News :
Impact of Hyperthermia on Quality of Life (QoL): Pain Relief, Fatigue Reduction, and Adjuvant Immunological Benefits Hyperthermia and Survival of Cancer Patients: Clinical Evidence Demonstrating an Increase in Overall Survival (OS) by Over 50% Therapeutic Integration of Hyperthermia in Modern Oncology: A Critical Analysis of Phase III Trials and Meta-Analyses (OS, DFS, CR Endpoints) Quasi feasibility study(case control) associating deep local hyperthermia treatment with standard cancer treatments and describing patterns of response ESHO Preliminary results of chemoradiation plus hyperthermia and high dose rate brachytherapy for locally advanced cervical carcinoma ESHO

Cutting-Edge 13.56 MHz RF Modulation Protocol: ASK-OOK + Specific RFs

The Andromedic HY-DEEP 600WM advanced RF-hyperthermia device boasts a series of cutting-edge, high-quality, and innovative technological features, making it a unique solution in the oncological hyperthermia market.

Thermal Modulation System (TMS): ASK-OOK and Specific RFs

This sophisticated oncologic hyperthermia equipment utilizes a highly complex RF modulation protocol designed to deliver precise and effective hyperthermia therapy. The TMS protocol uses ASK-OOK (Amplitude-Shift Keying – ON-OFF Keying) combined with specific RFs, a technology considered more advanced than random noise modulation protocols found in other 13.56 MHz mHT devices.

I. 13.56 MHz RF Modulated with RadioFrequencies Specific for Each Pathology

The mHT device utilizes specific RF modulation protocols tailored according to:

  • • Cancer type and location: Specific hyperthermia protocols for both deep and shallow tumors.
  • • Patient’s weight & height.
  • • Distance between electrodes.
  • • ~22 amplitude modulations per hour.
Video: Andromedic HyDeep 600WM: Specific Protocols for Each Cancer Type.

Non-Oncological Integration: The advanced hyperthermia device also integrates specific protocols for pathologies including inflammation, pain (including Lyme disease), endometriosis, fibrosis, benign tumors, polyps, hepatopathy, pancreatitis, prostate/uterine pathologies, cervical adenomas, and myomas.

Theoretical & Clinical Advantages: Tumor-Specific RFs vs. Random Noise in Modulated RF Hyperthermia

Theoretically, employing tumor-specific frequencies for modulation (as explored in some clinical studies on amplitude-modulated electromagnetic fields – AM-EMF) could offer superior advantages compared to using a general “random noise” as implemented in some RF hyperthermia devices.

Key Differences and Theoretical Arguments:

1. Specificity vs. Broad Spectrum:

  • Tumor-specific frequencies (e.g., AM-EMF): These are premised on the idea that cancer cells possess unique “resonances” or vulnerabilities to very precise electromagnetic frequencies. The aim is to achieve extremely specific and efficient targeting of malignant cells without significantly affecting healthy cells.
  • “Random Noise”: Many devices use a 13.56 MHz carrier frequency modulated with a “random noise” signal. The mechanism relies on induced energy absorption based on higher electrical conductivity in tumor cells.

2. Non-Thermal vs. Combined Mechanism of Action:

  • AM-EMF or similar: One focus is on non-thermal effects (proliferation, gene expression) through interaction with the EM field at specific frequencies, added to the thermal effect.
  • Random noise modulation devices: Combine thermal effect with the non-thermal effects of the modulated electric field to induce apoptosis.
The Theoretical Argument for Specific Radio Frequencies: If it’s confirmed that precise frequencies can disrupt vital functions (akin to a “mortal oscillatory rate”), then targeted application leads to greater efficacy and minimal toxicity to healthy tissues.

Clinical Research with Tumor-Specific RF / Amplitude Modulated Electromagnetic Fields:

• Targeted treatment of cancer with RF fields amplitude-modulated at tumor-specific frequencies
• Discovery of tumor-specific frequencies and assessment of a novel therapeutic approach
• Metastatic Colon Cancer – Effective Treatment Protocol Including RIFE frequencies
• Treatment of advanced hepatocellular carcinoma with amplitude-modulated EMF
• Pancreatic Cancer Case Report – RIFE Frequencies
• European Journal of Clinical Cancer Research: Assessment of AM-EMF
• Cancer cell proliferation is inhibited by specific modulation frequencies
• Targeted treatment of cancer at tumor-specific frequencies (CJC)

Definitive clinical evidence directly comparing the superiority of one over the other is still accumulating, and rigorous comparative studies are needed to draw firm conclusions.

II. Additional ASK-OOK Modulation: High Intensity Electromagnetic Impulses (“PEMF”)

The Andromedic HyDeep 600WM modulated RF HyperThermia device is capable of generating high-intensity electromagnetic (im)pulses programmed to persist over time with ASK (Amplitude-Shift Keying) modulation in OOK (ON-OFF Keying) mode.

This modality provides three critical operational advantages:

    • Enhanced Power: Allows for more power delivery than in continuous mode.
    • Stress Adaptation Prevention: Prevents cancer cells from adapting to electromagnetic stress.
    • Thermal Wash-out: Allows healthy cells to wash out heat during the “OFF” mode.

This approach amplifies biological effects and, crucially, offers the possibility of transmitting biological information to the involved tissues or organisms.

The synergy of these effects produces:

  • Vasodilation while limiting dissemination of malignant cells (ref).
  • Deep hyperthermia: mHT RF 13.56 MHz penetrates deep into tissues up to 38.4 cm; showing better effects than cCHT 8MHz (ref).
  • Joule effect of fever: Deep tissue temperature increase.

Advanced Biological Achievements via ASK Modulation

  • Stimulation of gene expression.
  • Variations in protein synthesis.
  • Permeability variations and ionic displacement.
  • Changes in oxygenation of tumor and adjacent tissue.
  • Release of cytokines that stimulate the arrival of leukocytes to the heated area.
  • Immunogenic effects: TME (Tumor Micro Environment) modulation, DAMP, and ICD (Immunogenic Cell Death) (ref).
  • Drug Amplification: Enhancing effects of drugs specific to the resonance of membranes, DNA, organelles, and pathogens (viruses/bacteria).

Comparison: Advanced RF Modulation vs. Other 13.56 MHz mHT Devices

Standard 13.56 MHz RF modulation
Standard 13.56 MHz RF
ASK-OOK Modulation Graph Andromedic
Andromedic ASK-OOK Protocol
Final modulated RF Waveform
Final Modulated RF Waveform
HyDeep 600WM Device Comparison Matrix
Device Comparison Matrix

Resonant Frequency Principle

  • The modulating frequencies are cellular resonant frequencies (following the principle of oscillation stimulation- in this case cells or their parts, has its own oscillation frequency that, if stimulated by an external source oscillating at the same frequency, will amplify its effects.).
  • The modulating frequencies in OOK mode aim to necrotize tumor cells in various stages (similar to PEMF technology).

Simultaneous Multiple Therapeutic Effects

  • Hyperthermic and Electromagnetic effect.
  • Cell bio-resonance treatment.
  • Homogeneous heat diffusion.

Unlock the Potential of Cellular Bio-Resonance

The Hy-Deep 600WM advanced oncologic hyperthermia device aims to necrotize tumor cells using resonant radio frequencies delivered via high intensity electromagnetic impulses similar to advanced PEMF technology.

CONTACT US FOR TECHNICAL SPECIFICATIONS