{"id":4298,"date":"2017-08-12T11:10:18","date_gmt":"2017-08-12T11:10:18","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/2017\/08\/12\/clinical-and-translational-oncology-feasibility-of-a-deep-hyperthermia-and-radiotherapy-programme-for-advanced-tumors-first-spanish-experience\/"},"modified":"2025-09-03T10:18:53","modified_gmt":"2025-09-03T10:18:53","slug":"klinicke-skusanie-hypertermie","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/sk\/klinicke-skusanie-hypertermie\/","title":{"rendered":"Klinick\u00e1 \u0161t\u00fadia: Predbe\u017en\u00e9 v\u00fdsledky chemoradi\u00e1cie s hypertermiou a brachyterapie s vysokou d\u00e1vkou pri lok\u00e1lne pokro\u010dilom karcin\u00f3me kr\u010dka maternice"},"content":{"rendered":"
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Klinick\u00e1 \u0161t\u00fadia: Predbe\u017en\u00e9 v\u00fdsledky chemoradi\u00e1cie s hypertermiou a brachyterapie s vysokou d\u00e1vkou pri lok\u00e1lne pokro\u010dilom karcin\u00f3me kr\u010dka maternice<\/span><\/span><\/a><\/h1>\n

Klinick\u00e9 sk\u00fa\u0161anie Andromedic hypertermie – kongres Eur\u00f3pskej spolo\u010dnosti pre hypertermick\u00fa onkol\u00f3giu 2014\u00a0<\/span><\/span><\/a><\/h2>\n

<\/h2>\n
\"klinick\u00e1
Predbe\u017en\u00e9 v\u00fdsledky chemoradi\u00e1cie s andromedickou hypertermiou a brachyterapiou s vysokou d\u00e1vkou pri lok\u00e1lne pokro\u010dilom karcin\u00f3me kr\u010dka maternice<\/span><\/span><\/figcaption><\/figure>\n

E. Clarke, V. De Sanctis, C. Scaringi, M. Valeriani, MF Osti, R. Maurizi Enrici Nemocnica Sant’Andrea, R\u00e1dioterapeutick\u00e9 oddelenie, Univerzita R\u00edm ‚Sapenza, R\u00edm. Taliansko<\/span><\/span><\/p>\n

CIELE<\/span><\/span><\/strong> Presk\u00fama\u0165 v\u00fdsledok chemoradi\u00e1cie s hypertermiou (HT) a brachyterapie s vysokou d\u00e1vkou (BRT) pri lok\u00e1lne pokro\u010dilom karcin\u00f3me kr\u010dka maternice (LACC). \u010ci sa chemoradioterapia pova\u017euje za \u0161tandardn\u00fa lie\u010dbu pri LACC. Pridanie HT k r\u00e1dioterapii (RT) samotnej preuk\u00e1zate\u013ene zlep\u0161uje lok\u00e1lnu kontrolu n\u00e1doru a celkov\u00e9 pre\u017eitie bez ovplyvnenia ak\u00fatnej alebo neskorej toxicity 3. a\u017e 4. stup\u0148a s\u00favisiacej s lie\u010dbou v tejto skupine pacientok.<\/span><\/span><\/p>\n

MATERI\u00c1LY A MET\u00d3DY<\/span><\/span><\/strong> Od janu\u00e1ra 2013 do decembra 2013 bolo do pilotnej \u0161t\u00fadie kombinuj\u00facej t\u00fd\u017edenn\u00fa cisplatinu a HT s r\u00e1dioterapiou s modulovanou intenzitou (IMRT), po ktorej nasledovala BRT. D\u00e1vka 50,4 Gy do panvov\u00fdch lymfatick\u00fdch uzl\u00edn so s\u00fa\u010dasn\u00fdm integrovan\u00fdm zosilnen\u00edm (SIB) na hrub\u00fd objem n\u00e1doru (GTV) v celkovej d\u00e1vke 61,8 Gy v 28 frakci\u00e1ch bola podan\u00e1 v priebehu 5,5 t\u00fd\u017ed\u0148a. D\u00e1vka BRT bola 21 Gy v 3 frakci\u00e1ch. S\u00fabe\u017en\u00fd chemoterapeutick\u00fd re\u017eim pozost\u00e1val z t\u00fd\u017edennej cisplatiny 4\/mg\/m2 a HT bola pod\u00e1van\u00e1 raz t\u00fd\u017edenne.<\/span><\/span><\/p>\n

