{"id":11187,"date":"2025-10-02T14:50:09","date_gmt":"2025-10-02T14:50:09","guid":{"rendered":"https:\/\/andromedichyperthermia.com\/oncologic-hyperthermia-phase-3-trials\/"},"modified":"2025-10-03T09:03:45","modified_gmt":"2025-10-03T09:03:45","slug":"%e7%83%ad%e7%96%97%e8%82%bf%e7%98%a4%e5%ad%a6-iii-%e6%9c%9f%e8%af%95%e9%aa%8c%e8%8d%9f%e8%90%83%e5%88%86%e6%9e%90","status":"publish","type":"post","link":"https:\/\/andromedichyperthermia.com\/zh-hans\/%e7%83%ad%e7%96%97%e8%82%bf%e7%98%a4%e5%ad%a6-iii-%e6%9c%9f%e8%af%95%e9%aa%8c%e8%8d%9f%e8%90%83%e5%88%86%e6%9e%90\/","title":{"rendered":"\u70ed\u7597\u5728\u73b0\u4ee3\u80bf\u7624\u5b66\u4e2d\u7684\u6cbb\u7597\u6574\u5408\uff1a\u5bf9 III \u671f\u8bd5\u9a8c\u548c\u835f\u8403\u5206\u6790\u7684\u6279\u5224\u6027\u5206\u6790\uff08OS\u3001DFS\u3001CR \u7ec8\u70b9\uff09"},"content":{"rendered":"<p><script type=\"application\/ld+json\">\n    {\n      \"@context\": \"https:\/\/schema.org\",\n      \"@type\": \"MedicalScholarlyArticle\",\n      \"headline\": \"\u70ed\u7597\u5728\u73b0\u4ee3\u80bf\u7624\u5b66\u4e2d\u7684\u6cbb\u7597\u6574\u5408\uff1a\u5bf9 III \u671f\u8bd5\u9a8c\u548c\u835f\u8403\u5206\u6790\u7684\u6279\u5224\u6027\u5206\u6790\uff08OS\u3001DFS\u3001CR \u7ec8\u70b9\uff09\",\n      \"author\": {\n        \"@type\": \"Person\",\n        \"name\": \"Gologan Cristian, M.Sc.\",\n        \"jobTitle\": \"CEO\",\n        \"affiliation\": {\n          \"@type\": \"MedicalOrganization\",\n          \"name\": \"Andromedichyperthermia Center\"\n        }\n      },\n      \"keywords\": \"\u70ed\u7597\u3001\u80bf\u7624\u5b66\u3001III \u671f\u8bd5\u9a8c\u3001\u751f\u5b58\u671f\u3001OS\u3001\u5b8c\u5168\u7f13\u89e3\u3001CR\u3001\u8089\u7624\u3001\u5bab\u9888\u764c\u3001E-E-A-T\"\n      \/* ... Schema FAQPage would be added separately for the FAQ section *\/\n    }\n<\/script><\/p>\n<div class=\"author-info\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6743\u5a01\u4e0e\u4e13\u4e1a (EEAT)\uff1a<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7531<\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/zh-hans\/doctor-veronica-iatan\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u533b\u5b66\u535a\u58eb Veronica Iatan<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u548c<\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/zh-hans\/cristian-gologan\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7406\u5b66\u7855\u58eb Cristian Gologan \u64b0\u5199<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0cAndromedichyperthermia<\/span><\/span><\/strong><\/div>\n<h1><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u70ed\u7597\u5728\u73b0\u4ee3\u80bf\u7624\u5b66\u4e2d\u7684\u6cbb\u7597\u6574\u5408\uff1a\u5bf9 III \u671f\u8bd5\u9a8c\u548c\u835f\u8403\u5206\u6790\u7684\u6279\u5224\u6027\u5206\u6790\uff08OS\u3001DFS\u3001CR \u7ec8\u70b9\uff09<\/span><\/span><\/h1>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u70ed\u7597\uff08HT\uff09\u7684\u6267\u884c\u6458\u8981\u548c\u57fa\u672c\u539f\u7406<\/span><\/span><\/h2>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80bf\u7624\u70ed\u7597 (HT)\u5b9a\u4e49\u4e3a\u5728<\/span><\/span><\/strong><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">39\u00b0C \u81f3 45\u00b0C \u7684<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6e29\u5ea6\u4e0b\u63a7\u5236\u52a0\u70ed<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c\u662f\u4e00\u79cd\u8f85\u52a9\u6cbb\u7597\u65b9\u5f0f\uff0c\u5df2\u8bc1\u660e\u5bf9\u4e00\u7cfb\u5217\u665a\u671f\u548c\u590d\u53d1\u6027\u5b9e\u4f53\u7624<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5177\u6709\u663e\u8457\u7684\u4e34\u5e8a\u76ca\u5904\uff0c\u5e76\u5df2\u5f97\u5230 1A \u7ea7\u8bc1\u636e<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III \u671f\u968f\u673a\u8bd5\u9a8c\u548c\u835f\u8403\u5206\u6790<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09\u7684\u8bc1\u5b9e\u3002<\/span><\/span><\/p>\n<div class=\"key-points\">\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5173\u952e\u8981\u70b9 &#8211; 1A \u7ea7\u8bc1\u636e\uff1a<\/span><\/span><\/h3>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5c\u7528\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u4e0d\u4f1a\u76f4\u63a5\u7834\u574f\u80bf\u7624\uff1b\u5b83\u5145\u5f53\u5f3a\u5927\u7684<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u7269\u589e\u654f\u5242<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5df2\u786e\u8ba4\u7684\u76ca\u5904\uff1a 1A \u7ea7\u6570\u636e\u7684\u7efc\u5408\u51f8\u663e\u4e86<\/span><\/span><\/strong><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u603b\u4f53\u751f\u5b58\u7387 (OS)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u548c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u7f13\u89e3\u7387 (CR)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7684\u6301\u7eed\u6539\u5584<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u8981\u9002\u5e94\u75c7\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u5bab\u9888\u764c\u3001\u590d\u53d1\u6027\u4e73\u817a\u764c\u3001\u6076\u6027\u9ed1\u8272\u7d20\u7624\u3001\u8180\u80f1\u764c\u3001\u76f4\u80a0\u764c\u3001\u5934\u9888\u90e8\u80bf\u7624\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b89\u5168\u6027\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u79cd\u5f3a\u5927\u7684\u6cbb\u7597\u76ca\u5904\u59cb\u7ec8\u5982\u4e00\uff0c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e14\u4e0d\u4f1a\u663e\u8457\u589e\u52a0\u5168\u8eab\u6bd2\u6027\u6216\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff083 \u7ea7\u6216 4 \u7ea7\uff09\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed3\u8bba\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u662f\u9488\u5bf9\u7279\u5b9a\u80bf\u7624\u7684\u6807\u51c6\u591a\u6a21\u5f0f\u65b9\u6848\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/span><\/span><\/li>\n<\/ul>\n<\/div>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1. \u80bf\u7624\u70ed\u7597\u7684\u5206\u7c7b\u548c\u65b9\u6cd5<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.1. \u5c40\u90e8\u533a\u57df\u70ed\u7597\uff08LR HT\uff09<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u9879\u6280\u672f\u7528\u4e8e\u76c6\u8154\u3001\u80f8\u90e8\u548c\u8179\u90e8\u80bf\u7624\u7684\u6df1\u5c42\u52a0\u70ed\u3002\u5e38\u7528\u6280\u672f\u5305\u62ec\u7535\u5bb9\u5f0f\u5c04\u9891 (RF) \u7cfb\u7edf\u548c\u5929\u7ebf\u9635\u5217\u5339\u914d\u7684\u8f90\u5c04\u7cfb\u7edf\u3002\u8fd9\u4e9b\u65b9\u6cd5\u65e8\u5728\u5c06\u70ed\u80fd\u8f93\u9001\u81f3\u6df1\u5c42\uff0c\u5728\u80bf\u7624\u4f53\u79ef\u5185\u8fbe\u5230\u6cbb\u7597\u6e29\u5ea6\uff0c\u540c\u65f6\u5c06\u5065\u5eb7\u7ec4\u7ec7\u4fdd\u6301\u5728\u8010\u53d7\u8303\u56f4\u5185\u3002\u76ee\u6807\u662f\u5bf9\u6574\u4e2a\u80bf\u7624\u5757\u8fdb\u884c\u6700\u5747\u5300\uff08\u7b49\u6e29\uff09\u7684\u52a0\u70ed\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.2. \u5c04\u9891\u70ed\u7597\uff08mHT\uff09<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8c03\u5236\u5c04\u9891\u70ed\u7597 (mHT) \u662f\u4e00\u79cd\u72ec\u7279\u7684\u975e\u4fb5\u5165\u5f0f\u65b9\u6cd5\u3002\u4e0e\u4f20\u7edf\u7684\u7b49\u6e29\u52a0\u70ed\u4e0d\u540c\uff0cmHT \u91c7\u7528\u7535\u5bb9\u8026\u5408\u6280\u672f\uff0c\u8f7d\u6ce2\u9891\u7387\u4e3a 13.56 MHz\uff0c\u5e76\u53d7\u968f\u65f6\u95f4\u53d8\u5316\u7684\u5206\u5f62\u6ce2\u52a8\u8c03\u5236\u3002\u5176\u5de5\u4f5c\u539f\u7406\u4f9d\u8d56\u4e8e\u805a\u7126\u4e8e\u7ec6\u80de\u819c\u5c42\u9762\u7684\u80fd\u91cf\u8f6c\u79fb\u3002\u7531\u4e8e\u764c\u7ec6\u80de\u819c\u7684\u7535\u7279\u6027\u6539\u53d8\uff0c\u5176\u4ecb\u7535\u635f\u8017\u4f1a\u4f18\u5148\u53d1\u751f\u5728\u764c\u7ec6\u80de\u819c\u4e0a\uff0c\u4ece\u800c\u4ea7\u751f\u7279\u5b9a\u7684\u6e29\u5ea6\u68af\u5ea6\uff0c\u4ece\u800c\u6fc0\u53d1\u7ec6\u80de\u51cb\u4ea1\u9014\u5f84\u3002\u8fd9\u79cd\u201c\u7531\u5185\u800c\u5916\u52a0\u70ed\u201d\u7684\u673a\u5236\u53ef\u63d0\u9ad8\u80bf\u7624\u5185\u90e8\u6e29\u5ea6\uff0c\u5e76\u51cf\u5c11\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u635f\u4f24\uff0c\u8fd9\u4e0e\u6807\u51c6\u7684\u8f90\u5c04\u6216\u7535\u5bb9\u52a0\u70ed\u65b9\u6cd5\u6709\u7740\u6839\u672c\u6027\u7684\u533a\u522b\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.1.3. \u95f4\u8d28\u70ed\u7597<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u79cd\u65b9\u6cd5\u6d89\u53ca\u4fb5\u5165\u6027\u5730\u4f20\u9012\u70ed\u91cf\uff0c\u901a\u5e38\u901a\u8fc7\u89e6\u89d2\u3001\u68d2\u72b6\u7269\u6216\u7c92\u5b50\u76f4\u63a5\u63d2\u5165\u80bf\u200b\u200b\u7624\u3002\u5b83\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u8111\u80bf\u7624\uff08\u795e\u7ecf\u80f6\u8d28\u7624\uff09\u6216\u590d\u53d1\u6027\u6d45\u8868\u75be\u75c5\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.2. \u4e3a\u4ec0\u4e4839-45\u00b0C\u7684\u6cbb\u7597\u7a97\u53e3\u6709\u6548\uff1f\uff08\u751f\u7269\u5b66\u673a\u5236\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT \u5728 III \u671f\u4e34\u5e8a\u4e2d\u5c55\u73b0\u51fa\u7684\u7597\u6548\uff0c\u4e0e\u5176\u590d\u6742\u7684\u751f\u7269\u5b66\u673a\u5236\u5bc6\u4e0d\u53ef\u5206\u3002\u8fd9\u4e9b\u673a\u5236\u8d85\u8d8a\u4e86\u7b80\u5355\u7684\u7ec6\u80de\u7834\u574f\uff0c\u4f7f HT \u6210\u4e3a<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6807\u51c6\u6cbb\u7597\u7684<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u529f\u80fd\u589e\u654f\u5242\u3002<\/span><\/span><\/strong><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9009\u62e9*39-45\u00b0C*\u7684\u6700\u4f73\u6e29\u5ea6\uff0c\u662f\u56e0\u4e3a\u8be5\u6e29\u5ea6\u80fd\u591f\u6700\u5927\u9650\u5ea6\u5730\u8c03\u8282\u80bf\u7624\u7279\u5f02\u6027\u7ec6\u80de\u5931\u8861\u3002\u968f\u673a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u603b\u4f53\u6210\u529f\u6b63\u662f\u6e90\u4e8e\u8fd9\u79cd\u589e\u654f\u4f5c\u7528\uff0c\u5b83\u901a\u8fc7\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u548c\u7ec6\u80de\u673a\u5236\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u589e\u5f3a\u4e86\u653e\u7597(RT)\u548c\u5316\u7597(CHT)\u7684\u7597\u6548\u3002<\/span><\/span><\/p>\n<hr \/>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u4f5c\u7528\u673a\u5236\uff1a\u70ed\u7597\u5982\u4f55\u589e\u5f3a\u80bf\u7624\u6cbb\u7597\uff1f<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8054\u5408\u6cbb\u7597\u7684\u5353\u8d8a\u4e34\u5e8a\u7597\u6548\u662f\u5f3a\u5927\u7684\u751f\u7269\u534f\u540c\u4f5c\u7528\u7684\u7ed3\u679c\uff0c\u9488\u5bf9\u591a\u4e2a\u5c42\u9762\u7684\u80bf\u7624\u8010\u836f\u6027\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.1. \u653e\u5c04\u589e\u654f\uff1a\u514b\u670d\u80bf\u7624\u8010\u836f\u6027\u548cDNA\u4fee\u590d<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u70ed\u7597\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u6709\u6548\u7684\u653e\u5c04\u589e\u654f\u5242\uff0c\u53ef\u4ee5\u89e3\u51b3\u653e\u5c04\u6cbb\u7597\u5931\u8d25\u7684\u4e24\u4e2a\u6700\u4e3b\u8981\u539f\u56e0\uff1a<\/span><\/span><\/p>\n<ol>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6291\u5236 DNA \u4fee\u590d\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u6291\u5236\u53d7\u8f90\u5c04\u635f\u4f24\u7684 DNA \u4fee\u590d\u673a\u5236\uff0c\u786e\u4fdd\u66f4\u6709\u6548\u3001\u4e0d\u53ef\u9006\u7684\u7ec6\u80de\u6b7b\u4ea1\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5fae\u73af\u5883\u6c27\u5408\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u589e\u52a0\u8840\u6d41\u91cf\u5e76\u6539\u5584\u80bf\u7624\u6c27\u5408\uff0c\u51cf\u5c11\u7f3a\u6c27\uff08\u6297\u8f90\u5c04\uff09\u90e8\u5206\u3002<\/span><\/span><\/li>\n<\/ol>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80bf\u7624\u5fae\u73af\u5883\u7684\u8fd9\u79cd\u529f\u80fd\u6027\u6539\u53d8\u4f7f\u5f97\u5148\u524d\u8010\u836f\u7684\u764c\u7ec6\u80de\u5bf9\u5e38\u89c4\u653e\u5c04\u6cbb\u7597\u66f4\u52a0\u654f\u611f\u3002\u5fae\u5faa\u73af\u7684\u8fd9\u79cd\u53d8\u5316\u662f\u5bfc\u81f4\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c (LACC) \u548c\u5934\u9888\u764c (HNC) \u7b49\u80bf\u7624\u5728\u653e\u5316\u7597\u8054\u5408\u70ed\u7597\u65b9\u6848 (CCRT+HT) \u4e2d\u53d6\u5f97\u9ad8\u5c40\u90e8\u533a\u57df\u63a7\u5236\u7387\u548c\u5b8c\u5168\u7f13\u89e3\u7387\u7684\u51b3\u5b9a\u6027\u56e0\u7d20\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2. \u5316\u5b66\u589e\u654f\uff1a\u6539\u5584\u836f\u7269\u8fd0\u8f93\u548c\u7ec6\u80de\u6444\u53d6<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2.1. \u4e0e\u4e3b\u8981\u836f\u7269\u7684\u534f\u540c\u4f5c\u7528\u548c\u52a0\u548c\u4f5c\u7528<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT \u4e0e\u67d0\u4e9b\u7c7b\u578b\u7684\u57fa\u7840\u80bf\u7624\u5316\u7597\u836f\u7269\u8868\u73b0\u51fa\u5f3a\u5927\u7684\u534f\u540c\u4f5c\u7528\u3002\u7279\u522b\u662f\uff0cHT \u4e0e\u94c2\u7c7b\u836f\u7269\uff08\u987a\u94c2\u3001\u5361\u94c2\uff09\u548c\u4e1d\u88c2\u9709\u7d20 C \u5177\u6709\u534f\u540c\u4f5c\u7528\u3002\u8fd9\u4e9b\u836f\u7269\u5e38\u7528\u4e8e\u4e3b\u8981\u7684 III \u671f\u9002\u5e94\u75c7\uff0c\u4f8b\u5982\u5bab\u9888\u764c\u548c\u5934\u9888\u90e8\u80bf\u7624 (HNC)\uff0c\u8fd9\u8868\u660e\u5728\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u76ca\u5904\u4f9d\u8d56\u4e8e\u4e92\u8865\u7684\u751f\u7269\u5b66\u5173\u8054\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u70ed\u6548\u5e94\u3002HT \u8fd8\u4e0e\u963f\u9709\u7d20\u3001\u73af\u78f7\u9170\u80fa\u548c\u5409\u897f\u4ed6\u6ee8\u7b49\u836f\u7269\u5177\u6709\u53e0\u52a0\u6548\u5e94\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.2.2. \u836f\u4ee3\u52a8\u529b\u5b66\u653e\u5927<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u901a\u8fc7\u589e\u52a0\u836f\u7269\u5411\u80bf\u7624\u548c\u6dcb\u5df4\u7ed3\uff08LN\uff09\u7684\u8fd0\u8f93\uff0c\u4f18\u5316\u4e86\u836f\u7269\u5411\u80bf\u7624\u6c34\u5e73\u7684\u8f93\u9001\u3002\u8fd9\u79cd\u6548\u5e94\u5f52\u56e0\u4e8eHT\u5f15\u8d77\u7684\u704c\u6ce8\uff08\u8840\u6d41\uff09\u589e\u52a0\u548c\u7ec6\u80de\u819c\u901a\u900f\u6027\u7684\u6539\u53d8\u3002\u5728mHT\u4e2d\uff0c\u9ad8\u4ecb\u7535\u635f\u8017\u4fc3\u8fdb\u7ec6\u80de\u819c\u6c34\u5e73\u5c40\u90e8\u52a0\u70ed\u7684\u673a\u5236\uff0c\u53ef\u80fd\u589e\u5f3a\u5316\u7597\u836f\u7269\u5728\u7ec6\u80de\u5185\u7684\u5438\u6536\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2.3. \u514d\u75ab\u8c03\u8282\uff1a\u5c06\u201c\u51b7\u201d\u80bf\u7624\u8f6c\u5316\u4e3a\u201c\u70ed\u201d\uff08\u514d\u75ab\u539f\u6027\uff09\u80bf\u7624<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u79cd\u8d8a\u6765\u8d8a\u88ab\u8ba4\u53ef\u7684\u4f5c\u7528\u673a\u5236\u662f HT \u80fd\u591f\u8c03\u8282\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u6709\u6548\u5730\u5c06\u514d\u75ab\u5b66\u4e0a\u201c\u51b7\u201d\u80bf\u7624\u8f6c\u5316\u4e3a\u201c\u70ed\u201d\uff08\u53d1\u708e\uff09\u80bf\u7624\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT \u901a\u8fc7\u8bf1\u5bfc\u70ed\u4f11\u514b\u86cb\u767d (HSP) \u548c\u80bf\u7624\u6297\u539f\u7684\u91ca\u653e\uff0c\u53d1\u6325\u201c\u539f\u4f4d\u80bf\u7624\u75ab\u82d7\u201d\u7684\u4f5c\u7528\u3002HSP\uff08\u4f8b\u5982 HSP70\uff09\u53ef\u4f5c\u4e3a\u5371\u9669\u4fe1\u53f7\uff0c\u4fc3\u8fdb\u6811\u7a81\u72b6\u7ec6\u80de (DC) \u6444\u53d6\u6297\u539f\u3002\u4e00\u65e6\u88ab\u5185\u5316\uff0cDC \u4fbf\u4f1a\u8fc1\u79fb\u81f3\u6dcb\u5df4\u7ed3 (LN)\uff0c\u5e76\u5728\u90a3\u91cc\u6fc0\u6d3b\u5e76\u542f\u52a8\u7ec6\u80de\u6bd2\u6027 CD8+ T \u7ec6\u80de\u3002\u8fd9\u79cd\u514d\u75ab\u8c03\u8282\u8fc7\u7a0b\u53ef\u4fc3\u8fdb\u81ea\u7136\u6740\u4f24 (NK) \u7ec6\u80de\u548c CD8+ T \u7ec6\u80de\u88c2\u89e3\u764c\u7ec6\u80de\u3002\u6b64\u5916\uff0cHT \u8fd8\u80fd\u4fc3\u8fdb\u7ec6\u80de\u7c98\u9644\u5206\u5b50 (CAM) \u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4fc3\u8fdb\u6dcb\u5df4\u7ec6\u80de\u5411\u80bf\u7624\u90e8\u4f4d\u8f6c\u79fb\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 1 \u603b\u7ed3\u4e86\u70ed\u7597\u4e0e\u6807\u51c6\u80bf\u7624\u6cbb\u7597\u7684\u673a\u5236\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 1\uff1a\u70ed\u7597\u4e0e\u6807\u51c6\u80bf\u7624\u7597\u6cd5\u76f8\u4e92\u4f5c\u7528\u7684\u673a\u5236<\/span><\/span><\/strong><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76ee\u6807\u673a\u5236<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u7269\u6548\u5e94\uff0839\u2103-45\u2103\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cbb\u7597\u534f\u540c\u4f5c\u7528<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u589e\u6548\u5242<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">DNA\u4fee\u590d\u6291\u5236<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6291\u5236 DNA \u4fee\u590d\u673a\u5236\uff1b<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f7f S \u671f\u7ec6\u80de\u654f\u611f<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f3a\u6548\u653e\u5c04\u589e\u654f\u5242\uff08\u8865\u4f53 RT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u6cbb\u7597\uff08RT\uff09<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80bf\u7624\u5fae\u73af\u5883<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u589e\u52a0\u8840\u6d41\u91cf\uff0c\u6539\u5584\u80bf\u7624\u6c27\u5408\uff0c\u589e\u52a0\u8840\u7ba1\u5316<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u589e\u5f3a RT \u529f\u6548\uff1b\u6539\u5584\u836f\u7269\u8d29\u8fd0\uff08\u5316\u5b66\u589e\u654f\u5242\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RT\u3001\u987a\u94c2\u3001\u4e1d\u88c2\u9709\u7d20C<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ec6\u80de\u819c\/\u7ed3\u6784<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ecb\u7535\u635f\u8017\u589e\u52a0\uff1b<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u63a5\u51cb\u4ea1\u4fe1\u53f7\u4f20\u5bfc<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584\u836f\u7269\u5438\u6536\uff1b<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u987a\u94c2\u3001\u5361\u94c2\u3001\u535a\u6765\u9709\u7d20<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u7cfb\u7edf<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HSP \u91ca\u653e\u3001DC \u6fc0\u6d3b\u3001T \u7ec6\u80de\u542f\u52a8\u3001NK\/CD8+ T \u7ec6\u80de\u88c2\u89e3\u4e0a\u8c03<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80bf\u7624\u514d\u75ab\u8c03\u8282\u5242\uff1b\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u514d\u75ab\u7597\u6cd5\u3001\u653e\u5c04\u6cbb\u7597\u3001\u6162\u6027\u809d\u75c5\u6cbb\u7597<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_11120\" aria-describedby=\"caption-attachment-11120\" style=\"width: 747px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-11120 size-full\" src=\"https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie.jpg\" alt=\"\u751f\u7269\u673a\u5236 \u9ad8\u70ed -\u70ed\u7597 \" width=\"747\" height=\"412\" title=\"\" srcset=\"https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie.jpg 747w, https:\/\/andromedichyperthermia.com\/wp-content\/uploads\/2025\/10\/mecanisme-biologice-hipertermie-300x165.jpg 300w\" sizes=\"auto, (max-width: 747px) 100vw, 747px\" \/><figcaption id=\"caption-attachment-11120\" class=\"wp-caption-text\">\u751f\u7269\u673a\u5236 \u9ad8\u70ed<\/figcaption><\/figure>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. 1A \u7ea7\u8bc1\u636e\u7684\u7efc\u5408\uff1a\u835f\u8403\u5206\u6790\u548c\u6c47\u603b\u6570\u636e\u7684\u7ed3\u679c<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bf9HT\u7684\u7a33\u5065\u8bc4\u4f30\u57fa\u4e8eIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7efc\u5408\u5206\u6790\u30021A<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ea7\u8bc1\u636e\u7684\u7efc\u5408\u8bc1\u5b9e\uff0cHT\u5728\u591a\u79cd\u80bf\u7624\u7c7b\u522b\u7684\u6807\u51c6\u6cbb\u7597\u57fa\u7840\u4e0a\u6dfb\u52a0\u5177\u6709\u666e\u904d\u7684\u4e34\u5e8a\u76ca\u5904\u3002<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3.1. \u5143\u5206\u6790\u7ed3\u8bba\u6982\u8ff0<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u8fd1\u4e00\u9879\u5305\u542b12\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684HT\u7597\u6548\u5206\u6790\uff0c\u786e\u5b9a\u4e866\u9879\u5c40\u90e8\u533a\u57dfHT\u7814\u7a76\u548c6\u9879\u5305\u542b\u8179\u8154\u70ed\u704c\u6ce8\u5316\u7597(HIPEC)\u7684\u7814\u7a76[2]\u3002\u5176\u4e2d\uff0c5\u9879\u5c40\u90e8\u533a\u57dfHT\u7814\u7a76\u8bc1\u5b9e\uff0c\u5728\u6807\u51c6\u5316\u7597\u548c\/\u6216\u653e\u7597\u57fa\u7840\u4e0a\u8054\u5408HT\u53ef\u5ef6\u957f\u603b\u751f\u5b58\u671f(OS)\u548c\/\u6216\u63d0\u9ad8\u5b8c\u5168\u7f13\u89e3\u7387(CR)\u3002[2]\u8fd9\u786e\u7acb\u4e86\u575a\u5b9e\u7684\u79d1\u5b66\u5171\u8bc6\uff0c\u652f\u6301\u5c06HT\u4f5c\u4e3a1A\u7ea7\u8f85\u52a9\u6cbb\u7597\uff0c\u7528\u4e8e\u5e7f\u6cdb\u7684\u5c40\u90e8\u533a\u57df\u80bf\u7624\u90e8\u4f4d\u3002<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3.2. \u53ef\u91cf\u5316\u7684\u6536\u76ca\uff1a\u603b\u751f\u5b58\u671f (OS)\u3001\u5b8c\u5168\u7f13\u89e3 (CR) \u548c\u5c40\u90e8\u63a7\u5236<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT \u7684\u4e34\u5e8a\u83b7\u76ca\u5728\u5173\u952e\u80bf\u7624\u5b66\u7ec8\u70b9\u4e0a\u662f\u53ef\u91cf\u5316\u7684\u3002*\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c (LACC)* \u7684\u6c47\u603b\u6570\u636e\u663e\u793a\uff1a<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u7f13\u89e3 (CR)\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6dfb\u52a0 HT \u540e CR \u7387\u663e\u8457\u589e\u52a0\uff08\u76f8\u5bf9\u98ce\u9669 &#8211; *RR \u4e3a 0.56\uff0c95% CI 0.39 \u81f3 0.79\uff1b**p &lt; 0.001*\uff09\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u90e8\u590d\u53d1\u63a7\u5236\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u663e\u8457\u964d\u4f4e\u5c40\u90e8\u590d\u53d1\u7387\uff08\u98ce\u9669\u6bd4 &#8211; *HR \u4e3a 0.48\uff0c95% CI 0.37 \u81f3 0.63\uff1b**p &lt; 0.001*\uff09\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u603b\u751f\u5b58\u671f (OS)\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> HT \u591a\u6a21\u5f0f\u6cbb\u7597\u53ef\u5e26\u6765\u66f4\u597d\u7684 OS\uff08HR \u4e3a *0.67\uff0c95% CI 0.45 \u81f3 0.99\uff1b**p = 0.05*\uff09\u3002<\/span><\/span><\/li>\n<\/ul>\n<h2><\/h2>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u6309\u764c\u75c7\u7c7b\u578b\u5206\u6790\u7279\u5b9a III \u671f\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u9879\u8be6\u7ec6\u5206\u6790\u68c0\u67e5\u4e86\u90a3\u4e9b*HT \u5f97\u5230\u6700\u9ad8\u6c34\u5e73\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u652f\u6301\u7684\u80bf\u7624\u90e8\u4f4d\uff0c\u91cd\u70b9\u5173\u6ce8\u4e3b\u8981\u751f\u5b58\u548c\u53cd\u5e94\u7ed3\u679c*\u3002<\/span><\/span><\/p>\n<h3><\/h3>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.1. \u8f6f\u7ec4\u7ec7\u8089\u7624\uff08STS\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8f6f\u7ec4\u7ec7\u8089\u7624\u662fHT\u6574\u5408\u6cbb\u7597\u7684\u57fa\u51c6\u9002\u5e94\u75c7\u4e4b\u4e00\uff0c\u5e76\u5f97\u5230\u4e86III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u652f\u6301\u3002\u6bd4\u8f83\u6807\u51c6\u65b0\u8f85\u52a9\u5316\u7597\u4e0e\u65b0\u8f85\u52a9\u5316\u7597\u8054\u5408\u5c40\u90e8\u70ed\u7597\uff08RHT\uff09\u7684\u8bd5\u9a8c\u8868\u660e\uff0c*\u8054\u5408HT\u53ef\u63d0\u9ad8\u751f\u5b58\u7387\u5e76\u6539\u5584\u5c40\u90e8\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08LPFS\uff09\u3002*<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bf9\u4e8e\u5c40\u90e8\u9ad8\u5371\u8089\u7624\uff0c\u5bf9\u4e8e\u7b26\u5408\u65b0\u8f85\u52a9\u6cbb\u7597\u6761\u4ef6\u7684\u60a3\u8005\uff0c\u57fa\u4e8e\u5176\u751f\u5b58\u7ed3\u679c\u7684\u6539\u5584\uff0c\u7eb3\u5165RHT\u662f\u5408\u7406\u7684\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u7814\u7a76\u7684\u8f6c\u5316\u5206\u6790\u63ed\u793a\u4e86\u4e00\u79cd\u91cd\u8981\u7684\u514d\u75ab\u673a\u5236\u3002\u7814\u7a76\u8868\u660e\uff0c\u672f\u524d\u8054\u5408RHT\u6cbb\u7597\u53ef\u5c06\u539f\u672c\u65e0\u708e\u75c7\u7684\u80bf\u7624\u8f6c\u5316\u4e3a\u708e\u75c7\u80bf\u7624\u3002\u8fd9\u79cd\u80bf\u7624\u5fae\u73af\u5883\u7684\u91cd\u7f16\u7a0b\u53ef\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\u3002\u8fd9\u4e00\u6548\u5e94\u8868\u660e\uff0c\u957f\u671f\u751f\u5b58\u83b7\u76ca\u4e0d\u4ec5\u6e90\u4e8e\u5316\u7597\u7684\u76f4\u63a5\u589e\u654f\uff0c\u8fd8\u6e90\u4e8e\u5f3a\u5927\u7684\u514d\u75ab\u542f\u52a8\uff0c\u8fd9\u4f7f\u5f97HT\u6210\u4e3a\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u5fae\u73af\u5883\u8c03\u8282\u5de5\u5177\u3002<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2. \u5987\u79d1\u764c\u75c7\uff1a\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c\uff08LACC\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728 LACC \u4e2d\uff0cHT \u4e0e\u540c\u6b65\u653e\u5316\u7597 (CCRT) \u76f8\u7ed3\u5408\u7684\u8bc1\u636e\u662f\u80bf\u7624\u5b66\u4e2d\u6700\u4ee4\u4eba\u4fe1\u670d\u7684\u8bc1\u636e\u4e4b\u4e00\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.1. \u8bd5\u9a8c\u5171\u8bc6\uff08CR \u548c\u5c40\u90e8\u590d\u53d1\uff09<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7cfb\u7edf\u5730\uff0c\u6765\u81ea\u968f\u673a\u8bd5\u9a8c\u7684\u835f\u8403\u5206\u6790\u548c\u6c47\u603b\u6570\u636e\u8bc1\u5b9e\u4e86\u4e09\u8054\u7597\u6cd5\uff08CCRT + HT\uff09\u7684\u4f18\u52bf\u3002<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6c47\u603b\u6570\u636e\u5206\u6790\u663e\u793a\uff0c\u8054\u5408\u6cbb\u7597\u663e\u8457\u63d0\u9ad8\u4e86\u5b8c\u5168\u7f13\u89e3\u7387 (CR)\uff08RR 0.56\uff1bp &lt; 0.001\uff09\uff0c\u5e76\u964d\u4f4e\u4e86\u5c40\u90e8\u590d\u53d1\u7387\uff08HR 0.48\uff1bp &lt; 