{"id":4307,"date":"2017-08-12T11:01:57","date_gmt":"2017-08-12T11:01:57","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/2017\/08\/12\/feasibility-of-deep-local-hyperthermia-treatment-in-conjunction-with-standard-cancer-treatments-and-patterns-of-response-esho\/"},"modified":"2025-09-03T10:25:49","modified_gmt":"2025-09-03T10:25:49","slug":"klinicke-skusanie-hlbokej-hypertermie","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/sk\/klinicke-skusanie-hlbokej-hypertermie\/","title":{"rendered":"\u00a0Hlbok\u00e1 region\u00e1lna hypertermia v kombin\u00e1cii s r\u00e1dioterapiou cel\u00e9ho mozgu (WBRT) u pacientov so zlou progn\u00f3zou a mozgov\u00fdmi metast\u00e1zami"},"content":{"rendered":"

\u00a0Hlbok\u00e1 region\u00e1lna hypertermia v kombin\u00e1cii s r\u00e1dioterapiou cel\u00e9ho mozgu (WBRT) u pacientov so zlou progn\u00f3zou a mozgov\u00fdmi metast\u00e1zami<\/span><\/span><\/a><\/h1>\n
\"Klinick\u00e1
Hlbok\u00e1 lok\u00e1lna hypertermia v kombin\u00e1cii s r\u00e1dioterapiou cel\u00e9ho mozgu (WBRT) u pacientov so zlou progn\u00f3zou a mozgov\u00fdmi metast\u00e1zami<\/span><\/span><\/figcaption><\/figure>\n

Abstrakt<\/span><\/strong> Klinick\u00e9 sk\u00fa\u0161anie<\/span><\/span><\/h2>\n

Cie\u013e:<\/span><\/span><\/strong> Cie\u013eom tejto klinickej \u0161t\u00fadie je po prv\u00fdkr\u00e1t pos\u00fadi\u0165 \u00falohu region\u00e1lnej hlbokej hypertermie v kombin\u00e1cii s r\u00e1dioterapiou a syst\u00e9movou terapiou u pacientov so zlou progn\u00f3zou mozgov\u00fdch metast\u00e1z (GPI \u2264 2,5).<\/span><\/span><\/p>\n

Met\u00f3dy:<\/span><\/span><\/strong> Do tejto prospekt\u00edvnej \u0161t\u00fadie boli zaraden\u00ed pacienti s potvrden\u00fdmi mozgov\u00fdmi metast\u00e1zami a klasifikovan\u00fdmi ako GPI sk\u00f3re \u2264 2,5. Stratifik\u00e1cia pred lie\u010dbou bola definovan\u00e1 ako pacienti s GPI sk\u00f3re 0-1 (skupina A) a pacienti s GPI sk\u00f3re 1,5-2,5 (skupina B). HT bola aplikovan\u00e1 dvakr\u00e1t t\u00fd\u017edenne, \u0161es\u0165desiat min\u00fat na sedenie, po\u010das RT pomocou region\u00e1lneho kapacitn\u00e9ho zariadenia ( <\/span>hypertermick\u00fd pr\u00edstroj <\/span><\/a><\/span>Andromedic<\/span><\/span><\/a> HyDeep 600WM ) pri r\u00e1diofrekvencii 13,56 MHz.<\/span><\/span><\/p>\n

V\u00fdsledky:<\/span><\/span><\/strong> Medzi j\u00fanom 2015 a j\u00fanom 2017 bolo do protokolu zahrnut\u00fdch 15 pacientov a celkovo 49 mozgov\u00fdch metast\u00e1z. V\u0161etci pacienti absolvovali v\u0161etky sedenia hypertermie pod\u013ea pl\u00e1nu. RT a syst\u00e9mov\u00e1 terapia boli tie\u017e dokon\u010den\u00e9 pod\u013ea predpisu. <\/span><\/span>Tolerancia lie\u010dby bola vynikaj\u00faca a nebola zaznamenan\u00e1 \u017eiadna toxicita. Pacienti s dobou \u00fa\u010dinnej lie\u010dby hypertermie dlh\u0161ou ako je medi\u00e1n (W90time > 88 %) vykazovali lep\u0161ie aktu\u00e1rske PFS po 6 a 12 mesiacoch (100 % a 66,7 %) v porovnan\u00ed s pacientmi s krat\u0161ou dobou \u00fa\u010dinnej lie\u010dby HT (50 % a 0 %)<\/span><\/span><\/strong> (p < 0,031). Medi\u00e1n OS bol 6 mesiacov (rozsah 1 \u2013 36 mesiacov). Stratifik\u00e1cia pod\u013ea sk\u00f3re GPI uk\u00e1zala medi\u00e1n OS 3 mesiace (CI 95 % 2,49 \u2013 3,51) v skupine A a 8,0 mesiacov (CI 95 % 5,15 \u2013 10,41) v skupine B (p = 0,035).<\/span><\/span><\/p>\n