V\u00ddSLEDKY V\u0161etci pacienti dosiahli lok\u00e1lnu kontrolu. U jedn\u00e9ho pacienta sa vyskytla recid\u00edva mimo panvy s postihnut\u00edm viacer\u00fdch kost\u00ed a paraaort\u00e1lnych uzl\u00edn. Nebola pozorovan\u00e1 \u017eiadna ak\u00fatna ani neskor\u00e1 toxicita 3. a\u017e 4. stup\u0148a s\u00favisiaca s lie\u010dbou.<\/span><\/span><\/strong><\/p>\n

Z\u00c1VERY Tento re\u017eim bol dobre tolerovan\u00fd s dobrou klinickou odpove\u010fou. Pridanie HT k chemor\u00e1dioterapii predstavuje s\u013eubn\u00fa nov\u00fa strat\u00e9giu.<\/span><\/span><\/strong> Na potvrdenie jej \u00fa\u010dinnosti je potrebn\u00e1 spolupr\u00e1ca viacer\u00fdch in\u0161tit\u00faci\u00ed a dlh\u0161ie sledovanie.<\/span><\/span><\/p>\n

BIBLIOGRAFIA<\/span><\/span><\/p>\n

1. Lutgens L. van der Zee J. Pijls-Johannesma M, De Haas-Kock DF, Buijsen J. Mastrigt GA. Lammering G. De Ruysscher DK. Lambin R Kombinovan\u00e9 pou\u017eitie hypertermie a r\u00e1dioterapie na lie\u010dbu lok\u00e1lne pokro\u010dil\u00e9ho karcin\u00f3mu kr\u010dka maternice. Cochrane Database Syst Rev. 2010 Mar 17:(3):CD008377. doi:10.1002\/14851858.CD006377.pub3.<\/span><\/span><\/p>\n

2. van der Zee J. Gonzalez Gonzalez D. van Rhoon GC, van Dijk JD. van Pullen WL, Hart AA. Porovnanie samotnej r\u00e1dioterapie s r\u00e1dioterapiou plus hypertermiou pri lok\u00e1lne pokro\u010dil\u00fdch panvov\u00fdch n\u00e1doroch: prospekt\u00edvna, randomizovan\u00e1, multicentrick\u00e1 \u0161t\u00fadia. Dutch Deep Hyperthemba Group. Lancet. 2000 Apr 1:355(9210):1119-25.<\/span><\/span><\/p>\n

3. Green J, Kirwan .1, Tremey J. Vale C. Symonds R Fresco L. Williams C. Collingwood M. S\u00fabe\u017en\u00e1 chemoterapia a r\u00e1dioterapia pri rakovine kr\u010dka maternice. Cochrane Database Syst Rev. 20. j\u00fala 2005;(3):C0002225.<\/span><\/span><\/p>\n

 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Klinick\u00e1 \u0161t\u00fadia: Predbe\u017en\u00e9 v\u00fdsledky chemoradi\u00e1cie s hypertermiou a brachyterapie s vysokou d\u00e1vkou pri lok\u00e1lne pokro\u010dilom karcin\u00f3me kr\u010dka maternice Klinick\u00e9 sk\u00fa\u0161anie Andromedic hypertermie – kongres Eur\u00f3pskej spolo\u010dnosti pre hypertermick\u00fa onkol\u00f3giu 2014\u00a0 E. Clarke, V. De Sanctis, C. Scaringi, M. Valeriani, MF Osti, R. Maurizi Enrici Nemocnica Sant’Andrea, R\u00e1dioterapeutick\u00e9 oddelenie, Univerzita R\u00edm ‚Sapenza, R\u00edm. Taliansko CIELE Presk\u00fama\u0165…<\/p>\n","protected":false},"author":1,"featured_media":7028,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[179],"tags":[212,320,213,214,215,216],"class_list":["post-4298","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-sk","tag-advanced-tumors-sk","tag-hypertermie-sk","tag-hyperthermia-sk","tag-local-hyperthermia-sk","tag-meht-sk","tag-radiotherapy-sk"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts\/4298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/comments?post=4298"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts\/4298\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/media\/7028"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/media?parent=4298"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/categories?post=4298"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/tags?post=4298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}