0.001\uff09\u3002\u8fd9\u79cd\u4f18\u8d8a\u7684\u5c40\u90e8\u533a\u57df\u63a7\u5236\u7387\u4f7f\u4e09\u8054\u7597\u6cd5\u6210\u4e3a\u4e00\u79cd\u53ef\u884c\u4e14\u6709\u6548\u7684\u65b9\u6cd5\u3002<\/span><\/span><\/strong><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.2. \u603b\u751f\u5b58\u671f\uff08OS\uff09\u7684\u91cf\u5316<\/span><\/span><\/h4>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CCRT \u8054\u5408 HT \u6cbb\u7597\u663e\u8457\u6539\u5584\u4e86\u603b\u751f\u5b58\u671f (OS)\uff0c\u98ce\u9669\u6bd4 (HR) \u4e3a 0.67\uff0895% CI 0.45 \u81f3 0.99\uff1bp = 0.05\uff09\u3002<\/span><\/span><\/strong><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u867d\u7136\u5386\u53f2\u6570\u636e\u5fc5\u987b\u7ed3\u5408\u5f53\u524d\u6cbb\u7597\u6807\u51c6\u8fdb\u884c\u89e3\u8bfb\uff0c\u4f46\u610f\u5927\u5229\u4e00\u9879 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u5f53\u65f6 N3 \u9cde\u72b6\u9888\u90e8\u6dcb\u5df4\u7ed3\u7684\u653e\u7597 + HT \u6cbb\u7597\u6548\u679c\uff0c\u7ed3\u679c\u663e\u793a\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff1a*\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u5b8c\u5168\u7f13\u89e3 (CR) \u7387\u4e3a 82.3%\uff0c\u800c\u5355\u7eaf\u653e\u7597\u7ec4\u7684\u5b8c\u5168\u7f13\u89e3 (CR) \u7387\u4e3a 36.8%* [3,4]\u3002\u540c\u4e00\u9879\u7814\u7a76\u7684\u957f\u671f\u5206\u6790\u663e\u793a\uff0c*\u70ed\u7597\u7ec4\u7684 5 \u5e74\u603b\u751f\u5b58\u7387\u5206\u522b\u4e3a 55% \u548c 0%\uff0c\u800c\u5355\u7eaf\u653e\u7597\u7ec4\u4e3a 0%* [3,4]\u3002\u5c3d\u7ba1\u63a7\u5236\u65b9\u6848\uff08RT \u5355\u4e00\u7597\u6cd5\uff09\u6309\u7167\u73b0\u4ee3\u6807\u51c6\uff08\u4f7f\u7528 CCRT\uff09\u88ab\u8ba4\u4e3a\u8f83\u5dee\uff0c\u4f46\u8fd9\u4e9b\u5386\u53f2\u7ed3\u679c\u4ecd\u7136\u975e\u5e38\u6709\u4ef7\u503c\uff0c\u8bc1\u660e\u4e86 HT \u975e\u51e1\u7684\u653e\u5c04\u589e\u654f\u80fd\u529b\uff0c\u7279\u522b\u662f\u5728\u901a\u5e38\u9ad8\u5ea6\u7f3a\u6c27\u548c\u6cbb\u7597\u62b5\u6297\u7684\u5927\u5bb9\u91cf\u6dcb\u5df4\u7ed3\u75be\u75c5\u4e2d\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3. \u9644\u52a0\u8bc1\u636e\uff08OS\uff09<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u300a\u5bab\u9888\u764c\u300b\u63d0\u4f9b\u4e86\u6700\u6709\u529b\u7684\u989d\u5916\u8bc1\u636e\uff0c\u5176\u4e2d\u5c40\u90e8\u533a\u57df\u70ed\u7597\u4e0e\u653e\u5c04\u7597\u6cd5 (RT) \u6216\u5316\u5b66\u653e\u5c04\u7597\u6cd5 (CTRT) \u76f8\u7ed3\u5408\u5df2\u5728\u8bb8\u591a\u968f\u673a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u4e9b\u7ed3\u679c\uff08\u5bab\u9888\u764c\u7684\u9ad8\u7ea7\u522b\u8bc1\u636e\uff09\u662f\u4ece\u6bd4\u8f83\u6807\u51c6\u6cbb\u7597\uff08RT \u6216 CTRT\uff09\u4e0e\u8054\u5408\u6cbb\u7597\uff08RT\/CTRT + \u70ed\u7597\uff09\u7684\u835f\u8403\u5206\u6790\u4e2d\u63d0\u53d6\u7684\uff1a<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e34\u5e8a\u6307\u6807<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u6cbb\u7597 + \u70ed\u7597\u53d6\u5f97\u7684\u6210\u679c<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003\u6587\u732e\uff08\u5df2\u5ba1\u9605\u7684\u5f15\u6587\uff09<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u7f13\u89e3 (CR)<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR \u7387\u6301\u7eed\u6539\u5584\uff1a<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u5355\u7eaf RT \u76f8\u6bd4<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u589e\u52a0 22.1% \u3002<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u835f\u8403\u5206\u6790<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5730\u65b9\u533a\u57df\u7ba1\u5236\uff08LRC\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u663e\u8457\u6539\u5584\uff1a<\/span><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u7b80\u5355 RT \u76f8\u6bd4\u63d0\u9ad8\u4e86<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">+23.1% \u3002<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u835f\u8403\u5206\u6790<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u603b\u751f\u5b58\u671f\uff08OS\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6dfb\u52a0\u70ed\u7597\u540e\uff0c\u89c2\u5bdf\u5230\u957f\u671f OS \u6709\u6240\u6539\u5584\uff08HR 0.67\uff1bp = 0.03\uff09\u3002<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u66f4\u65b0\u7684\u835f\u8403\u5206\u6790<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e CTRT \u7ed3\u5408\u65f6\uff0c2 \u5e74\u548c 3 \u5e74 DFS \u663e\u8457\u6539\u5584\u3002<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III\u671f\u968f\u673a\u8bd5\u9a8c<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ee5\u4e0b\u662f\u63d0\u5230\u7684\u4e09\u9879\u835f\u8403\u5206\u6790\u548c III \u671f\u8bd5\u9a8c\uff0c\u4ee5\u53ca\u76f8\u5e94\u7684\u94fe\u63a5\uff1a<\/span><\/span><\/p>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.1. \u835f\u8403\u5206\u6790\uff1aCR\u3001\u5c40\u90e8\u533a\u57df\u63a7\u5236\uff08LRC\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff08Lutgens \u7b49\u4eba\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u88ab\u8ba4\u4e3a\u662f\u4e00\u9879\u57fa\u7840\u7814\u7a76\uff08Cochrane Review\uff09\uff0c\u5b83\u7efc\u5408\u4e86\u591a\u9879\u968f\u673a\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u8bc1\u5b9e\u4e86\u6dfb\u52a0\u70ed\u7597\u7684\u4e3b\u8981\u76ca\u5904\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5df2\u786e\u8ba4\u7684\u6307\u6807<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u8981\u6210\u679c<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5b8c\u5168\u7f13\u89e3 (CR)<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u663e\u8457\u6539\u5584\uff08RR 0.56\uff1bp &lt; 0.001\uff09<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5730\u65b9\u533a\u57df\u7ba1\u5236\uff08LRC\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u663e\u8457\u6539\u5584\uff08HR 0.48\uff1bp &lt; 0.001\uff09<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u603b\u751f\u5b58\u671f\uff08OS\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3 \u5e74\u540e\u663e\u8457\u6539\u5584\uff08HR 0.67\uff1bp = 0.05\uff09<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6807\u9898\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u70ed\u7597\u8054\u5408\u653e\u5c04\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5c\u8005\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Lutgens L\u3001van der Zee J\u3001Pijls-Johannesma M \u7b49\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">PubMed \u94fe\u63a5\uff082010 \u5e74\u66f4\u65b0\uff09\uff1a<\/span><\/span><\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20091593\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/20091593\/<\/span><\/span><\/a><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.2. \u7f51\u7edc\u5143\u5206\u6790\uff08NMA\uff09\uff1a\u6700\u4f73\u7b56\u7565\uff08Datta \u7b49\u4eba\uff0c2019\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672c\u7814\u7a76\u91c7\u7528\u5148\u8fdb\u7684\u65b9\u6cd5\uff08\u7f51\u7edc\u835f\u8403\u5206\u6790\uff09\u5c06\u70ed\u7597\u4e0e\u5176\u4ed6 13 \u79cd\u6cbb\u7597\u5e72\u9884\u63aa\u65bd\u8fdb\u884c\u6bd4\u8f83\uff0c\u5e76\u5c06\u5176\u5217\u4e3a\u6700\u4f73\u9009\u62e9\u4e4b\u4e00\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5df2\u786e\u8ba4\u7684\u6307\u6807<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u8981\u6210\u679c<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cbb\u7597\u6392\u540d<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RT+HT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u548c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CTRT+HT<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bf9 LRC\u3001OS \u548c\u6bd2\u6027\u7684\u7efc\u5408\u5f71\u54cd\u4f4d\u5217\u524d\u4e09\u540d\u3002<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6807\u9898\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c\u5404\u79cd\u6cbb\u7597\u65b9\u6848\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u8bc4\u4f30\uff1a\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7cfb\u7edf\u8bc4\u4ef7\u548c\u7f51\u7edc\u835f\u8403\u5206\u6790<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5c\u8005\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Datta NR\u3001Stutz E\u3001Gomez S\u3001Bodis S\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">PubMed\u94fe\u63a5\uff1a<\/span><\/span><\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30391522\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30391522\/<\/span><\/span><\/a><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.2.3.3. III\u671f\u8bd5\u9a8c\uff1amEHT\u7684\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u548c\u751f\u6d3b\u8d28\u91cf<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u662f\u6700\u8fd1\u7684 III \u671f\u8bd5\u9a8c\u4e4b\u4e00\uff0c\u8bc1\u5b9e\u4e86\u5728\u5316\u653e\u7597 (CTRT) \u4e2d\u6dfb\u52a0\u73b0\u4ee3\u70ed\u7597\u6280\u672f (mEHT) \u53ef\u5e26\u6765 DFS \u548c\u6539\u5584\u751f\u6d3b\u8d28\u91cf (QoL) \u7b49\u76ca\u5904\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5df2\u786e\u8ba4\u7684\u6307\u6807<\/span><\/span><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u8981\u6210\u679c<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728 CTRT \u4e2d\u6dfb\u52a0 mEHT \u540e\uff0c2 \u5e74\u548c 3 \u5e74 DFS \u663e\u8457\u6539\u5584\u3002<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u6d3b\u8d28\u91cf\uff08QoL\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"312\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u6d3b\u8d28\u91cf\u663e\u8457\u6539\u5584\uff0c\u4e14\u6bd2\u6027\u4e0d\u589e\u52a0\u3002<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6807\u9898\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8c03\u5236\u7535\u70ed\u7597\uff08mEHT\uff09\u5bf9\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c\u60a3\u8005\u4e24\u5e74\u548c\u4e09\u5e74\u751f\u5b58\u7387\u7684\u5f71\u54cd<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5c\u8005\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Minnaar CA\u3001Maposa I\u3001Kotzen JA \u7b49\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">MDPI \u94fe\u63a5\uff08\u5168\u6587\u53ef\u7528\uff09\uff1a<\/span><\/span><\/strong> <a href=\"https:\/\/www.mdpi.com\/2072-6694\/14\/3\/656\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.mdpi.com\/2072-6694\/14\/3\/656<\/span><\/span><\/a><\/li>\n<\/ul>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bf9\u4e8e\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c\uff0c\u52a0\u5165\u5c40\u90e8\u533a\u57df\u70ed\u7597\u4e0d\u4ec5\u53ef\u4ee5\u589e\u52a0\u5c40\u90e8\u80bf\u7624\u6839\u9664\uff08CR\uff09\u7684\u673a\u4f1a\uff0c\u800c\u4e14\u5bf9\u957f\u671f\u751f\u5b58\uff08OS\u548cDFS\uff09\u4e5f\u6709\u663e\u8457\u7684\u79ef\u6781\u5f71\u54cd\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.3. \u5934\u9888\u764c\uff08HNC\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u90e8\u533a\u57df\u70ed\u7597\u662f\u9488\u5bf9\u5404\u79cd\u5934\u9888\u90e8\u80bf\u7624\uff08\u5305\u62ec\u590d\u53d1\u548c\u665a\u671f\u75be\u75c5\uff09\u7684 1A \u7ea7\u6cbb\u7597\uff0c\u5c40\u90e8\u63a7\u5236\u5bf9\u751f\u6d3b\u8d28\u91cf\u548c\u751f\u5b58\u6709\u76f4\u63a5\u5f71\u54cd\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.3.1. III\u671f\u968f\u673a\u8bd5\u9a8c\u6570\u636e<\/span><\/span><\/h4>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u524d\u77bb\u6027\u968f\u673a III \u671f\u8bd5\u9a8c\u8bc1\u660e\uff0c\u5bf9\u4e8e\u9f3b\u54bd\u764c (NPC) \u60a3\u8005\uff0c\u653e\u5316\u7597 (CRT) \u8054\u5408 HT \u6bd4\u5355\u72ec\u4f7f\u7528 CRT \u5177\u6709\u660e\u663e\u76ca\u5904\u3002<\/span><\/span><\/strong><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u25cf <\/span><\/span><strong><a href=\"https:\/\/doi.org\/10.7314\/apjcp.2013.14.12.7395\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Kang 2013<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (NPC)\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u9879 III \u671f\u8bd5\u9a8c\u62a5\u544a\u4e86\u663e\u8457\u7684\u6539\u5584\u30025<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e74\u65e0\u75c5\u751f\u5b58\u7387 (DFS) \u4ece 25.5% \u589e\u52a0\u5230 51.3% (p &lt; 0.005)\uff0c5 \u5e74 OS \u4ece 50% \u589e\u52a0\u5230 68.4% (p &lt; 0.005)\u3002CR \u7387\u4e5f\u4ece 62.8% \u589e\u52a0\u5230 81.6%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf <\/span><\/span><strong><a href=\"https:\/\/journals.lww.com\/cancerjournal\/fulltext\/2010\/06040\/hyperthermia_with_radiation_in_the_treatment_of.16.aspx\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Huilgol 2010<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> (\u53e3\u8154\/\u53e3\u54bd\/\u4e0b\u54bd)\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4ec5\u653e\u7597\u7ec4\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">42.4%\uff0c\u800c HT \u6cbb\u7597\u7ec4\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a 78.6%<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49 (&lt; 0.05)\u3002 Kaplan-Meir\u751f\u5b58\u5206\u6790\u4e5f\u663e\u793a\u653e\u7597\u8054\u5408HT\u7ec4\u751f\u5b58\u7387\u663e\u8457\u6539\u5584\u3002\u672a\u8bb0\u5f55\u5230\u5242\u91cf\u9650\u5236\u6027\u70ed\u707c\u4f24\u6216\u8fc7\u5ea6\u7c98\u819c\u6216\u70ed\u6bd2\u6027\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728\u5c40\u90e8\u590d\u53d1\u7387\u901a\u5e38\u8f83\u9ad8\u7684 HNC \u4e2d\uff0cDFS \u548c OS \u7684\u6301\u7eed\u663e\u8457\u63d0\u9ad8\u5f3a\u8c03\u4e86 HT \u53ef\u6709\u6548\u514b\u670d\u5c40\u90e8\u653e\u5c04\u6297\u6027\uff0c\u4f7f\u5176\u6210\u4e3a\u6cbb\u6108\u6027\u6cbb\u7597\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206 [5]\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4. \u80c3\u80a0\u9053\u764c\u75c7\uff1a\u76f4\u80a0\u764c\u548c\u809b\u95e8\u764c<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT \u4e0e\u65b0\u8f85\u52a9\u653e\u5316\u7597 (CRT) \u76f8\u7ed3\u5408\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\u5df2\u8bc1\u660e\u5bf9\u5c40\u90e8\u533a\u57df\u63a7\u5236\u548c\u751f\u5b58\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4.1. \u76f4\u80a0\u764c III \u671f\u7ed3\u679c<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u524d\u77bb\u6027\u968f\u673a\u8bd5\u9a8c * <\/span><\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Ott 2019<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> * \u6bd4\u8f83\u4e86 CRT \u4e0e CRT + HT\uff0c\u5e76\u62a5\u544a HT \u7ec4\u7684 5 \u5e74\u751f\u5b58\u7387\u663e\u8457\u6539\u5584\uff1a<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u603b\u751f\u5b58\u7387 (OS)\uff1a95.8% vs. 74.5% (P = 0.045)\u3002<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u65e0\u75c5\u751f\u5b58\u7387 (DFS)\uff1a89.1% vs. 70.4% (P = 0.027)\u3002<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u5c40\u90e8\u65e0\u590d\u53d1\u751f\u5b58\u7387 (LRFS)\uff1a97.7% vs. 78.7% (P = 0.006)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.4.2. \u75c5\u7406\u53cd\u5e94\u548c\u4e34\u5e8a\u610f\u4e49<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u901a\u8fc7\u6dfb\u52a0 HT\uff0c\u75c5\u7406\u5b8c\u5168\u7f13\u89e3 (pCR) \u7387\u4e5f\u5f97\u5230\u4e86\u63d0\u9ad8\uff0c*\u835f\u8403\u5206\u6790\u663e\u793a\u4ece 16% (CRT) \u589e\u52a0\u5230 22.5% (CRT+HT\uff0cp = 0.043)\u3002*<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u91cd\u8981\u7684\u662f\uff0c\u66f4\u9ad8\u7684 LRFS \u7387 (97.7%) \u548c\u65e0\u7ed3\u80a0\u9020\u53e3\u751f\u5b58\u7387\u7684\u63d0\u9ad8 (87.7% vs. 69.0%\uff0cP = 0.016) \u7a81\u51fa\u4e86 HT \u4e0d\u4ec5\u5728\u5c40\u90e8\u80bf\u7624\u706d\u83cc\u4e2d\u7684\u4f5c\u7528\uff0c\u800c\u4e14\u5728\u62ec\u7ea6\u808c\u4fdd\u7559\u7b56\u7565\u4e2d\u7684\u4f5c\u7528\u3002<\/span><\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.5. \u6076\u6027\u9ed1\u8272\u7d20\u7624\uff08\u5c40\u90e8\u533a\u57df\u6027\u75be\u75c5\uff09<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u57fa\u7840 III \u671f\u7814\u7a76\uff08<\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">Overgaard \u7b49\u4eba\uff0c1995 \u5e74<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09\u8868\u660e\uff0c\u653e\u5c04\u7597\u6cd5\u4e0e HT \u76f8\u7ed3\u5408\u53ef\u63d0\u9ad8\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u5b8c\u5168\u7f13\u89e3\u7387\u548c OS\u3002<\/span><\/span><\/strong><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u8981\u7ed3\u679c\uff1a\u653e\u7597 + \u70ed\u7597 vs. \u653e\u5c04\u6cbb\u7597<\/span><\/span><\/strong><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u9879\u6b27\u6d32\u591a\u4e2d\u5fc3\u7814\u7a76\u5c06 70 \u540d\u60a3\u8005\u7684 134 \u4e2a\u8f6c\u79fb\u6027\u6216\u590d\u53d1\u6027\u9ed1\u8272\u7d20\u7624\u75c5\u53d8\u968f\u673a\u5206\u914d\u63a5\u53d7\u5355\u72ec\u653e\u5c04\u6cbb\u7597\u6216\u653e\u5c04\u6cbb\u7597\u540e\u8fdb\u884c\u70ed\u7597\uff0843\u00b0C\uff0c\u6301\u7eed 60 \u5206\u949f\uff09\u3002<\/span><\/span><\/p>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u5c40\u90e8\u80bf\u7624\u63a7\u5236\uff08\u4e3b\u8981\u7ec8\u70b9\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u91cd\u8981\u7684\u7ed3\u679c\u662f\u957f\u671f\u5c40\u90e8\u80bf\u7624\u63a7\u5236\u7684\u663e\u8457\u6539\u5584\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7aef\u70b9<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5355\u72ec\u653e\u5c04\u6cbb\u7597\uff08RT\uff09<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u653e\u5c04\u6cbb\u7597+\u70ed\u7597\uff08RT+HT\uff09<\/span><\/span><\/td>\n<td width=\"156\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u8981\u533a\u522b<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2 \u5e74\u7cbe\u7b97\u672c\u5730\u63a7\u5236<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28%<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46%<\/span><\/span><\/strong><\/td>\n<td width=\"156\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u663e\u8457\u6539\u5584\uff08p = 0.008\uff09<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed3\u8bba\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6dfb\u52a0 HT \u53ef\u5728 2 \u5e74\u5185\u4f7f\u5c40\u90e8\u80bf\u7624\u63a7\u5236\u7387\u63d0\u9ad8 *18 \u4e2a\u767e\u5206\u70b9*\u3002<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u591a\u53d8\u91cf\u5206\u6790\uff08\u9884\u540e\u56e0\u7d20\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u591a\u5143 Cox \u56de\u5f52\u5206\u6790\u8bc1\u5b9e\uff0c*\u9ad8\u70ed*\u662f 2 \u5e74\u5c40\u90e8\u63a7\u5236\u7684\u6700\u91cd\u8981\u9884\u540e\u56e0\u7d20\u3002<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9884\u540e\u53d8\u91cf<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u98ce\u9669\uff08\u6bd4\u503c\u6bd4\uff09<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P\u503c<\/span><\/span><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ad8\u6e29<\/span><\/span><\/strong><\/td>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.73<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08\u7528\u4e8e\u672c\u5730\u63a7\u5236\uff09<\/span><\/span><\/td>\n<td width=\"208\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0.023<\/span><\/span><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8f90\u5c04\u5242\u91cf<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1.17<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0.05<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80bf\u7624\u5927\u5c0f<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">0.91<\/span><\/span><\/td>\n<td width=\"208\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">p = 0.05<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed3\u8bba\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u8868\u660e HT \u63d0\u4f9b\u7684\u76ca\u5904\u662f\u72ec\u7acb\u7684\uff0c\u5e76\u4e14\u81f3\u5c11\u4e0e\u6240\u4f7f\u7528\u7684\u653e\u5c04\u5242\u91cf\u548c\u80bf\u7624\u5927\u5c0f\u4e00\u6837\u91cd\u8981\u3002<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u751f\u5b58\u671f\uff08\u5c40\u90e8\u63a7\u5236\u5373\u53ef\u6cbb\u6108\uff09<\/span><\/span><\/h5>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u53d1\u73b0\u6210\u529f\u7684\u5c40\u90e8\u63a7\u5236\u4e0e\u957f\u671f\u751f\u5b58\u4e4b\u95f4\u5b58\u5728\u5bc6\u5207\u7684\u8054\u7cfb\uff1a<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u603b\u751f\u5b58\u7387\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u603b\u4f53\u751f\u5b58\u7387\u4e3a19%\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u75c5\u60c5\u5b8c\u5168\u63a7\u5236\u7684\u60a3\u8005\u7684 5 \u5e74\u751f\u5b58\u7387\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u63d0\u9ad8\u81f3 *38%*\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed3\u8bba\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6210\u529f\u5c40\u90e8\u63a7\u5236\u5355\u4e2a\u6216\u5c11\u6570\u8f6c\u79fb\u6027\u75c5\u53d8\u5177\u6709*\u663e\u8457\u7684\u6cbb\u7597\u6f5c\u529b*\uff0c\u5f3a\u8c03\u4e86 HT \u63d0\u9ad8\u5c40\u90e8\u7597\u6548\u7684\u91cd\u8981\u6027\u3002<\/span><\/span><\/li>\n<\/ul>\n<h5><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u6bd2\u6027\u548c\u5b89\u5168\u6027<\/span><\/span><\/h5>\n<ul>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u589e\u52a0\u70ed\u91cf*\u4e0d\u4f1a\u663e\u8457\u589e\u52a0\u6025\u6027\u6216\u665a\u671f\u653e\u5c04\u53cd\u5e94*\u3002<\/span><\/span><\/li>\n<li><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u52a0\u70ed\u5904\u7406\u901a\u5e38*\u8010\u53d7\u200b\u200b\u6027\u826f\u597d*\u3002<\/span><\/span><\/li>\n<\/ul>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6ce8\u610f\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u63d0\u5230\u4e86\u5b9e\u73b0\u70ed\u534f\u8bae\u76ee\u6807\uff0843\u00b0C\uff09\u7684\u56f0\u96be\uff0c\u53ea\u6709 14% \u7684\u6cbb\u7597\u6210\u529f\uff0c\u8fd9\u8868\u660e\u4f18\u5316\u52a0\u70ed\u534f\u8bae\u7684\u5b9e\u9645\u76ca\u5904\u53ef\u80fd\u4f1a\u66f4\u5927\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9274\u4e8e\u9ed1\u8272\u7d20\u7624\u662f\u4e00\u79cd\u9ad8\u5ea6\u514d\u75ab\u539f\u6027\u75be\u75c5\uff0c\u5e76\u4e14\u662f\u514d\u75ab\u6cbb\u7597\u7684\u9996\u6279\u76ee\u6807\u4e4b\u4e00\uff0cHT \u5df2\u88ab\u8bc1\u660e\u80fd\u591f\u8bf1\u5bfc\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u5e76\u589e\u5f3a\u5c40\u90e8\u63a7\u5236\uff0c\u8fd9\u4e3a\u4e0e\u65b0\u7684\u514d\u75ab\u80bf\u7624\u836f\u7269\u7684\u6574\u5408\u5f00\u8f9f\u4e86\u91cd\u8981\u7684\u4e34\u5e8a\u673a\u4f1a\uff0c\u4ece\u800c\u589e\u5f3a\u4e86\u68c0\u67e5\u70b9\u963b\u6ede\u5242\u7684\u529f\u6548 [4]\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6 \u590d\u53d1\u6027\u4e73\u817a\u764c<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.1. Meta\u5206\u6790\u8bc1\u5b9e\u70ed\u653e\u5c04\u6cbb\u7597\u5bf9\u590d\u53d1\u6027\u4e73\u817a\u764c\u7684\u7597\u6548<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u835f\u8403\u5206\u6790\u6574\u5408\u4e86\u6765\u81ea III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u5c55\u793a\u4e86\u5c40\u90e8\u533a\u57df\u590d\u53d1\u6027\u4e73\u817a\u764c (LRBC) \u8054\u5408\u6cbb\u7597 (\u653e\u5c04\u6cbb\u7597 + \u70ed\u7597) \u7684\u5b8c\u5168\u7f13\u89e3\u7387 (CR)\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u662f\u652f\u6301 1A \u7ea7\u8bc1\u636e\u7ed3\u8bba\u7684\u7814\u7a76\uff0c\u5305\u62ec\u8054\u5408\u6cbb\u7597\u7684 *60-66% CR* \u7387\uff1a<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\uff1a<\/span><\/span><\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u90e8\u533a\u57df\u590d\u53d1\u6027\u4e73\u817a\u764c\u7684\u70ed\u7597\u548c\u653e\u5c04\u6cbb\u7597\uff1a\u7cfb\u7edf\u8bc4\u4ef7\u548c\u835f\u8403\u5206\u6790\u3002<\/span><\/span><\/strong><\/a><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5c\u8005\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> Datta NR\u3001Puric E\u3001Klingbiel D\u3001Gomez S\u3001Bodis S\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53d1\u8868\u4e8e\uff1a<\/span><\/span><\/strong> <em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56fd\u9645\u653e\u5c04\u80bf\u7624\u751f\u7269\u7269\u7406\u5b66\u6742\u5fd7<\/span><\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c2016 \u5e74\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7ed3\u8bba\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u5355\u72ec\u653e\u5c04\u6cbb\u7597\u76f8\u6bd4\uff0c\u70ed\u653e\u5c04\u6cbb\u7597\uff08RT + \u70ed\u7597\uff09\u53ef\u4f7f\u5b8c\u5168\u7f13\u89e3\u7387 (CR) \u63d0\u9ad8\u7ea6 *22%*\uff1b\u5728\u6bd4\u8f83\u4e24\u79cd\u6cbb\u7597\u65b9\u6848\u7684\u7814\u7a76\u4e2d\uff0cRT + \u70ed\u7597 (HT) \u7684\u5b8c\u5168\u7f13\u89e3\u7387 (CR) \u4e3a *60.2%*\uff0c\u800c\u5355\u72ec RT\uff08\u653e\u5c04\u6cbb\u7597\uff09\u7684\u5b8c\u5168\u7f13\u89e3\u7387 (CR) \u4e3a 38.1%\uff0c\u5728\u518d\u6b21\u8fdb\u884c\u70ed\u7597\u7684\u60c5\u51b5\u4e0b\uff0cCR \u7387\u8fbe\u5230 *66.6%*\u3002<\/span><\/span><\/li>\n<\/ul>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.2 \u4e73\u817a\u764c\u80f8\u90e8\u590d\u53d1<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u70ed\u7597\u901a\u5e38\u4e0e\u653e\u7597\u8054\u5408\u4f7f\u7528\uff0c\u5df2\u83b7\u5f971A\u7ea7\u8bc1\u636e\uff0c\u7528\u4e8e\u6cbb\u7597\u4e73\u817a\u764c\u80f8\u90e8\u590d\u53d1\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bf9\u4e8e\u80f8\u58c1\u590d\u53d1\uff0c\u7531\u4e8e\u6cbb\u7597\u65b9\u6848\u901a\u5e38\u6709\u9650\uff0c\u8fd9\u79cd\u8054\u5408\u7597\u6cd5\u5c24\u5176\u6709\u4ef7\u503c\u3002\u7814\u7a76\u8868\u660e\uff0c\u653e\u7597\u8054\u5408\u70ed\u7597\u53ef\u83b7\u5f97\u8f83\u9ad8\u7684\u5b8c\u5168\u7f13\u89e3\u7387 (CR)\uff0c\u8303\u56f4\u4e3a40%\u81f386%\uff0c\u5c40\u90e8\u63a7\u5236\u7387 (LC) \u4e3a70%\u81f376%\u3002\u6b64\u5916\uff0c\u5bf9\u4e8e\u8fd9\u79cd\u590d\u53d1\u6027\u75be\u75c5\uff0c5\u5e74\u603b\u751f\u5b58\u7387 (OS) \u53ef\u9ad8\u8fbe50%\u3002\u653e\u7597\u8054\u5408\u70ed\u7597<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u662f\u4e00\u79cd\u6709\u6548\u7684\u5c40\u90e8\u59d1\u606f\u6cbb\u7597\u548c\u957f\u671f\u63a7\u5236\u7b56\u7565\uff0c\u901a\u5e38\u53ef\u51cf\u5c11\u5bf9\u9ad8\u5242\u91cf\u633d\u6551\u6027\u6cbb\u7597\u6216\u6839\u6cbb\u6027\u624b\u672f\u7684\u9700\u6c42\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.6.3. \u5c40\u90e8\u533a\u57df\u6cbb\u7597\u7684\u603b\u4f53\u8d8b\u52bf\u2014\u2014\u5177\u6709 1 \u7ea7\u8bc1\u636e\u7684\u5176\u4ed6\u80bf\u7624\u9002\u5e94\u75c7<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c06\u7ed3\u8bba\u6269\u5c55\u5230\u5c40\u90e8\u533a\u57df\u6cbb\u7597\uff1a<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8bc1\u636e\u6574\u5408\uff1a<\/span><\/span><\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2c\u4e8c\u6b21\u7cfb\u7edf\u8bc4\u4ef7<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08<\/span><\/span><em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2c\u4e00\u6b21\u662f Hildenbrandt \u7b49\u4eba\u8fdb\u884c\u7684<\/span><\/span><\/em><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09\u8868\u660e\uff0c*6 \u9879 III \u671f\u8bd5\u9a8c\u4e2d\u6709 5 \u9879*\uff08\u9488\u5bf9\u6d45\u8868\u548c\u5c40\u90e8\u533a\u57df\u80bf\u7624 &#8211; \u5305\u62ec\u4e73\u817a\u764c\u3001\u5934\u9888\u90e8\u764c\u3001\u9ed1\u8272\u7d20\u7624\uff09\u8868\u660e\uff0c\u5f53\u5c06\u70ed\u7597\u6dfb\u52a0\u5230\u6807\u51c6\u6cbb\u7597\u4e2d\u65f6\uff0c*\u603b\u4f53\u751f\u5b58\u7387 (OS)* \u548c\/\u6216 *\u5b8c\u5168\u7f13\u89e3 (CR)* \u6709\u6240\u589e\u52a0\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u59d1\u606f\u6cbb\u7597\u5e94\u7528\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u8868\u660e\uff0c\u70ed\u7597\u4e0e\u653e\u5c04\u6cbb\u7597\u76f8\u7ed3\u5408\uff0c\u53ef\u663e\u8457\u63d0\u9ad8\u9aa8\u8f6c\u79fb\u75bc\u75db\u75c5\u4f8b\u7684*\u5b8c\u5168\u75bc\u75db\u53cd\u5e94*\uff0c\u4ece\u800c\u663e\u8457\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf (QoL)\u3002<\/span><\/span><\/li>\n<\/ul>\n<h3><\/h3>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7. \u8180\u80f1\u764c\uff1a\u8180\u80f1\u70ed\u704c\u6ce8\u5316\u7597\uff08HIVEC\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8180\u80f1\u70ed\u704c\u6ce8\u5316\u7597 (HIVEC) \u662f\u6307\u5728\u8180\u80f1\u704c\u6ce8\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u52a0\u70ed\uff08\u901a\u5e38\u81f3 43\u00b0C\uff09\u7684\u4e1d\u88c2\u9709\u7d20 C (MMC) \u6765\u6cbb\u7597\u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c (NMIBC) [6]\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7.1. HIVEC-1 III\u671f\u8bd5\u9a8c\u7ed3\u679c<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HIVEC-1 \u7814\u7a76\u662f\u4e00\u9879\u968f\u673a 3 \u671f\u8bd5\u9a8c\uff0c\u65e8\u5728\u6bd4\u8f83\u4e2d\u5371 NMIBC (IR-NMIBC) \u60a3\u8005\u4f7f\u7528\u5e38\u6e29 MMC \u4e0e\u9ad8\u6e29 MMC\uff0843\u00b0C\uff0c30 \u6216 60 \u5206\u949f\uff09\u7684\u65e0\u590d\u53d1\u751f\u5b58\u671f (RFS) [6]\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e3b\u8981\u7ec8\u70b9 (RFS)\uff1a\u610f\u5411\u6cbb\u7597 (ITT) \u4eba\u7fa4 24 \u4e2a\u6708\u65f6\u7684 RFS \u5728\u5bf9\u7167\u7ec4\uff08\u5e38\u6e29\uff09\u4e2d\u4e3a 77%\uff0c\u800c\u9ad8\u6e29 30 \u5206\u949f\u548c 60 \u5206\u949f\u5206\u522b\u4e3a 82% \u548c 80%\uff08\u9ad8\u6e29 60 \u5206\u949f\uff09\u3002\u7814\u7a76\u5f97\u51fa\u7ed3\u8bba\uff0c\u5728 24 \u4e2a\u6708\u65f6\u7684 RFS \u65b9\u9762\uff0c\u9ad8\u6e29\u6cbb\u7597\u5e76\u4e0d\u6bd4\u5e38\u6e29 MMC \u5177\u6709\u7edf\u8ba1\u5b66\u4f18\u52bf\uff0cp \u503c\u4e3a 0.6 [6]\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e34\u5e8a\u610f\u4e49\uff1a\u5728 IR-NMIBC \u4e2d\u7f3a\u4e4f\u4f18\u52bf\u8868\u660e\u4e2d\u5371\u4eba\u7fa4\u53ef\u80fd\u6ca1\u6709\u4ece\u70ed\/\u5316\u5b66\u534f\u540c\u4f5c\u7528\u4e2d\u5145\u5206\u83b7\u76ca\uff0c\u6216\u8005\u8bd5\u9a8c\u4e2d\u4f7f\u7528\u7684\u7279\u5b9a\u70ed\u7597\u65b9\u6848\uff08\u4f8b\u5982\u56fa\u5b9a\u6301\u7eed\u65f6\u95f4\uff09\u4e0d\u662f\u6700\u7406\u60f3\u7684\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4.7.2. \u7ec6\u5fae\u5dee\u522b\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e IR-NMIBC \u7684 RFS \u7ed3\u679c\u76f8\u6bd4\uff0c\u5176\u4ed6\u7814\u7a76\u6570\u636e\u5f3a\u8c03\u4e86\u9ad8\u5371\u60a3\u8005\uff0c\u5c24\u5176\u662f BCG \u6cbb\u7597\u5931\u8d25\u60a3\u8005\u7684\u83b7\u76ca\u3002\u4e00\u9879\u5206\u6790\u663e\u793a*\u5728 ITT \u5206\u6790\u4e2d\uff0cHIVEC \u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f (PFS) \u663e\u8457\u4f18\u4e8e BCG\uff0895.7% vs 71.8%\uff1bp = 0.043\uff09[7]*\u3002\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u867d\u7136 HIVEC \u8054\u5408\u5316\u7597\u70ed\u7597\u53ef\u5b9e\u73b0 1 \u5e74 RFS \u7387 60% \u548c\u8180\u80f1\u4fdd\u7559\u7387 92.4%\uff0c\u4f46\u5bf9\u4e8e BCG \u6cbb\u7597\u5931\u8d25\u7684\u6781\u9ad8\u5371\u60a3\u8005\uff0c\u8180\u80f1\u5207\u9664\u672f\u4ecd\u7136\u662f\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u5c3d\u7ba1\u5bf9\u4e8e\u4e0d\u9002\u5408\u624b\u672f\u7684\u60a3\u8005\uff0cHIVEC \u53ef\u80fd\u662f\u4e00\u79cd\u66ff\u4ee3\u65b9\u6848 [8]\u3002\u8fd9\u8bc1\u5b9e\u4e86 HT \u5bf9\u8180\u80f1\u764c\u7684\u7597\u6548\u4e3b\u8981\u53d6\u51b3\u4e8e\u60a3\u8005\u5206\u5c42\u3002<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 2 \u603b\u7ed3\u4e86\u70ed\u7597\u6574\u5408\u7684\u5173\u952e III \u671f\u4e34\u5e8a\u7ed3\u679c\u3002<\/span><\/span><\/strong><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 2\uff1a\u80bf\u7624\u70ed\u7597\u7684\u5173\u952e III \u671f\u4e34\u5e8a\u7ed3\u679c\uff08HT + \u6807\u51c6\u6cbb\u7597 vs. \u5355\u72ec\u6807\u51c6\u6cbb\u7597\uff09<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u764c\u75c7\u7c7b\u578b\uff08HT \u6cbb\u7597\u65b9\u5f0f\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u7c7b\u578b\/\u7ec8\u70b9<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT + \u6807\u51c6\u62a4\u7406<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6807\u51c6\u62a4\u7406\u5355\u4e00\u7597\u6cd5<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7edf\u8ba1\u663e\u8457\u6027\/\u7ec8\u70b9\u7ed3\u679c<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8f6f\u7ec4\u7ec7\u8089\u7624\uff08LR HT + CT\uff0911.3\u5e74<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III \u671f\u968f\u673a\uff08<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u603b\u751f\u5b58\u671f<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">10\u5e74OS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">62.7%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">52.6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">51.3%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">42.7%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u5355\u72ec\u7684\u65b0\u8f85\u52a9\u5316\u7597\u76f8\u6bd4\uff0c\u6dfb\u52a0\u533a\u57df\u70ed\u7597\u53ef\u5c40\u90e8\u6539\u5584*\u65e0\u75c5\u751f\u5b58\u671f DFS*\uff08\u98ce\u9669\u6bd4 [HR]\uff0c0.65\uff1b95% CI\uff0c0.49-0.86\uff1bP = 0.002\uff09\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u5355\u72ec\u63a5\u53d7\u65b0\u8f85\u52a9\u5316\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u968f\u673a\u63a5\u53d7\u5316\u7597\u52a0\u70ed\u7597\u6cbb\u7597\u7684\u60a3\u8005\u7684*\u603b\u4f53\u751f\u5b58\u7387 (OS) \u66f4\u957f\uff08HR\uff0c0.73\uff1b95% CI\uff0c0.54-0.98\uff1bP = 0.04\uff09\uff0c5 \u5e74\u751f\u5b58\u7387\u5206\u522b\u4e3a 62.7%\uff0895% CI\uff0c55.2%-70.1%\uff09\u548c 51.3%\uff0895% CI\uff0c43.7%-59.0%\uff09\uff0c10 \u5e74\u751f\u5b58\u7387\u5206\u522b\u4e3a 52.6%\uff0895% CI\uff0c44.7%-60.6%\uff09\u548c 42.7%\uff0895% CI\uff0c35.0%-50.4%\uff09\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bab\u9888\u764c (LACC) (LR HT + RT) 12 \u5e74<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III \u671f\u968f\u673a\u8bd5\u9a8c\uff08<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12 \u5e74\u603b\u751f\u5b58\u671f<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">20%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u663e\u8457\u6539\u5584 OS (P &lt; 0.05)<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17881144\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17881144\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u80a0\u764c\uff08CRT + HT\uff095\u5e74<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III\u671f\u968f\u673a<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5 \u5e74\u603b\u751f\u5b58\u671f<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff0c<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74DFS<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u5c40\u90e8\u65e0\u590d\u53d1LRF<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5 \u5e74\u65e0\u7ed3\u80a0\u9020\u53e3\u751f\u5b58\u7387 CFSR<\/span><\/span><\/p>\n<p>&nbsp;<\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">95.8%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">89.1<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">97.7<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">87.7<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">74.5%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">70.4%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">78.7%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69.0%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584 OS (P = 0.045)<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584 DFS\uff08<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.027\uff09\uff0c<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584 LRF\uff08<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.006\uff09\uff0c<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u8fdb\u7684 CFSR\uff08<\/span><\/span><i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">P<\/span><\/span><\/i><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> \u202f= 0.016\uff09<\/span><\/span><\/p>\n<p>&nbsp;<\/td>\n<td width=\"104\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5934\u9888\u764c\uff08NPC\uff09\uff08CRT + HT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III \u671f\u968f\u673a\u8bd5\u9a8c\uff085 \u5e74 DFS<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u548c<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5\u5e74\u603b\u751f\u5b58\u671f<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u548c<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR )<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">51.3%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">68.4%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">81.6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">25.5%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">50%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">62.8%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672c\u6b21 III \u671f\u8bd5\u9a8c\u62a5\u544a\u4e86\u663e\u8457\u7684\u6539\u5584\u3002<\/span><\/span><\/td>\n<td width=\"104\"><strong><a href=\"https:\/\/doi.org\/10.7314\/apjcp.2013.14.12.7395\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5eb7 2013<\/span><\/span><\/a><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5934\u9888\u764c<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53e3\u8154\/\u53e3\u54bd\/\u4e0b\u54bd<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08RT + HT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III\u671f\u968f\u673a\uff08CR\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">78.6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">42.4%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08&lt; 0.05\uff09\u3002Kaplan-Meir\u751f\u5b58\u5206\u6790\u4e5f\u663e\u793a\u653e\u7597\u8054\u5408HT\u7ec4\u751f\u5b58\u7387\u663e\u8457\u6539\u5584\u3002\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u70ed\u707c\u4f24\u6216\u8fc7\u5ea6\u7c98\u819c\u6216\u70ed\u6bd2\u6027\u53cd\u5e94\u3002<\/span><\/span><\/td>\n<td width=\"104\"><strong><a href=\"https:\/\/journals.lww.com\/cancerjournal\/fulltext\/2010\/06040\/hyperthermia_with_radiation_in_the_treatment_of.16.aspx\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u60e0\u5c14\u6208\u5c14 2010<\/span><\/span><\/a><\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6076\u6027\u9ed1\u8272\u7d20\u7624\uff08RT + HT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III\u671f\u968f\u673a\uff08CR\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">46%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">28%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2 \u5e74\u7cbe\u7b97\u5c40\u90e8\u63a7\u5236\u663e\u8457\u6539\u5584 (p = 0.008)<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/7776772\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u590d\u53d1\u6027\u4e73\u817a\u764c\uff08RT + HT\uff09- HT \u5df2\u7eb3\u5165 NCCN \u6307\u5357<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III\u671f\u968f\u673a\uff08CR\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">60.2%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">38.1%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR \u7387\u76f8\u5bf9\u63d0\u9ad8\u4e86 57%<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0360301615271994<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8180\u80f1\u764c IR NMI (HIVEC-1)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III \u671f\u968f\u673a\u8bd5\u9a8c\uff0824 \u4e2a\u6708 RFS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">80%-82%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">77%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65e0\u663e\u8457\u5dee\u5f02\uff08p = 0.6\uff09<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9aa8\u8f6c\u79fb\uff08WBH + RT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III \u671f\u968f\u673a\u8bd5\u9a8c\uff08\u75bc\u75db\u5b8c\u5168\u7f13\u89e3\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">47.4%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.3%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CR \u6539\u5584\uff08P &lt; 0.05\uff09\uff1b\u7f13\u89e3\u65f6\u95f4\u7f29\u77ed\u81f3 10 \u5929<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38460451\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38460451\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9aa8\u8f6c\u79fb\uff08RF HT + RT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">III \u671f\u968f\u673a\u8bd5\u9a8c\uff08\u75bc\u75db\u5b8c\u5168\u7f13\u89e3\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37.9%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">58.6%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.1%<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">32.1%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3 \u4e2a\u6708\u65f6 CR \u6539\u5584\uff08P = 0.006\uff09\uff1b<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cbb\u7597\u540e3\u4e2a\u6708\u5185\u7d2f\u79efCR P=0.045);<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29066122\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nihs.gov\/29066122\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div id=\"IDtable-wrap-foot\" class=\"NLM_table-wrap-foot\">\n<div id=\"TF4\">\n<p class=\"first last\"><span dir=\"auto\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">mEHT\uff1a\u8c03\u5236\u7535\u70ed\u7597\uff1bCT\uff1a\u5316\u7597\uff1bRT\uff1a\u653e\u7597\uff1bHT\uff1a\u70ed\u7597\uff1bRITE\uff1a\u5c04\u9891\u8bf1\u5bfc\u70ed\u5316\u7597\uff1bHIPEC\uff1a\u8179\u8154\u70ed\u704c\u6ce8\u5316\u7597\uff1bOS\uff1a\u603b\u751f\u5b58\u671f\uff1bDFS\uff1a\u65e0\u75c5\u751f\u5b58\u671f\uff1bCR\uff1a\u5b8c\u5168\u7f13\u89e3\uff1bLC\uff1a\u5c40\u90e8\u63a7\u5236\uff1bPFS\uff1a\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff1bST\uff1a\u751f\u5b58\u65f6\u95f4<\/span><\/span><\/span><\/p>\n<\/div>\n<\/div>\n<h2><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5. \u4fb5\u88ad\u6027\u548c\u590d\u53d1\u6027\u75be\u75c5\u7684\u8bc1\u636e\uff08\u65b0\u5174\u9002\u5e94\u75c7\uff09<\/span><\/span><\/strong><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u672c\u8282\u5206\u6790\u5177\u6709\u6311\u6218\u6027\u7684\u80bf\u7624\u90e8\u4f4d\uff0c\u5176\u4e2d 1A \u7ea7\u8bc1\u636e\u6709\u9650\u6216\u6b63\u5728\u5f00\u53d1\u4e2d\uff0c\u4f46\u9ad8\u8d28\u91cf\u7684\u6bd4\u8f83\u7814\u7a76\u8868\u660e HT \u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5c24\u5176\u662f\u901a\u8fc7 mHT\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.1. \u80f6\u8d28\u7624\uff08\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624 &#8211; GBM \u548c\u661f\u5f62\u7ec6\u80de\u7624 &#8211; AST\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80f6\u8d28\u7624\uff0c\u5c24\u5176\u662f\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624 (GBM)\uff0c\u4ee5\u5176\u6781\u5f3a\u7684\u6cbb\u7597\u8010\u836f\u6027\u800c\u95fb\u540d\u30021998 \u5e74\u7684\u4e00\u9879\u5386\u53f2\u6027\u968f\u673a\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u8fd1\u8ddd\u79bb\u653e\u5c04\u6cbb\u7597\u52a0\u91cf\u52a0\u6e29\u7597\u6cd5\u6cbb\u7597 GBM \u7684\u6548\u679c\uff0c\u7ed3\u679c\u663e\u793a\u8054\u5408\u7597\u6cd5\u7684\u751f\u5b58\u83b7\u76ca\u66f4\u9ad8 [9]\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.1.1. \u5c04\u9891\u70ed\u7597\uff08mHT\uff09\u6570\u636e<\/span><\/span><\/h4>\n<p><a href=\"https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u8fd1\u7684\u835f\u8403\u5206\u6790<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868\u660e\uff0cmEHT \u548c\u80bf\u7624\u7535\u573a\u6cbb\u7597 (TTF) \u5747\u53ef\u6539\u5584\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u7684\u751f\u5b58\u671f [10]\u3002\u8fd9\u79cd\u76ca\u5904\u4f3c\u4e4e\u5728\u65b0\u8bca\u65ad\u60a3\u8005\u4e2d\u6700\u4e3a\u663e\u8457\u3002\u4f8b\u5982\uff0c*mHT \u7814\u7a76\u4e2d\uff0c\u65b0\u8bca\u65ad\u60a3\u8005\u7684 1 \u5e74\u751f\u5b58\u7387\u4e3a 73%\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a 37%* (p = 0.0021) [10]\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bf9\u4e8e\u590d\u53d1\u6027\u75be\u75c5\uff0c*\u4e00\u9879\u89c2\u5bdf\u6027\u6bd4\u8f83\u5206\u6790\u62a5\u544a\u79f0\uff0cmHT \u53ef\u5ef6\u957f\u603b\u751f\u5b58\u671f (GBM \u4e2d\u4f4d\u751f\u5b58\u671f 14 \u4e2a\u6708 vs. 12 \u4e2a\u6708\uff0cp=0.026)\u3002\u5bf9\u4e8e\u661f\u5f62\u7ec6\u80de\u7624 (AST)\uff0cmHT \u663e\u793a\u51fa\u663e\u8457\u76ca\u5904\uff0c\u5e73\u5747\/\u4e2d\u4f4d\u751f\u5b58\u671f\u5206\u522b\u4e3a 72\/91.6 \u4e2a\u6708\uff0c\u800c\u6700\u4f73\u59d1\u606f\u652f\u6301\u7ec4\u4e3a 17\/34 \u4e2a\u6708 (p=0.0006)\u3002\u5373\u4f7f\u5728\u590d\u53d1\u6027 GBM \u4e2d\uff0c\u63a5\u53d7 mHT \u6cbb\u7597\u7684\u60a3\u8005\u7684 5 \u5e74\u751f\u5b58\u7387\u4e5f\u4e3a 3.5%\uff0c\u800c\u6700\u4f73\u652f\u6301\u7ec4\u4e3a 1.2% [*11]\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5373\u4f7f\u5728\u80f6\u8d28\u7624\u8fd9\u79cd\u56f0\u96be\u7684\u4e34\u5e8a\u73af\u5883\u4e0b\uff0c\u5bf9\u6bd4\u7814\u7a76\u4e5f\u663e\u793a\u51fa\u4e86\u5f3a\u70c8\u7684\u751f\u5b58\u4fe1\u53f7\uff0c\u8fd9\u8bc1\u660e\u5c06 HT \u7eb3\u5165\u4e34\u5e8a\u6307\u5357\u4e2d\u7684 1A \u7ea7\u9002\u5e94\u75c7\u662f\u5408\u7406\u7684\u3002<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2. \u80f0\u817a\u764c\uff08PC\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80f0\u817a\u764c\u662f\u4e00\u79cd\u6781\u5176\u81f4\u547d\u7684\u5168\u8eab\u6027\u75be\u75c5\uff0cHT\u76ee\u524d\u88ab\u5f52\u7c7b\u4e3a\u201c\u5e38\u89c1\u7684\u59d1\u606f\u4e34\u5e8a\u8bc1\u636e\uff08\u6765\u81eaII\u671f\u7814\u7a76\uff09\u201d\u3002\u7136\u800c\uff0c\u8fd1\u5e74\u6765\u7684\u5927\u578b\u5bf9\u7167\u7814\u7a76\u5df2\u4ea7\u751f\u5f3a\u70c8\u7684\u4e34\u5e8a\u4fe1\u53f7\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2.1. \u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u4e2dmEHT\u7684\u6bd4\u8f83\u5206\u6790<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e00\u9879<\/span><\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37398545\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5927\u578b\u56de\u987e\u6027\u89c2\u5bdf\u6027\u591a\u4e2d\u5fc3\u7814\u7a76<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08N=217 \u540d III-IV \u671f PC \u60a3\u8005\uff09\u6bd4\u8f83\u4e86 mEHT + CHT\uff08\u4e3b\u8981\u4ee5\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\uff09\u4e0e\u5355\u72ec CHT\u3002<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u603b\u751f\u5b58\u671f (OS)\uff1amEHT \u7ec4\u7684 OS \u663e\u8457\u6539\u5584\uff0820 \u4e2a\u6708\uff0cvs. CHT \u7ec4 9 \u4e2a\u6708\uff0cP &lt; 0.001\uff09\u3002<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u65e0\u8fdb\u5c55\u751f\u5b58\u671f (PFS)\uff1aPFS \u4e5f\u663e\u8457\u6539\u5584\uff087 \u4e2a\u6708\uff0cvs. 5 \u4e2a\u6708\uff0cP &lt; 0.05\uff09\u3002<\/span><\/span><\/strong><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u80bf\u7624\u53cd\u5e94\uff1a\u63a5\u53d7 mEHT \u6cbb\u7597\u7684\u60a3\u8005\u8bb0\u5f55\u4e86\u66f4\u9ad8\u7684\u90e8\u5206\u7f13\u89e3\u7387 (PR)\uff0845% vs. 24%\uff0cP = 0.0018\uff09\u548c\u66f4\u4f4e\u7684\u75be\u75c5\u8fdb\u5c55 (PD) \u7387\uff084% vs. 31%\uff0cP &lt; 0.01\uff09\u3002<\/span><\/span><\/strong><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5.2.2. HT\u5bf9\u5e74\u9f84\u7684\u5f71\u54cd<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6309\u5e74\u9f84\u8fdb\u884c\u7684\u751f\u5b58\u5206\u6790\u63ed\u793a\u4e86\u4e00\u4e2a\u72ec\u7279\u7684\u4e34\u5e8a\u65b9\u9762\uff1a\u65e0\u8bba\u60a3\u8005\u5e74\u9f84\u662f &lt;= 70 \u5c81\u8fd8\u662f &gt; 70 \u5c81\uff0c\u8c03\u5236\u5c04\u9891\u70ed\u7597 (mHT) \u5e26\u6765\u7684 OS \u76ca\u5904\u5747\u5f97\u4ee5\u7ef4\u6301\uff08\u4e24\u7ec4\u7684\u4e2d\u4f4d OS \u5747\u4e3a 20 \u4e2a\u6708\uff09\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4ec5\u63a5\u53d7 CHT \u7684\u8001\u5e74\u60a3\u8005\u7684 OS\uff088 \u4e2a\u6708\uff09\u660e\u663e\u4f4e\u4e8e\u5e74\u8f7b\u60a3\u8005\uff0812 \u4e2a\u6708\uff09\uff0c\u8868\u660e CHT \u7597\u6548\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u4e0b\u964d\u3002*\u8fd9\u8868\u660e mHT \u5177\u6709\u5f3a\u5927\u7684\u7597\u6548\uff0c\u4e14\u6ca1\u6709\u6807\u51c6 CHT \u6240\u89c2\u5bdf\u5230\u7684\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u4e0b\u964d\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u5176\u826f\u597d\u7684\u6bd2\u6027\u7279\u5f81\u3002*<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u91cd\u5927\u7684\u4e34\u5e8a\u6539\u8fdb\uff08\u4e2d\u4f4d OS \u7ffb\u500d\uff0c\u4ece 9 \u4e2a\u6708\u589e\u52a0\u5230 20 \u4e2a\u6708\uff09\u5f3a\u70c8\u8981\u6c42\u7ec4\u7ec7\u56fd\u9645\u968f\u673a III \u671f\u8bd5\u9a8c\uff0c\u5176\u4e2d\u4e00\u4e9b\u8bd5\u9a8c\u5df2\u7ecf\u5728\u8fdb\u884c\u4e2d\uff08\u4f8b\u5982 NCT02862015\uff0c\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u80bf\u7624\u70ed\u7597\u591a\u4e2d\u5fc3 RCT\uff09\u3002<\/span><\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6. \u5b89\u5168\u6027\u548c\u751f\u6d3b\u8d28\u91cf\uff08QALY\uff09\uff1aHT\u7684\u9ad8\u6cbb\u7597\u6307\u6570<\/span><\/span><\/h2>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT\u7684\u9ad8\u6cbb\u7597\u6307\u6570<\/span><\/span><\/h2>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5e94\u7528\u53d6\u51b3\u4e8e\u7ef4\u6301\u826f\u597d\u7684\u6cbb\u7597\u6307\u6570\u3002*III\u671f\u8bc1\u636e\u538b\u5012\u6027\u5730\u652f\u6301HT\u6ee1\u8db3\u8fd9\u4e00\u8981\u6c42\uff0c\u4e14\u4e0d\u4f1a\u663e\u8457\u589e\u52a0\u4e25\u91cd\u6bd2\u6027\u3002*<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.1. \u5168\u8eab\u6bd2\u6027\u5206\u6790\uff083-4\u7ea7\uff09<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u968f\u673a\u8bd5\u9a8c\u7684\u7cfb\u7edf\u5206\u6790\u8bc1\u5b9e\uff0cHT*\u4e0d\u4f1a\u52a0\u5267RT\u6216CHT\u5f15\u8d77\u7684\u5168\u8eab\u6bd2\u6027*\uff1a<\/span><\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bab\u9888\u764c (LACC)\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6025\u6027\u6216\u665a\u671f 3-4 \u7ea7\u6bd2\u6027\u672a\u89c2\u5bdf\u5230\u663e\u8457\u5dee\u5f02 (RR \u2248 1.0)\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u80a0\u764c\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6bd2\u6027\u7279\u5f81\u76f8\u4f3c\u3002\u672a\u53d1\u73b03-4\u7ea7\u4e25\u91cd\u76ae\u80a4\u6216\u80c3\u80a0\u9053\u53cd\u5e94\u589e\u52a0\u3002<\/span><\/span><\/li>\n<li><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80f0\u817a\u764c (mHT)\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0d\u4f1a\u589e\u52a0\u5316\u7597\u5f15\u8d77\u7684\u8840\u6db2\u3001\u809d\u810f\u3001\u80ba\u6216\u4ee3\u8c22\u6bd2\u6027\u3002<\/span><\/span><\/li>\n<\/ul>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.2. \u70ed\u7597\u65b9\u5f0f\u7279\u6709\u7684\u4e0d\u826f\u4e8b\u4ef6<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0e\u70ed\u7597\u76f4\u63a5\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3b\u8981\u96c6\u4e2d\u5728\u5c40\u90e8\uff0c\u901a\u5e38\u53ef\u63a7\uff1a<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf \u5c40\u90e8\u533a\u57df\u70ed\u7597 (LR HT)\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> 10% \u81f3 32% \u7684\u590d\u53d1\u6027\u4e73\u817a\u764c\u75c5\u4f8b\u62a5\u544a\u4e86 3-4 \u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e3b\u8981\u4e0e\u5c40\u90e8\u76ae\u80a4\u53cd\u5e94\uff08\u8f7b\u5ea6\u70e7\u4f24\u6216\u4e0d\u9002\uff09\u6709\u5173\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf<\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c04\u9891\u70ed\u7597 (mHT)<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff1amHT \u7684\u5b89\u5168\u6027\u5c24\u5176\u51fa\u8272\u3002\u5728\u80f0\u817a\u764c\u7814\u7a76\u4e2d\uff0c\u4ec5 2.6% \u7684 mHT \u7597\u7a0b\u62a5\u544a\u4e86\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5305\u62ec 1 \u7ea7\u76ae\u80a4\u75bc\u75db\u6216 1-2 \u7ea7\u70e7\u4f24\uff08\u5360 1.1%\uff09\uff0c\u8fd9\u4e9b\u4e0d\u826f\u4e8b\u4ef6\u5f88\u5feb\u5f97\u5230\u7f13\u89e3\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u25cf <\/span><\/span><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HIVEC-1 \u8bd5\u9a8c\uff08\u8180\u80f1\u764c\uff09\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c3d\u7ba1\u4e24\u7ec4\u4e4b\u95f4\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u76f8\u4f3c\uff08p = 0.5\uff09\uff0c\u4f46 HT \u7ec4\u7684\u603b\u4e0d\u826f\u4e8b\u4ef6\uff08\u4e3b\u8981\u662f\u5c40\u90e8\u4e0d\u9002\u548c\u75c9\u631b\uff09\u7565\u9ad8\uff0835%-48% \u5bf9\u6bd4\u5bf9\u7167\u7ec4\u7684 33%\uff0cp = 0.05\uff09\uff0c\u8bc1\u5b9e\u4e86\u5bf9\u4e25\u91cd\u53d1\u75c5\u7387\u7684\u5c40\u90e8\u4f46\u4e0d\u663e\u8457\u7684\u5f71\u54cd\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6.3. \u5bf9\u8d28\u91cf\u8c03\u6574\u751f\u547d\u5e74\uff08QALY\uff09\u7684\u5f71\u54cd<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u901a\u8fc7\u5c06\u5bff\u547d\u5ef6\u957f\u4e0e\u751f\u6d3b\u8d28\u91cf\u63d0\u5347\u76f8\u7ed3\u5408\uff0cQALY\uff08\u8d28\u91cf\u8c03\u6574\u751f\u547d\u5e74\uff09\u6982\u5ff5\u4ece\u7ecf\u6d4e\u548c\u4eba\u6587\u89d2\u5ea6\u5c55\u73b0\u4e86\u6cbb\u7597\u6548\u76ca\u3002HT \u5df2\u8bc1\u5b9e\u7684\u4e34\u5e8a\u76ca\u5904\u2014\u2014\u6539\u5584\u751f\u5b58\u7387\u3001\u66f4\u9ad8\u7684\u5b8c\u5168\u7f13\u89e3\u7387\u548c\u66f4\u4f73\u7684\u5c40\u90e8\u63a7\u5236\u7387\u2014\u2014\u8868\u660e\u5176\u5f88\u53ef\u80fd\u957f\u671f\u8282\u7701\u6210\u672c\u5e76\u6539\u5584\u60a3\u8005\u7684 QALY\uff0c\u4ece\u800c\u589e\u5f3a\u4e86\u4e34\u5e8a\u5e94\u7528\u7684\u53ef\u884c\u6027\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 3 \u6bd4\u8f83\u4e86 HT \u4e0e\u6807\u51c6\u6cbb\u7597\u6574\u5408\u7684\u5b89\u5168\u6027\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 3\uff1a\u5b89\u5168\u6027\u548c\u6bd2\u6027\u6bd4\u8f83\uff08HT \u6574\u5408\u4e0e\u6807\u51c6\u62a4\u7406\uff09<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u764c\u75c7\u7c7b\u578b<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6807\u51c6\u6cbb\u7597\uff08\u5bf9\u7167\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e72\u9884\uff08HT + \u6807\u51c6\u6cbb\u7597\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3-4\u7ea7\u6bd2\u6027\u7ed3\u679c<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e34\u5e8a\u7ed3\u8bba<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5355\u72ecCCRT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8054\u5408\u653e\u7597 + \u5de6\u5fc3\u623f<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6025\u6027\u6216\u665a\u671f\u6bd2\u6027\u65e0\u663e\u8457\u5dee\u5f02\uff08RR \\sim 1.0\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6cbb\u7597\u6307\u6570\u826f\u597d\uff1b\u4e0d\u52a0\u91cd\u5168\u8eab\u526f\u4f5c\u7528\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u80a0\/\u809b\u95e8\u764c<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9634\u6781\u5c04\u7ebf\u7ba1<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">CRT + LR HT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6bd2\u6027\u7279\u5f81\u76f8\u5f53\uff1b\u4e25\u91cd\u80c3\u80a0\u9053\u6216\u76ae\u80a4\u53cd\u5e94\u6ca1\u6709\u589e\u52a0<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT \u4e0e\u76c6\u8154 CRT \u65b9\u6848\u7ed3\u5408\u4f7f\u7528\u662f\u5b89\u5168\u7684\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/link.springer.com\/article\/10.1007\/s00066-018-1396-x<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8089\u7624\uff08EORTC\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2d\u534e\u6c11\u56fd<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RHT + CHT<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e25\u91cd\u6bd2\u6027\u7387\u5e76\u672a\u59a8\u788d\u7814\u7a76\u5b8c\u6210<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8010\u53d7\u6027\u9ad8\uff1b\u957f\u671f\u5b89\u5168\u6027\u5f97\u5230\u786e\u8ba4\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29450452\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8180\u80f1\u764c IR NMI (HIVEC-1)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5e38\u6e29MMC<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ad8\u6e29MMC<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u65e0\u5dee\u5f02\uff08p = 0.5\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e25\u91cd\u53d1\u75c5\u7387\u4fdd\u6301\u4e0d\u53d8\u3002<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7. \u7ed3\u8bba\u3001\u4e34\u5e8a\u6574\u5408\u548c\u672a\u6765\u65b9\u5411<\/span><\/span><\/h2>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.1. \u786e\u5b9a\u60271A\u7ea7\u9002\u5e94\u75c7\u6458\u8981<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u57fa\u4e8eIII\u671f\u968f\u673a\u8bd5\u9a8c\u548c\u835f\u8403\u5206\u6790\u7684\u6587\u732e\u5206\u6790\u8bc1\u5b9e\uff0c\u70ed\u7597\u5e76\u975e\u4e00\u79cd\u5b9e\u9a8c\u6027\u7597\u6cd5\uff0c\u800c\u662f\u9488\u5bf9\u7279\u5b9a\u80bf\u7624\u90e8\u4f4d\u7684\u591a\u6a21\u5f0f\u80bf\u7624\u6cbb\u7597\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002HT<\/span><\/span><br \/>\n<strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u5c40\u90e8\u665a\u671f\u5bab\u9888\u764c\u3001\u5934\u9888\u764c\u3001\u76f4\u80a0\/\u809b\u95e8\u764c\u3001\u9ed1\u8272\u7d20\u7624\uff08\u5c40\u90e8\u533a\u57df\u6027\u75be\u75c5\uff09\u4ee5\u53ca\u4e73\u817a\u764c\u80f8\u90e8\u590d\u53d1\u7684\u6cbb\u7597\u4e2d\uff0c\u62e5\u67091A\u7ea7\u8bc1\u636e\u8868\u660e\u5176\u5177\u6709\u786e\u5b9a\u6027\u751f\u5b58\u7387\u3001\u65e0\u75c5\u751f\u5b58\u7387\u548c\u5b8c\u5168\u7f13\u89e3\u7387[2]\u3002<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bf9\u4e8e\u8fd9\u4e9b\u9002\u5e94\u75c7\uff0cHT\u5fc5\u987b\u88ab\u89c6\u4e3a\u6807\u51c6\u591a\u6a21\u5f0f\u6cbb\u7597\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u7ec4\u6210\u90e8\u5206\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.2. \u529f\u6548\u548c\u6280\u672f\u91cd\u8981\u6027\u7684\u7ec6\u5fae\u5dee\u522b<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT \u6cbb\u7597\u7684\u7597\u6548\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u6280\u672f\u7cbe\u5ea6\u548c\u52a0\u70ed\u65b9\u5f0f\u3002\u5c40\u90e8\u533a\u57df HT \u5728\u6df1\u90e8\u5b9e\u4f53\u7624\uff08\u4f8b\u5982 LACC\u3001HNC\uff09\u4e2d\u53d6\u5f97\u7684\u663e\u8457\u4e14\u6301\u7eed\u7684\u6210\u529f\uff0c\u4e0e HIVEC \u5728\u4e2d\u5371 NMIBC \u4e2d\u53d6\u5f97\u7684\u6df7\u5408\u7ed3\u679c\u5f62\u6210\u9c9c\u660e\u5bf9\u6bd4\u3002<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8fd9\u79cd\u5bf9\u6bd4\u5f3a\u8c03\uff0c\u6700\u4f73\u4e34\u5e8a\u83b7\u76ca\u5e76\u975e\u4ec5\u4ec5\u901a\u8fc7\u52a0\u70ed\u5c31\u80fd\u5b9e\u73b0\uff0c\u8fd8\u9700\u8981\u4e25\u683c\u7684\u8d28\u91cf\u4fdd\u8bc1 (QA) \u548c\u6280\u672f\u4f18\u5316\uff0c\u4ee5\u786e\u4fdd\u5728\u6574\u4e2a\u80bf\u7624\u4f53\u79ef\u5185\u83b7\u5f97\u5747\u5300\u4e14\u751f\u7269\u6709\u6548\u7684\u70ed\u5242\u91cf\u3002\u6570\u636e\u8fd8\u8868\u660e\uff0cHT \u7684\u83b7\u76ca\u53ef\u6839\u636e\u98ce\u9669\u5206\u5c42\uff0c\u5728\u9ad8\u8010\u836f\u73af\u5883\u4e2d\u6700\u4e3a\u660e\u663e\uff0c\u4f8b\u5982\u590d\u53d1\u6027\u75be\u75c5\u3001\u9ad8\u5371\u8089\u7624\u6216 BCG \u96be\u6cbb\u6027 NMIBC\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3. \u6709\u524d\u666f\u7684\u9002\u5e94\u75c7\u548c\u672a\u6765\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/span><\/h3>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3.1. \u80f0\u817a\u764c<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6bd4\u8f83\u89c2\u5bdf\u6570\u636e\u8868\u660e*\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u4e2d\u8c03\u5236\u5c04\u9891\u70ed\u7597 (mHT) + CHT \u7684\u4e2d\u4f4d OS \u589e\u52a0\u4e00\u500d\uff08\u4ece 9 \u4e2a\u6708\u589e\u52a0\u5230 20 \u4e2a\u6708\uff09\uff0c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u5f3a\u70c8\u7684\u4e34\u5e8a\u4fe1\u53f7\u3002*\u8fd9\u4e9b\u7ed3\u679c\u9700\u8981\u7d27\u6025\u542f\u52a8\u56fd\u9645\u968f\u673a III \u671f\u8bd5\u9a8c\uff08\u4f8b\u5982 NCT02862015\uff09\uff0c\u4ee5\u5728\u6700\u9ad8\u8bc1\u636e\u6c34\u5e73\u4e0a\u786e\u8ba4\u8fd9\u4e9b\u603b\u4f53\u751f\u5b58\u76ca\u5904\u3002<\/span><\/span><\/p>\n<h4><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.3.2. \u4e0e\u514d\u75ab\u80bf\u7624\u5b66\u7684\u6574\u5408<\/span><\/span><\/h4>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7531\u4e8eHT\u901a\u8fc7\u91ca\u653eHSP\u548c\u542f\u52a8T\u7ec6\u80de\uff0c\u5c06\u514d\u75ab\u5b66\u4e0a\u201c\u51b7\u201d\u7684\u80bf\u7624\u8f6c\u5316\u4e3a\u201c\u70ed\u201d\uff08\u53d1\u708e\uff09\u7684\u80bf\u7624\uff0c\u672a\u6765\u7684III\u671f\u8bd5\u9a8c\u5e94\u63a2\u7d22HT\u4e0e\u73b0\u4ee3\u514d\u75ab\u7597\u6cd5\u836f\u7269\uff08\u4f8b\u5982\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff09\u7684\u534f\u540c\u4f5c\u7528\u3002\u8fd9\u79cd\u7ec4\u5408\u53ef\u4ee5\u589e\u5f3a\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\uff0c\u5c24\u5176\u662f\u5728\u5148\u524d\u96be\u6cbb\u7684\u80bf\u7624\u4e2d\u3002<\/span><\/span><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e34\u5e8a\u7ecf\u9a8c\uff08EEAT\uff09\uff1a<\/span><\/span><\/strong><\/p>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5728 Andromedichyperthermia\uff0c\u6211\u4eec\u5c06\u8fd9\u4e9b 1A \u7ea7\u65b9\u6848\uff08<\/span><\/span><a href=\"https:\/\/andromedichyperthermia.com\/zh-hans\/%e4%b8%b4%e5%ba%8a%e5%92%8c%e8%bd%ac%e5%8c%96%e8%82%bf%e7%98%a4%e5%ad%a6-%e6%99%9a%e6%9c%9f%e8%82%bf%e7%98%a4%e6%b7%b1%e5%ba%a6%e7%83%ad%e7%96%97%e5%92%8c%e6%94%be%e7%96%97%e6%96%b9%e6%a1%88%e7%9a%84\/\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f8b\u5982\u9488\u5bf9 LACC \u7684\u70ed\u7597 + CCRT + BRT \u7ec4\u5408<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09\u4f5c\u4e3a\u62a4\u7406\u6807\u51c6\u8fdb\u884c\u7814\u7a76\uff0c\u5c06\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u8bc1\u5b9e\u7684\u76ca\u5904\u76f4\u63a5\u8f6c\u5316\u4e3a\u6211\u4eec\u60a3\u8005\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u8ba1\u5212\u3002<\/span><\/span><\/strong><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7.4. \u4e34\u5e8a\u5e94\u7528\u6807\u51c6<\/span><\/span><\/h3>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6210\u529f\u5b9e\u65bdHT\u9700\u8981\u591a\u5b66\u79d1\u4e13\u4e1a\u77e5\u8bc6\uff08\u533b\u5b66\u7269\u7406\u5b66\u5bb6\u3001\u653e\u5c04\u80bf\u7624\u5b66\u5bb6\u3001\u5316\u7597\u6cbb\u7597\u5e08\uff09\u5e76\u4e25\u683c\u9075\u5b88\u70ed\u5242\u91cf\u6d4b\u5b9a\u65b9\u6848\u3002\u4e3a\u4e86\u8fbe\u52301A\u7ea7\u7597\u6548\uff0c\u6cbb\u7597\u4e2d\u5fc3\u5fc5\u987b\u9075\u5b88\u7531\u4e13\u4e1a\u7ec4\u7ec7\u5236\u5b9a\u7684\u56fd\u9645\u6307\u5357\u548c\u6807\u51c6\u3002<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8868 4\uff1a\u65b0\u5174\u9002\u5e94\u75c7\u548c II \u671f\/\u89c2\u5bdf\u6027\u6570\u636e\uff08\u751f\u5b58\u7ec8\u70b9\uff09<\/span><\/span><\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u764c\u75c7\u7c7b\u578b\uff08HT \u6cbb\u7597\u65b9\u5f0f\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7814\u7a76\u7c7b\u578b\/\u7ec8\u70b9<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">HT + \u6807\u51c6\u6cbb\u7597 (OS\/PFS\/QoL)<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5355\u72ec\u6807\u51c6\u6cbb\u7597\uff08OS\/PFS\/QoL\uff09<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5173\u952e\u53d1\u73b0\/P\u503c<\/span><\/span><\/strong><\/td>\n<td width=\"104\"><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u53c2\u8003<\/span><\/span><\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u80f0\u817a\u764c\uff08mEHT + CHT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56de\u987e\u6027\u6bd4\u8f83\uff08OS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff1a20\u4e2a\u6708<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff1a9\u4e2a\u6708<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u64cd\u4f5c\u7cfb\u7edf\u663e\u8457\u6539\u5584\uff08\u76f8\u5bf9\u589e\u52a0 