{"id":4285,"date":"2017-08-12T11:12:57","date_gmt":"2017-08-12T11:12:57","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/2017\/08\/12\/quasi-feasibility-studycase-control-associating-deep-local-hyperthermia-treatment-with-standard-cancer-treatments-and-describing-patterns-of-response-esho-poster\/"},"modified":"2025-09-03T10:22:51","modified_gmt":"2025-09-03T10:22:51","slug":"klinicka-studia-hypertermie-andromedic","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/sk\/klinicka-studia-hypertermie-andromedic\/","title":{"rendered":"Kv\u00e1zi uskuto\u010dnite\u013en\u00e1 klinick\u00e1 \u0161t\u00fadia sp\u00e1jaj\u00faca lie\u010dbu hlbokou lok\u00e1lnou hypertermiou so \u0161tandardnou lie\u010dbou rakoviny a opisuj\u00faca vzorce reakcie"},"content":{"rendered":"

Kv\u00e1zi uskuto\u010dnite\u013en\u00e1 klinick\u00e1 \u0161t\u00fadia sp\u00e1jaj\u00faca lie\u010dbu hlbokou lok\u00e1lnou hypertermiou so \u0161tandardnou lie\u010dbou rakoviny a opisuj\u00faca vzorce reakcie<\/span><\/span><\/a><\/h1>\n

Klinick\u00e1 \u0161t\u00fadia Andromedic hypertermie – kongres Eur\u00f3pskej spolo\u010dnosti pre hypertermick\u00fa onkol\u00f3giu 2014\u00a0<\/span><\/span><\/a><\/h2>\n
\"Klinick\u00e1
Kv\u00e1zi \u0161t\u00fadia uskuto\u010dnite\u013enosti (pr\u00edpadov\u00e1 kontrola) sp\u00e1jaj\u00faca lie\u010dbu hlbokou lok\u00e1lnou hypertermiou HyDeep 600WM so \u0161tandardn\u00fdmi lie\u010dbami rakoviny a opisuj\u00faca vzorce reakcie<\/span><\/span><\/figcaption><\/figure>\n

\u00davod:<\/span><\/span><\/strong><\/p>\n

Ide o prv\u00fa klinick\u00fa \u0161t\u00fadiu kombinuj\u00facu hlbok\u00fa lok\u00e1lnu hypertermiu so \u0161tandardnou lie\u010dbou rakoviny v \u0160panielsku a Andal\u00fazii.<\/span><\/span><\/p>\n

Materi\u00e1ly a met\u00f3dy:<\/span><\/span><\/strong><\/p>\n

Ciele:<\/span><\/span><\/strong><\/p>\n

Prv\u00e1:<\/span><\/span><\/strong> Analyzova\u0165 klinick\u00e9 pr\u00ednosy, odpove\u010f na lie\u010dbu, uskuto\u010dnite\u013enos\u0165 lie\u010dby a pohodlie spojen\u00e9 s hypertermiou v kombin\u00e1cii so \u0161tandardn\u00fdmi lie\u010dbami rakoviny v r\u00e1mci syst\u00e9mu verejn\u00e9ho zdravotn\u00edctva. <\/span><\/span>
\nSekund\u00e1rne:<\/span><\/span><\/strong> Analyzova\u0165 pre\u017eitie, kvalitu \u017eivota a toxicitu (v\u0161eobecn\u00e1 a \u0161pecifick\u00e1 hypertermia pri rakovine).<\/span><\/span><\/p>\n

Dizajn:<\/span><\/span><\/strong> Prospekt\u00edvna, kv\u00e1ziexperiment\u00e1lna \u0161t\u00fadia pr\u00edpadov a kontrol, v ktorej bola hypertermia (6 \u2013 10 seden\u00ed s frekvenciou 2 \u2013 3 za t\u00fd\u017ede\u0148) pod\u00e1van\u00e1 v spojen\u00ed so \u0161tandardnou r\u00e1dioterapiou (RT), chemoterapiou (CT) alebo kombin\u00e1ciou oboch. Pacienti s prim\u00e1rnymi n\u00e1dormi v 9 lokaliz\u00e1ci\u00e1ch alebo metastatick\u00fdmi n\u00e1dormi, lie\u010den\u00ed radik\u00e1lnou alebo kombinovanou lie\u010dbou, boli retrospekt\u00edvne porovn\u00e1van\u00ed s dvoma kontroln\u00fdmi pr\u00edpadmi lie\u010den\u00fdmi v predch\u00e1dzaj\u00facom roku.<\/span><\/span><\/p>\n

