{"id":4283,"date":"2017-08-12T11:10:18","date_gmt":"2017-08-12T11:10:18","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/2017\/08\/12\/clinical-and-translational-oncology-feasibility-of-a-deep-hyperthermia-and-radiotherapy-programme-for-advanced-tumors-first-spanish-experience\/"},"modified":"2025-09-04T16:16:55","modified_gmt":"2025-09-04T16:16:55","slug":"kliniskais-petijums-par-hipertermiju","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/lv\/kliniskais-petijums-par-hipertermiju\/","title":{"rendered":"Kl\u012bniskais p\u0113t\u012bjums: \u0137\u012bmijterapijas un staru terapijas kop\u0101 ar hipertermiju un augstas devas brahiterapijas provizoriskie rezult\u0101ti lok\u0101li progres\u0113jo\u0161as dzemdes kakla karcinomas \u0101rst\u0113\u0161an\u0101"},"content":{"rendered":"
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Kl\u012bniskais p\u0113t\u012bjums: \u0137\u012bmijterapijas un staru terapijas kop\u0101 ar hipertermiju un augstas devas brahiterapijas provizoriskie rezult\u0101ti lok\u0101li progres\u0113jo\u0161as dzemdes kakla karcinomas \u0101rst\u0113\u0161an\u0101<\/span><\/span><\/a><\/h1>\n

Andromedic hipertermijas kl\u012bniskais p\u0113t\u012bjums – Eiropas Hipertermisk\u0101s onkolo\u0123ijas biedr\u012bbas kongress 2014. gad\u0101\u00a0<\/span><\/span><\/a><\/h2>\n

<\/h2>\n
\"kl\u012bniskais
Lok\u0101li progres\u0113jo\u0161as dzemdes kakla karcinomas \u0137\u012bmijterapijas un staru terapijas, k\u0101 ar\u012b androm\u0113disk\u0101s hipertermijas un augstas devas brahiterapijas provizoriskie rezult\u0101ti<\/span><\/span><\/figcaption><\/figure>\n

E. Clarke, V. De Sanctis, C. Scaringi, M. Valeriani, MF Osti, R. Maurizi Enrici Sant’Andrea Hospital, Radiotherapy Dept, University of Roma “Sapienza”, Roma. Italy<\/span><\/span><\/p>\n

M\u0112R\u0136I<\/span><\/span><\/strong> Izp\u0113t\u012bt \u0137\u012bmijterapijas un staru terapijas kop\u0101 ar hipertermiju (HT) un augstas devas jaudas brahiterapijas (BRT) rezult\u0101tus lok\u0101li progres\u0113jo\u0161as dzemdes kakla karcinomas (LACC) \u0101rst\u0113\u0161an\u0101. Vai \u0137\u012bmijterapija un staru terapija tiek uzskat\u012bta par standarta \u0101rst\u0113\u0161anas metodi LACC gad\u012bjum\u0101. Ir pier\u0101d\u012bts, ka HT pievieno\u0161ana tikai staru terapijai (RT) uzlabo lok\u0101lu audz\u0113ja kontroli un kop\u0113jo dz\u012bvildzi, neietekm\u0113jot ar \u0101rst\u0113\u0161anu saist\u012bto 3. l\u012bdz 4. pak\u0101pes ak\u016bto vai v\u0113l\u012bno toksicit\u0101ti \u0161aj\u0101 pacientu grup\u0101.<\/span><\/span><\/p>\n

MATERI\u0100LI UN METODES<\/span><\/span><\/strong> No 2013.\u00a0gada janv\u0101ra l\u012bdz 2013.\u00a0gada decembrim 8 pacienti ar LACC jeb lok\u0101li recidiv\u0113jo\u0161u dzemdes kakla karcinomu (LRCC) p\u0113c histerektomijas (attiec\u012bgi 3\u00a0IIB, I, IIIB stadijas, 2\u00a0NEI un 3\u00a0LRCC) tika iesaist\u012bti pilotp\u0113t\u012bjum\u0101, kur\u0101 tika apvienota cisplat\u012bna un HT lieto\u0161ana reizi ned\u0113\u013c\u0101 ar intensit\u0101tes modul\u0113tu staru terapiju (IMRT), kam sekoja BRT. 5,5 ned\u0113\u013cu laik\u0101 iegur\u0146a limfmezglos tika ievad\u012bta 50,4 Gy deva ar vienlaic\u012bgu integr\u0113tu pastiprin\u0101jumu (SIB) kop\u0113jam audz\u0113ja tilpumam (GTV), sasniedzot kop\u0101 61,8 Gy 28 frakcij\u0101s. BRT deva bija 21 Gy 3 frakcij\u0101s. Vienlaic\u012bga \u0137\u012bmijterapijas sh\u0113ma sast\u0101v\u0113ja no cisplat\u012bna 4\/mg\/m2 reizi ned\u0113\u013c\u0101 un HT tika ievad\u012bta reizi ned\u0113\u013c\u0101.<\/span><\/span><\/p>\n

