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News :
Impact of Hyperthermia on Quality of Life (QoL): Pain Relief, Fatigue Reduction, and Adjuvant Immunological Benefits Hyperthermia and Survival of Cancer Patients: Clinical Evidence Demonstrating an Increase in Overall Survival (OS) by Over 50% Therapeutic Integration of Hyperthermia in Modern Oncology: A Critical Analysis of Phase III Trials and Meta-Analyses (OS, DFS, CR Endpoints) Quasi feasibility study(case control) associating deep local hyperthermia treatment with standard cancer treatments and describing patterns of response ESHO Preliminary results of chemoradiation plus hyperthermia and high dose rate brachytherapy for locally advanced cervical carcinoma ESHO
Clinical Research on Amplitude Modulated RF Hyperthermia (mHT)
The Andromedic HyDeep 600WM advanced oncologic hyperthermia device is a cornerstone in targeted modulated RF-hyperthermia therapy for cancer. Explore compelling clinical trials, ESHO posters, and peer-reviewed results validating the therapeutic benefits of locoregional hyperthermia as a potent radiosensitizer and chemosensitizer in oncology.
Evidence-Based Advantages of HyDeep 600WM modulated RF hyperthermia system mHT:
- Synergistic Efficacy: Enhances tumor response rates when combined with radiotherapy and chemotherapy.
- Survival Outcomes: Demonstrated increase in Overall Survival (OS) for glioblastoma and cervical cancers.
- Safety Profile: Proven feasibility with no recorded grade 3-4 toxicities in featured trials.
- Deep Tissue Penetration: Effective thermal distribution in target organs up to 38.4 cm in depth.
Featured Clinical Trials with HyDeep 600WM Advanced Oncologic Hyperthermia Device
Clinical and Translational Oncology: Feasibility for Advanced Tumors
Background: Prospective study (EudraCT 2018-001089-40) assessing the safety of deep local hyperthermia concomitant with radiotherapy using the HyDeep 600WM RF hyperthermia device at 13.56 MHz.
“Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment. 86.8% of cases received all planned sessions.”
Quasi Feasibility Study (Case-Control) – deep local hyperthermia device (HyDeep 600WM) & standard cancer treatment
ESHO Poster: Patterns of Response – hyperthermia system (HyDeep 600WM) & chemo/radiotherapy
Locally Advanced Cervical Carcinoma (LACC)
Outcome: All cancer patients achieved local control. Combined weekly cisplatin, modulated RF hyperthermia device(HyDeep 600WM), and brachytherapy showed no grade 3-4 toxicity.
Deep Regional Hyperthermia in Combination with Whole Brain Radiotherapy (WBRT)
Abstract: Assessed for the first time the role of regional deep hyperthermia for cancer patients with poor prognosis brain metastases (GPI≤2.5).
Results: Tolerance was excellent and no toxicity was registered. Patients with HT effective treatment time longer than the median showed better actuarial PFS at 6 and 12 months.
Conclusions: Deep hyperthermia seems to be easier and safe to administer than complicated intraoperative treatments. Median overall survival OS was improved to 6 months.Read Full Text – Andromedic hyperthermia for Brain Metastases – Clinical Trial
Results: Tolerance was excellent and no toxicity was registered. Patients with HT effective treatment time longer than the median showed better actuarial PFS at 6 and 12 months.
Conclusions: Deep hyperthermia seems to be easier and safe to administer than complicated intraoperative treatments. Median overall survival OS was improved to 6 months.Read Full Text – Andromedic hyperthermia for Brain Metastases – Clinical Trial
Additional Clinical Research on Modulated RF Hyperthermia (mHT)
Modulated RF hyperthermia (mHT) as adjuvant, neoadjuvant, and palliative therapy to support oncological pathologies is a subject of extensive research.
Extensive research has been conducted using amplitude modulated RF-hyperthermia in conjunction with various chemoradiation, immunotherapies, or as stand-alone/palliative treatment.
Expert Insight – Prof. Dr. Giammaria Fiorentini:
Hyperthermia – Recent Clinical Trials Results and Case Reports (Rome, 2023 Presentation)
Clinical Validation of mHT – Recent Review (2023)
Recommended reading – Dr. Veronica Iatan:
- Impact of Hyperthermia on Quality of Life (QoL): Pain Relief, Fatigue Reduction, and Adjuvant Immunological Benefits
- Hyperthermia and Survival of Cancer Patients: Clinical Evidence Demonstrating an Increase in Overall Survival (OS) by Over 50%
- Therapeutic Integration of Hyperthermia in Modern Oncology: A Critical Analysis of Phase III Trials and Meta-Analyses (OS, DFS, CR Endpoints)
Scientific Papers: Hyperthermia Research
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Regional hyperthermia combined with radiotherapy for cervical cancers: a prospective multi-institutional randomized trial by the International Atomic Energy Agency
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A novel strategy of radiofrequency hyperthermia (neothermie) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study
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Immune-related effects of local hyperthermia in patients with primary liver cancer
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Reirradiation plus regional hyperthermia for recurrent non-small cell lung cancer: a potential modality for inducing long-term survival in selected patients
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8 MHz radiofrequency capacitive regional hyperthermia radiotherapy for stage III non-small cell lung cancer: radiofrequency power output correlates with intraesophageal temperature and clinical outcomes
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Deep regional hyperthermia for the entire thoracic region using an 8MHz radiofrequency capacitive heating device: Relationship between RF output power and intra-esophageal temperature (59 patients)
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Hyperthermia combined with chemotherapy for patients with residual or recurrent esophageal cancer after definitive chemoradiotherapy
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Definitive radiotherapy plus regional hyperthermia with or without chemotherapy for superior sulcus tumors: a 20-year, single-center experience
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Feasibility study of postoperative intraperitoneal hyperthermochemotherapy using a radiofrequency capacitive heating system for advanced gastric cancer with peritoneal seeding
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Quality Assurance Guide for Clinical Trials of Superficial Hyperthermia (I & II)
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Effect of tumor properties on energy absorption, temperature mapping, and thermal dose in 13.56 MHz radiofrequency hyperthermia
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Hyperthermia combined with radiotherapy in locally advanced recurrent or metastatic disease
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The utility of movable insulating plates for optimizing the deep heating area for regional hyperthermia using a capacitively coupled heating method
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Locoregional hyperthermia of deep tumors applied with capacitive and radiative systems: a simulation study
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Bevacizumab-based chemotherapy combined with deep regional capacitive hyperthermia in patients with metastatic cancer: a pilot study
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A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia
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Quality Assurance: Recommended Guidelines for Safe Heating by Capacitive Heating Technique for Treating Patients with Metallic Implants
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Thermo-chemo-radiotherapy for advanced biliary tract carcinoma
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Numerical model for deep regional RF capacitive hyperthermia in pelvic tumors
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Capacitive hyperthermia appears to improve pain response during palliative radiotherapy of painful bone metastases
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Preliminary results of chemoradiation plus hyperthermia and high-dose rate brachytherapy for locally advanced cervical carcinoma
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Feasibility of local deep hyperthermia treatment in combination with standard cancer treatments and response patterns
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Quasi-feasibility study (case-control) associating deep local hyperthermia treatment with standard cancer treatments and describing the response pattern