{"id":4310,"date":"2017-08-12T11:01:57","date_gmt":"2017-08-12T11:01:57","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/2017\/08\/12\/feasibility-of-deep-local-hyperthermia-treatment-in-conjunction-with-standard-cancer-treatments-and-patterns-of-response-esho\/"},"modified":"2025-09-04T13:45:03","modified_gmt":"2025-09-04T13:45:03","slug":"klinik-calisma-derin-hipertermi-wbrt","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/tr\/klinik-calisma-derin-hipertermi-wbrt\/","title":{"rendered":"Beyin Metastazlar\u0131 Olan K\u00f6t\u00fc Prognozlu Hastalarda T\u00fcm Beyin Radyoterapisi (WBRT) ile Birlikte Derin B\u00f6lgesel Hipertermi"},"content":{"rendered":"

\u00a0Beyin Metastazlar\u0131 Olan K\u00f6t\u00fc Prognozlu Hastalarda T\u00fcm Beyin Radyoterapisi (WBRT) ile Birlikte Derin B\u00f6lgesel Hipertermi<\/span><\/span><\/a><\/h1>\n

Klinik \u00c7al\u0131\u015fma<\/h2>\n
\"K\u00f6t\u00fc
Beyin Metastazlar\u0131 Olan K\u00f6t\u00fc Prognozlu Hastalarda T\u00fcm Beyin Radyoterapisi (WBRT) ile Birlikte Derin Lokal Hipertermi<\/span><\/span><\/figcaption><\/figure>\n

Klinik ara\u015ft\u0131rma <\/span><\/span>\u00f6zeti<\/span><\/span><\/strong><\/h2>\n

Ama\u00e7:<\/span><\/span><\/strong> Bu klinik \u00e7al\u0131\u015fman\u0131n amac\u0131, k\u00f6t\u00fc progonozlu beyin metastazlar\u0131 (GPI\u22642,5) olan hastalarda, b\u00f6lgesel derin hiperterminin radyoterapi ve sistemik tedavi ile kombinasyonunun rol\u00fcn\u00fc ilk kez de\u011ferlendirmektir.<\/span><\/span><\/p>\n

Y\u00f6ntemler:<\/span><\/span><\/strong> Do\u011frulanm\u0131\u015f serebral metastaz\u0131 olan ve GPI skoru \u22642,5 olarak s\u0131n\u0131fland\u0131r\u0131lan hastalar bu prospektif \u00e7al\u0131\u015fmaya dahil edildi. Tedavi \u00f6ncesi s\u0131n\u0131fland\u0131rma, GPI skoru 0-1 olan hastalar (A grubu) ve GPI skoru 1,5-2,5 olan hastalar (B grubu) olarak tan\u0131mland\u0131. HT, RT s\u0131ras\u0131nda haftada iki kez, seans ba\u015f\u0131na altm\u0131\u015f dakika, b\u00f6lgesel kapasitif cihaz ( <\/span><\/span>Andromedic <\/span><\/span><\/a> HyDeep 600WM hipertermi cihaz\u0131<\/span><\/span><\/a> ) ile 13,56 MHz radyofrekansta uyguland\u0131.<\/span><\/span><\/p>\n

Bulgular:<\/span><\/span><\/strong> Haziran 2015 ile Haziran 2017 aras\u0131nda protokole 15 hasta ve toplam 49 beyin metastaz\u0131 dahil edildi. T\u00fcm hastalar planland\u0131\u011f\u0131 gibi t\u00fcm HT seanslar\u0131n\u0131 ald\u0131. RT ve sistemik tedavi de re\u00e7ete edildi\u011fi gibi tamamland\u0131. <\/span><\/span>Tedaviye tolerans m\u00fckemmeldi ve herhangi bir toksisite kaydedilmedi. HT etkili tedavi s\u00fcresi medyandan daha uzun olan hastalar (W90time>%88), daha az etkili tedavi s\u00fcresi olan hastalara k\u0131yasla (s\u0131ras\u0131yla %50 ve %0) 6 ve 12 ayda daha iyi akt\u00fceryal PFS g\u00f6sterdi (s\u0131ras\u0131yla %100 ve %66,7)<\/span><\/span><\/strong> (p<0,031). Medyan OS 6 ay idi (aral\u0131\u011f\u0131 1-36 ay). GPI skoruna g\u00f6re yap\u0131lan s\u0131n\u0131fland\u0131rmada Grup A’da ortanca OS 3 ay (CI %95 2,49-3,51) ve Grup B’de 8,0 ay (CI %95 5,1510,41) olarak bulundu (p=0,035).<\/span><\/span><\/p>\n