REZULT\u0100TI Visiem pacientiem tika pan\u0101kta lok\u0101la kontrole. Vienam pacientam bija recid\u012bvs \u0101rpus iegur\u0146a ar vair\u0101ku kaulu un paraaort\u0101lo limfmezglu iesaist\u012b\u0161anos. Netika nov\u0113rota ar \u0101rst\u0113\u0161anu saist\u012bta ak\u016bta vai v\u0113l\u012bna 3. l\u012bdz 4. pak\u0101pes toksicit\u0101te.<\/span><\/span><\/strong><\/p>\n

SECIN\u0100JUMI \u0160\u012b sh\u0113ma bija labi panesama ar labu kl\u012bnisko atbildes reakciju. HT pievieno\u0161ana \u0137\u012bmijterapijai un staru terapijai ir daudzsolo\u0161a jauna strat\u0113\u0123ija.<\/span><\/span><\/strong> Lai apstiprin\u0101tu t\u0101s efektivit\u0101ti, nepiecie\u0161ami daudzu iest\u0101\u017eu sadarb\u012bbas centieni un ilg\u0101ki nov\u0113ro\u0161anas periodi.<\/span><\/span><\/p>\n

BIBLIOGR\u0100FIJA<\/span><\/span><\/p>\n

1. Lutgens L. van der Zee J. Pijls-Johannesma M, De Haas-Kock DF, Buijsen J. Mastrigt GA. Lammering G. De Ruysscher DK. Lambin R. Hipertermijas un staru terapijas kombin\u0113ta lieto\u0161ana lok\u0101li progres\u0113jo\u0161as dzemdes kakla karcinomas \u0101rst\u0113\u0161anai. Cochrane Database Syst Rev. 2010. gada 17. marts:(3):CD008377. doi:10.1002\/14851858.CD006377.pub3.<\/span><\/span><\/p>\n

2. van der Zee J. Gonzalez Gonzalez D. van Rhoon GC, van Dijk JD. van Pullen WL, Hart AA. Staru terapijas vientul\u012bbas sal\u012bdzin\u0101jums ar staru terapiju kop\u0101 ar hipertermiju lok\u0101li progres\u0113jo\u0161u iegur\u0146a audz\u0113ju gad\u012bjum\u0101: prospekt\u012bvs, randomiz\u0113ts, daudzcentru p\u0113t\u012bjums. Dutch Deep Hyperthemba Group. Lancet. 2000. gada 1. apr\u012blis: 355(9210): 1119\u201325.<\/span><\/span><\/p>\n

3. Green J, Kirwan 0,1, Tremey J., Vale C., Symonds R, Fresco L., Williams C., Collingwood M. Vienlaic\u012bga \u0137\u012bmijterapija un staru terapija dzemdes kakla v\u0113\u017ea gad\u012bjum\u0101. Cochrane Database Syst Rev. 2005. gada 20. j\u016blijs;(3):C0002225.<\/span><\/span><\/p>\n

 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Kl\u012bniskais p\u0113t\u012bjums: \u0137\u012bmijterapijas un staru terapijas kop\u0101 ar hipertermiju un augstas devas brahiterapijas provizoriskie rezult\u0101ti lok\u0101li progres\u0113jo\u0161as dzemdes kakla karcinomas \u0101rst\u0113\u0161an\u0101 Andromedic hipertermijas kl\u012bniskais p\u0113t\u012bjums – Eiropas Hipertermisk\u0101s onkolo\u0123ijas biedr\u012bbas kongress 2014. gad\u0101\u00a0 E. Clarke, V. De Sanctis, C. Scaringi, M. Valeriani, MF Osti, R. Maurizi Enrici Sant’Andrea Hospital, Radiotherapy Dept, University of Roma “Sapienza”,…<\/p>\n","protected":false},"author":1,"featured_media":7021,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[172],"tags":[178,381,180,181,182,183],"class_list":["post-4283","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-lv","tag-advanced-tumors-lv","tag-hipertermija-lv","tag-hyperthermia-lv","tag-local-hyperthermia-lv","tag-meht-lv","tag-radiotherapy-lv"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/posts\/4283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/comments?post=4283"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/posts\/4283\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/media\/7021"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/media?parent=4283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/categories?post=4283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/lv\/wp-json\/wp\/v2\/tags?post=4283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}