Dve f\u00e1zy:<\/span><\/span><\/strong> prv\u00e1 f\u00e1za u\u010denia (20 pacientov). Druh\u00e1 f\u00e1za akt\u00edvnej lie\u010dby s 97 zaraden\u00fdmi pacientmi v porovnan\u00ed so 196 kontroln\u00fdmi pacientmi lie\u010den\u00fdmi r\u00e1dioterapiou alebo terapiou QT intervalu bez hypertermie v roku 2012 v oboch nemocniciach (celkovo 293 pacientov).<\/span><\/span><\/p>\n

Dev\u00e4\u0165 n\u00e1dorov\u00fdch miest:<\/span><\/span><\/strong><\/p>\n

\n
    \n
  • Kr\u010dok maternice, prostata, mo\u010dov\u00fd mech\u00far<\/span><\/span><\/li>\n
  • Pankreas, neoperovate\u013en\u00e1 hlava a krk<\/span><\/span><\/li>\n
  • Mozgov\u00e9 n\u00e1dory, predopera\u010dn\u00fd kone\u010dn\u00edk<\/span><\/span><\/li>\n
  • Neoperabiln\u00e1 neoadjuvantn\u00e1 lie\u010dba pokro\u010dil\u00e9ho karcin\u00f3mu prsn\u00edka<\/span><\/span><\/li>\n
  • Nemalobunkov\u00fd karcin\u00f3m p\u013e\u00fac (NSCLC)<\/span><\/span><\/li>\n
  • Paliat\u00edvna lie\u010dba na r\u00f4znych miestach<\/span><\/span><\/li>\n<\/ul>\n<\/blockquote>\n

    V\u00fdsledky:<\/span><\/span><\/strong><\/p>\n

    Predbe\u017en\u00e9 \u00fadaje zo zoznamu:<\/span><\/span><\/strong> 22 pacientov (9 v nemocnici Juan Roman Jimenez a 13 v nemocnici Carlos Haya).<\/span><\/span><\/p>\n

    Pohlavie: 13 mu\u017eov a 9 \u017eien.<\/span><\/span><\/p>\n

    Priemern\u00fd vek: 55 rokov (34 \u2013 76 rokov).<\/span><\/span><\/p>\n

    Lokaliz\u00e1cia n\u00e1doru: glioblast\u00f3m (2c), hlava a krk (7c), predopera\u010dn\u00fd kone\u010dn\u00edk (3c), prsn\u00edk (3c1), p\u013e\u00faca (11c), prostata (4c), kr\u010dok maternice (lc), metast\u00e1zy do sakroiliak\u00e1lnej kosti.<\/span><\/span><\/p>\n

    Lie\u010dba:<\/span><\/span><\/strong> Hypertermick\u00fd pr\u00edstroj HyDeep 600WM (Andromedic) s 10 sedeniami, 2-3 kr\u00e1t t\u00fd\u017edenne, v trvan\u00ed 1 hodiny, s v\u00fdkonom od 150 W do 400 W v z\u00e1vislosti od miesta, v spojen\u00ed so \u0161tandardnou onkologickou lie\u010dbou.<\/span><\/span><\/p>\n

    D\u00f4vody na ukon\u010denie lie\u010dby:<\/span><\/span><\/strong><\/p>\n

    Nemocnica Juana R. Jim\u00e9neza v Huelve: 3 pr\u00edpady, infekcia namiesto lie\u010dby (celulit\u00edda pri rakovine kone\u010dn\u00edka), krv\u00e1canie z maternice (rakovina kr\u010dka maternice) a dobrovo\u013en\u00e9 ukon\u010denie lie\u010dby.<\/span><\/span><\/p>\n

