\u0161anas metod\u0113m. Materi\u0101li un metodes: M\u0113r\u0137i:…<\/p>\n","protected":false},"author":1,"featured_media":1943,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[172,951],"tags":[],"class_list":["post-4271","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-lv","category-studii-clinice-lv"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/posts\/4271","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/comments?post=4271"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/posts\/4271\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/media\/1943"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/media?parent=4271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/categories?post=4271"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/tags?post=4271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}