Sonu\u00e7lar: <\/span><\/span><\/strong> B\u00f6lgesel hipertermi, beyin metastazl\u0131 hastalarda RT ile birlikte kullan\u0131labilen, uygulanabilir ve g\u00fcvenli bir tekniktir; k\u00f6t\u00fc prognozlu beyin metastazl\u0131 hastalarda PFS’yi ve sa\u011fkal\u0131m\u0131 iyile\u015ftirir.<\/span><\/span><\/strong><\/p>\n

 <\/p>\n

\u00c7al\u0131\u015fmam\u0131za, en olumsuz GPA gruplar\u0131na ait 15 hastadan 49 beyin metastaz\u0131 dahil edildi: 6 hastan\u0131n skor indeksi 0-1 (A Grubu) ve 9 hastan\u0131n skor indeksi 1,5-2,5 (B Grubu) idi. T\u00fcm hastalara radyoterapi ve b\u00f6lgesel HT kombinasyonu uyguland\u0131. \u00c7al\u0131\u015fmam\u0131z\u0131n ilk sonucu, kombine RT ve b\u00f6lgesel HT’nin beyin metastazl\u0131 hastalarda iyi tolere edilen bir tedavi oldu\u011fudur. T\u00fcm tedaviler re\u00e7ete edildi\u011fi \u015fekilde uyguland\u0131 <\/span><\/span>.<\/span><\/span><\/strong><\/p>\n

HT’ye ba\u011fl\u0131 herhangi bir toksisite kaydedilmedi. Buna kar\u015f\u0131l\u0131k, Byun ve arkada\u015flar\u0131 [13], intraoperatif HT ile yapt\u0131klar\u0131 \u00e7al\u0131\u015fmada, n\u00f6betleri ve yara enfeksiyonunu, ilgili say\u0131da vakada kombine tedavinin komplikasyonlar\u0131 olarak tan\u0131mlad\u0131lar. <\/span><\/span><\/strong> Derin hipertermi, karma\u015f\u0131k intraoperatif tedavilere g\u00f6re uygulanmas\u0131 daha kolay ve g\u00fcvenli g\u00f6r\u00fcnmektedir<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n

HT tedavisinin kalitesi (W90time >%88), sa\u011f kal\u0131m i\u00e7in en g\u00fc\u00e7l\u00fc \u00f6ng\u00f6r\u00fcc\u00fc fakt\u00f6r olarak ortaya \u00e7\u0131km\u0131\u015ft\u0131r. Bu nedenle, tedavi s\u00fcresinin %88’inden fazlas\u0131n\u0131 re\u00e7ete edilen g\u00fcc\u00fcn %90’\u0131nda (150W) alan hastalarda m\u00fckemmel PFS oranlar\u0131 elde edilmi\u015f ve bu da HT’nin t\u00fcm\u00f6rleri radyokemoterapiye duyarl\u0131 hale getirmedeki rol\u00fcn\u00fcn kabul edildi\u011fini g\u00f6stermektedir [4-7].<\/span><\/span><\/p>\n

Genel sa\u011fkal\u0131ma g\u00f6re, serimizde medyan genel sa\u011fkal\u0131m 6 ayd\u0131 ve bu, bu vakalarda standart tedavinin zay\u0131f sonu\u00e7lar\u0131n\u0131 iyile\u015ftirdi [3]. Hiperterminin RT +\/- sistemik tedaviye ba\u011flanmas\u0131, beyin metastaz\u0131 BM hastalar\u0131m\u0131zda 6 ayda %53,1 ve 12 ayda %30,6 hayatta kalma olas\u0131l\u0131\u011f\u0131na ula\u015ft\u0131<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/32748093\/<\/span><\/span><\/p>\n

https:\/\/link.springer.com\/article\/10.1007\/s12094-020-02404-9<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0Beyin Metastazlar\u0131 Olan K\u00f6t\u00fc Prognozlu Hastalarda T\u00fcm Beyin Radyoterapisi (WBRT) ile Birlikte Derin B\u00f6lgesel Hipertermi Klinik \u00c7al\u0131\u015fma Klinik ara\u015ft\u0131rma \u00f6zeti Ama\u00e7: Bu klinik \u00e7al\u0131\u015fman\u0131n amac\u0131, k\u00f6t\u00fc progonozlu beyin metastazlar\u0131 (GPI\u22642,5) olan hastalarda, b\u00f6lgesel derin hiperterminin radyoterapi ve sistemik tedavi ile kombinasyonunun rol\u00fcn\u00fc ilk kez de\u011ferlendirmektir. Y\u00f6ntemler: Do\u011frulanm\u0131\u015f serebral metastaz\u0131 olan ve GPI skoru \u22642,5 olarak…<\/p>\n","protected":false},"author":1,"featured_media":7057,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[197],"tags":[],"class_list":["post-4310","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-tr"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/posts\/4310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/comments?post=4310"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/posts\/4310\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/media\/7057"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/media?parent=4310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/categories?post=4310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/tr\/wp-json\/wp\/v2\/tags?post=4310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}