77%\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[Fiorentini\u7b49\u4eba\uff0c2021]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u65b0\u8bca\u65ad\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08mEHT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u835f\u8403\u5206\u6790\uff081\u5e74OS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">73%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">37%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u663e\u8457\u7684 OS \u83b7\u76ca (p=0.0021)<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff08<\/span><\/span><a href=\"https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/www.mdpi.com\/2072-6694\/15\/3\/880<\/span><\/span><\/a><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\uff09<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u661f\u5f62\u7ec6\u80de\u7624\uff08mEHT\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u56de\u987e\u6027\u6bd4\u8f83\uff08OS\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff1a72\u4e2a\u6708<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff1a17\u4e2a\u6708<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u64cd\u4f5c\u7cfb\u7edf\u663e\u8457\u6539\u5584\uff08p=0.0006\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[Fiorentini\u7b49\u4eba\uff0c2019]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u76f4\u80a0\u764c\uff08pCR\uff0c\u529f\u80fd\u6027\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b2c\u4e09\u9636\u6bb5\uff08\u65e0\u7ed3\u80a0\u9020\u53e3\u751f\u5b58\u671f\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">87.7%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">69.0%<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u6d3b\u8d28\u91cf\/\u529f\u80fd\u6539\u5584\uff08P=0.016\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">[\u7b2c\u4e09\u9636\u6bb5\uff0c2019\u5e7410\u6708]<\/span><\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5bab\u9888\u764c\uff08LACC\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">RCT\uff08DFS\/\u751f\u6d3b\u8d28\u91cf\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6539\u5584\u60c5\u7eea\/\u8eab\u4f53\u751f\u6d3b\u8d28\u91cf<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u6d3b\u8d28\u91cf\u7a33\u5b9a\/\u4e0b\u964d<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u751f\u6d3b\u8d28\u91cf\u663e\u8457\u6539\u5584\uff0c\u4e14\u6bd2\u6027\u4e0d\u589e\u52a0<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8833695\/\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8833695\/<\/span><\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8179\u819c\u8f6c\u79fb\u7624\uff08HIPEC\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u89c2\u5bdf\u6027\u56de\u987e\uff08\u60c5\u7eea\u751f\u6d3b\u8d28\u91cf\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5feb\u901f\u6062\u590d\uff08\u672f\u540e3\u4e2a\u6708\uff09<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7f13\u6162\u6062\u590d<\/span><\/span><\/td>\n<td width=\"104\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5feb\u901f\u7684\u5fc3\u7406\u6548\u76ca<\/span><\/span><\/td>\n<td width=\"104\"><a href=\"https:\/\/dmr.amegroups.org\/article\/view\/6846\/html\" target=\"_blank\" rel=\"noopener\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">https:\/\/dmr.amegroups.org\/article\/view\/6846\/html<\/span><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">8. \u80bf\u7624\u70ed\u7597\u5e38\u89c1\u95ee\u9898 (FAQ)<\/span><\/span><\/h2>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1a\u70ed\u7597\u662f\u80bf\u7624\u5b66\u4e2d\u7684\u4e00\u79cd\u5b9e\u9a8c\u6027\u6cbb\u7597\u65b9\u6cd5\u5417\uff1f<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b54\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e0d\u662f\u3002\u70ed\u7597 (HT) \u662f\u4e00\u79cd\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u62e5\u6709*1A \u7ea7\u8bc1\u636e*\uff08\u57fa\u4e8e III \u671f\u968f\u673a\u8bd5\u9a8c\u548c\u835f\u8403\u5206\u6790\uff09\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u4e3b\u8981\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u4f8b\u5982\uff1a\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u5bab\u9888\u764c\u3001\u590d\u53d1\u6027\u4e73\u817a\u764c\u3001\u6076\u6027\u9ed1\u8272\u7d20\u7624\u3001\u76f4\u80a0\u764c\u3001\u8180\u80f1\u764c\u548c\u5934\u9888\u90e8 (HNC) \u80bf\u7624\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1a\u70ed\u7597\u7684\u6700\u4f73\u64cd\u4f5c\u6e29\u5ea6\u662f\u591a\u5c11\uff1f<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b54\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6700\u4f73\u64cd\u4f5c\u6e29\u5ea6\u8303\u56f4\u4e3a*39\u00b0C \u81f3 45\u00b0C*\u3002\u8fd9\u4e2a\u201c\u6cbb\u7597\u7a97\u53e3\u201d\u5e76\u975e\u65e8\u5728\u76f4\u63a5\u6467\u6bc1\uff08\u6d88\u878d\uff09\uff0c\u800c\u662f\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u764c\u7ec6\u80de\u5bf9\u5316\u7597\u548c\u653e\u7597\u7684\u751f\u7269\u589e\u654f\u4f5c\u7528\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1a\u70ed\u7597\u4f1a\u589e\u52a0\u5316\u7597\u6216\u653e\u7597\u7684\u6bd2\u6027\u5417\uff1f<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b54\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\"> III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5206\u6790\u8bc1\u5b9e\uff0c\u52a0\u7528\u70ed\u7597*\u4e0d\u4f1a\u663e\u8457\u589e\u52a0\u4e25\u91cd\u5168\u8eab\u6bd2\u6027\uff083-4\u7ea7\uff09*\u3002\u4e0e\u70ed\u7597\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3b\u8981\u5c40\u9650\u4e8e\u5c40\u90e8\uff0c\u4e14\u6613\u4e8e\u63a7\u5236\uff08\u4f8b\u5982\u8f7b\u5ea6\u76ae\u80a4\u53cd\u5e94\uff09\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1a\u70ed\u7597\u5982\u4f55\u6539\u5584\u653e\u5c04\u6cbb\u7597\uff1f<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b54\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9ad8\u6e29\u901a\u8fc7\u4e24\u79cd\u5173\u952e\u673a\u5236\u53d1\u6325\u5f3a\u6548\u653e\u5c04\u589e\u654f\u5242\u7684\u4f5c\u7528\uff1a*1)* \u5b83\u6291\u5236\u88ab\u8f90\u5c04\u635f\u574f\u7684 DNA \u4fee\u590d\u673a\u5236\uff0c*2)* \u5b83\u6539\u5584\u8840\u6db2\u6d41\u52a8\u548c\u80bf\u7624\u6c27\u5408\uff0c\u4f7f\u5148\u524d\u5177\u6709\u6297\u6027\u7684\u7ec6\u80de\u5bf9\u8f90\u5c04\u66f4\u52a0\u654f\u611f\u3002<\/span><\/span><\/p>\n<h3><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u95ee\uff1a\u54ea\u4e9b\u7c7b\u578b\u7684\u764c\u75c7\u6700\u53d7\u76ca\u4e8e\u70ed\u7597\uff1f<\/span><\/span><\/h3>\n<p><strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7b54\uff1a<\/span><\/span><\/strong><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u6839\u636e 1A \u7ea7\u8bc1\u636e\uff0c\u5df2\u8bc1\u660e\u5bf9\u4ee5\u4e0b\u75be\u75c5\u5177\u6709\u751f\u5b58\u76ca\u5904\uff1a*\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u5bab\u9888\u764c\u3001\u590d\u53d1\u6027\u4e73\u817a\u764c\u3001\u6076\u6027\u9ed1\u8272\u7d20\u7624\u3001\u76f4\u80a0\u764c\u3001\u8180\u80f1\u764c\u548c HNC\u3002*<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5f15\u7528\uff08\u5f15\u7528\u6587\u672c\u4fdd\u6301\u539f\u6837\uff09<\/span><\/span><br \/>\n<span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">1. \u5c40\u90e8\u533a\u57df\u4e2d\u5ea6\u70ed\u7597\u5728\u764c\u75c7\u8f85\u52a9\u6cbb\u7597\u4e2d\u7684\u5f53\u524d\u4e34\u5e8a\u8bc1\u636e\u56de\u987e\uff0chttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9856725\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">2. \u5168\u6587\uff1a\u80bf\u7624\u70ed\u7597\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7cfb\u7edf\u8bc4\u4ef7 &#8211; Taylor &amp; Francis Online\uff0chttps:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2022.2076292<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">3. \u70ed\u7597\u3001\u653e\u7597\u548c\u5316\u7597\uff1a\u70ed\u7597\u5728\u591a\u5b66\u79d1\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\u3002- Jefferson Digital Commons\uff0chttps:\/\/jdc.jefferson.edu\/cgi\/viewcontent.cgi?article=1070&amp;context=radoncfp<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">4. \u5168\u6587\uff1a\u70ed\u7597\u4e0e\u514d\u75ab\u7597\u6cd5\uff1a\u4e34\u5e8a\u673a\u9047 &#8211; Taylor &amp; Francis Online\uff0chttps:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2019.1653499<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">5. \u70ed\u7597\u53ef\u51cf\u5c11\u764c\u7ec6\u80de\u4fb5\u88ad\u5e76\u5bf9\u6297\u4eba\u7c7b\u8180\u80f1\u764c\u7684\u5316\u5b66\u8010\u836f\u6027\u548c\u514d\u75ab\u9003\u907f &#8211; PMC\uff0chttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11575926\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">6. \u4e2d\u5371\u975e\u808c\u8089\u4fb5\u5165\u6027\u60a3\u8005\u70ed\u7597\u4e1d\u88c2\u9709\u7d20C&#8230;\uff0chttps:\/\/pubmed.ncbi.nlm.nih.gov\/36435738\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">7. \u5faa\u73af\u70ed\u704c\u6ce8\u4e1d\u88c2\u9709\u7d20C\u8180\u80f1\u5316\u7597\uff08HIVEC\uff09\u4e0eBCG\u6cbb\u7597\u9ad8\u5371\u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c\u7684\u7597\u6548\u6bd4\u8f83\uff0chttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8994727\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">8. \u5168\u6587\uff1aHIVEC \u5bf9\u7981\u5fcc\u4f7f\u7528 BCG \u7684\u9ad8\u5371\u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c\u60a3\u8005\u548c BCG \u6cbb\u7597\u5931\u8d25\u60a3\u8005\u7684\u7597\u6548 &#8211; Taylor &amp; Francis Online\uff0chttps:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02656736.2021.2002435<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">9. \u80bf\u7624\u6cbb\u7597\u573a\u4e0e\u70ed\u7597\u76f8\u7ed3\u5408\uff0c\u901a\u8fc7\u4e0b\u8c03 STAT3 \u5bf9\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7ec6\u80de\u4ea7\u751f\u534f\u540c\u6cbb\u7597\u4f5c\u7528 &#8211; PubMed Central\uff0chttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8984886\/<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">10. \u8c03\u5236\u7535\u70ed\u7597\u548c\u80bf\u7624\u6cbb\u7597\u573a\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6cbb\u7597\u4e2d\u7684\u835f\u8403\u5206\u6790 &#8211; MDPI\uff0chttps:\/\/www.mdpi.com\/2072-6694\/15\/3\/880<\/span><\/span><\/p>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">11.\u8c03\u63a7\u7535\u70ed\u7597\u6cd5\u5728\u590d\u53d1\u6027\u6076\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u661f\u5f62\u7ec6\u80de\u7624\u7efc\u5408\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\uff1a\u56de\u987e\u6027\u591a\u4e2d\u5fc3\u5bf9\u7167\u7814\u7a76\uff0c\u56de\u987e\u6027\u7814\u7a76\uff0c\u4f5c\u8005\uff1a<\/span><\/span><\/p>\n<div class=\"entry-content\">\n<div class=\"container\">\n<div class=\"acf-fields \">\n<div class=\"publ-acf acf-row acf-flex\">\n<div class=\"szerzok\"><span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5b\u7f57\u4f26\u8428 G<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u8428\u5c14\u8482 D<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u7c73\u5170\u5fb7\u91cc C<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4e39\u8482\u79d1 P<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u66fc\u5e03\u91cc\u5c3c A<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u4f5b\u7f57\u4f26\u8428 C<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u9a6c\u8482\u5965\u5229 G<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u5361\u8428\u5fb7<\/span><\/span><\/span>\u00a0<span class=\"sz-nev\"><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">\u74dc\u8fbe\u5c3c S<\/span><\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><span dir=\"auto\" style=\"vertical-align: inherit;\"><span dir=\"auto\" style=\"vertical-align: inherit;\">12. \u76ee\u524d\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u8c03\u5236\u7535\u70ed\u7597\u6cd5\u7684\u7406\u89e3 -\uff1bKosin Medical Journal\uff0chttps:\/\/www.kosinmedj.org\/journal\/view.php?number=1294<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6743\u5a01\u4e0e\u4e13\u4e1a (EEAT)\uff1a \u7531\u533b\u5b66\u535a\u58eb Veronica Iatan\u548c\u7406\u5b66\u7855\u58eb Cristian Gologa&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[863,119,21],"tags":[355],"class_list":["post-11187","post","type-post","status-publish","format-standard","hentry","category-studii-clinice-zh-hans","category-119","category-21","tag-iii-oscr"],"gutentor_comment":0,"_links":{"self":[{"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/posts\/11187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=11187"}],"version-history":[{"count":0,"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/posts\/11187\/revisions"}],"wp:attachment":[{"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=11187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=11187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/andromedichyperthermia.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=11187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}