    Nemocnica C Haya de Melaga: 2 pacienti, 1 v 6. seden\u00ed, ktor\u00fd lie\u010dbu dobre toleroval, a \u010fal\u0161\u00ed v 6. seden\u00ed, kv\u00f4li dobre tolerovan\u00e9mu pokroku.<\/span><\/span><\/p>\n

    V\u00fdsledok lie\u010dby pacienta:<\/span><\/span><\/strong> 19 pacientov \u017eije, \u010dak\u00e1 sa na vyhodnotenie odpovede a 3 pacienti zomreli v d\u00f4sledku progresie ochorenia (2 dost\u00e1vali v\u00fdlu\u010dne chemoterapiu a HT v d\u00f4sledku relapsu n\u00e1doru v predt\u00fdm o\u017eiarenej oblasti hlavy a krku a \u010fal\u0161\u00ed pacient s relapsom n\u00e1doru hltana dost\u00e1val paliat\u00edvnu r\u00e1dioterapiu a HT).<\/span><\/span><\/p>\n

    Tolerancia: 81,2 % pacientov (18 os\u00f4b) uviedlo, \u017ee boli spokojn\u00ed alebo ve\u013emi spokojn\u00ed a 18,8 % (4 osoby) uviedlo, \u017ee boli prijate\u013en\u00ed.<\/span><\/span><\/strong><\/p>\n

    Toxicita: Toxicita podobn\u00e1 p\u00e1leniu 1. stup\u0148a sa vyskytla u 8 z 22 pacientok (36,3 %). \u017diadna toxicita sa nevyskytla u 66,6 %. Boles\u0165\/pocit premie\u0161ania v lie\u010denej oblasti 1. stup\u0148a (v ulcerovanom prsn\u00edku) u jednej pacientky.<\/span><\/span><\/strong><\/p>\n

    Na\u0161e predbe\u017en\u00e9 sk\u00fasenosti nazna\u010duj\u00fa uskuto\u010dnite\u013enos\u0165 lie\u010dby vo verejn\u00fdch nemocniciach, v r\u00e1mci be\u017enej rutinnej starostlivosti bez potreby mimoriadnych zdrojov a s vysokou toleranciou.<\/span><\/span><\/strong><\/p>\n

    Z\u00c1VER: Lie\u010dba je uskuto\u010dnite\u013en\u00e1 a pohodln\u00e1 pre 81,2 % na\u0161ich pacientov vo verejnom zdravotn\u00edctve, pri\u010dom mierna toxicita sa u 33 % pripisuje lie\u010dbe hypertermiou. Vhodn\u00fd v\u00fdber pacientov je k\u013e\u00fa\u010dov\u00fd.<\/span><\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

    Kv\u00e1zi uskuto\u010dnite\u013en\u00e1 klinick\u00e1 \u0161t\u00fadia sp\u00e1jaj\u00faca lie\u010dbu hlbokou lok\u00e1lnou hypertermiou so \u0161tandardnou lie\u010dbou rakoviny a opisuj\u00faca vzorce reakcie Klinick\u00e1 \u0161t\u00fadia Andromedic hypertermie – kongres Eur\u00f3pskej spolo\u010dnosti pre hypertermick\u00fa onkol\u00f3giu 2014\u00a0 \u00davod: Ide o prv\u00fa klinick\u00fa \u0161t\u00fadiu kombinuj\u00facu hlbok\u00fa lok\u00e1lnu hypertermiu so \u0161tandardnou lie\u010dbou rakoviny v \u0160panielsku a Andal\u00fazii. Materi\u00e1ly a met\u00f3dy: Ciele: Prv\u00e1: Analyzova\u0165 klinick\u00e9 pr\u00ednosy,…<\/p>\n","protected":false},"author":1,"featured_media":1950,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[179,999],"tags":[],"class_list":["post-4285","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-sk","category-studii-clinice-sk"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts\/4285","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/comments?post=4285"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts\/4285\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/media\/1950"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/media?parent=4285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/categories?post=4285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/tags?post=4285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}