Z\u00e1very: <\/span><\/span><\/strong> Region\u00e1lna hypertermia je uskuto\u010dnite\u013en\u00e1 a bezpe\u010dn\u00e1 technika, ktor\u00e1 sa m\u00f4\u017ee pou\u017e\u00edva\u0165 v kombin\u00e1cii s r\u00e1dioterapiou u pacientov s mozgov\u00fdmi metast\u00e1zami, \u010d\u00edm sa zlep\u0161uje PFS a pre\u017e\u00edvanie u pacientov s mozgov\u00fdmi metast\u00e1zami so zlou progn\u00f3zou.<\/span><\/span><\/strong><\/p>\n

 <\/p>\n

Do na\u0161ej \u0161t\u00fadie bolo zahrnut\u00fdch 49 mozgov\u00fdch metast\u00e1z od 15 pacientov, ktor\u00ed patrili do najnepriaznivej\u0161\u00edch skup\u00edn GPA: 6 pacientov malo sk\u00f3re index 0-1 (skupina A) a 9 pacientov malo sk\u00f3re index 1,5-2,5 (skupina B). V\u0161etci pacienti boli lie\u010den\u00ed kombin\u00e1ciou r\u00e1dioterapie a region\u00e1lnej HT. Prv\u00fdm z\u00e1verom na\u0161ej \u0161t\u00fadie je, \u017ee kombinovan\u00e1 RT a region\u00e1lna HT je dobre tolerovan\u00e1 lie\u010dba u pacientov s mozgov\u00fdmi metast\u00e1zami. V\u0161etky lie\u010dby boli pod\u00e1van\u00e9 pod\u013ea predpisu <\/span><\/span>.<\/span><\/span><\/strong><\/p>\n

Nebola zaznamenan\u00e1 \u017eiadna toxicita sp\u00f4soben\u00e1 HT. Naproti tomu Byun a kol. [13] vo svojej \u0161t\u00fadii s intraopera\u010dnou HT op\u00edsali z\u00e1chvaty a infekciu rany ako komplik\u00e1cie kombinovanej lie\u010dby v relevantnom po\u010dte pr\u00edpadov. <\/span><\/span><\/strong> Hlbok\u00e1 hypertermia sa zd\u00e1 by\u0165 jednoduch\u0161ia a bezpe\u010dnej\u0161ia na pod\u00e1vanie ako komplikovan\u00e1 intraopera\u010dn\u00e1 lie\u010dba<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n

Kvalita lie\u010dby HT (\u010das W90 > 88 %) viedla k najsilnej\u0161iemu predikt\u00edvnemu faktoru pre pre\u017eitie. Pacienti, ktor\u00ed dost\u00e1vali > 88 % \u010dasu lie\u010dby pri 90 % predp\u00edsan\u00e9ho v\u00fdkonu (150 W), mali teda vynikaj\u00face miery PFS, \u010do potvrdzuje \u00falohu HT pri senzibiliz\u00e1cii n\u00e1dorov na r\u00e1diochemoterapiu [4-7].<\/span><\/span><\/p>\n

Pod\u013ea celkov\u00e9ho pre\u017eitia bol medi\u00e1n celkov\u00e9ho pre\u017eitia v na\u0161ej s\u00e9rii 6 mesiacov, \u010do zlep\u0161ilo slab\u00e9 v\u00fdsledky \u0161tandardnej lie\u010dby v t\u00fdchto pr\u00edpadoch [3]. Spojenie hypertermie s RT +\/- syst\u00e9movou lie\u010dbou dosiahlo u na\u0161ich pacientov s metast\u00e1zami v mozgu pravdepodobnos\u0165 pre\u017eitia 53,1 % a 30,6 % po 12 mesiacoch<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/32748093\/<\/span><\/span><\/p>\n

https:\/\/link.springer.com\/article\/10.1007\/s12094-020-02404-9<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0Hlbok\u00e1 region\u00e1lna hypertermia v kombin\u00e1cii s r\u00e1dioterapiou cel\u00e9ho mozgu (WBRT) u pacientov so zlou progn\u00f3zou a mozgov\u00fdmi metast\u00e1zami Abstrakt Klinick\u00e9 sk\u00fa\u0161anie Cie\u013e: Cie\u013eom tejto klinickej \u0161t\u00fadie je po prv\u00fdkr\u00e1t pos\u00fadi\u0165 \u00falohu region\u00e1lnej hlbokej hypertermie v kombin\u00e1cii s r\u00e1dioterapiou a syst\u00e9movou terapiou u pacientov so zlou progn\u00f3zou mozgov\u00fdch metast\u00e1z (GPI \u2264 2,5). Met\u00f3dy: Do tejto prospekt\u00edvnej…<\/p>\n","protected":false},"author":1,"featured_media":7053,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[179],"tags":[],"class_list":["post-4307","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-sk"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts\/4307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/comments?post=4307"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/posts\/4307\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/media\/7053"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/media?parent=4307"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/categories?post=4307"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/sk\/wp-json\/wp\/v2\/tags?post=4307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}